• The Journal of Korean Academy of Prosthodontics
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• v.45 no.2
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• pp.263-273
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• 2007

Statement of problem: Alteration of tooth function is assumed to be changed by stress/strain on the adjacent alveolar bone, producing changes in morphology similar to those described for other load-bearing bones. When teeth are removed, opposing teeth will not be functioned. When edentulous area is restored by implant prostheses, opposing teeth will be received physiologic mechanical stimuli. Purpose: The aim of this study was to evaluate the bone changes around the teeth opposing implant restoration installed mandibular posterior area. Material and method: Eight patients who had mandibular posterior edentulous area were treated with implants. Radiographs of the opposing teeth were taken at implant prostheses delivery(baseline), 3 months, and 6 months later. Customized film holding device was fabricated to standardize the projection geometry for serial radiographs of opposing teeth. Direct digital image was obtained. Gray values of region of interest at each digital image were measured and compared according to time lapse. Repeated measured analysis of variance and post-hoc Scheffe's test were performed at the 95% significance level. Results: Alveolar bone changes around the natural teeth opposing the posterior implant in mandible showed statistically significant difference compared to control group(P<0.05). And gray values of alveolar bone around the teeth opposing implants were increased. There were no statistically significant differences of alveolar bone changes between crestal group and middle group and between mesial group and distal group according to time lapse(P>0.05). There were no statistically significant differences of alveolar bone changes among mesial-crestal group, mesial-middle group, distal-crestal group, distal-middle group, and control group(P>0.05). Conclusion: Alveolar bone around the natural teeth opposing the implant prosthesis showed gradual bony apposition.

• Journal of the Korean Institute of Landscape Architecture
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• v.36 no.4
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• pp.100-110
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• 2008

The purposes of the study were to analyze the effects of determinants and persuasive messages on the willingness-to-pay cultural & heritage assets' admission fees. Recently visitors have responded to a nationwide boycott of the fees within national parks due to feelings of disapproval and resentment. Data were collected through onsite surveys of 302 visitors in the Mt. Gyeryong National Park. Regression analysis and two-way ANOVA were employed to obtain the results. The results indicate that credit card payment was the most prominent predictor of willingness-to-pay at the .05 level. The second highest coefficient was obtained in the condition levying of admission fees and parking fees at the same time, providing temple interpretive services, followed by free days for everyone on special days each month. In addition, the most persuasive message was the descriptive content, which stated that fees were profoundly committed to the protection of the cultural heritage for future generations. As a result, it is effective to continually persuade visitors to use posters or reminders that stress the preservation of cultural assets at the entrance gate.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.5
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• pp.275-282
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• 2005

By using differential display, we identified one of the genes encoding the multi-subunit complex protein V-ATPase, c subunit gene (ATP6L), and showed alterations of the gene expression by oxidative stresses. Expression of the ATP6L gene in Neuro-2A cells was increased by the treatment with $H_2O_2$ and incubation in hypoxic chamber, implying that the expression of the ATP6L gene is regulated by oxidative stresses. To examine mechanisms involved in the regulation of the gene expression by oxidative stresses, the transcriptional activity of the rat ATP6L promoter was studied. Transcription initiation site was determined by primer extension analysis and DNA sequencing, and promoter of the rat ATP6L and its deletion clones were constructed in reporter assay vector. Significant changes of the promoter activities in Neuro-2A cells were observed in two regions within the proximal 1 kbp promoter, and one containing a suppressor was in -195 to -220, which contains GC box that is activated by binding of Sp1 protein. The suppression of promoter activity was lost in mutants of the GC box. We confirmed by electrophoretic mobility shift and supershift assays that Sp1 protein specifically binds to the GC box. The promoter activity was not changed by the $H_2O_2$ treatment and incubation in hypoxic chamber, however, $H_2O_2$ increased the stability of ATP6L mRNA. These data suggest that the expression of the ATP6L gene by oxidative stresses is regulated at posttranscriptional level, whereas the GC box is important in basal activities of the promoter.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.16 no.3
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• pp.339-346
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• 2018

