• 한국군사과학기술학회지
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• 제22권4호
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• pp.460-466
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• 2019

It takes a lot of time and human resources to build a detailed three-dimensional finite element analysis model that is almost similar to the actual structure for sophisticated analysis, and a lot of experience and know-how is required to form a reliable analytical model. In this paper, the one-dimensional beam model connected by stiffness matrix through blade analysis library was compared with the results of three-dimensional analysis with the stress calculated through the process of dimensional restoration analysis based on the principle of virtual work. By comparing the stress calculated through dimensional restoration analysis with the three-dimensional analytical model, We will introduce the development status and application case of the blade analysis library by comparing efficiency and accuracy.

• Journal of Power Electronics
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• 제19권2호
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• pp.353-362
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• 2019

To address the problem of circulating current loss in the traditional zero-current switching (ZCS) full-bridge (FB) DC/DC converter, a ZCS FB DC/DC converter topology and modulation strategy is proposed in this paper. The strategy can achieve ZCS turn on and zero-voltage and zero-current switching (ZVZCS) turn off for the primary switches and realize ZVZCS turn on and zero-voltage switching (ZVS) turn off for the auxiliary switches. Moreover, its resonant circuit power is small. Compared with the traditional phase shift full-bridge converter, the new converter decreases circulating current loss and does not increase the current stress of the primary switches and the voltage stress of the rectifier diodes. The diodes turn off naturally when the current decreases to zero. Thus, neither reverse recovery current nor loss on diodes occurs. In this paper, we analyzed the operating principle, steady-state characteristics and soft-switching conditions and range of the converter in detail. A 740 V/1 kW, 100 kHz experimental prototype was established, verifying the effectiveness of the converter through experimental results.

• 한국기계가공학회지
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• 제20권12호
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• pp.8-15
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• 2021

Cold forging is a method in which molding is performed at room temperature. It has a high material recovery rate and dimensional precision and produces excellent surface quality, and it is mainly used for the production of bolted or housing products. The lifespan of cold forging molds is generally determined by the wear of the mold, plastic deformation of the mold, and fatigue strength. Cold forging molds are frequently damaged due to fatigue destruction rather than wear and plastic deformation in a high-temperature environment as it is molded at room temperature without preheating the raw material and mold. Based on the results analyzed through FEM, an effective mold structure design method was proposed by analyzing the changes in tensile and compressive stresses on molds according to the number of molds and reinforcement rings and comparing the product geometry and mold stress using three existing mold models.

• Structural Engineering and Mechanics
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• 제88권6호
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• pp.583-588
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• 2023

Total hip replacement is a crucial intervention for patients with fractured hips who face challenges in natural recovery. The design of durable prostheses requires a comprehensive understanding of the natural processes occurring in bone. This article focuses on static loading analysis, specifically during stumbling activity, aiming to enhance the longevity of prosthetic implants. Three distinct implants, Charnley, Osteal, and Thompson, were selected for a detailed study to determine the most appropriate model. The results revealed critical insights into the distribution of Von Mises stresses on the components of femoral arthroplasty, including the cement, implant, and cortical bone. Furthermore, the examination of shear stress within the cement emerged as a pivotal aspect for all three implants, playing a crucial role in evaluating the performance and durability of hip prostheses. The conclusions drawn from this study strongly suggest that the Thompson model stands out as the most suitable choice for hip joint implants.

• 한국산학기술학회논문지
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• 제18권9호
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• pp.322-333
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• 2017

본 연구는 응급의료종사자의 수면의 질이 스트레스와 직무만족도에 미치는 영향을 알아보고자 K도와, C도에 소재한 종합병원 응급의료센터에서 교대 근무하는 응급의료종사자 209명을 대상으로 2015년 3월 1일부터 6월 30일까지 조사하였다. 수집된 자료는 Windows용 SPSS 20.0을 사용하여 빈도분석, 요인분석과, Cronbach's ${\alpha}$ 분석, 기술통계와 상관관계, 다중회귀 분석을 실시하였다. 연구결과는 다음과 같다. 첫째, 수면의 질과 스트레스, 직무만족도의 요인 간에는 유의한 상관관계가 있었다. 둘째, 수면의 질은 신체적 스트레스와 심리적 스트레스에 영향을 미치는 것으로 나타났다(p<.001). 셋째, 수면의 질이 직무만족도에 영향을 미치는 것으로 나타났다. 수면 후 회복, 잠들기 어려움, 일어나기 어려움, 수면유지 어려움이 직무만족에 유의한 영향을 미쳤다. 넷째, 심리적 스트레스는 직무만족도에 부분적으로 영향을 미치는 것으로 나타났다(p<.01). 본 연구결과로 볼 때 수면의 질을 향상시키기 위한 적절한 인력의 확충을 도모하고 응급의료종사자의 업무 외 적정의 수면시간을 보장하며 신체적 스트레스와 심리적 스트레스 감소를 위한 직장 내 표준화된 프로그램을 개발하여 직원들의 직무만족도를 높이기 위해 다양하고 전문적인 제도적 방안이 필요할 것으로 사료된다.

