• Structural Engineering and Mechanics
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• v.14 no.1
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• pp.99-118
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• 2002

The scaled-boundary finite element method is a novel semi-analytical technique, combining the advantages of the finite element and the boundary element methods with unique properties of its own. The method works by weakening the governing differential equations in one coordinate direction through the introduction of shape functions, then solving the weakened equations analytically in the other (radial) coordinate direction. These coordinate directions are defined by the geometry of the domain and a scaling centre. This paper presents a general development of the scaled boundary finite-element method for two-dimensional problems where two boundaries of the solution domain are similar. Unlike three-dimensional and axisymmetric problems of the same type, the use of logarithmic solutions of the weakened differential equations is found to be necessary. The accuracy and efficiency of the procedure is demonstrated through two examples. The first of these examples uses the standard finite element method to provide a comparable solution, while the second combines both solution techniques in a single analysis. One significant application of the new technique is the generation of transition super-elements requiring few degrees of freedom that can connect two regions of vastly different levels of discretisation.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.8
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• pp.1458-1467
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• 1992

Recently, the composite materials have been researched actively by many researchers because of its useful properties. Especially, an interface crack on the dissimilar material exposes the behavior of the mixed mode crack even though under only the tension stress. In the previous papers, crack energy density(CED) was shown as the crack behavior evaluation parameter which can be expressed consistently from the onset until a final fracture. In a present paper, the basic properties of CED on the interface crack are examined because the results by CED at the homogeneous material above are also expected to be held at the dissimilar material. And we proposed that the contribution of each mode of CED can be separated and be evaluated. Furthermore, the total CED and contribution of each mode are evaluated by domain integral through a finite element analysis at the elastic crack model and the basic examination are carried out.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.5
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• pp.799-804
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• 2015

This study aims at the new analysis of heart beat fluctuations by applying physiological Heart Rate Variability Model with representing the cardiac control system in sympathetic and parasympathetic-coupling oscillator constants, C_s and C_p. To find the effects of coupling constants on the beat-to-beat fluctuations, Integral Pulse Frequency Modulation (IPFM) model is adopted to generate the time series data of ECG R-peaks and represent them by poincaré scattergram plot in the time domain and HRV in the frequency domain, respectively. The actual poincaré plots and HRV spectrum are also analyzed by acquiring the experimental data from the subjects exposed to the emotional-stress invoking environment and the function of the coupling constants are verified in terms of antagonism in sympathetic and parasympathetic activity.

• Molecules and Cells
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• v.37 no.1
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• pp.43-50
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• 2014

Jumonji domain-containing proteins (JMJD) catalyze the oxidative demethylation of a methylated lysine residue of histones by using $O_2$, ${\alpha}$-ketoglutarate, vitamin C, and Fe(II). Several JMJDs are induced by hypoxic stress to compensate their presumed reduction in catalytic activity under hypoxia. In this study, we showed that an H3K27me3 specific histone demethylase, JMJD3 was induced by hypoxia-inducible factor (HIF)-$1{\alpha}/{\beta}$ under hypoxia and that treatment with Clioquinol, a HIF-$1{\alpha}$ activator, increased JMJD3 expression even under normoxia. Chromatin immunoprecipitation (ChIP) analyses showed that both HIF-$1{\alpha}$ and its dimerization partner HIF-$1{\beta}$/Arnt occupied the first intron region of the mouse JMJD3 gene, whereas the HIF-$1{\alpha}/{\beta}$ heterodimer bound to the upstream region of the human JMJD3, indicating that human and mouse JMJD3 have hypoxia-responsive regulatory regions in different locations. This study shows that both mouse and human JMJD3 are induced by HIF-1.

• Geomechanics and Engineering
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• v.9 no.6
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• pp.793-813
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• 2015

Characterization of discontinuous media is an endeavor that poses great challenge to engineers in practice. Since the inherent defects in cracked domains can substantially influence material resistance and govern its behavior, a lot of work is dedicated to efficiently model such effects. In order to overcome difficulties of material instability problems, one needs to comprehensively represent the geometry of cracks along with their impact on the mechanical properties of the intact material. In the present study, stress-strain results from laboratory experiments on Inada granite was used to derive crack tensor as a tool for the evaluation of fractured domain stability. It was found that the formulations proposed earlier could satisfactorily be employed to attain crack tensor via the invariants of which judgment on cracks population and induced anisotropy is possible. The earlier criteria based on crack tensor analyses were reviewed and compared to the results of the current study. It is concluded that the geometrical parameters calculated using mechanical properties could confidently be used to judge the anisotropy as well as strength of the cracked domain.

• Geomechanics and Engineering
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• v.24 no.6
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• pp.545-557
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• 2021

Since the functionally graded materials (FGMs) are used extensively as thermal barriers in many of applications. Therefore, the current article focuses on studying and presenting dynamic responses of multilayer functionally graded (FG) deep beams placed in a thermal environment that is not addressed elsewhere. The material properties of each layer are proposed to be temperature-dependent and vary continuously through the height direction based on the Power-Law function. The deep layered beam is exposed to harmonic sinusoidal load and temperature rising. In the modelling of the multilayered FG deep beam, the two-dimensional (2D) plane stress continuum model is used. Equations of motion of deep composite beam with the associated boundary conditions are presented. In the frame of finite element method (FEM), the 2D twelve-node plane element is exploited to discretize the space domain through the length-thickness plane of the beam. In the solution of the dynamic problem, Newmark average acceleration method is used to solve the time domain incrementally. The developed procedure is verified and compared, and an excellent agreement is observed. In numerical examples, effects of graduation parameter, geometrical dimension and stacking sequence of layers on the time response of deep multilayer FG beams are investigated with temperature effects.