A geological repository system consists of a disposal canister with packed spent fuel, buffer material, backfill material, and intact rock. The buffer is indispensable to assure the disposal safety of high-level radioactive waste. Since the heat generated from spent nuclear fuel in a disposal canister is released to the surrounding buffer materials, the thermal properties of the buffer material are very important in determining the entire disposal safety. Especially, since thermal expansion can cause thermal stress to the intact rock mass in the near-field, it is very important to evaluate thermal expansion characteristics of bentonite buffer materials. Therefore, this paper presents a thermal expansion coefficient prediction model of the Gyeongju bentonite buffer materials which is a Ca-bentonite produced in South Korea. The linear thermal expansion coefficient was measured considering heating rate, dry density and temperature variation using dilatometer equipment. Thermal expansion coefficient values of the Gyeongju bentonite buffer materials were $4.0{\sim}6.0{\times}10^{-6}/^{\circ}C$. Based on the experimental results, a non-linear regression model to predict the thermal expansion coefficient was suggested and fitted according to the dry density.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.9
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• pp.5683-5692
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• 2014

This study examined the correlation among the Korean language ability, health promotion behaviors and health status of immigrant women by marriage. Data on the subjects of 148 immigrant women were collected from September to December, 2013. Constructed self-administered questionnaires were used to gather information on the general characteristics of the immigrant women, their Korean language ability, health promotion behaviors and emotional health status. The health examination results of the subjects were used for information on their health status. There were significant differences in the Korean language reading ability, drinking habits, total cholesterol and body mass index between the diseased group and the intact group. An analysis of the relationship between the Korean language ability and health conditions revealed a significant positive correlation between the total cholesterol and neutral fat, but negative correlations between the density of hemoglobin and the total cholesterol, the neutral fat and body mass index. There was a significant negative correlation between the Korean language ability and the level of stress. Based on these results, a program was suggested and developed to decrease the rate of drinking, cholesterol and body mass index of immigrant women and to promote their ability to understand health information and express their diseases properly in the Korean language.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.77-84
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• 2017

Recently, interest in safety has been increasing in every area, especially in the field of transportation. The accurate evaluation of the stability of road facilities is needed to improve the level of safety in the field of transportation and the application of new technologies is required to reduce the number of natural disasters. In this study, the wind data were compared and analyzed according to the type of measurement, and an evaluation of the stability of road signs using the wind data was conducted. In addition, a stability plan to secure road signs was elaborated and its effect on the wind load was analyzed. It was found that the wind data measured by a mobile atmospheric observing system (MAOS) was 2.43 times bigger than that measured by the Korea meteorological administration (KMA) and road weather information system (RWIS). In terms of their stability, the road signs were susceptible to failure caused by gusty winds and it was found necessary to ensure their stability. In the future, it will be possible to evaluate the stability of road facilities using road line weather data and the application of wind load reduction technologies is expected to improve road safety.

• The Journal of the Korea Contents Association
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• v.4 no.4
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• pp.45-51
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• 2004

The number of development in educational software is currently decreasing despite rapid improvement in computer technology. This is partly due to the fact that the current software relies on the conventional hypermedia method or on the hierarchical method, both of which have inherent limitations. To compensate their limitations while keeping their merits, a hybrid method called the structured hypermedia link method has recently been proposed in the literature. It has been found that the structured hypermedia link method is far superior than the conventional methods in terms of educational effectiveness because it can help a learner to search various data by navigating between the study topics on his own while maintaining his level of cognitively overloaded stress to the minimum. The clinical microbiology laboratories were chosen as the candidate site for this study because its educational system has not been standardized and has been relying heavily on the personal experience. In this study, the hypermedia link method was applied to the development of an education system for the image analysis in clinical microbiology laboratories. For this purpose, a web-based computer aided instruction(CAI) program was designed to systematically organize the Gram stain method based on the standardized image data. In the future, CAI program must be intended to educate for beginner and developed to accept for variable knowledge. And it will be useful program for technicians in case of applying various examinations based Gram stain method of this study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.4
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• pp.293-300
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• 2018