• 대한지역사회영양학회지
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• 제23권4호
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• pp.289-301
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• 2018

Objectives: The aim of this study was to examine the current status of consumption of energy drinks among college students and investigate the effects of general environmental factors, health behavior factors, caffeine knowledge levels, and perceived stress levels on consumption of energy drinks. Methods: A survey was conducted among a total of 479 college students in Gwangju, using self-administered questionnaires. The questionnaire consisted of items about general environmental factors, health behavior, caffeine knowledge, perceived stress, and energy drink consumption behaviors. Results: 69.1% of participants experienced consumption of energy drinks, and specifically 82.8% of male students and 54.1% of female students experienced consumption of energy drinks (p<0.001). The reasons for drinking energy drinks were found to be recovery from fatigue, curiosity, taste, habit, thirst relief, and stress relief. In addition, 40.7% of participants experienced drinking energy drinks mixed with alcohol, and specifically 48.6% of male students and 27.4% of female students reported drinking energy drinks with alcohol (p<0.001). Moreover, 51.5% of participants responded that they experienced the effects of energy drinks, 31.9% reported experiencing adverse effects, and 41.1% were found to perceive the health risks. As a result of the assessment of caffeine knowledge, the participants showed a high level of knowledge of the arousal effect (77.7%) and the concentration increasing effect (70.8%) of caffeine, whereas they exhibited a low level of understanding of the health problems due to caffeine (32.6%) and adequate caffeine intake levels (24.4%). The higher levels of consumption experience of energy drinks was associated with higher body mass indexes (BMI) (p<0.01), higher academic years (p<0.01), lower levels of interest in health (p<0.05), smoking (p<0.001), alcohol consumption (p<0.05), and higher levels of perceived stress (p<0.05). Conclusions: The risk groups related to consumption of energy drinks among college students were identified as male students rather than female students, students in the third or fourth year of study associated with increased stress levels, and students with negative health behaviors. Therefore, support for diverse health and nutrition education for college students is required along with the improvement of internal and external environments of schools in order for college students to manage increased stress levels due to the schoolwork and preparation for employment and maintain positive health behaviors.

• Molecules and Cells
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• 제37권11호
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• pp.833-840
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• 2014

Cullin4-RING ubiquitin ligase (CRL4) is a family of multi-subunit E3 ligases. To investigate the possible involvement of CRL4 in heat stress response, we screened T-DNA insertion mutants of putative CRL4 substrate receptors that exhibited altered patterns in response to heat stress. One of the mutants exhibited heat stress tolerance and was named heat stress tolerant DWD1 (htd1). Introduction of HTD1 gene into htd1-1 led to recovery of heat sensitivity to the wild type level, confirming that the decrease of HTD1 transcripts resulted in heat tolerance. Therefore, HTD1 plays a negative role in thermotolerance in Arabidopsis. Additionally, HTD1 directly interacted with DDB1a in yeast two-hybrid assays and associated with DDB1b in vivo, supporting that it could be a part of a CRL4 complex. Various heat-inducible genes such as HSP14.7, HSP21, At2g03020 and WRKY28 were hyper-induced in htd1-1, indicating that HTD1 could function as a negative regulator for the expression of such genes and that these genes might contribute to thermotolerance of htd1-1, at least in part. HTD1 was associated with HSP90-1, a crucial regulator of thermotolerance, in vivo, even though the decrease of HTD1 did not affect the accumulation pattern of HSP90-1 in Arabidopsis. These findings indicate that a negative role of HTD1 in thermotolerance might be achieved through its association with HSP90-1, possibly by disturbing the action of HSP90-1, not by the degradation of HSP90-1. This study will serve as an important step toward understanding of the functional connection between CRL4-mediated processes and plant heat stress signaling.

