• Journal of Korean Society of Industrial and Systems Engineering
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• v.31 no.1
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• pp.32-40
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• 2008

According to the statistic of industrial disaster in 2006 presented by the Ministry of Labor, there were 10,235 people with occupational diseases adding 2,740 more people (36.6%) compared to the previous year. Concerning the occupational diseases, 1,607 people had brain-cardiovascular diseases comprising more than 15% of all occupational diseases, and excessive workload and occupational stress seemed to play important parts. According to Korean Society of Occupational Stress, among 7,000 workers at 254 businesses in Korea, 73% of them were reported to be exposed to potential occupational stress and 22% of them were reported to be under severe stress. The increase of occupational stress among workers comes from excessive competition caused by business restructuring, promotion competition, annual salary system and so forth. Occupational stress threatens the heath and even the life of workers and lowers business competitiveness. Using the Korean occupational stress reduction model to the workers at small and medium businesses in Incheon area, therefore, the project intends to measure the level of stress among office workers and examine its relatedness to the VTD subjective symptoms. In addition, the project intends to present some methods to reduce occupational stress and increase business efficiency at work by studying and analyzing the various elements that workers use to reduce their occupational stress.

• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.395-401
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• 2023

Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.

• Korean Journal of Adult Nursing
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• v.21 no.6
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• pp.639-651
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• 2009

Purpose: This study examined relationships among stress, stress coping strategies, and somatization in mothers-in-law from multi-cultural families in a rural area. Methods: Elderly mothers-in-law (n=227) living with foreign daughters-in-law completed a self-reporting questionnaire. Data were collected from April to August 2009. Questions related to stress (Visual Analog Scale, VAS), coping strategies (Coping Strategy Scale) for stress, and somatization (Symptom Check List 90, Revised). SPSS/WIN 12.0 program was used for descriptive analysis, t-test, one-way ANOVA, Pearson correlation, and multiple regression analyses. Results: Subjects had a moderate level of stress (5.03). There were significant differences in stress level according to age, educational level, religion, chronic disease, health status, number of children, agreement of an international marriage of her sons, satisfaction in living with a foreign daughter-in-law, and family conflict. Stress showed a significant positive correlation with offensive coping strategy, passive strategy, and somatization. Stress, offensive coping strategy, and passive coping strategy affected the level of somatization. Conclusion: In a family situation involving co-habitation of mother- and foreign daughter-in-law, increased stress experienced by the mother-in-law can lead to increased offensive and passive coping strategies, and increased somatization. More effective means of stress reduction are needed for mothers-in-law from multi-cultural families.

• Biomolecules & Therapeutics
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• v.11 no.4
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• pp.249-256
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• 2003

Pyroligneous liquid(PL) is produced by carbonizing Oak in 350-40$0^{\circ}C$. It is traditionally used for treating stress-related disorder, hepatic disease, immune disorder, G-I disorder and inflammatory disease. The aim of this study is to investigate anti-stress effects of PL. The experiments were performed with the use of young(9 weeks of age) male rats of SD strain and the male ICR mice (20-25 g). Animals of the normal group were not exposed to any stress and the control group were exposed to stress. The rats of the Ginseng, diazepam(BZ) and PL supplementary group were orally administered once a day 100 g of Ginseng extract-kg body weight, 5 mg of BZ/kg body weight and 1 ml of PL100 g body weight and then exposed to stress. The mice of the Ginseng, BZ and PL supplementary group were given water containing 100 g of Ginseng extract/100 ml potable water, 5 mg of BZ/kg 100 ml of drinking water and 10 ml of PL/100 ml of drinking water and exposed to stress. Animals were given materials for 7 days after stabilizing them, and then were given supplementary materials for 5 days with stress. They were stressed by immobilization for 30 minutes and then the animals were exposed to electroshocks for 5 minutes. We recorded stress-related behavioral changes of experimental animals by stressing them using the Etho-vision system and measured the levels of corticosterone in blood While stress suppressed locomotor activity of animals, PL-supplementation partially blocked the stress effect of locomotion in rats and mice, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, smelling and rearing activity in rats and freezing, grooming, tailing and rearing in mice. The staying time of stressed rats and mice in open area decreased and in closed area it increased relatively in elevated plus maze test. However, these changes also partially were blocked by PL-supplementation. PL-supplementation decreased levels of blood corticosterone increased by stress in rats. These results suggest that PL protects partially the living organism from stress attack in some cases.

• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.698-708
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• 2017

Objectives: The aim of this study was to report the clinical effects of a combination of Gamiguibi-tang and sweet bee venom on a patient with Raynaud's disease. Methods: The patient with Raynaud's disease was treated with Gamiguibi-tang three times a day for 43 days and with sweet bee venom daily. The effects on Raynaud's disease were measured on both hands using a cold stress test and an infrared thermometer and by digital infrared thermographic imaging and a NRS (Numeric Rating Scale). We conducted the cold stress test at 6-8 day intervals from 2016.04.27 to 2016.06.08. Results: After treatment, the symptoms of pain were decreased in both hands and digital infrared thermographic imaging (DITI) confirmed a rise in the temperature of the fingers. The fingertip temperature increased from 29.6 to 30.4 degrees and the cooling/rewarming ratio (CRR) increased steadily. No adverse events were found at discharge. Conclusions: Gamiguibi-tang combined sweet bee venom may improve symptoms in patients with Raynaud's disease.

