• Nutrition Research and Practice
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• 제10권3호
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• pp.274-281
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• 2016

BACKGROUND/OBJECTIVES: The accumulation of amyloid-${\beta}$ ($A{\beta}$) in the brain is a hallmark of Alzheimer's disease (AD) and plays a key role in cognitive dysfunction. Perilla frutescens var. japonica extract (PFE) and its major compound, rosmarinic acid (RA), have shown antioxidant and anti-inflammatory activities. We investigated whether administration of PFE and RA contributes to cognitive improvement in an $A{\beta}_{25-35}$-injected mouse model. MATERIALS/METHODS: Male ICR mice were intracerebroventricularly injected with aggregated $A{\beta}_{25-35}$ to induce AD. $A{\beta}_{25-35}$-injected mice were fed PFE (50 mg/kg/day) or RA (0.25 mg/kg/day) for 14 days and examined for learning and memory ability through the T-maze, object recognition, and Morris water maze test. RESULTS: Our present study demonstrated that PFE and RA administration significantly enhanced cognition function and object discrimination, which were impaired by $A{\beta}_{25-35}$, in the T-maze and object recognition tests, respectively. In addition, oral administration of PFE and RA decreased the time to reach the platform and increased the number of crossings over the removed platform when compared with the $A{\beta}_{25-35}$-induced control group in the Morris water maze test. Furthermore, PFE and RA significantly decreased the levels of nitric oxide (NO) and malondialdehyde (MDA) in the brain, kidney, and liver. In particular, PFE markedly attenuated oxidative stress by inhibiting production of NO and MDA in the $A{\beta}_{25-35}$-injected mouse brain. CONCLUSIONS: These results suggest that PFE and its active compound RA have beneficial effects on cognitive improvement and may help prevent AD induced by $A{\beta}$.

• 한국대기환경학회지
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• 제32권3호
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• pp.237-247
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• 2016

Global climate change is becoming one of the greatest challenges facing humanity. This article proposes a psychological perspective of climate change adaptation. Climate change-related severe adverse weather events may trigger mental health problems, including increased post-traumatic stress disorder (PTSD), depression, anxiety, violence, and even suicide. Forced migration could be considered a coping method for dealing with weather events, but it may also pose a psychological threat. People respond to severe weather events in different ways based on their individual characteristics. Psychological risks from adverse weather events are mediated and moderated by these factors, which are influenced by personal cognition, affect, and motivation. Examinations from a psychological perspective, which have been neglected in the science of climate change thus far, may provide keys to successful adaptation and the prevention of serious psychological problems resulting from the experience of severe weather events. A new prevention strategy has been suggested for coping with climate threats through encouraging attitude change, establishing proactive support systems for vulnerable groups, establishing a PTSD network, and implementing a stress inoculation program.

• Toxicological Research
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• 제32권2호
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• pp.123-132
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• 2016

The impact of mobile phone (MP) radiation on the brain is of specific interest to the scientific community and warrants investigations, as MP is held close to the head. Studies on humans and rodents revealed hazards MP radiation associated such as brain tumors, impairment in cognition, hearing etc. Melatonin (MT) is an important modulator of CNS functioning and is a neural antioxidant hormone. Zebrafish has emerged as a popular model organism for CNS studies. Herein, we evaluated the impact of GSM900MP (GSM900MP) radiation exposure daily for 1 hr for 14 days with the SAR of 1.34W/Kg on neurobehavioral and oxidative stress parameters in zebrafish. Our study revealed that, GSM900MP radiation exposure, significantly decreased time spent near social stimulus zone and increased total distance travelled, in social interaction test. In the novel tank dive test, the GSM900MP radiation exposure elicited anxiety as revealed by significantly increased time spent in bottom half; freezing bouts and duration and decreased distance travelled, average velocity, and number of entries to upper half of the tank. Exposed zebrafish spent less time in the novel arm of the Y-Maze, corroborating significant impairment in learning as compared to the control group. Exposure decreased superoxide dismutase (SOD), catalase (CAT) activities whereas, increased levels of reduced glutathione (GSH) and lipid peroxidation (LPO) was encountered showing compromised antioxidant defense. Treatment with MT significantly reversed the above neurobehavioral and oxidative derangements induced by GSM900MP radiation exposure. This study traced GSM900MP radiation exposure induced neurobehavioral aberrations and alterations in brain oxidative status. Furthermore, MT proved to be a promising therapeutic candidate in ameliorating such outcomes in zebrafish.

