• Advances in materials Research
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• 제6권2호
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• pp.221-231
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• 2017

The concept design of the typha strawbale masonry came up as a result of the urgent demand for a means of constructing sustainable buildings, both in rural and urban settlement, not only suitable for dwellers but for keeping farm products by structures that will respond to the environmental eco-system, coupled with the fact that such structures are also affordable, durable and easy to maintain during their service period. The effects of contact between plaster and the stacked strawbale of a masonry needs to be established and design optimization for durability and stability of the masonry be obtained. The assessment will involve the application of plaster materials (cement and natural earth) to the wall specimen panels. Past works have shown that plastered strawbale walls have adequate resistance against the appropriate vertical loads, and further showed that the earth plaster can bear higher stress than the cement plastered straw bale. There is the implication that the collapse or response of the earth-strawbale wall is significantly higher compared to that of cement-strawbale from other straw-based masonries. Therefore the allowable stresses of plastered typha strawbale shall be predicted for their optimum values using SAP2000. The stress stability of each masonry is obtained by analytical model using the best fit variables for the wall height and thickness.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2003년도 추계학술발표대회 논문집
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• pp.207-210
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• 2003

Vacuum hot pressing has been used for the development of Ti-MMCs using foil-fiber-foil method, and subsequent micro-mechanical characteristics of the composites are evaluated by means of several experimental processes. As shown by the results, fiber strength degradation occurs during the consolidation, and particularly residual stresses results from the thermal expansion mismatch between fiber and matrix materials during cooling process are incorporated in the changes of mechanical properties of the composites. In industrial applications, the processing conditions avoiding micro-material failures are important together with the properties of finished products, and therefore should be included in the assesment of the material characterization.

• Genomics & Informatics
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• 제13권4호
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• pp.94-101
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• 2015

tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.

• 한국철도학회논문집
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• 제6권1호
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• pp.21-28
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• 2003

Environment-dependent fatigue life of Cu-Cd alloy wires used as messenger wires was investigated. Tensile test results showed the decrease of tensile strength and elongation of messenger wires by 3.7% and 16.8%, respectively, in used specimens when compared to new ones. Messenger wires used at industrial region for 26 yeras showed 35∼50% decrease in fatigue life, which is partly due to the in stress concentrations by formation of corrosion products at the surface. Single wires showed better fatigue properties than stranded wires, especially at low cycle regions with higher stresses. Stranded wires showed shorter fatigue lives than single wires because of friction between wires by surface contact. Service life of messenger wires was dependent upon the environments which they were exposed to. SO$_2$ and humidity deteriorated the fatigue properties by environmental degradation.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2000년도 하계학술대회 논문집
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• pp.631-635
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• 2000

Recently, the epoxy molded type PT for indoor and applied 25.8kV was often distroyed by degradation of insulation that effected many electric stress and defect of manufactured goods. therefore In this work, We can present a method of solution in the process of produce the PT through analysis of experiments. In order to reduce the PD (Partial Discharge) which was occurred at the insulation material of epoxy resin, we has many tried to remove faults In the process of the products,

• BMB Reports
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• 제54권5호
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• pp.260-265
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• 2021

Dysregulation of inflammation induced by noninfectious stress conditions, such as nutrient deprivation, causes tissue damage and intestinal permeability, resulting in the development of inflammatory bowel diseases. We studied the effect of autophagy on cytokine secretion related to intestinal permeability under nutrient deprivation. Autophagy removes NLRP3 inflammasomes via ubiquitin-mediated degradation under starvation. When autophagy was inhibited, starvation-induced NLRP3 inflammasomes and their product, IL-1β, were significantly enhanced. A prolonged nutrient deprivation resulted in an increased epithelial mesenchymal transition (EMT), leading to intestinal permeability. Under nutrient deprivation, IL-17E/25, which is secreted by IL-1β, demolished the intestinal epithelial barrier. Our results suggest that an upregulation of autophagy maintains the intestinal barrier by suppressing the activation of NLRP3 inflammasomes and the release of their products, including pro-inflammatory cytokines IL-1β and IL-17E/25, under nutrient deprivation.

• 분석과학
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• 제36권1호
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• pp.32-43
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• 2023

