• Biomolecules & Therapeutics
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• v.4 no.2
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• pp.162-166
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• 1996

This study was done to investigate whether cholic acid derivatives have anti-stress activity and what is a cause of this anti-stress effect. Seven cholic acid derivatives (cholic acid, taurocholic acid, ursodeoxycholic acid, tauroursodeoxychoic acid, chenodeoxy cholic acid, dehydrocholic acid, hyodeoxycholic acid) were used, silymarin and valproic acid were used as positive controls. Stress was induced by restraint immobilization technique plus water immersion (24hrs) and adrenal weight, spleen weight, adrenal ascorbic acid, serum cholesterol, lactate dehydrogenase (LDH), alkaline phosphatase (ALP), adrenal cholesterol, glucose and corticosterone levels were measured as stress indicators. Most cholic acid derivatives markedly decreased the adrenal weight, and TUDCA and DHCA increased the spleen weight. The restraint stress induced increments in serum LDH, ALP and cholesterol were attenuated by most cholic acid derivatives. Cholic acid, taurocholic acid and tauroursodeoxycholic acid only increased the content of adrenal ascorbate. While valproic acid showed an inhibitory effect against stress, silymarin did not. Our findings suggest that most cholic acid derivatives have anti-stress effect and that their anti-stress effect is, in part, related to choleretic activity.

• Structural Engineering and Mechanics
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• v.33 no.1
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• pp.67-77
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• 2009

The soil response calculation is described, by which, threw the fictive path of stress, the stress-deformation diagrams are determined, considering the nonlinear soil behavior. The calculation are lead incrementally, by which is shown that in the presented soil model (modified Cam Clay), considering the influence of overconsolidated soil pressure OCR, the number of calculation steps may, but not necessarily, have a sufficient influence on the value of failure load and definite soil deformation. The simplicity and the practicalness of the procedure, the enables modeling the complex relations in soil.

• Geomechanics and Engineering
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• v.22 no.6
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• pp.553-564
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• 2020

In this study, a simple numerical approach for a circular tunnel opening in strain-softening surrounding rock is proposed considering out-of-plane stress and seepage force based on Biot's effective stress principle. The plastic region of strain-softening surrounding rock was divided into a finite number of concentric rings, of which the thickness was determined by the internal equilibrium equation. The increments of stress and strain for each ring, starting from the elastic-plastic interface, were obtained by successively incorporating the effect of out-of-plane stress and Biot's effective stress principle. The initial value of the outmost ring was determined using equilibrium and compatibility equations. Based on the Mohr-Coulomb (M-C) and generalized Hoek-Brown (H-B) failure criteria, the stress-increment approach for solving stress, displacement, and plastic radius was improved by considering the effects of Biot's effective stress principle and the nonlinear degradation of strength and deformation parameters in plastic zone incorporating out-of-plane stress. The correctness of the proposed approach is validated by numerical simulation.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.30 no.7 s.250
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• pp.826-832
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• 2006

For the improvement of safety and endurance in welded steel structure, it is needed to consider welding residual stress distribution and rolling directional characteristics of materials. In this study, it was investigated experimentally about characteristics of fatigue crack propagation according to welding residual stress and rolling in FCAW(flux cored arc welding) butt-jointed steel plates. SS400 steel plates of 3mm thickness were selected and tested for this study. When the angles between tensile loading direction and rolling direction in welded materials are increased from $0^{\circ}\;to\;90^{\circ}$, their fatigue crack propagation rates are increased. These results are same as predicted increments of fatigue crack propagation rate when stress ratio is increased from 0 to 0.5. When the angles of rolling direction and welding direction to tensile loading direction are $0^{\circ}\;and\;90^{\circ}$ respectively, fatigue crack propagation rate in welded material is lowest.

• Geotechnical Engineering
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• v.14 no.4
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• pp.129-140
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• 1998

Elasto-plastic finite element analysis of geotechnical boundary value problems necessitate the stress integration for the known strain increments. For the elasto-plastic constitutive model, the stress integration is generally achieved by numerical schemes, because analytical integration is impossible for general strain path. In this case, the accuracy of numerical stress integration has an important role on the overall accuracy of nonlinear finite element solution. In this study, the Sloan's substepping method which is one of explicit integration methods has been adopted and iris applicability has been checked. The unstability and inaccuracy of ifs results initiated from initial stress level were revealed. So. a new modified numerical integration method which employs the basic concept of modified Euler scheme for error control is proposed and accuracy and stability of the solutions are confirmed by triaxial test simulation.

