• 한국전산유체공학회지
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• 제21권2호
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• pp.12-24
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• 2016

The standard ${\kappa}-{\varepsilon}$ and realizable ${\kappa}-{\varepsilon}$ models are adopted to improve the prediction performance on the recirculating flow. In this paper, the backward facing step flows are used to assess the prediction performance of the recirculation zone. The model constants of turbulence model are obtained by the experimental results and they have a different value according to the flow. In the case of an isotropic flow situation, decaying of turbulent kinetic energy should follow a power law behavior. In accordance with the power law, the coefficients for the dissipation rate of turbulent kinetic energy are not universal. Also, the other coefficients as well as the dissipation coefficient are not constant. As a result, a suitable coefficients can be varied according to each of the flow. The changes of flow over the backward facing step in accordance with model constants of the ${\kappa}-{\varepsilon}$ models show that the reattachment length is dependent on the growth rate(${\lambda}$) and the ${\kappa}-{\varepsilon}$ models can be improved the prediction performance by changing the model constants about the recirculating flow. In addition, it was investigated for the curvature correction effect of the ${\kappa}-{\varepsilon}$ models in the recirculating flow. Overall, the curvature corrected ${\kappa}-{\varepsilon}$ models showed an excellent prediction performance.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.721-733
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• 2018

BACKGROUND: Because three-dimensional (3D) models more closely mimic native tissues, one of the goals of 3D in vitro tissue models is to aid in the development and toxicity screening of new drug therapies. In this study, a 3D skin wound healing model comprising of a collagen type I construct with fibrin-filled defects was developed. METHODS: Optical imaging was used to measure keratinocyte migration in the presence of fibroblasts over 7 days onto the fibrin-filled defects. Additionally, cell viability and growth of fibroblasts and keratinocytes was measured using the $alamarBlue^{(R)}$ assay and changes in the mechanical stiffness of the 3D construct was monitored using compressive indentation testing. RESULTS: Keratinocyte migration rate was significantly increased in the presence of fibroblasts with the cells reaching the center of the defect as early as day 3 in the co-culture constructs compared to day 7 for the control keratinocyte monoculture constructs. Additionally, constructs with the greatest rate of keratinocyte migration had reduced cell growth. When fibroblasts were cultured alone in the wound healing construct, there was a 1.3 to 3.4-fold increase in cell growth and a 1.2 to 1.4-fold increase in cell growth for keratinocyte monocultures. However, co-culture constructs exhibited no significant growth over 7 days. Finally, mechanical testing showed that fibroblasts and keratinocytes had varying effects on matrix stiffness with fibroblasts degrading the constructs while keratinocytes increased the construct's stiffness. CONCLUSION: This 3D in vitro wound healing model is a step towards developing a mimetic construct that recapitulates the complex microenvironment of healing wounds and could aid in the early studies of novel therapeutics that promote migration and proliferation of epithelial cells.

• Journal of Forest and Environmental Science
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• 제13권1호
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• pp.66-80
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• 1997

잣나무는 최근 10년간 우리나라 인공조림실적 중 31%를 차지하는 주요 조림수종이다. 현재 우리나라 산림(山林)은 대부분의 인공조림지를 포함하여 30년생 이하의 유령림(幼齡林)이 87%를 점유하고 있음에도 보육간벌은 거의 실시되지 못하고 있는 실정이다. 또한 현실정에 적합한 잣나무의 보육간벌 지침도 충분히 확립되어 있지 못하다. 본 연구는 잣나무림의 장기적 보육간벌 시험을 통하여 장차 최적(最適)한 간벌계획(間伐計劃) 및 방법(方法)의 확립 에 기여하고자, 우선 강원대학교(江原大學校) 연습림(演習林)에 설정된 잣나무의 간벌시험지와 기존의 임분수확표를 대상으로 생장함수를 이용하여 잣나무의 생장과정의 변화 등을 분석 고찰하였다. 간벌과정을 파악하기 위한 기초적인 단계로 생장과정을 표현하기 적합한 이론적 생장함수를 선정할 필요가 있다. 이를 위해 Mitscherlich, 4 parameter Richards, 3 parameter Richards의 3종의 생장함수식(生長函數式)을 간벌시험지에서 채취한 임령 18년 전후의 공시목의 직경생장 과정에 적용하였다. 그 결과 3변수 Richards 생장함수식이 가장 적합한 것으로 나타났다. 또한 산림청에서 작성한 잣나무 수확표의 직경과 수고생장, 입목본수의 감소 과정도 3변수 Richards 생장함수식에 의하여 적합하게 추정할 수 있음을 확인하였다. 장래 단목의 간벌에 따른 생장의 변화과정을 추정하기 위해, 단목의 점유 면적에 관계하는 계수 h를 포함하는 생장(生長)모델을 제안하였다. 현재 설치된 간벌시험지에서 향후 일정간격으로 얻어질 간벌시험지의 직경생장 공시자료를 이용하면 계수 h를 추정할 수 있고, 이를 이용하여 제안된 모델의 유용성을 검증, 보완한다면 단목의 생장과정을 사전에 유추하여 간벌의 효과를 표현할 수 있는 수식을 구축할 수 있을 것으로 사료된다.