This study reports for the first time about a stability indicating RP-HPLC method for qualitative and quantitative determination of acalabrutinib in bulk and dosage form and in presence its impurities 1, 2 and 3. The chromatographic separation was carried on Zorbax XDB-C18 (250×4.6 mm; 5 µ id) as stationary phase, Phosphate buffer pH 6.4 and methanol 80:20 (v/v) as mobile phase at a flow rate of 1.0 mL/min, UV detection was carried at wavelength of 238 nm and the analysis was completed with a run time of 15 min. In these conditions the retention time of acalabrutinib and its impurities 1, 2 and 3 was observed to be 3.50, 4.83, 8.40 and 9.93 min respectively. The method was validated for system suitability, range of analysis, precision, specificity, stability and robustness. Spiked recovery at 50 %, 100 % and 150 % was carried for both standard and impurities and the acceptable % recovery of 98-102 was observed for acalabrutinib and both impurities studied and the % RSD in each spiked level was found to be less than 2. Stability tests were done through exposure of the analyte solution to five different stress conditions i.e expose to 1N hydrochloric acid, 1 N sodium hydroxide, 3 % peroxide, 80 ℃ temperature and UV radiation at 254 nm. In all the degradation condition, standard drug acalabrutinib was detected along with both the impurities studied and the degradation products were successfully separated. In the formulation analysis there is no other chromatographic detection of other impurities and formulation excipients. Hence the developed method was found to be suitable for the quantification of acalabrutinib and can separate and analyse impurities 1 and 2.

• The Korean Journal of Physiology and Pharmacology
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• 제20권3호
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• pp.229-236
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• 2016

Resveratrol (RSV) may provide numerous protective effects against chronic inflammatory diseases. Due to local hypoxia and hypertonicity, the renal medulla is subject to extreme oxidative stress, and aldehyde products formed during lipid peroxidation, such as 4-hydroxy-2-hexenal (HHE), might be responsible for tubular injury. This study aimed at investigating the effects of RSV on renal and its signaling mechanisms. While HHE treatment resulted in decreased expression of Sirt1, AQP2, and nuclear factor erythroid 2-related factor 2 (Nrf2), mouse cortical collecting duct cells (M1) cells treated with HHE exhibited increased activation of p38 MAPK, extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and increased expression of NOX4, $p47^{phox}$, Kelch ECH associating protein 1 (Keap1) and COX2. HHE treatment also induced $NF-{\kappa}B$ activation by promoting $I{\kappa}B-{\alpha}$ degradation. Meanwhile, the observed increases in nuclear $NF-{\kappa}B$, NOX4, $p47^{phox}$, and COX2 expression were attenuated by treatment with Bay 117082, N-acetyl-l-cysteine (NAC), or RSV. Our findings indicate that RSV inhibits the expression of inflammatory proteins and the production of reactive oxygen species in M1 cells by inhibiting $NF-{\kappa}B$ activation.

• 분석과학
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• 제36권4호
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• pp.180-190
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• 2023

The presence of process related impurities in any drug or the drug product was associated with its safety, stability and efficacy. The overall literature survey proved that there is no method published on the assessment of process related impurities in brigatinib. In this study, a simple, reliable and stable HPLC qualitative method was reported for quantification of process related impurities with easy and quick extraction procedure. The impurities along with standard brigatinib was resolved on Lichrospher^® C18 (250 mm × 4.6 mm; 5 ㎛ particle size) column in room temperature using methanol, acetonitrile, pH 4.5 phosphate buffer in 55:25:20 (v/v) at 1.0 mL/min as mobile phase and UV detection at 261 nm. The method produces well resolved peaks at retention time of 4.60 min, 12.28 min, 3.37 min, 7.34 min and 8.39 min respectively for brigatinib, impurity A, B, C and D. The method produces a very sensitive detection limit of 0.0065 ㎍/mL, 0.0068 ㎍/mL, 0.0053 ㎍/mL and 0.0058 ㎍/mL for impurity A, B, C and D respectively with calibration curve linear in the concentration range of 22.5-135 ㎍/mL for brigatinib and 0.0225-0.135 ㎍/mL for impurities. The method produces all the validation parameters under the acceptable level and doesn't produces any considerable changes in peak area response while minor changes in the developed method conditions. The method can effectively resolve the unknown stress degradation products along with known impurities with less % degradation. The method can efficiently resolve and quantify the impurities in formulation and hence can suitable for the routine quality analysis of brigatinib in raw material and formulation.

• Composites Research
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• 제17권1호
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• pp.47-54
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• 2004

고온진공가압 기술 및 포일-섬유-포일 방식을 이용하여 티타늄 금속기 복합재료를 개발하였으며, 완성된 복합재료의 미시-기계적 특성평가를 위해 다양한 실험을 수행하였다. 또한 열-음향방출 실험을 통해 강화공정 진행정도와 더불어 공정 중 발생한 복합재료의 결함을 검출하고, 변형기구를 바탕으로 한 파손과정을 분석하였다. 결과에서 보듯이 강화공정 중 발생하는 섬유 손상뿐만 아니라 냉각 과정에서의 섬유와 모재간의 열팽창 차이에 따른 미시손상이 복합재료의 기계적 성능에 영향을 미침을 확인하였다. 금속기 복합재료의 개발과 이를 이용한 산업으로의 적용은 완성된 복합재료의 미시-기계적 특성에 대만 정량-정성적인 분석과 함께 적합한 평가를 요구하며 따라서 공정 개발에 반드시 수반되어야 한다.