• Journal of Electrochemical Science and Technology
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• 제7권3호
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• pp.234-240
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• 2016

The effect of initial electrolyte loading (IEL) on cell performance in a coin-type molten carbonate fuel cell (MCFC) was investigated in this work. Since the material of MCFC depends on the manufacturer, optimisation requires experimental investigation. In total, four IEL values, 1.5, 2.0, 3.0, and 4.0 g, were used, corresponding to a pore filling ratio (PFR) of 38, 51, 77, and 102%, respectively. The cell performance with respect to the PFR was analysed via steady-state polarisation, step-chronopotentiomtery, and impedance methods. The electrochemical analyses revealed that internal resistance and overpotential of the cell decreased with increasing PFR, and a large overpotential was observed when the PFR was 102%, probably due to the flooding phenomenon. After operation, cross-section of the cell was analysed via surface analysis of SEM and EDS methods, and the remaining electrolyte was estimated by dissolution of the cell in 10 wt% acetic acid. A linear relationship between IEL and the weight reduction ratio by dissolution was obtained. Thus, the remaining amount of electrolyte could be measured after operation. The results of SEM and EDS showed that a PFR of 38 and 102% showed a lack and flooding of electrolytes at the cell, respectively, which led to a large overpotential. This work reports that MCFC performance is allowed only in the narrow range of PFR.

• 한국산업정보학회논문지
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• 제23권2호
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• pp.29-39
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• 2018

본 논문에서는 일량제어정책과 복수휴가정책이 혼합된 서버제어정책 하에서 운영되는 이산시간 대기행렬시스템을 다룬다. 고객들은 베르누이 도착과정으로 시스템에 도착하고, 서버는 한대가 운영되며 시스템 내 서비스할 고객이 없으면 유휴기간을 갖는 서버가 이산 확률변수 V만큼의 휴가를 떠났다가 돌아와서 대기 중인 고객들의 총 일량이 임계값 D를 넘길 때까지 휴가를 반복한다. 본 논문에서는 이산시간 시스템을 대상으로 하여 보다 현실적이며 유연한 혼합제어 정책 하에서 운영되는 대기행렬시스템의 안정상태 일량분포를 유도하고 평균일량을 계산하였다. 이는 시스템 내 고객수, 대기시간, 체재시간과 같은 시스템의 여러 성능척도를 분석하는데 기본이 된다.

• Nuclear Engineering and Technology
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• 제51권8호
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• pp.1871-1885
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• 2019

The deterministic MOC code STREAM of the Computational Reactor Physics and Experiment (CORE) laboratory of Ulsan National Institute of Science and Technology (UNIST), was initially designed for the calculation of pressurized water reactor two- and three-dimensional assemblies and cores. Since fast reactors play an important role in the generation-IV concept, it was decided that the code should be upgraded for the analysis of fast neutron spectrum reactors. This paper presents a coupled code - TULIP/STREAM, developed for the fast reactor assembly and core calculations. The TULIP code produces self-shielded multi-group cross-sections using a one-dimensional cylindrical model. The generated cross-section library is used in the STREAM code which solves eigenvalue problems for a two-dimensional assembly and a multi-assembly whole reactor core. Multiplication factors and steady-state power distributions were compared with the reference solutions obtained by the continuous energy Monte-Carlo code MCS. With the developed code, a sensitivity study of the number of energy groups, the order of anisotropic P_N scattering, and the multi-group cross-section generation model was performed on the k_eff and power distribution. The 2D core simulation calculations show that the TULIP/STREAM code gives a k_eff error smaller than 200 pcm and the root mean square errors of the pin-wise power distributions within 2%.