• Parasites, Hosts and Diseases
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• v.59 no.2
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• pp.173-178
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• 2021

The DM9 domain is a protein unit of 60-75 amino acids that has been first detected in the fruit fly Drosophila as a repeated motif of unknown function. Recent research on proteins carrying DM9 domains in the mosquito Anopheles gambiae and the oyster Crassostrea gigas indicated an association with the uptake of microbial organisms. Likewise, in the trematode Fasciola gigantica DM9-1 showed intracellular relocalization following microbial, heat and drug stress. In the present research, we show that FgDM9-1 is a lectin with a novel mannose-binding site that has been recently described for the protein CGL1 of Crassostrea gigas. This property allowed FgDM9-1 to agglutinate gram-positive and -negative bacteria with appropriate cell surface glycosylation patterns. Furthermore, FgDM9-1 caused hemagglutination across all ABO blood group phenotypes. It is speculated that the parenchymal located FgDM9-1 has a role in cellular processes that involve the transport of mannose-carrying molecules in the parenchymal cells of the parasite.

• Journal of Korean Clinical Nursing Research
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• v.15 no.3
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• pp.143-155
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• 2009

Purpose: This study was conducted to develop and evaluate the collaborate transitional care program for improving continuity of care in patients transferred to general wards from ICUs. Methods: 18 years and older who were hospitalized in adult intensive care units at A university affiliated medical center was recruited for the study. The experimental group for patients transferred from an ICU consisted of 33 patients and family caregivers; 34 patients and family caregivers for the control group. This study was utilized a quasi-experimental research design. The collaborative transitional care program was administered in transfer process. Data were collected two times by interviews, medical records, and telephone using questionnaires. Results: There were statistically significant differences between the two groups on relocation stress (p<.001), perceived health status (p<.001), satisfaction of caring (p=.011), physical domain (p=.022) and mental domain (p<.001) of the QOL. There were significant differences between the families of the two groups on burden (p<.001) and satisfaction of caring (p<.001). Conclusion: The collaborative transitional care programs administered in transfer process to general wards from an ICU have positive effects on patients and families' intrinsic and extrinsic factors. This program will be able to be utilized in clinical fields to improve continuity of care for patients and families between ICUs and general wards.

• Journal of Family Resource Management and Policy Review
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• v.16 no.4
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• pp.171-194
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• 2012

This study focuses on immigrant women who are married to Korean men and who live in a multicultural family situation in Gyeonggi-do. These women experience acculturative stress and marital conflict and this study aims to determine how social support seeks to mediate the effects of those stressors. The women in this study participated in activities and received services from one of Gyeonggi-do Province's civic organizations, religious organizations, or social service organizations, such as the Social Welfare Agency and the Multicultural Family Support Center. In order to verify the study's hypothesis, the researchers used the following statistical analytical methods : t-test, two-way ANOVA and multi-regression analysis. Analysis of the study's results showed that the highest degree of marital conflict was found in the sub-zones and variables that were personal. Those variable were : the difference in mindset and values (personal domain), economic problems (communal living area), a child's upbringing and education issues (third party area), and the participant's sex life (in the marital relationship). The hypothesis was tested using the research model validation and the results are summarized as follows. First, in order to analyze the relationship between the marriage migration females' acculturative stress and the impact of that stress on marriage conflict, the hierarchical regression analysis was used. It identified that a direct correlation existed between acculturative stress and marriage conflict; where a higher degree of acculturative stress was present, a higher degree of marriage conflict was found. Second, the study found a statistical significance in the correlation and relationship (${\beta}$=.208, p<0.05) between the acculturative stress of the marriage migration female and material support. In other words, the material support can be seen as having a moderating effect on the acculturative stress, which is the independent variable, and the marital conflict, which is the dependent variable.

• Journal of the Society of Naval Architects of Korea
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• v.49 no.4
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• pp.350-358
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• 2012

This paper deals with accuracy of accumulated fatigue damage estimation using stochastic fatigue analysis method based on Rayleigh PDF. From full scale measurement data on an 8100TEU container vessel, zero-order spectral moments for wave- and vibration-induced energy spectral densities are determined on the probability level of 99%. 80 simulation cases in total are prepared according to the variation of ratio of zero-order spectral moments and center frequency of vibration ESD. By using inverse Fourier transformation and rainflow cycle counting for the combined ESD of wave and vibration, exact fatigue damages are derived. Fatigue damages in frequency domain based on Rayleigh PDF show large conservativeness compared to exact fatigue damages in times domain. The main cause of the excessive conservativeness is analyzed by two aspects: ratio of zero crossing and peak frequencies and ratio of initial zero order spectral moments and zero order spectral moments from rainflow stress range distributions. Finally, a guideline of applicability of Rayleigh PDF is proposed for wide band processes.