• The Korean Journal of Physiology and Pharmacology
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• 제18권6호
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• pp.509-516
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• 2014

Radiation therapy for variety of human solid tumors utilizes mechanism of cell death after DNA damage caused by radiation. In response to DNA damage, cytochrome c was released from mitochondria by activation of pro-apoptotic Bcl-2 family proteins, and then elicits massive $Ca^{2+}$ release from the ER that lead to cell death. It was also suggested that irradiation may cause the deregulation of $Ca^{2+}$ homeostasis and trigger programmed cell death and regulate death specific enzymes. Thus, in this study, we investigated how cellular $Ca^{2+}$ metabolism in RKO cells, in comparison to radiation-resistant A549 cells, was altered by gamma (${\gamma}$)-irradiation. In irradiated RKO cells, $Ca^{2+}$ influx via activation of NCX reverse mode was enhanced and a decline of $[Ca^{2+}]_i$ via forward mode was accelerated. The amount of $Ca^{2+}$ released from the ER in RKO cells by the activation of $IP_3$ receptor was also enhanced by irradiation. An increase in $[Ca^{2+}]_i$ via SOCI was enhanced in irradiated RKO cells, while that in A549 cells was depressed. These results suggest that ${\gamma}$-irradiation elicits enhancement of cellular $Ca^{2+}$ metabolism in radiation-sensitive RKO cells yielding programmed cell death.

• 한국정보통신학회논문지
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• 제8권1호
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• pp.65-73
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• 2004

이동 IP 망에서 이동 IP의 삼각 라우팅 문제를 해결한 최적경로 IP 라우팅 기법은 이동 IPv6망에서의 이동성을 지원하는 기본 동작으로 되어있다. 본 논문에서는 이동 IP망의 최적 경로 기법을 ATM망에서의 NHRP를 이용한 단거리 터널설정 기법을 적용하여 그 성능을 평가하였다. 종단간 패킷 전달지연 시간 측면에서 기존 IP 라우팅 기법과 최적경로에서의 단거리 터널링 기법을 상호 비교하기 위하여 수학적 분석 및 모의실험을 수행하였다. 최적 경로의 단거리 터널링 기법은 기존 IP 라우팅 방식보다 초기 데이터의 경우 종단간 전달 지연시간이 클 수 있으나 이후 패킷부터는 종단간 데이터 전달 지연시간이 대폭 개선됨을 확인하였다.

• 대한의용생체공학회:의공학회지
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• 제27권5호
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• pp.274-281
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• 2006

In this paper, we propose a ubiquitous $SaO_2$ monitoring system for patients using oxygen therapy. For these patients, the ability to monitor oxygen saturation ubiquitously is very important fur accurate adjustment of ventilator's flow rate to match the patient's time-varying requirements with the shortest lag time possible. We have developed a portable device to measure $SaO_2$ and transmit it to hospital in real-time or in store-and-forward mode through the integration of $Bluetooth^{TM}$ technology and the code division multiple access (CDMA) cellular network. We also developed software for doctors to receive and manage the patients' $SaO_2$ information. Performance of the developed system was evaluated as acceptable by assessing the accuracy of the measured oxygen saturation value and the stability of communication network. Test results in real clinical setting demonstrate that our system is feasible for immediate use in home oxygen therapy.

• Asia Marketing Journal
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• 제15권1호
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• pp.169-188
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• 2013

Established in 2006 as the forward integration effort by Taesung Industry, the major cosmetic packaging company, TONYMOLY has phenomenally grown to one of the major cosmetic brand companies in the submarket called, 'one brand-shop' of cosmetic market since 2008, after overcoming the crisis of 'going out of business' in a couple of early years. Within a relatively short period of time, TONYMOLY's performances have dramatically improved in terms of metrics such as growth in sales revenue, the number of stores, the average sales per store, transaction value per customer, the number of monthly transactions, the number of membership-based customers, and overseas sales. In this case study, we have examined TONYMOLY's recent marketing activities which may explain the plausible reasons behind the substantial growth of a small but smart cosmetic company. Above all, the first key success factor of TONYMOLY would be found in its adherence to the clear philosophy of the customer value proposition and/or the differentiated position of TONYMOLY as a brand of providing value. Second, this brand concept of value was first penetrated and welcomed among the foothold customer target group of mid and late teens with appropriate products, while the target groups were later expanded into the age group of twenties along with expansion of relevant products. Third, its differentiation efforts have been concrete and meaningful by utilizing unique ingredients in its product development and marketing efforts, unique fun packaging, and continuously introducing new hit-selling products as well as managing steady-selling products. Fourth, TONYMOLY has been smart enough to use its limited marketing money efficiently and effectively in its marketing communication activities. Viral marketing, PPL, and concentrated media planning and execution turned out to produce effective and efficient market-based performances such as awareness, word-of-mouth, and sales. Lastly, the marketing leadership of CEO and top management, emphasizing communications and interactions, was confirmed in the relationship quality with and trust level of its franchisees and internal employees. These key success factors may explain the recent phenomenal market performances of TONYMOLY. Despite recent successes, the major issues are presented for TONYMOLY to consider for maintaining its sustainable advantages and growth. The first issue concerns TONYMOLY's choice of growth philosophy between product/brand-centric marketing and customer-centric marketing. The second challenging issue relates to how TONYMOLY can cope with 'growing pains' plausibly accompanied with the rapid growth.