• 대한조선학회논문집
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• 제33권4호
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• pp.142-149
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• 1996

선체 외관을 이루는 판부재 중에서 일차곡만을 가진 부품은 피라미드 형의 롤러 굽힘장치를 이용하여 제작한다. 일차곡 부재를 생산하기 위한 공정에서 가장 중요한 작업 변수는 중앙 롤러의 수직변위값이다. 본 연구에서는 이러한 굽힘 현상을 보의 탄소성 굽힘현상으로 모델링하여 해석해를 구하였으며, 엄밀한 역학적 이해를 위하여 유한요소해석법을 이용하여 굽힘현상을 해석하였다. 해석을 통하여 일정한 굽힘 곡률을 얻기 위한 중앙 롤러의 수직변위 값을 계산하였으며, 유한요소해석법은 보 요소와 평면변형율 요소를 이용하여 모델링하고 각각의 경우에 대한 해석을 수행하였으며 이 결과를 해석해와 비교하였다. 계산을 통하여 판에 가해야 할 굽힘곡률과 중앙롤러의 수직변위 사이의 관계를 도출하였으며 일차곡가공의 중요한 작업변수인 중앙롤러의 수직변위와 잔류곡률상의 관계를 수치 데이터로써 정식화 하였다.

• Archives of Pharmacal Research
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• 제17권2호
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• pp.124-130
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• 1994

Plasma phamacokinetics and renal excretion of theophylline (TP) and its metabolities were ivnestigated in rats. Plasma concentrations of TP declined in a monoexponential manner, while those of 1-methyluric (MU) and 1,3-dimethyluric(DMU) declined in a biexponential manner upon respective iv bolus injection of each compound at 6mg/kg dose. The total body clearances $(CL_r)$ of the metabolites were 4-6 fold larger than that of TP, while the distribution volumes of them at steady-state $(Vd_{ss})$ were 40-50% smaller than that of TP. The metabolites showed their plasma peaks in 30 min after iv injection of TP indicating than that to MU. Renal excretion of TP and its metabolites was studied in urine flow rate (UFR)-controlled rats. The renal clearance $(CL_r)$ of TP was inversely related to pasma TP concentrations, and much smaller than the glomerular filtration rate (GFR) suggesting tubular secretion and profound reabsorption in the renal tubule. The $(CL_r)$ of each metabolite also showed that inverse relationship, but far exceeded GFR suggesting that tubular secretion than GFR by ip injection of probenecid (142.7 mg/kg). It supports that the metabolies are secreted in the renal tubule, and suggests that they share a common transport system in their sectrtion processes with probenecid. On the other hand, the $(CL_r)$ of TP was not affected significantly by the probenecid treatment. Considering the inverse relationship of TP between the $(CL_r)$ and its ploasma concentrations,no effect of probenecid on $(CL_r)$ of TP is most likely due to negligible contribution of the secretion to the overall $(CL_r)$ of TP.

• 한국임상수의학회지
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• 제24권1호
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• pp.5-9
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• 2007

본 연구에서는 랫트, 토끼, 닭, 개 등의 각종 동물들의 약물동태학적 파라미터를 이용하여 록시스로마이신의 이종간 예측모델을 수립하였으며, 이때 약물동태학적 파라미터는 반감기, 청소율, 분포용적, 평균체류시간 등을 이용하였다. 이종간 약물동태학적 파라미터의 변화 예측은 체중과 지수적 상관관계 $(Y=aW^b)$를 이용하였으며, 이때 Y는 약물동태학적 파라미터, W는 체중, a는 allometric coefficient를 의미한다. B는 약물동태학적 파라미터와 체중간의 상관관계를 의미하는 비례상수이다. 랫트, 토끼, 닭, 개 등의 약물동태학적 파라미터인 분포용적, 청소율, 반감기, 평균체류시간 등은 체중과 유의한 선형관계를 나타내었다. 본 연구에 의해 수립된 록시스로마이신에 대한 이종간 약물동태학적 파라미터의 이종간 예측모델은 다양한 종의 동물종에 대한 좀 더 정확한 용법용량을 구하는 기초자료로 이용할 수 있을 것이다.

