• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.27 no.5
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• pp.482-485
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• 2016

In this work, a transcranial magnetic stimulation(TMS) experiment on animals is performed to stimulate the brain cortex of the mouse using modulated signals. The proposed TMS system is composed of the inverter, transformer, capacitor, variable inductor, and stimulation coil to generate 1.5 mT magnetic field in the brain cortex of the mouse. The stimulation signal is modulated to square wave where the carrier frequency is swept from 85 to 91 kHz to investigate the stimulation effect. The experimental result shows that when the carrier frequency of the stimulation signal is lower than 89 kHz, the reaction of the mouse does not change while the stimulation signal which has the carrier frequency higher than 89 kHz results in decreasing the threshold of the stimulus for the pressure.

• Journal of Korean Physical Therapy Science
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• v.10 no.1
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• pp.180-189
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• 2003

The experiments were designated to evaluate the anti-nociceptive effect of low power laser stimulation on acupoint or non-acupoint using arthrogenic solution induced poly arthritis animal model. Evaluation of potential antinociceptive effect of low power laser on arthritis has employed measurements of the foot bending test, the development of either thermal or mechanical hyperalgesia following the arthritis induction. The analysis of thermal hyperalgesia includes Hargreaves's method. Randall-Sellitto test was utilized for evaluating mechanical hyperalgesia. In addition, the antinociceptive effect of low power laser stimulation on arthritis induced spinal Fos expression was analyzed using a computerized image analysis system. The results were summerized as follows: 1. In laser stimulation on acupoint treated animal, laser stimulation dramatically inhibited the development of pain in foot bending test as compared to those of non acupoint treated animal group and non treated animal group. 2. The threshold of thermal stimulation was significantly increased by low power laser stimulation on acupoint as compared to that of non treated control group. 3. Laser stimulation on acupoint dramatically attenuated the development of mechanical hyperalgesia as compared to that of non treated group. 4. Low power laser stimulation on acupoint significantly suppressed arthritis induced Fos expression in the lumbar spinal cord at 3 week post arthritis induction. In conclusion, the results of the present study demonstrated that low power laser stimulation on acupoint has potent anti-nociceptive effect on arthritis. Additional supporting data for an antinociceptive effect of laser stimulation was obtained using Fos immunohistochemical analysis on spinal cord section. Those data indicated that laser stimulation induced antinociception was mediated by suppression of spinal neuron activity in pain sensation.

• The Korean Journal of Pain
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• v.34 no.2
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• pp.156-164
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• 2021

Several types of pain occur following spinal cord injury (SCI); however, neuropathic pain (NP) is one of the most intractable. Invasive and non-invasive brain stimulation techniques have been studied in clinical trials to treat chronic NP following SCI. The evidence for invasive stimulation including motor cortex and deep brain stimulation via the use of implanted electrodes to reduce SCI-related NP remains limited, due to the small scale of existing studies. The lower risk of complications associated with non-invasive stimulation, including transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), provide potentially attractive alternative central neuromodulation techniques. Compared to rTMS, tDCS is technically easier to apply, more affordable, available, and potentially feasible for home use. Accordingly, several new studies have investigated the efficacy of tDCS to treat NP after SCI. In this review, articles relating to the mechanisms, clinical efficacy and safety of tDCS on SCI-related NP were searched from inception to December 2019. Six clinical trials, including five randomized placebo-controlled trials and one prospective controlled trial, were included for evidence specific to the efficacy of tDCS for treating SCI-related NP. The mechanisms of action of tDCS are complex and not fully understood. Several factors including stimulation parameters and individual patient characteristics may affect the efficacy of tDCS intervention. Current evidence to support the efficacy of utilizing tDCS for relieving chronic NP after SCI remains limited. Further strong evidence is needed to confirm the efficacy of tDCS intervention for treating SCI-related NP.

• The Journal of Korean Physical Therapy
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• v.12 no.2
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• pp.121-132
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• 2000

