• Journal of Korean Society of Forest Science
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• v.106 no.2
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• pp.130-149
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• 2017

The subalpine zone which is vulnerable to climate change could be functioning as a habitat for northern plant species especially in the Korean peninsula. In this study, classification of phytosociological community type and investigation on flora of vascular plants of Daecheongbong area in Mt. Seorak were carried out in order to provide a basic information for an ecological restoration and management of the vegetation through community ecological approach. Vegetation data were collected from 31 of quadrates from May to October, 2016. We analyzed vegetation types with phytosociological method, importance value with Curtis & McIntosh method, CCA using PC-ORD program tool, and flora of vascular plants. As a result, the forest vegetation was classified into Abies nephrolepis community. The community was divided 3 groups such as Pinus pumila group, Rhododendron brachycarpum group and Angelica decursiva group. Therefore, the vegetation had 3 kinds of units. The differential species group, it was classified into total of 7 species group units including Thuja koraiensis and Smilacina bicolor differential species group. The mean importance percentage (MIP) in VU 1 was shown Pinus koraiensis (24.1), A. nephrolepis (23.6) and Betula ermanii (10.5), and in VU 2, it was P. koraiensis (26.2), A. nephrolepis (20.8) and B. ermanii (10.5), and in VU 3, it was P. koraiensis (22.2), A. nephrolepis (16.4), B. ermanii (13.5) in the order, respectively. As for importance values of P. koraiensis and A. nephrolepis representative competition species, were different at each layers. The former (46.7) was higher than the latter (26.1) in tree layer, but the latter was higher than the former in subtree and, shrub and herb layers of VU 1. VU 2 and VU 3 also indicated the same tendency. P. pumila group and A. decursiva group were shown to have positive correlation with altitude and present species, respectively. The designated as the endemic plant was 11 taxa and, as the rare plant 24 taxa and 62.5% of vascular plant was northern plant species. It is necessary to continue further long-term monitoring of 3 vegetation units, IV of main competition species (P. koraiensis and A. nephrolepis) with stratum and main specific species (rare plants and endemic plants) considering vegetation science and, population and community ecology approaches.

• Progress in Medical Physics
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• v.17 no.2
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• pp.83-88
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• 2006

Purpose: We Investigated to achieve high resolution magnetic resonance (MR) Imaging and spectra of human skin in vitro with using a 14.1 T MRI/MRS system, and to evaluate the hydration effect of a moisturizer by measuring the skin's water concentration. Materials and Methods: We used the Brukrer 14.1 T MRI/MRS system with a vertical standard bore that was equipped with a DMX spectrometer gradient system (200 G/cm at a maximum 40 A), RF resonators (2, 5 and 10 mm) and Para Vision software. Spin echo and fast spin echo pulse sequences were employed for obtaining the high resolution MR images. The 3D-localized point resolved spectroscopy (PRESS) method was used to acquire the MR spectra. Results: The high resolution MR images and spectra of human skin in vitro were successfully obtained on a 14.IT system. The water concentration of human skin after applying a moisturizer was higher than that before applying a moisturizer. Conclusions: The present study demonstrated that the high-resolution MR images and spectra of human skin from a high field MRS instrument could be applicable to evaluating the hydration state of the stratum corneum.

• Economic and Environmental Geology
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• v.44 no.4
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• pp.273-288
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• 2011

Chon-Ashuu copper mining claim area is located, in terms of the geotectonic setting, in the northern part of the suture line which is bounded with the marginal part of Issik-kul micro-continent on the southern part of North Tien-Shan terrane. The geological blocks of Chon-Ashuu districts belong to the southern tip of Kazakhstan orocline. The rock formation of this area are composed of the continental crust or/and arc collage and the paleo-continental fragments-accretionary wedge complex of pre-Altaid orogenic materials. ASI(Alumina Saturation Index) of Paleozoic plutonic rocks in Chon-Ashuu area belong to the peraluminous and metaluminous rocks which were generated from fractional crystallization of Island and volcanic arc crusts in syn-post collisional plate. The geology of the ChonAshuu area consists of upper Proterozoic and Paleozoic rock formations. According to Harker variation diagrams for Chon-Ashuu arenaceous sedimentary rocks, the silty sandstone of Chon-Ashuu area showing the mineralogical immaturity were derived from Island arc or the marginal environments of active continent in Cambro-Carboniferous period. Numerous intrusive rocks of Chon-Ashuu area are distributed along north east trending tectonic structures and are bounded on four sides by the conjugate pattern. The most common type of the plutonic rocks are granodiorite and monzodiorite. According to the molecular normative An-Ab-Or composition (Barker, 1979), the plutonic rocks in Chon-Ashuu area are classified into tonalite - trondhjemite - granodiorite (TTG) series which are an aggregation of rocks which is the country rock of copper mineralization, that are formed by melting of hydrous mafic crust at high pressure.