• 유통과학연구
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• 제13권4호
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• pp.89-98
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• 2015

Purpose - In today's globalized and modern business environment, corporate social responsibility (CSR) activities are considered to be essential for the sustainable development of enterprises. In addition, the corporate philanthropy that is related to CSR practices, as well as their being capable of reducing the anti-corporate sentiment of people have facilitated a qualitative forward leap into the quantitative growth phase. This study aims to undertake a comparative evaluation of corporate philanthropy through the Importance-Performance Analysis (IPA) method focusing on service and manufacturing industries, and to eventually determine a differentiated approach that is needed for corporate philanthropy. Research design, data, and methodology - The survey responses were collected through online research on specialized companies from consumers nationwide who were aged from 20 to 60 and who are aware of corporate philanthropy. A total of 408 sheets of questionnaire survey were used. Frequency analysis was undertaken in this study. The interviewees had demographic characteristics of gender: 206 males (50.5%) and 202 females (49.5%). They also had demographic characteristics of age: 82 people were over 20 (20.1%), 96 over 30 (23.5%), 105 over 40 (25.7%), and 125 over 50 (30.7%) years of age. The distribution of interviewees' residences is as follows: 154 persons (37.7%) in the Special City, 102 persons (25.0%) in the Metropolitan City, and 152 persons (37.3%) in the Provincial Region. The interviewees have been working for the following companies: 34 persons (8.3%) in LG Display, 80 (19.6%) in KT&G, 49 (12.0%) in Amore Pacific, 42 (10.3%) in KIA Motors, 47 (11.5%) in SBS, 52 (12.8%) in Shinhan Bank, 86 (21.1%) in Asiana Airlines, and 18 (4.4%) in Hyundai Department Store. We applied the paired t-test for the IPA analysis. PASW Statistics 18 was used for statistical analysis. Results - The results of IPA analysis indicated that the importance and performance degrees in both manufacturing and service industries were significantly different. Major empirical results showed that, in consumer, social, economic, philanthropic, and environmental dimensions, in the sub-factors of philanthropy activities in both manufacturing and service industries, the importance degree was found to be higher than performance degree. Further, the average difference between importance degree and performance degree by the sub-factors of philanthropy activities. On the other hand, the average difference of environmental dimension was found to be highest in both service and manufacturing industries. Thus, while consumers consider the philanthropy activities of the environmental dimension as most important, actual companies treat performance of philanthropy activities of the environmental dimension insufficiently or negligibly to some degree. Conclusions - The differentiated approach method that is required for corporate philanthropy may be proposed to uplift corporate accomplishments by analyzing the IPA of the attributes of the sub-factors of corporate philanthropy. This is, to an extent, insufficient in the existing studies related to the use of the IPA technique, and it shows the items that are to be conducted intensively.

• 정보관리연구
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• 제38권2호
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• pp.153-173
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• 2007

[ $OntoFrame^{(R)}$ ]은 연구자들의 연구개발을 전주기적으로 지원하기 위해 시맨틱 웹 프레임워크를 기반으로 하여 정보유통 서비스와 추론 서비스를 제공하는 시스템이다. 기능성 측면에서 기존에 유사한 서비스를 찾지 못할 만큼 강력함을 가지고 있지만, 시스템 설계와 개발 단계에서 사용성 평가를 수행하지 않아 사용성 측면에서도 만족스러울 지의 여부를 판단하기 힘들다. 이에 본 연구를 통해 국내에서 거의 이루어지고 있지 않은 사용성 평가를 해당 시스템을 대상으로 수행하며, 평가 결과 분석을 통해 기능 중심적이 아닌 사용자 중심적 시스템으로 발전하기 위한 방향을 제시한다. 사용성 평가를 위해 소프트웨어 인간공학(Software Ergonomics) 전문가에 의한 '이론 중심 사용성 평가'와 사용자 그룹에 의한 '사용자 중심 평가(사용자 테스트)'를 병행하였으며, 본 연구 결과가 실제 서비스를 목표로 하는 시스템 개발에 있어서의 기반 연구가 될 것이라 기대한다.

• 디지털융복합연구
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• 제14권7호
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• pp.403-409
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• 2016

본 연구는 옴니채널 환경의 식품쇼핑 경험연구이다. 안전한 먹거리에 대한 관심은 IT의 발전에 따라 소비자의 다양한 요구에 합리적 방식으로 진화하며 이를 충족한 다양한 채널 증가로 이어졌다. 옴니채널은 소비자의 필요와 욕구를 채우는 것뿐 아니라 고객 행동 이해와 경험 가치를 부여한 실증적 사용자 유형 고찰이 필요했다. 온라인 설문 결과, (1)오프라인 식품쇼핑은 대 소형 마트, 1개월에 2~3회, 품질상태 고려, 신선식품을 직접 구매하기 위해 방문 (2)온라인 식품쇼핑은 온라인 커머스, 1개월에 2~3회, 가격/혜택을 고려, 과일/견과를 주로 구매로 나타났다. 이후 고관여자 8인의 심층면접에서 식품구매여정 4단계를 통해 식품쇼핑 경험을 파악하였다. '건강'과 '식단'을 식품쇼핑 핵심 가치로 한 퍼소나는 가족과 건강을 중요시하고 '절약'을 우선하는 프라이머리 퍼소나와 일과 개인을 중시하며 '자동수급'을 하는 원하는 세컨더리 퍼소나로 세분된 방안을 제시하였다. 본 연구를 통해 옴니채널 식품쇼핑 경험을 위해서는 건강하고 균형 잡힌 식생활의 맥락에서 기능과 서비스 방안을 모색하는 데 도움이 될 것으로 기대한다.