• 대한상한금궤의학회지
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• v.13 no.1
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• pp.45-59
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• 2021

Objectives: This study was conducted to confirm the reproducibility of the diagnosis of greater yin disease (太陰病) and the efficacy of herbal treatment using Gyejigajakyak-tang or Gyejigadaehwang-tang in somatic symptom disorder (SSD). We also further refined the characteristics of greater yin disease in SSD. Methods: We analyzed the demographic and treatment data of seven patients with SSD from four Korean medical clinics. The reliability of diagnosis and the efficacy of the treatments were evaluated by the Beck Anxiety Inventory (BAI), a numerical rating scale (NRS), and the patients' statements. Finally, we analyzed patients according to the diagnostic points of Shanghanlun provision 273. Results: Seven SSD patients took Gyejigajakyak-tang or Gyejigadaehwang-tang. The mean age of the patients was 52.1±15.8 years old, and the herbal medication period was 82.2±38.2 days. At the first visit, the patients showed hypochondriasis, obvious stress, and a severe BAI score (40.4±10.9). The NRS significantly decreased from 8.9±1.6 to 0.7±0.7 after the treatments. There were no side effects reported. As a result of analyzing these 7 cases, hypochondriasis, obvious stress, and anxiety were identified, which had been previously suggested as 自痛, 因爾, and 結硬. Conclusions: We confirmed the reproducibility of greater yin disease in 7 SSD cases from 4 medical institutions. These results imply that there could be a considerable relation between SSD and greater yin disease as defined by the Shanghanlun provisions.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.365-374
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• 2023

Crohn's disease (CD) is a chronic inflammatory illness of the digestive system with unknown etiology, and its incidence is increasing worldwide. However, there are currently no effective treatments or medications available for individuals with CD. Therefore, novel therapeutic strategies are urgently needed. The bioactive compounds and targets associated with compounds of Qinghua Xiaoyong Formula (QHXYF) were examined using The Traditional Chinese Medicine Systems Pharmacology database, and 5 disease target databases were also used to identify CD-related disease targets. A total of 166 overlapping targets were identified from QHXYF-related and CD-related disease targets and they were found to be enriched in oxidative stress-related pathways and the PI3K/AKT signaling pathway. Molecular docking was then used to predict how the bioactive compounds would bind to the hub targets. It was found that quercetin could be the core bioactive compound and had good binding affinity to the top 5 hub targets. Finally, animal experiments were performed to further validate the findings, and the results revealed that QHXYF or quercetin inhibited 2,4,6-trinitrobenzenesulfonic acid-induced inflammation and oxidative stress processes by inhibiting the PI3K/AKT pathway, thereby improving CD symptoms. These findings suggest that QHXYF and quercetin may be potential novel treatments for CD.

• Journal of the Korean Society of Safety
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• v.35 no.1
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• pp.62-69
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• 2020

Most people suffer from stress during day life because modernized society is very complex and changes fast. Because stress can affect to many kind of physiological phenomena it is even considered as a disease. Therefore, it should be detected earlier, then must be released. When a person is being stressed several bio-signals such as heart rate, etc. are changed. So, those can be detected using medical electronics techniques. In this paper, stress assessment system is studied using random forest algorithm based on heart rate, RR interval and Galvanic skin response. The random forest model was trained and tested using the data set obtained from the bio-signals. It is found that the stress assessment procedure developed in this paper is very useful.

• Korean Journal of Oriental Medicine
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• v.3 no.1
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• pp.119-151
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• 1997

Conclusions for the relationship between a conceptional model of stress theory and its examination based on the Oriental medicine; 1. It was considered that a general conception of stress is included into the meaning of Ki in the Oriental medicine. 2. The response-based model to stress could be comparable to a conception of Ki-pathogens interchange In the Onental medicine. 3. The stimulus-based model may be explained as a modern conception of immoderation feeling related with an internal etiological factor, specially injury of seven emotions, among three groups of etiological factors for disease. 4. The feedback conception based on the interaction model could explain the principal of reversible emotion therapy in the nine Ki. 5. In the Oriental medicine, a study to clarify a emotional etiologic factor and its pathophysiologlcal mechanism has been continued for long time before establishment of stress theory.

• Korean Journal of Poultry Science
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• v.34 no.4
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• pp.295-300
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• 2007

In addition to reduction in performance, immune functions are reduced in chickens under stress. These birds are more likely to be vulnerable to diseases compared with those raised under better environmental conditions and thus to require medication more frequently to cope with the diseases. In this review, two of the stress markers frequently used in chickens are exemplified first, followed by relationship between stress and immune functions, and the effects of stress on performance and immune functions.