This study was carried out to determine the influencing of electrical stimulation to cervicothoracic sympathetic ganglion(CTSG; stellate ganglion) u the sympathetic tone. For the purpose of this study. the stimulation was given to both the interferential current stimulation(ICS: AMF 100Hz) group consisting of 10 person(males 8, females 2) and the transcutaneous nerve electrical stimulation(TENS: 100 Hz) group of 10(males 7, females 3) in the right side of the trachea with probe electrodes. Then. the temperature changes on the surfaces of the forehead. cheek, neck and internal ear of cephalocervix, which is subject to the influence of the cervicothoracic sympathetic ganglion, and the palm. which is the end of the upper limbs. measured before. immediately alter. 10 minutes after and 20 minutes after experiment. The results are summarized as follows. 1. The emergence of remarkable Horner's symptoms which appear due to the changes of the tone of cervicothoracic sympathetic ganglion was not seen. However, in the interferential current stimulation group there were two felt the sense of warmth in the facial region and one person who felt it in the upper limbs, and in the transcutaneous nerve electrical stimulation group there was each one person who felt the sense of warmth in the facial region and in the upper limbs, respectively. Both groups have each one person who felt the sense of oppression in the eyelids. Three persons of the interferential current stimulation group and two persons of the transcutaneous nerve electrical stimulation group have the sense of hoarse voice or numbness in the neck. These are the symptoms that appeared during stimulation, so it is difficult for them to be considered as the direct effects of the changes of the tone of cervicothoracic sympathetic ganglion. 2. The t-test was performed to determine the significance between the right, which is the experimental side, and the left, which is the non-experimental side. Significance between the right, which is the experimental side, and the left, which is the non-experimental side. Significant changes were seen in the necks of the interferential current stimulation group and in the cheeks and internal ears of the transcutaneous nerve electrical stimulation immediately after experiment(P<.05). And the interferential current stimulation group showed a very high significance in the cheeks immediately after experiment and in the necks ten minutes after experiment(p<.01). Therefore, it could be seen that the electrical stimulation had an influencing on the changes of body temperature of the cephalocervix. 3. In both the interferential current stimulation group and the transcutaneous nerve electrical stimulation group, the forecheads, checks and necks of the cephalocervix in the experimental side(right) rather than the non-experimental side(left) had mostly a statistically significant rise in temperature immediately after experiment. The one-way ANOVA was carried out to determine the temperature change of on the surface of the body with the lapse of time; before, immediately after, ten minutes after and tewenty minutes after experiment. But no statistical significance was found from both the right and left sides.

• The Journal of Korean Academy of Sensory Integration
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• v.3 no.1
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• pp.57-65
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• 2005

Objective : The purpose of this study was to investigate the effect of sensory stimulation for static balance on normal children. Sensory input was consisted of colors, and music tempo stimulation. Methods : Participants were consisted of 20 normal kindergarten children ranging in age from six to seven years. The static balance was tested by a BPM(Balance Performance Monitor). In this study one-way ANOVA was used and the statistical significance level of results was determined at 0.05. Results : 1. According to color stimulation, there was no significant difference in static balance among red, yellow, green(p>0.05). 2. According to music tempo stimulation, there was no significant difference in static balance, among the high music tempo and low music tempo children in a general environment(p>0.05). 3. However, both green color and low music tempo stimulation have a little effect on static balance on normal children. Conclusion : These results indicate the possibility that the application method of green color and low music tempo stimulation may help in the improvement of static balance for the disabled children. This study will be used as the foundational data of therapeutic environment for the disabled children.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1232-1235
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• 2004

The purpose of this study is to design electrical stimulation system for pharyngeal dysfunction(dysphagia) in stroke patients. Pharyngeal muscle group activity is important, because contracting muscles provide the driving force at the initiation of the swallow and generate the pressure gradients necessary for bolus movement into the esophagus. Although we have many treatment methods for dysphagia, electrical stimulation system will be useful for stroke patients having dysphagia. Electrical stimulation can be divided into the body stimulation and electrodes. The body stimulation is divided again into frequency counter, time control and current measurement part. These parts are to control the current intensity, frequency and stimulating time. And they can be variable according to the patient's clinical assessment. The electrode plays a role to deliver the current from the system to the muscle. Also the position of the electrode can be variable according to the treatment method. We performed the clinical experiment with the stroke patient who has swallowing disorder. The videofluoroscopy was used for the observation. From the result of clinical experiment based on electrical stimulation, we expected that the dysfunction(in pharynx) level of the patient can be improved. However we could not have enough effectiveness of the treatment because of the number of patients, patient's adaptation and treatment period. We will design the optimized electrical stimulation system based on enough clinical experiment in the future.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.10 no.2
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• pp.1-6
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• 2012

Purpose : This study is to investigate the modulatory effects to the ultraviolet induced erythema of pain processing system. Methods : Thirty six healthy volunteers were divided into none treatment group (n=6), indomethacine group (n=6), subsensory level electrical stimulation group (n=6), sensory level electrical stimulation group (n=6), motor level electrical stimulation group (n=6), noxious level electrical stimulation group (n=6). Subjects were induced erythema for three times minimal erythema dose (MED) at upper arm of dermatome C6 level. Each experimental group had mechanical pain threshold (MPT), electrical pain threshold (EPT), thermal pain threshold (TPT). Results : This study revealed that we observed that pain thresholds were significantly correlated with each other in pain processing system. The effect of electrical stimulation levels evaluates were shown to be significant differences pain control effect in electrical stimulation group (sensory, motor level electrical stimulation groups) more than indomethacine group, subsensory level and control group. Conclusion : In this study, it was found that the effect of ultraviolet induced erythema of pain control by modulatory electrical stimulation.