• 가정과삶의질연구
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• 제21권5호
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• pp.51-59
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• 2003

Many parents recognize the importance of social development during early childhood but they feel difficulty in helping their children develop socially. Recently, many researchers have suggested that maternal cognition is an important factor on their parenting behavior and children's development. Thus, this study attempted to investigate the mother's perception and attribution of parenting efficacy for children's social development. Total 247 mothers of three to five year-old children reported self-questionnaire consisting of Melson, Ladd, & Hsu(l993)'s Perceived Difficulty at Parenting Tasks, Criniic & Greenberg(1990)'s Parenting Daily Hassles and Abdin(1990)'s Parenting Alliance Inventory. Also, 82 of the subject's children were individually tested with McGinnis & Goldstein(1990)'s Skill Situations Measure. The major results were as follows: 1) Mothers' parenting efficacy for children's social development was significantly related with child's age, mother's education and the father's cooperation of parenting. 2) Mothers' perceived parenting efficacy was significantly correlated with some dimension of the child's actual social skill (i.e., maintenance of peer relation). 3) Mothers of young children were more likely to attribute to their children for their parenting efficacy than those of old children. 4) Mothers were more likely attribute to their children than themselves when they perceive parenting difficult. 5) Mothers who perceive parenting easy and attributed it to their children had less parenting stress than those of attributing it to themselves.

• 한국건축시공학회지
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• 제20권1호
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• pp.93-102
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• 2020

본 연구는 건설 근로자의 안전사고를 예방하기 위해 사고와 밀접한 관련이 있는 스트레스를 건설현장에서 즉각적이면서도 편리하게 측정할 수 있는 방법에 대해 알아보고자 하였다. 이에 따라 인간의 복잡한 심리와 관련된 스트레스를 감정, 인지, 신체, 행동적 반응을 통합하여 측정할 수 있는 설문 도구와 뇌파를 통해 수집된 기본 뇌파, SEF-90, 집중도, 스트레스 지수 간의 상관관계를 분석하였다. 그 결과 설문을 통한 스트레스 측정값과 가장 상관관계가 높게 나온 뇌파는 SEF-90였으며, 두 독립변수간 회귀분석을 실시한 결과 특정 회귀식을 도출하였다. 이는 건설 현장에서 뇌파 신호를 통해 건설근로자의 통합적 스트레스를 측정할 수 있는 가능성을 제시한 것으로 향후 건설 현장의 안전관리에 활용할 수 있을 것이라 기대한다.

• 한국약용작물학회지
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• 제27권2호
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• pp.115-125
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• 2019

Background: Glycyrrhiza radix (licorice root) have been used as an oriental medicine material for long time, and its protective effects on oxidative stress, inflammation and cognition deficit have been recently reported. However, the cultivation of Glycyrrhiza species as medicinal crops is associated with some problems such as low productivity and early leaf fall, etc. To resolve this problems, Glycyrrhiza cultivars have been developed by direct hybridization of each Glycyrrhiza species by Korean researchers. The present study was conducted to compare the Glycyrrhiza cultivar radix (Dagam, Sinwongam and Wongam) for their anti-oxidation, anti-inflammation, and cognition improvement effects and levels of liquiritin, isoliquiritigenin and licochalcone in order to select an excellent cultivar as a material resource. Methods and Results: For evaluating the inhibitory efficacies of the Glycyrrhiza cultivar extracts on oxidative stress and inflammation in BV2 cells, we measured their reactive oxygen species (ROS) production and nitric oxide (NO) release after treating them with lipopolysccharide. The scavenging activities on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and peroxynitrite ($NOO^-$) radicals were evaluated. Cell proliferation and N-methyl-D-aspartate receptor (NMDAR) inhibition were analyzed. The total phenol, liquiritin, isoliquiritigenin and licochalcone A content in the extracts of the three culivars were quantified. Furthermore, the correlation coefficient between the activities and contents of total phenol, liquiritin, isoliquiritigenin and licochalcone A were also calculated. The results indicated that Sinwongam exhibited potent anti-oxidant, anti-inflammatory and NMDAR inhibititory activities. Sinwongam also showed higher total phenol and licochalcone A contents than the other cultivars. Among the three cultivars, Dagam exhibited a positive effects on NO release inhibition, cell proliferation and contents of liquiritin and isoliquiritigenin. Conclusions: Sinwongam is expected to be the most useful resource as a functional material for anti-oxidation/anti-inflammation and cognition improvement among the three studied licorice cultivars.

• 동의생리병리학회지
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• 제21권1호
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• pp.126-135
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• 2007