The purpose of this study is to investigate the educational needs for career development according to the job type of nursing college students. In order to achieve the purpose of the study, 146 nursing college students from K and P universities in the Busan and Kyungnam areas were analyzed using a career anchor questionnaire. In addition, 28 nursing college students who showed a higher level of tendency among job types were selected and divided into 4 teams, and a focus group interview was conducted based on the contents of the created map. Its purpose is to investigate the educational needs of nursing college students to enhance their career development. First, the career anchor types of the nursing college students showed the highest score in the areas of lifestyle, security and stability, while the lowest types of career anchor were pure challenge and general managerial competence. Second, the educational needs for career development were categorized into four areas, namely major competence, practical competence, personality competence, and resource management competence. The major competences are nursing expertise and skills. The practical competences consisted of ward task management, communication, crisis coping ability and personality competence and these were divided into cooperation and responsibility recognition. The resource management competence consists of time management ability and stress management ability. The results of this study are meaningful in that they can be used as the basic educational data for the career development of nursing college students in the future. In addition, it is expected that they can be applied to the development of a curriculum for the improvement of nursing practice.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2707-2712
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• 2015

Background: The human homologue of the mouse double minute 2 (MDM2) gene is a negative regulator of Tp53. MDM2-309T>G a functional promoter polymorphism was found to be associated with overexpression thereby attenuation of Tp53 stress response and increased cancer susceptibility. We have planned to evaluate the possible role of MDM2-309T>G polymorphism with risk and response to chemotherapy in AML. Materials and Methods: A total of 223 de novo AML cases and 304 age and sex matched healthy controls were genotyped for the MDM2-309T>G polymorphism through the tetra-primer amplification refractory mutation system (ARMS)-PCR method. In order to assess the functional relationship of -309T>G SNP with MDM2 expression level, we quantified MDM2 mRNA in 30 primary AML blood samples through quantitative RT-PCR. Both the (-309T>G) genotypes and the MDM2 expression were correlated with disease free survival (DFS) rates among patients who have achieved complete remission (CR) after first induction chemotherapy. Results: MDM2-309T>G polymorphism was significantly associated with AML development (p<0.0001). The presence of either GG genotype or G allele at MDM2-309 confered 1.79 (95% CI: 1.12-2.86; p<0.001) and 1.46 fold (95%CI: 1.14-1.86; p= 0.003) increased AML risk. Survival analysis revealed that CR+ve cases with GG genotype had significantly increased DFS rates (16months, p=0.05) compared to CR+ve TT (11 months) and TG (9 months) genotype groups. Further, MDM2 expression was also found to be significantly elevated in GG genotype patients (p=0.0039) and among CR+ve cases (p=0.0036). Conclusions: The MDM2-309T>G polymorphism might be involved in AML development and also serve as a good prognostic indicator.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.23 no.2
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• pp.217-225
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• 2010

Most of the steel bridges in Korea are being currently designed by the allowable stress design method that uses the conventional deterministic factors of safety. However the limit state design based on the concept of probability, statistics and reliability engineering is becoming very popular as a global standard deign method, leading the rational and economic bridge design. As part of the fundamental research to establish the load and resistance factor design(LRFD) of steel bridges considering domestic environmental conditions and regional characteristics, an experimental design is conducted by applying AASHTO-LRFD specification especially to a steel closed-box girder, which occupies relatively a large portion of steel bridges in Korea. Throughout the experimental design according to various sectional changes, some of the issues to be considered in the LRFD design of a composite steel closed-box girder bridge are examined. In this process, an Excel-based design verification program is developed for easy computation and prevention of errors. Quantitative reliability levels of the bridge sections designed by LRFD are also estimated using a reliability analysis method, and compared with the target reliability indexes applied in the LRFD design to verify the validity of the procedure and methodology used in this study.