• Journal of Veterinary Clinics
• /
• v.36 no.6
• /
• pp.345-348
• /
• 2019

A four-year old, indoor-living neutered male Old English Bulldog was presented for generalized ulcerative dermatitis. Generalized alopecia and multifocal papules and ulcers with crusting were observed mainly in the dorsal trunk. Cytology of the skin lesions revealed a pyogranulomatous inflammation comprising macrophages and nondegenerate neutrophils. Histopathology also revealed a nodular dermatitis characterized by mixed infiltration of monocytes and neutrophils involving the superficial and deep dermis. Neither of bacteria nor fungus was identified in microscopic exam and culture. From those findings, a diagnosis of cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) was made. Treatment with immunosuppressive drugs of prednisone and cyclosporine was performed and visible ulcerative skin lesions were resolved after 4 weeks of initiation of therapy. Treatment with combination of cyclosporine and prednisone may be effective for the case of SPGS.

• Journal of the korean veterinary medical association
• /
• v.50 no.9
• /
• pp.526-529
• /
• 2014

• Journal of Veterinary Clinics
• /
• v.21 no.4
• /
• pp.402-405
• /
• 2004

A 5-year-old Rottweiler neutered female dog was presented with signs of mandibular and popliteal lymphadenopathy, erosion in mucocutaneous junction of muzzle and lips, multiple papules and nodules in right rear limb and neck, and alopecia in right thorax. There was no further clinical sign except anorexia, sporadic fever and ocular hyperemia. She hadn't shown any response to carprofen prescribed by local veterinarian. Hematological abnormalities included mild anemia and severe lymphocytosis. On serum biochemical profile, only elevated AST level was noticed. On cytological examination, there was an evidence of mild bacterial infection which seemed to occur secondarily. Three sites were biopsied that included muzzle, upper lip and right thoracic region. Histopathologically, multifocal confluent pyogranulomatous dermatitis, scattered granulomatous inflammation in subcutis and severe septal panniculitis were observed. Special stainings(Gram, Acid-fast, PAS, Giemsa) were performed to reveal that a dog was negative for any organism. Finally, sterile pyogranuloma/granuloma syndrome (SPGS) was diagnosed. The treatment was initiated with predinsolone and enrofloxacin. The condition was successfully resolved after 4 weeks of treatment. This good response suggests that SPGS may be immune-mediated disease of its pathogenesis and this drug combination may be a viable therapeutic option for dogs suffering from SPGS. Also, this article reports a case of SPGS in Rottweiller for the first time.