This study was conducted to identify the effects of the oriental medicine Qigong Exercise on the brain power, HRV, pulsation, live blood condition among young boys and girls. The study was performed with two group(control group and experimental group) in a pre-test/post-test design. The subjects were 44 young boys and girls selected by a some middle school in Busan. The oriental medicine Qigong Exercise program consists of 80-minute sessions three times a week over 5 months. All of the subjects were examined on the congnition assessment tool, stress assessment tool, oriental medicine pulsation 3-D MAC, live blood condition analyzer Prior and post surveys were measured before and after the experiment. In the cognition assessment, the amplitude of ERS were increased afer Qigong Exercise. The Success and the Concentration were significantly increased afer Qigong Exercise, the Error was significantly decreased afer Qigong Exercise. The Cognition strength was significantly increased, but the Reponse time was not significantly decreased afer Qigong Exercise. And the Workload was not significantly decreased, the Total Score was not significantly increased afer Qigong Exercise. Among the stress assessment, RRV tachogram's ‘mean RR’ was significantly increased, ‘mean HRV’ was significantly decreased afer Qigong Exercise. SDNN was not significantly increased, Complexity was not significantly increased afer Qigong Exercise. And TP(RRV power's total power) was not significantly increased, VLF and HF was significantly increased, and LF was significantly decreased afer Qigong Exercise. ANS's norm LF was not significantly decreased, but norm HF was significantly increased afer Qigong Exercise. In the RRV's Phase Plot, RMSSD and SDSD were not significantly increased, pnn50 was not significantly decreased afer Qigong Exercise. On the whole, Parasympathetic Activity and Stress Endurance were significantly increased, but Cardiac Activity and Physical Arousal were not significantly increased afer Qigong Exercise. Cardiac Aging was not significantly decreased afer Qigong Exercise. Sympathetic Activity, Autonomic Nervous System Balance and Heart-load were not significantly decreased afer Qigong Exercise. In the pulsation, press power was increased(15%), and w/t(pressurization time / pulsation time) was decreased(20%) afer Oigong Exercise. And the live blood condition was not changed afer Qigong Exercise. As mentioned above; the oriental medicine Qigong Exercise program was identified the effects of the inspiration of the brain power, heart rate and anti-stress.

• 한국보육지원학회지
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• 제8권3호
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• pp.229-247
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• 2012

본 연구의 목적은 걸음마기 자녀를 둔 어머니의 양육지식, 양육행동과 양육스트레스와의 관계를 알아보는 데 있다. 구체적으로, 어머니의 아동발달에 관한 지식과 자녀발달을 위해 행하는 양육행동과의 관계를 살펴보고, 이러한 지식과 행동의 수준의 차이에 따라 지각되는 양육스트레스에 차이가 있는지를 규명해 보고자 하였다. 연구대상은 서울, 경기, 충청, 영남, 호남 지역에 거주하는 18~36개월 영아기 자녀를 둔 어머니 145명을 대상으로 하였다. 자료 분석을 위하여 빈도, 백분율, 평균, 표준편차, Pearson's 적률상관계수, 일원변량분석을 실시하였다. 연구 결과, 자녀발달과 관련된 어머니의 양육지식과 양육행동 간에는 유의미한 관계가 나타나지 않았으나, 양육행동과 양육스트레스 간에는 유의미한 부적 관계가 나타났다. 영역별 양육행동 중 인지발달에 관한 어머니의 양육행동이 양육 스트레스와 부적 상관을 보였다. 집단별 비교에서도 영역별 적합한 양육행동을 많이 행하지 못하는 하위집단이 중상위 집단에 비해 유의미하게 양육스트레스를 높게 지각하고 있었다.

• 대한의용생체공학회:의공학회지
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• 제23권4호
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• pp.301-308
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• 2002

연구는 인간에게 3차원 공간상에서 시청각 통합 환경을 만든 후 정신적 스트레스가 시각 자극을 통해 ERPs에 어떠한 영향을 미치는지를 정량적으로 분석하기 위하여 수행되었다. 이를 위하여, 정상 상태와 정신적 스트레스를 제시 상태를 구분하여 ERPs를 측정하였다. 실험은 정상상태의 남녀 10명의 피험자를 대상으로 하였고. 생체 신호는 Fpl, Fz, Cz. Pz, O1, O2의 영역에서 전자기적 영향을 받지 않는 차폐 공간에서 측정하였다. 그 결과 P300의 진폭은 스트레스를 제시한 경우에 좀더 커지고, 이때의 잠재기는 길어지는 결과를 얻었다 본 연구에서는 인간의 지각, 인지. 행동의 과정을 담당하는 뇌의 활동을 전위 변동으로 기록하여 정신적 스트레스의 영향을 측정하였다. 이러한 기초적 연구 검토를 통하여 인간의 제반 과정에 관한 뇌 기능의 이상을 평가 할 수 있을 것이라 기대된다.

• 한국콘텐츠학회논문지
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• 제19권1호
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• pp.385-395
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• 2019

본 연구는 일개 종합병원 간호사의 의료기관 인증평가 인지, 직무스트레스, 이직의도, 안전관리인지 변화에 대해 의료기관 인증평가 전 후를 비교하여 분석하였다. 자료수집은 2016년 6월1일부터 7월17일까지 실시 하였고 수집된 자료는 SPSS 21.0 version을 이용하여 평균, 표준편차, paired t-test를 분석하였다. 본 연구결과 의료기관인증 인지, 이직의도, 안전관리인지도의 인증평가 전 후 유의한 차이는 없었으나 인증평가 후 평균점수는 높게 나타났고 직무스트레스는 인증평가 전 후 유의한 차이를 보였다(t=2.825, p=<.005). 즉, 인증평가 전이 인증평가 후 보다 직무스트레스가 높은 것으로 나타났다. 그러므로 인증평가를 준비하는 간호사의 직무스트레스를 감소시키기 위해 업무 부담감을 줄일 수 있는 의료기관의 적극적이고 다양한 인적 물적 지원이 필요하다.