• Laboraroty Animal Research
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• 제34권4호
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• pp.288-294
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• 2018

A few clues about correlation between endoplasmic reticulum (ER) stress and mulberry (Morus alba) leaves were investigated in only the experimental autoimmune myocarditis and streptozotocin-induced diabetes. To investigate whether a novel extract of mulberry leaves fermented with Cordyceps militaris (EMfC) could suppress ER in fatty liver, alterations in the key parameters for ER stress response were measured in high fat diet (HFD)-induced obese C57L/6 mice treated with EMfC for 12 weeks. The area of adipocytes in the liver section were significantly decreased in the HFD+EMfC treated group as compared to the HFD+Vehicle treated group, while their level was higher in HFD+Vehicle treated group than No treated group. The level of the eukaryotic initiation factor 2 alpha ($eIF2{\alpha}$) and inositol-requiring enzyme 1 beta ($IRE1{\alpha}$) phosphorylation and CCAAT-enhancer-binding protein homologous protein (CHOP) expression were remarkably enhanced in the HFD+Vehicle treated group. However, their levels were restored in the HFD+EMfC treated group, although some differences were detected in the decrease rate. Similar recovery was observed on the ER stress-induced apoptosis. The level of Caspase-3, Bcl-2 and Bax were decreased in the HFD+EMfC and HFD+orlistat (OT) treated group compared to the HFD+Vehicle treated group. The results of the present study therefore provide first evidence that EMfC with the anti-obesity effects can be suppressed ER stress and ER stress-induced apoptosis in the hepatic steatosis of HFD-induced obesity model.

• The Korean Journal of Pain
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• 제35권4호
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• pp.423-432
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• 2022

Background: The decreased expression of mu-opioid receptors (MOR) in the amygdala may be a key molecular in chronic post-surgical pain (CPSP). It is known that miR-339-5p expression in the amygdala of a stressed rat model was increased. Analyzed by RNAhybrid, miR-339-5p could target opioid receptor mu 1 (oprm1) which codes MOR directly. So, the authors hypothesized that miR-339-5p could regulate the expression of MOR via targeting oprm1 and cause the effects to CPSP. Methods: To simulate perioperative short-term stress, a perioperative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception rat model was built. A pmiR-RB-REPORT^TM dual luciferase assay was taken to verify whether miR-339-5p could act on oprm1 as a target. The serum glucocorticoid level of rats was test. Differential expressions of MOR, GFAP, and pERK1/2 in each group of the rats' amygdala were tested, and the expressions of miR-339-5p in each group of rats' amygdalas were also measured. Results: Perioperative stress prolonged the recovery time of incision pain. The expression of MOR was down-regulated in the amygdala of rats in stress + incision (S + IN) group significantly compared with other groups (P < 0.050). miR-339-5p was up-regulated in the amygdala of rats in group S + IN significantly compared with other groups (P < 0.050). miR-339-5p acts on oprm1 3'UTR and take MOR mRNA as a target. Conclusions: Perioperative stress could increase the expression of miR-339-5p, and miR-339-5p could cause the expression of MOR to decrease via targeting oprm1. This regulatory pathway maybe an important molecular mechanism of CPSP.

• 지질공학
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• 제32권4호
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• pp.643-659
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• 2022

최근 지중저장기술(예, 온실가스 심지층 처분, 인공지열저류층 발전 등)이 활발히 수행됨에 따라, 유체 주입과 저장부지 안정성 사이의 역학적 관계에 관한 정량적 이해의 중요성이 인지되고 있다. 지중 유체 주입은 공극압 및 지중응력 교란과 지층의 역학적 불안정성을 야기할 수 있어, 유체 주입에 대한 다공탄성 수치 모형 구축이 요구된다. 본 연구에서는 순차적인 COMSOL-PyLith-COMSOL 유체 주입-유발지진 다공탄성 수치 모사를 수행한다. 유한요소 상용 소프트웨어인 COMSOL을 이용해 단층에 가해지는 쿨롱 파괴 응력(CFS) 변화를 시간에 따라 추적하였고, CFS 변화량이 임계값(예, 0.1 MPa)을 초과할 경우, 모형의 정보(기하구조, 물성 등)를 유한요소 오픈소스 코드인 PyLith로 이동시키는 알고리즘을 구축했다. PyLith는 단층의 미끄러짐을 모사하고, 미끌림에 의한 변위장을 획득한다. 이후 변위장을 COMSOL로 이동시켜 지진에 의한 응력 및 표면 변위를 계산한다. 수치 모사 결과, 주입 기간 중엔 주입정 근거리에서 큰 변화(공극압, CFS 변화 등)를 보였고, 주입 종류 후에는 잔류 응력이 원거리 영역으로 확산하는 양상이 나타났다. 이는 주입 종료 후 지속적인 모니터링의 필요성을 제안한다. 또한, 단층과 주입층 물성(예, 투수계수, Biot-Willis 계수)에 따른 CFS 변화량 비교는 주입정 위치 선정 시 주입층 및 주변 지층에 대한 물성 파악이 중요함을 의미한다. 단층 미끄러짐 양에 따른 표면 변위 및 이암층에 가해지는 편차응력은 다양한 단층 미끌림 시나리오 설정의 필요성을 지시한다.