• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.581-584
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• 2008

Generally, durability of concrete structures under marine environment is grossly declined by detrimental ions such as chlorides, which penetrate concrete and was diffused to corrode reinforcing rod. Therefore, chloride diffusion properties in concrete are important for durability evaluation and design of concrete structure. For estimation of chloride diffusion coefficient in concrete, both evaluation methods are used for steady state and non-steady state derived from Fick's 1st and 2nd law, respectively. However, as it is very difficult to evaluate diffusion coefficient for non-steady state like service environment where concrete is actually exposed, indirect evaluation method by laboratory accelerated test is generally used. In this study, comparison of chloride diffusion behavior was investigated for fixed mix proportion and age of concrete using four accelerated test methods based on domestic and foreign standards. From test results, only relative comparison between concrete mixtures was possible using ASTM C 1202 test, and diffusion coefficient for steady state was estimated as low as 1/10 of that for non-steady state. In addition, diffusion coefficient estimated by immersion test was similar to result by NT build 492 test.

• Archives of Pharmacal Research
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• v.21 no.4
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• pp.411-417
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• 1998

In order to investigate the effect of the pretreatment with various doses of diltiazem (DTZ) on the pharmacokinetics of indocyanine green (ICG) at steady state, especially the hepatic blood clearance due to the change of hepatic blood flow, the following experiments were carried out with ICG, a hepatic function test marker, not metabolized in liver and only excreted in bile. The intravenous bolus injection ($3,780\mu\textrm{g}$/kg) and the constant-rate infusion ($10,100\mu\textrm{g}$/kg/hr) of ICG into the left femoral vein were made in order to check the steady-state plasma concentration ($C_{ss} of $10\mu\textrm{g}$/ml) of ICG at 20, 25 and 30 min. Following a 90-min washout period, the intravenous bolus injection (108, 430, 860 and $1,720\mu\textrm{g}$/kg) and the constant-rate infusion (108, 433, 866 and $1,730\mu\textrm{g}$/kg/hr) of DTZ into the right femoral vein were made and the achievement of the steady-state plasma levels ($C_{ss} of 50, 200, 400 and 800 ng/ml) of DTZ were conformed at 60, 70 and 80 min. During the steady state of DTZ, the intravenous bolus injection ($3,780\mu\textrm{g}$/kg) and the constant-rate infusion ($10,200\mu\textrm{g}$/kg/hr) of ICG into the left femoral vein were made and also the steady-state plasma concentration of ICG was checked at 20, 25 and 30 min. The plasma concentrations of DTZ and ICG were determined using a high performance liquid chromatographic technique. At the steady state, the hepatic blood clearance of ICG was obtained from the plasma concentration and blood-to-plasma concentration ratio ($R_B$) of ICG. The pretreatment with various doses of DTZ did not influence the plasma concentrations, $R_B$ and plasma free fraction ($f_p$) of ICG. So the hepatic blood clearance of ICG was independent of concentration of DTZ. The hepatic blood clearance of ICG could be affected by both hepatic bood flow and hepatic intrinsic clearance. But there was no change of the hepatic blood clearance of ICG between the control and the DTZ-pretreated rats in this study. So it may be suggested that DTZ does not influence hepatic blood flow.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.3407-3412
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• 2007

The performance characteristics of the polymer electrolyte fuel cells (PEFCs) were investigated under various humidification conditions at steady-state and transient conditions. The PEFC studied in this study was characterized by I-V curves in potentiostatic mode. The I-V curves representing steady-state performance were obtained from OCV to 0.25V, and the dynamic performance responses were obtained at some points of voltages. The anodic external humidification was applied and the humidity was controlled from 20% to 100%. The effects of relative humidity of hydrogen were measured with the dry air at the cathode. At high voltage region, the performance at high temperature was higher, but at low voltage region, low temperature condition showed the higher performance. The dynamic responses were observed at the instant when the voltage of the PEFC was changed. It was observed that the performance reached steady-state earlier with the increase of temperature.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.30 no.7 s.250
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• pp.833-840
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• 2006

The paper presents a numerical solution to the problem of a hot rigid indenter sliding over a thermoelastic Winkler foundation with a thermal contact resistance at constant speed. It is shown analytically that no steady-state solution can exist for sufficiently high temperature or sufficiently small normal load or speed, regardless of the thermal contact resistance. However the steady state solution may exist in the same situation if the thermal contact resistance is considered. This means that the effect of the large values of temperature difference and small value of force or velocity which occur at no steady state can be lessened due to the thermal contact resistance. When there is no steady state, the predicted transient behavior involves regions of transient stationary contact interspersed with regions of separation regardless of the thermal contact resistance. Initially, the system typically exhibits a small number of relatively large contact and separation regions, but after the initial transient, the trailing edge of the contact area is only established and the leading edge loses contact, reducing the total extent of contact considerably. As time progresses, larger and larger numbers of small contact areas are established, unlit eventually the accuracy of the algorithm is limited by the discretization used.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.05a
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• pp.330-333
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• 2005

The paper presents a numerical solution to the problem of a hot rigid indenter siding over a thermoelastic Winkler foundation with a thermal contact resistance at constant speed. It is shown analytically that no steady-state solution can exist for sufficiently high temperature or sufficiently small normal load or speed regardless of the thermal contact resistance. However, the steady state solution may exist in the same situation if the thermal contact resistance is considered. This means that the effect of the large values of temperature difference and small value of force or velocity which occur at no steady state can be lessened due to the thermal contact resistance. When there is no steady-state the predicted transient behavior involves regions of transient stationary contact interspersed with regions of separation regardless of the thermal contact resistance. Initially, the system typically exhibits a small number of relatively large contact and separation regions, but after the initial transient the trailing edge of the contact area is only established and the leading edge loses contact, reducing the total extent of contact considerably. As time progresses, larger and larger number of small contact areas are established, until eventually the accuracy of the algorithm is limited by the discretization used.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.15 no.1 s.94
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• pp.39-45
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• 2005

