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A Sterile Pyogranuloma/Granuloma Syndrome (SPGS) in a Rottweiler Dog  

Kim Youn-ju (경북대학교 수의과대학)
Jeong A-young (경북대학교 수의과대학)
Kim Jae-hoon (제주대학교 농업생명과학대학 수의학과)
Eom Ki-dong (경북대학교 수의과대학)
Lee Keun-woo (경북대학교 수의과대학)
Oh Tae-ho (경북대학교 수의과대학)
Publication Information
Journal of Veterinary Clinics / v.21, no.4, 2004 , pp. 402-405 More about this Journal
Abstract
A 5-year-old Rottweiler neutered female dog was presented with signs of mandibular and popliteal lymphadenopathy, erosion in mucocutaneous junction of muzzle and lips, multiple papules and nodules in right rear limb and neck, and alopecia in right thorax. There was no further clinical sign except anorexia, sporadic fever and ocular hyperemia. She hadn't shown any response to carprofen prescribed by local veterinarian. Hematological abnormalities included mild anemia and severe lymphocytosis. On serum biochemical profile, only elevated AST level was noticed. On cytological examination, there was an evidence of mild bacterial infection which seemed to occur secondarily. Three sites were biopsied that included muzzle, upper lip and right thoracic region. Histopathologically, multifocal confluent pyogranulomatous dermatitis, scattered granulomatous inflammation in subcutis and severe septal panniculitis were observed. Special stainings(Gram, Acid-fast, PAS, Giemsa) were performed to reveal that a dog was negative for any organism. Finally, sterile pyogranuloma/granuloma syndrome (SPGS) was diagnosed. The treatment was initiated with predinsolone and enrofloxacin. The condition was successfully resolved after 4 weeks of treatment. This good response suggests that SPGS may be immune-mediated disease of its pathogenesis and this drug combination may be a viable therapeutic option for dogs suffering from SPGS. Also, this article reports a case of SPGS in Rottweiller for the first time.
Keywords
sterile pyogranuloma/granuloma syndrome (SPGS); dog; glucocorticoid;
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