• Journal of Life Science
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• v.27 no.5
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• pp.575-578
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• 2017

Here we describe the histological lesion of a viral fibro-papilloma in a hedgehog. After surgical removal from maxilla, the solitary swollen mass was round to oval, yellowish with rough surface and measuring $6{\times}3{\times}2mm$ approximately. The tumor mass was submitted to the laboratory of pathology, college of veterinary medicine, Kyungpook National University for pathological diagnosis. Pathological examination of the tumor was established, the tumor was described grossly and sample was trimmed, sectioned and routinely prepared for histopathological evaluation. The tumor mass was diagnosed as viral fibro-papilloma, as the histological picture showed characteristic features of warts caused by papillomaviruses. The tumor characterized by thickening of the stratum spinosum (acanthosis) and basale, koilocytosis, intra-nuclear inclusion bodies in keratinocytes and fibrosis of submucosa. Further, viral inclusion bodies were demonstrated by Machiavello stain giving red color to the nuclei. No lymphocytes that responsible for regression of the wart could be detected, suggesting the poor possibility of spontaneous regression of the tumor. Papillomatosis is a disease of young animals, but in our case the infected Hedgehog was 5 years old, that maybe due to an impaired immune system, which is also shown by absence of lymphocytes. To the best knowledge of the author, this case presents the first report of viral fibropapillomatosis in Hedgehog.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.2
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• pp.179-184
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• 2020

Elasticity and softness of the skin depend on the level of moisture present in the stratum corneum, which is known to be affected by various environmental changes, such as cold and hot winds and dry environments. However, not many studies have been conducted on changes in skin moisture and the degree of recovery due to individual skin differences. In the present study, we aimed to investigate the effect of warm air heating on skin hydration levels and develop moisturizing formulas to improve lowered skin hydration levels. In order to deliver warm air heating condition, heating dryer (40 ℃, 6 m/s, 30 cm apart from forearm) was applied into inner forearm of healthy subjects (male: 10, female: 39, age: 25 - 63) Among 49 subjects, 26 subjects showed significantly lowered skin hydration levels until 30 min after warm air heating exposure (lowered group). In addition, moisturizing cream with high water holding capacity was applied to forearm of 10 subjects in lowered group for 3 weeks and skin hydration levels after warm air heating were significantly improved at the levels of before application of warm air heating. From this study, we found out that there is a skin type that skin hydration levels are significantly decreased under warm air heating condition (dehydrated skin) and this dehydrated skin can be improved by moisturizing formulas with high water holding capacity.

• Journal of Veterinary Clinics
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• v.25 no.5
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• pp.330-339
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• 2008

Ceramide, cholesterol and free fatty acids are the major intercellular lipids, maintaining the integrity of the skin barrier. However, the roles of these lipids in canine skin barrier function are little known. The aim of this study was to evaluate the repairing effects of 2% ceramide (CER), 2% cholesterol (CHO), 2% linoleic acid (LIN) and 2% intercellular lipid mixture (ILM) on damaged canine skin barrier by 1.25% sodium lauryl sulphate (SLS). Transepidermal water loss (TEWL), skin hydration, skin pH and skin thickness were assessed. Histological profiles and transmission electron microscopic (TEM) profiles were assessed on day 12. SLS effectively induced the canine skin barrier damage. TEWL was significantly decreased by topical application of CER and ILM in SLS and vehicle-treated skin on day 8 and 12, respectively (p < 0.05, p < 0.0 I). By end of the experiment all lipids significantly decreased the TEWL as compared with SLS and vehicle control, but CER and ILM more significantly decreased the TEWL than UN and CHO, respectively (p < 0.01). Skin hydration was significantly increased by CER and ILM during experimental periods (p < 0.01). Skin pH was significantly decreased by CER, LIN and ILM. In histological profiles, the thickness of the stratum corneum (SC) was significantly increased by the SC lipids as compared with vehicle and SLS (p < 0.01). Especially, CER and ILM showed more prominent improvement of barrier recovery. In TEM of the SC, SLS induced exfoliations of corneodesmosomes in the SC, and CER and ILM effectively protected exfoliations of corneodesmosomes on SLS-damaged canine skin. These results indicated that topical application of CER and ILM dramatically improved damaged-skin barrier function by SLS. Also, it was considered that the use of CER or ILM was recommended for the management of skin barrier dysfunction by irritant and inflammatory skin disorders such as atopic dermatitis.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.93-104
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• 2015