• The Korean Journal of Pain
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• v.7 no.2
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• pp.307-313
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• 1994

Cutaneous stimulation has had a long history as a method of pain control. While there is general agreement that modern techniques such as electrical stimulation and massage often provide relief from acute pain and may in some cases significantly affect chronic pain, the mechanism by which these techniques affect pain remain unclear. Significant attention has been focused on the effects of stimulation on the autonomic nervous system(ANS) along with the increasing evidence of important ANS modulation of nociceptive activity throughout the pain pathway. However, inconsistent results on the presence and direction of ANS changes from cutaneous stimulation characterize the recent literature. The present study investigated a non-electrical cutaneous stimulation device, the Dermapoints massage roller, as well as an active placebo massage. The results indicate that the Dermapoints massage roller has both general effects associated with simple skin stimulation (such as increased skin temperature), as well as specific effects from increased stimulation by the tooth design of the roller. These specific effects include decreased muscle tension (at least for some muscle sites) and increased sympathetic activation. The results are consistent with a model of activation of Pacinian receptors as a possible mechanism for the antinociceptive properties of cutaneous stimulation.

• Journal of Biomedical Engineering Research
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• v.32 no.2
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• pp.93-104
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• 2011

The purpose of this study was to investigate lower-limb joint torque of the two groups as it changed by somatosensory stimulation during the descent down three stairs of different heights and to describe the difference between the two groups, which are young people group and elderly people group. Subjects of each groups climbed down a stair at four stimulation conditions, which are non-stimulation, tibialis anterior tendon stimulation, achilles tendon stimulation, tibialis anterior - achilles tendon stimulation. Motion capture data were collected using 3D optoelectric motion tracking system that utilizes active infrared LEDs, near infrared sensor and force plate. The obtained motion capture data was used to build 3D computer simulation model. The results show that lower-limb joint torque of the two groups changed with somatosensory stimulation as they descended the stairs and the joint torque of the two groups differed from each other.

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.46-54
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• 2007

Objective: The first aim of this study is to determine the effects of acupuncture on the autonomic nervous system (ANS) via Heart Rate (HR) and Pupil Size (PS), and to compare the effects of acupuncture on the subjects' ANS when they are in a sitting position with the effects when they are in a supine position. Methods: Ten healthy male subjects were randomized to receive either verum acupuncture stimulation in a sitting position (SitV), verum acupuncture stimulation in a supine position (SupV), sham acupuncture stimulation in a sitting position (SitS), and sham acupuncture stimulation in a supine position (SupS). Acupuncture stimulation was applied to Neguan point (PC6) on the forearm. The subject's electrocardiogram (ECG) and pupil size were recorded continuously from 5 min before stimulation to 12 min after stimulation. Results: Verum and sham acupuncture stimulation were found to have reduced heart rate (p<0.01) and to have increased pupil size (p<0.01) in all the subjects. But when the reduction in HR and the increment in PS after verum acupuncture stimulation (both sitting and supine position) were compared with those after sham acupuncture stimulation, it was found that the reduction in HR (74.48 and 73.47 bpm, p<0.063) and the increment of PS (7.32 and, 6.10 mm, p<0.001) after verum acupuncture stimulation were greater than those after sham acupuncture stimulation, and that the corresponding values were statistically significant. In addition, at the baseline, it was found that the subjects had a larger PS and a faster HR in a sitting position than when they did so in a supine position. And then the reduction and increment ratio in the subject's HR and PS when they underwent acupuncture stimulation in a sitting position was significantly different from the reduction and increment in their HR and PS when they underwent the procedure in a supine position-i.e., the reduction ratio in HR was greater when they underwent the procedure in a sitting position, and such reduction ratio was statistically significant (p<0.05). As for the increment in PS, it was greater when the subjects underwent the procedure in a supine position, and such increment was significant (p<0.05). Conclusion: Manual acupuncture stimulation on Neguan point (PC6) has more significant influence on the autonomic nervous system rather than sham acupuncture (tactile stimulation). And the position-induced different states of ANS have different influence on the acupuncture effect.