• 한국재료학회지
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• 제13권10호
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• pp.677-682
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• 2003

SiC nanowires were synthesized by carbothermal reduction using metal catalysts. Synthesized nanowires had mean diameters of 30∼50 nm and several $\mu\textrm{m}$ length. The kind of catalysts affects form of SiC nanowire because of difference of growth mechanisms. These differences were made by catalyst's physical property and relative activities to the source gas. Ni acted a conventional catalyst of VLS growth mechanism. But, Case of Fe, SiC nanowire was grown by stable VLS growth mechanism without relation of growth conditions. SiC nanowire was grown by two step growth model using Cr catalyst. Conversion ratios to the SiC nanowire were increased with growth conditions. Case of Cr, conversion ratio was about 45% that was higher than other catalyst used. This high conversion ratio was obtained by the addition VS growth to radial direction on the as-grown nanowires.

• 대한기계학회논문집
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• 제16권8호
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• pp.1583-1594
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• 1992

본 연구에서는 동층류 축대칭 확산화염에서 이전까지의 화염해석 방법들을 면 밀히 고찰하여 층류 확산화염 방식의 연소문제를 해결하는데 있어서 접근이 용이하고 타당성을 가지는 화염해석 방법을 찾아내는데 있으며 매연 입자에 관한 생성및 산화모 델을 총체적으로 연결하여 실험결과와의 비교를 통해 적절한 모델인수를 결정하며 복 사효과와 열영동효과를 고려하여 화염해석과 화염내의 매연입자의 분포를 예측하는데 있다.

• KSBB Journal
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• 제9권2호
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• pp.230-237
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• 1994

회전식 여과기는 일종의 분리기로서 동물세포의 연속배양에 이용되어 높은 세포농도와 그와 비례한 높은 생산성을 가져다 준다. 회전식 여과기를 이용한 세포배양은 여러 인자들에 의해 세포농도의 변화가 결정되는데 이를 수학적으로 modeling하고 수치 모사와 sensitivity analysis를 통하여 조사하였다. 고농도 배양시 암모니아의 축적은 세포 성장을 크게 둔화시키고 최대세포농도도 따라서 낮게 된다. 운전 인자 중 세포유치율은 세포 성장속도와 최대세포농도의 크기에 가장 큰 영향을 끼침이 밝혀졌다. 비배지공급속도는 세포농도의 변화에 거의 영향을 끼치지 않으며 배지의 연속식공급과 계단식공급은 세포성장에 큰 차이를 보이지 않는다.

• 지능정보연구
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• 제20권4호
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• pp.1-23
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• 2014

시장 예측은 일정 기간 동안 소비자에게 판매되는 동종 제품 또는 서비스의 수량 혹은 매출액의 규모를 추정하는 활동으로 정의할 수 있다. 정확한 시장 예측은 기업의 입장에서 새로운 제품의 도입시기 결정, 제품 설계, 생산계획 수립, 마케팅 전략 수립 등에 활용됨으로써 경영활동에 있어 효율적인 의사결정을 내릴 수 있게 하고, 정부의 입장에서는 발전 가능성이 있는 분야에 국가예산을 더 배분할 수 있는 효율적인 예산수립이 가능하게 한다. 본 연구는 정보통신기술(Information and Communication Technology: ICT) 분야의 제품 및 서비스에 대해서 과거의 시계열 자료를 이용하여 시장 성장곡선을 도출하고, 성장패턴이 비슷한 그룹으로 분류하여, 산업 내 시장에 대해 이해하고, 제품들의 미래 전망을 예측하는 데 목적이 있다. 다양한 아이템들을 통일되고 일관적인 방법으로 예측하기 위하여, 로지스틱 모형, 곰페르츠 모형, Bass 모형의 세 가지 전통적인 성장모형과 로지스틱 모형이나 곰페르츠 모형에서 도출되는 잠재시장 크기를 Bass 모형에 결합시킨 두 가지 하이브리드 성장모형을 개발하여 비교 분석하였다. 데이터 설명력이 우수한 로지스틱 + Bass 모형을 최적의 모형으로 선정하여 ICT 제품 및 서비스들 각각의 시장 성장곡선 모수를 확인하였다. 도출된 모수를 데이터로 하여, 자기조직화 지도 알고리즘을 통해, 5개의 의미 있는 영역으로 구분된 시장 성장패턴 지도가 구축되었는데, 각 영역별로 차별화된 특징과 성장패턴을 가지고 있었다. 본 연구에서 제안한 프로세스 및 시스템은 산업 시장 분석 시스템의 수요 예측 기능으로 활용될 수 있으며, ICT 산업뿐만 아니라 다양한 산업 및 분야에도 적용 가능할 것으로 기대된다.