Purpose: This study aimed to analyze the research trends of Ophthalmic Optic by targeting the papers published in the Journal of Korean Ophthalmic Optics Society and serve it as a basis for future researches. Methods: This study was conducted through a statistical analysis of the general characteristics, researcher characteristics, research characteristics and the research trends from total 990 papers, from the first issue to the last issue in 2014, published in the Journal of Korean Ophthalmic Optics Society. Results: Most common number of the authors of the published papers were two or three, respectively 26.8%. Most of the lead authors belong to the schools in Jeolla-do province (31.3%). Most of the educational system of which lead authors belong to is four-year-course system (43.0%). Most common research methods were optometric tests (40.9%). The most common subjects of researches are about the field of optometry (29.8%). The study shows that there were significant differences in the research methods depending on the school systems of the universities to which the lead authors belong (p=0.000). There also were significant differences in the school systems of the universities to which the lead authors belong, and research methods depending on the research subjects (p=0.000). There were meaningful differences according to the period divisions (1996 to 2004 and 2005 to 2014), i.e. the number of authors has been growing, and it is the same case for the number of the authors who belong to four-year-course universities (p=0.000). The number of papers on optometry and contact lenses have increase. The benefits of the research funds have also increased (p<0.005). In addition, the number of the lead authors in the Seoul and Chungcheong province have increased (p=0.000). Conclusions: For the development of the Ophthalmic Optics, it is necessary to broaden the stratum of researchers and deal with various research topics, And joint efforts between eyewear industry and academia and international cooperations are needed.

• Journal of the Korean Applied Science and Technology
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• v.37 no.3
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• pp.484-495
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• 2020

This study is a mixed surfactant (MimicLipid-MSM1000) that forms the same structure as that of the stratum corneum, sucrose distearate, polyglyceryl-2 dioleate, fermented squalane, ergosterol, 10-hydroxystearic acid, mixture consisting of was synthesized. When using 2~5 wt% of this mixed surfactant, it was possible to make an artificial skin mimetic that forms a multi-layer lamellar structure of 5~30 layers. An emulsion was prepared using this mixed surfactant, and a multi-layered lamellar phase was formed and analyzed mechanically. The appearance of this surfactant was a light brown hard wax, the hydrophilic lipophilic balance (HLB) was 12.53, the critical parameter value was 0.987, and the acid value was 0.13. Stability according to pH change was also stable in acidic (3.8), neutral (7.2) and alkaline (10.8). The particle size of the liquid crystal was found to be the most stable maltese cross lamellar crystalline droplet at 5~25mm. The size of the emulsified particles according to the change in the speed of the homo agitator is 2500 rpm (17.9mm±2.6mm), 3500rpm (12.5mm±2.1mm), 4500rpm (6.2mm±1.8mm) particles were formed. Liquid crystal forming particles were observed through a polarization microscope, and the formation structure of the liquid crystal was precisely analyzed with a scanning electron microscope (cryo-SEM). As an application field, it is expected that it will be widely applicable to the development of various prescriptions, such as various skin care cosmetics, makeup care cosmetics, and scalp protection cosmetics, by using a skin-mimicking surfactant.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.29 no.2 s.43
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• pp.205-232
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• 2003