This research develops an experimental method to measure the motion of a FDB spindle system with a 3.5' disk by using three capacitance probes fixed on the xyz-micrometers, and it shows that a FDB spindle system has the whirling, flying and tilting motion. It also shows that the whirling, flying and tilting motion converge very quickly to the steady state at the same time when the rotor reaches the steady-state speed. However, they are quite large even at the steady state when they are compared with the 10nm flying height of a magnetic head. For the FDB spindle system used in this experiment, the whirl radius and the peak-to-peak variation of flying height and tilting angle at the steady-state speed of 7,200rpm are 0.675m, 30nm and $5.758\times10^{-3^{\circ}}$, respectively, so that the radial motion of the FDB spindle system exceeds a track pitch of a 3.5' HDD with 90,000 TPI.

• Journal of Pharmaceutical Investigation
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• v.23 no.3
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• pp.1-8
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• 1993

A simple and quick method based on the transient diffusion theory for predicting the steady state rate of penetration of a drug after transdermal drug administration was proposed. The amount of drug entering the stratum corneum was determined by 20 strippings with an adhesive tape. From the profile of the amount of drug as a function of the number of strippings, the quantity of drug on the surface of stratum corneum was extrapolated. Based on the amounts of drug entering the stratum corneum during two time intervals $(t_1\;and\;t_2)$ within 1 hour after the application, the diffusion and partition coefficient were determined. Once the diffusion coefficient of the drug in the stratum corneum and the partition coefficient (stratum corneum/vehicle) were determined from the present approach, the steady-state flux of penetration across the stratum corneum was calculated. The steady-state rates of penetration of ascorbic acid and estradiol across hairless mouse skin were evaluated from this approach and compared with those obtained from ill vitro penetration experiment using excised hairless mouse skin. The data confirmed that the proposed method can predict the steady-state rate of penetration of these drugs across the stratum corneum.

• Korean Journal of Applied Biomechanics
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• v.16 no.3
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• pp.75-83
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• 2006

The purpose of this study was to investigate steady-state force depression following active muscle shortening in human tibialis anterior muscle during voluntary contractions. Subjects (n = 7; age $24{\sim}39$ years; 7 males) performed isometric reference contractions and isometric-shortening-isometric contractions, using maximal voluntary effort. Force depression was assessed by comparing the steady-state isometric torque produced following active muscle shortening with the purely isometric reference torque obtained at the corresponding joint angle. In order to test for effects of the shortening conditions on the steady-state force depression, the speed of shortening were changed systematically in a random order but balanced design. Ankle dorsiflexion torque and joint angle were continuously measured using a dynamometer. During voluntary contractions, muscle activation of the tibialis anterior and the medical gastrocnemius was recorded using surface electromyography. Force depression during voluntary contractions, with a constant level of muscle activation, was 12 %, on average over all subjects. Force depression was independent of the speeds of shortening ($13.8{\pm}2.9%$, $10.3{\pm}2.6%$ for 15 and 45 deg/sec over 15 deg of shortening, respectively). The results of this study suggest that steady-state force depression is a basic property of voluntarily-contracting human skeletal muscle and has functional implication to human movements.

• Journal of the Korean Society for Precision Engineering
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• v.28 no.5
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• pp.565-571
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• 2011

Because most fatigue cracks in wheel and rail take place by rolling contact of wheel and rail in railroad industry, it is critical to understand the rolling contact phenomena, especially for the three-dimensional situation. This paper presents an approach to steady-state rolling contact problem of three-dimensional contact bodies, with or without tangential force, based on the finite element method. The steady-state conditions are controlled by the applied relative slip and tangential force. The three-dimensional distribution of tangential traction and contact stresses on the contact surface are investigated. Results show that the distribution of tangential traction and contact stresses on the contact surface varies rapidly as a result of the variation of stick-slip region. The tangential traction is very close in form to Carter's distribution.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2001.02a
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• pp.27-31
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• 2001

This study examined the extent of mammary excretion and placental transfer of bisphenol A in rats. Bisphenol A was given by simultaneous i.v. bolus injection plus infusion to steady-state at low, medium and high doses. The steady-state serum levels of bisphenol A were linearly increased with increasing the dosing rate. The systemic clearance (mean range, 119.2-154.1 ml/min/kg) remained unaltered over the dosing rate studied. The levels of bisphenol A in milk exceeded those in serum, with the steady-state milk to serum concentration ratio being 2.4-2.7. The steady-state milk levels of bisphenol A were also increased linearly with increasing the infusion rate. In a separate study, the kinetic disposition of bisphenol A in the rat maternal-fetal unit was studied in pregnant rats. After i.v. injection, bisphenol A concentration in the maternal serum declined biexponentially. Bisphenol A was rapidly distributed into placenta, fetus and amniotic fluid, with maximum concentrations in these tissues achieved within 1 hr of injection. The decline of bisphenol A in placenta, fetus and amniotic fluid paralleled that of maternal serum. A simultaneous computer simulation showed that the observed concentrations were well represented by a 5-compartmental model consisting of the maternal central, placenta, fetus, amniotic fluid, and maternal tissue compartments.