• Clinical and Experimental Reproductive Medicine
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• 제39권3호
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• pp.95-106
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• 2012

It has been revealed that multiple cohorts of tertiary follicles develop during some animal estrous cycle and the human menstrual cycle. To reach developmental competence, oocytes need the support of somatic cells. During embryogenesis, the primordial germ cells appear, travel to the gonadal rudiments, and form follicles. The female germ cells develop within the somatic cells of the ovary, granulosa cells, and theca cells. How the oocyte and follicle cells support each other has been seriously studied. The latest technologies in genes and proteins and genetic engineering have allowed us to collect a great deal of information about folliculogenesis. For example, a few web pages (http://www.ncbi.nlm. nih.gov; http://mrg.genetics.washington.edu) provide access to databases of genomes, sequences of transcriptomes, and various tools for analyzing and discovering genes important in ovarian development. Formation of the antrum (tertiary follicle) is the final phase of folliculogenesis and the transition from intraovarian to extraovian regulation. This final step coordinates with the hypothalamic-pituitary-ovarian axis. On the other hand, currently, follicle physiology is under intense investigation, as little is known about how to overcome women's ovarian problems or how to develop competent oocytes from in vitro follicle culture or transplantation. In this review, some of the known roles of hormones and some of the genes involved in tertiary follicle growth and the general characteristics of tertiary follicles are summarized. In addition, in vitro culture of tertiary follicles is also discussed as a study model and an assisted reproductive technology model.

• Korean Journal of Radiology
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• 제23권9호
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• pp.921-930
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• 2022

Objective: To identify epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma based on ¹⁸F-fluorodeoxyglucose (FDG) PET/CT radiomics and clinical features and to distinguish EGFR exon 19 deletion (19 del) and exon 21 L858R missense (21 L858R) mutations using FDG PET/CT radiomics. Materials and Methods: We retrospectively analyzed 179 patients with lung adenocarcinoma. They were randomly assigned to training (n = 125) and testing (n = 54) cohorts in a 7:3 ratio. A total of 2632 radiomics features were extracted from the tumor region of interest from the PET (1316) and CT (1316) images. Six PET/CT radiomics features that remained after the feature selection step were used to calculate the radiomics model score (rad-score). Subsequently, a combined clinical and radiomics model was constructed based on sex, smoking history, tumor diameter, and rad-score. The performance of the combined model in identifying EGFR mutations was assessed using a receiver operating characteristic (ROC) curve. Furthermore, in a subsample of 99 patients, a PET/CT radiomics model for distinguishing 19 del and 21 L858R EGFR mutational subtypes was established, and its performance was evaluated. Results: The area under the ROC curve (AUROC) and accuracy of the combined clinical and PET/CT radiomics models were 0.882 and 81.6%, respectively, in the training cohort and 0.837 and 74.1%, respectively, in the testing cohort. The AUROC and accuracy of the radiomics model for distinguishing between 19 del and 21 L858R EGFR mutational subtypes were 0.708 and 66.7%, respectively, in the training cohort and 0.652 and 56.7%, respectively, in the testing cohort. Conclusion: The combined clinical and PET/CT radiomics model could identify the EGFR mutational status in lung adenocarcinoma with moderate accuracy. However, distinguishing between EGFR 19 del and 21 L858R mutational subtypes was more challenging using PET/CT radiomics.

• Animal Bioscience
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• 제34권6호
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• pp.967-974
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• 2021

Objective: The objective of this study was to estimate the genetic correlation (rpc) of growth performance between purebred (Duroc and Korean native) and synthetic (WooriHeukDon) pigs using a single-step method. Methods: Phenotypes of 15,902 pigs with genotyped data from 1,792 pigs from a nucleus farm were used for this study. We estimated the rpc of several performance traits between WooriHeukDon and purebred pigs: day of target weight (DAY), backfat thickness (BF), feed conversion rate (FCR), and residual feed intake (RFI). The variances and covariances of the studied traits were estimated by an animal multi-trait model that applied the Bayesian inference. Results: rpc within traits was lower than 0.1 for DAY and BF, but high for FCR and RFI; in particular, rpc for RFI between Duroc and WooriHeukDon pigs was nearly 1. Comparison between different traits revealed that RFI in Duroc pigs was associated with different traits in WooriHeukDon pigs. However, the most of rpc between different traits were estimated with low or with high standard deviation. Conclusion: The results indicated that there were substantial differences in rpc of traits in the synthetic WooriHeukDon pigs, which could be caused by these pigs having a more complex origin than other crossbred pigs. RFI was strongly correlated between Duroc and WooriHeukDon pigs, and these breeds might have similar single nucleotide polymorphism effects that control RFI. RFI is more essential for metabolism than other growth traits and these metabolic characteristics in purebred pigs, such as nutrient utilization, could significantly affect those in synthetic pigs. The findings of this study can be used to elucidate the genetic architecture of crossbred pigs and help develop new breeds with target traits.