Ursolic acid (UA) and Oleanolic acid (ONA), known as urson, micromerol and malol, are pentacyclic triterpenoid compounds which naturally occur in a large number of vegetarian foods, medicinal herbs, and plants. They may occur in their free acid form or as aglycones for triterpenoid saponins, which are comprised of a triterpenoid aglycone, linked to one or more sugar moieties. Therefore UA and ONA are similar in pharmacological activity. Lately scientific research, which led to the identification of UA and ONA, revealed that several pharmacological effects, such as antitumor, hepato-protective, anti-inflammatory, anticarcinogenic, antimicrobial, and anti-hyperlipidemic could be attributed to UA and ONA. Here, we introduced the effect of UA and ONA on acutely barrier disrupted and normal hairless mouse skin. To evaluate the effects of UA and ONA on epidermal permeability barrier recovery, both flanks of 8-12 week-old hairless mice were topically treated with either 0.01-0.1 mg/ml UA or 0.1-1 mg/ml ONA after tape stripping, and TEWL (Transepidermal water loss) was measured . The recovery rate increased in those UA or ONA treated groups (0.1 mg/ml UA and 0.5 mg/ml ONA) at 6 h more than $20\%$ compared to vehicle treated group (p<0.05). Here, we introduced the effects of UA and ONA on acute barrier disruption and normal epidermal permeability barrier function. For verifying the effects of UA and ONA on normal epidermal barrier, hydration and TEWL were measured for 1 and 3 weeks after UA and ONA applications (2mg/ml per day). We also investigated the features of epidermis and dermis using electron microscopy (EM) and light microscopy (LM). Both samples increased hydration compared to vehicle group from f week without TEWL alteration (p<0.005). EM examination using RuO4 and OsO4 fixation revealed that secretion and numbers of lamellar bodies and complete formation of lipid bilayers were most prominent $(ONA{\geq}UA>Vehicle)$. LM finding showed that thickness of stratum corneum (SC) was slightly increased and especially epidermal thickening and flattening was observed (UA>ONA>Veh). We also observed that UA and ONA stimulate epidermal keratinocyte differentiation via $PPAR\;\alpha$. Protein expression of involucrin, loricrin, and filaggrin increased at least 2 and 3 fold in HaCaT cells treated with either $ONA\;(10{\mu}M)$ or UA $(10{\mu}M)$ for 24h respectively. This result suggested that the UA and ONA can improve epidermal permeability barrier function and induce the epidermal keratinocyte differentiation via $PPAR\;{\alpha}$. Using Masson-trichrome and elastic fiber staining, we observed collagen thickening and elastic fiber elongation by UA and ONA treatments. In vitro results of collagen and elastin synthesis and elastase inhibitory activity measurements were also confirmed in vivo findings. These data suggested that the effects of UA and ONA related to not only epidermal permeability barrier functions but also dermal collagen and elastic fiber synthesis. Taken together, UA and ONA can be relevant candidates to improve epidermal and dermal functions and pertinent agents for cosmeseutical applications.

• Korean Journal of Environment and Ecology
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• v.32 no.3
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• pp.313-322
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• 2018

To investigate the changing patterns of sub-alpine forest vegetation due to climate change requires accumulation of contiguous reference data and continuous monitoring. Furthermore, it is crucial to monitor short-term ecological change of lower level vegetation to understand the trend of long-term vegetation change. Therefore, this study carried out a vegetation survey and tree diameter measurement in 36 plots of Mt. Jiri inhabited by Abies koreana species from 2015 to 2017 to examine the short-term dynamics of Abies koreana seedling and the change of vegetation distribution according to altitude. We analyzed the importance value and MIV (mean importance value) of major species by each stratum as well as the importance value and species diversity index of major species and the change of seedling population by altitude. The results showed that Abies koreana had the highest importance value on tree layer, Rhododendron schlippenbachii on shrub layer and Tripterygium regelii on herb layer. MIV was high in the order of Abies koreana, Rhododendron schlippenbachii and Acer pseudosieboldianum. Regarding the species composition and species diversity index (H') along the altitudinal gradient, Sasa borealis showed high MI and low H' in the elevation less than 1,500 m, and IV of Tripterygium regelii and H' of herb layer were high in the elevation of 1,700 - 1,800 m. Abies koreana seedling decreased by 22.4% from 1,250 n/ha in 2015 to 970 n/ha in 2017 (p <0.05) throughout the investigated area. The decline rate along seedling and sapling height were 22.9% in less than 10 cm, 3.4% in 10-30 cm, 8.9% in 30-50 cm, 39.3% in 50-100 cm, and 55.1% more than 100 cm. Few of A. koreana seedlings appeared due to the dominance of Sasa borealis in the elevation of 1,500 m or less and due to the dominance and high species diversity of Tripterygium regelii in the elevation of 1,700-1,800 m. On the other hand, many of A. koreana seedlings appeared in the elevation of 1,600-1,700 m due to no distribution of S. borealis and T. regelii species in that altitude range. Therefore, we concluded that those seedlings and saplings of A. koreana could be more stable in the altitude of 1,600-1,700 m.