• Structural Engineering and Mechanics
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• v.18 no.5
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• pp.591-607
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• 2004

The substance of the use of the derived non-linear creep constitutive equations under variable stress levels (see first part of the paper, Kmet 2004) is explained and the strategy of their application is outlined using the results of one-step creep tests of the steel spiral strand rope as an example. In order to investigate the creep strain increments of cables an experimental set-up was originally designed and a series of tests were carried out. Attention is turned to the individual main steps in the production and application procedure, i.e., to the one-step creep tests, definition of loading history, determination of the kernel functions, selection and definition of constitutive equation and to the comparison of the resulting values considering the product and the additive forms of the approximation of the kernel functions. To this purpose, the parametrical study is performed and the results are presented. The constitutive equations of non-linear creep of cable under variable stress history offer a strong tool for the real simulation of stochastic variable load history and prediction of realistic time-dependent response (current deflection and stress configuration) of structures with cable elements. By means of suitable stress combination and its gradual repeating various loads and times effects can be modelled.

• Structural Engineering and Mechanics
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• v.35 no.3
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• pp.283-299
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• 2010

This paper addresses the numerical simulation of fatigue crack growth in arbitrary 2D geometries under constant amplitude loading by the using a new finite element software. The purpose of this software is on the determination of 2D crack paths and surfaces as well as on the evaluation of components Lifetimes as a part of the damage tolerant assessment. Throughout the simulation of fatigue crack propagation an automatic adaptive mesh is carried out in the vicinity of the crack front nodes and in the elements which represent the higher stresses distribution. The fatigue crack direction and the corresponding stress-intensity factors are estimated at each small crack increment by employing the displacement extrapolation technique under facilitation of singular crack tip elements. The propagation is modeled by successive linear extensions, which are determined by the stress intensity factors under linear elastic fracture mechanics (LEFM) assumption. The stress intensity factors range history must be recorded along the small crack increments. Upon completion of the stress intensity factors range history recording, fatigue crack propagation life of the examined specimen is predicted. A consistent transfer algorithm and a crack relaxation method are proposed and implemented for this purpose. Verification of the predicted fatigue life is validated with relevant experimental data and numerical results obtained by other researchers. The comparisons show that the program is capable of demonstrating the fatigue life prediction results as well as the fatigue crack path satisfactorily.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.6
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• pp.939-943
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• 2007

Two experiments were conducted to determine the lysine requirement of straight-run broiler chickens ($Hubbard{\times}Hubbard$) during the period 4-21 (Exp. 1) and 21-40 (Exp. 2) days of age. Experiments were conducted during the summer months (June-August) in open-sided houses, thus exposing chicks to chronic heat stress. Daily min-max temperature averaged $28-40^{\circ}C$ (Exp. 1) and $28-36^{\circ}C$ (Exp. 2). Lysine deficient basal diets were formulated to contain low-nutrient-density, i.e., 2,700 kcal per kg ME, 18.6% CP (Exp. 1), and 2,750 kcal per kg ME, 17.1% CP (Exp. 2), to mimic typical commercial broiler diets used in Pakistan. Diets were supplemented with L-lysine HCl to provide total lysine level ranging from 0.85 to 1.10% (six increments) and 0.72 to 1.02% (six increments), respectively in Exp. 1 and 2. Live performance data were subjected to quadratic analysis and requirement was defined as the level achieving 95% of maximum or minimum values. Lysine requirements were found to be 0.98 and 0.97% total lysine, respectively, for gain and feed efficiency during 4-21 days, and 0.87% total lysine for both gain and feed efficiency during 21-40 days of age. Calculated on a digestible lysine basis, the estimates were 0.85 and 0.84%, respectively, for gain and feed efficiency during 4-21 days of age; and 0.75% for gain and feed efficiency during 21-40 days of age.

• Journal of the Society of Naval Architects of Korea
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• v.34 no.1
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• pp.68-76
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• 1997

The welding-induced initial imperfections such as residual stresses and initial strains in plated structures of ships and offshore structures can be effectively evaluated by the thermal elasto-plastic analysis method proposed in this paper. In the analysis of heat conduction of plate structures, both the analytical method and the numerical method are used. For the thermal elasto-plastic analysis of plates, the finite element analysis is performed, based on the initial strain method. In the plastic domain during incremental process, the 2nd order terms of stress increments and yield stress increments were considered, so that time increment could be controlled for more stable solution. To measure temperature distribution and angular distortion of plates during welding, bead-on-plate experiment are perform with various heat input and plate thickness. Measured data show good agreement with the calculated results.

• International Journal of Concrete Structures and Materials
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• v.10 no.4
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• pp.425-434
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• 2016

In this experimental study, six post-tensioned light weight concrete (LWC) continuous one-way slabs were tested in the following manner: the flexural behaviors of the members were compared with the calculations from the existing standards. The test also examined the effect of prestressing in tendons and proper prestress conditions to reduce the deflection and crack width, and to enhance the flexural capacity and ductility of LWC members. Flexural capacity and stress increments in unbonded tendons of the specimens were compared with those of the simply supported normal and the lightweight concrete members. The suggested safety limit from the American Concrete Institute (ACI) regulation on the maximum capacity and the stress incremental in unbonded tendons were also compared with the test results under simple and continuous supporting conditions.