• 설비공학논문집
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• 제8권1호
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• pp.1-12
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• 1996

In lots of application to heat exchanger systems, closed two-phase thermosyphons are tilted from a horizontal. If the tilt angle, especially, is less than 30$^{\circ}$, the operational performances of thermosyphon are highly dependent on tilt angle. The present study was conducted to better understand such operational behaviors as mech-anni는 of phase change, and flow patterns inside a tilted thermosyphon. For experiment, an ethanol thermosyphon with a 35% of fill charge rate was designed and manufactured, using a copper tube with a diameter 19mm and a length 1500mm. Through a series of test, the tilt angle was kept constant at each of 4 different values in the range 10~25deg. and the heat supply to the evaporator was stepwisely increased up to 30㎾/$m^2$. When a steady state was established to the thermosyphon for each step of thermal loads, the wall temperature distribution and vapor temperature at the condenser were measured. The wall temperature distributions demonstrated a formation of dry patch in the top end zone of the evaporator, with a values of temperature 20~4$0^{\circ}C$ higher than the wetted surface for a moderate heat flux q≒20㎾/$m^2$. Inspite of the presence of hot dry patch, however, the mean values of boiling heat transfer coefficient at the evaporator wall were still in a good agreement with those predicted by Rohsenow's formula, which was based on nucleate boiling. For the condenser, the wall temperatures were practically uniform, and the measured values of condensation heat transfer coefficient were 1.7 times higher than the predicted values obtained from Nusselt's film condensation theory on tilted plate. Using those two expressions, a correlation was formulated as a function of heat flux and tilt angle, to determine the total thermal resistance of a tilted thermosyphon. The correlation formula showed a good agreement with the experimental data within 20%.

• 한국전산구조공학회논문집
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• 제24권4호
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• pp.429-438
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• 2011

본 논문에서는 Membrane형 LNG선의 구성 요소를 대상으로 단열창의 열적 분포를 알아보기 위해 극저온 상태에서부터 온도 별로 각 소재의 열적 물성치인 열전도도(thermal conductivity)를 실험을 통해서 알아보았다. 극저온 상태인 $-163^{\circ}C$의 온도상태로 유지되어야 하는 LNG선 화물탱크는 단열재료로 하여금 열을 차단하기 위해 많은 연구가 되어야 하는데 특히 여러 재료로 구성되어 있는 단열 화물창(CCS: Cargo containment system)은 열적 물성치가 온도에 따라 각각 어떠한 값을 가지는 것이 주요 관심대상이고, 이를 통해 전체 LNG 단열 화물창이 어떤 열적 분포를 가지는 것에 대한 연구가 필요하다. 실험을 통해 얻은 물성치를 가지고 전체 화물창의 온도분포를 정적 열해석을 통해 알아보았다. 또한 외부의 충격에 의해 LNG가 누수되었을때 2차 방벽 특히 hull 부분에서는 누수량에 대해서 어떠한 온도분포와 열적 안전성에 대해서 알아보았다.

• 약학회지
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• 제39권6호
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• pp.636-644
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• 1995

Comparison of bioavailabflity (BA) of three brands of ranitidine (RT) tablets has been studied m rats. The purpose of this study was to characterize the pharniacolunetics of RT tablets in the rat and to coinpare phannacolunetic parameters of three brands of RT tablets. In addition, it was investigated whether plasma RT concentrations m humans can be predicted from pharmacokinetic parameters obtained in rats. RT was administered intravenously in dose of RT.HCI 10mg/kg and orally in dose of RT.HCI 50mg/kg as solution or crushed sample of thablets. Plasma RT concentrations were determned by HPLC. Plasma RT concentrations as a function of time were fitted to two compartment model. Plasma RT concentrations declined with a terminal half life ($t_{{1}/2{\betha}}$) of 40.9 min. The plasma RT concentration-time curve showed two peak plasma concentrations following an oral administration of solution or crushed sample in rats like humans. No significant difference among pharmacokinetic parameters was observed except $T_{max2}$ (p<0.05). The BA for crushed sample A, B and C were found to be 54.6 40.7 and 40.0%, respectively. Equivalence of $C_{max1}$ and $T_{max2}$ were guaranteed in this study. However, it was concluded that three brands of RT tablets are bioequivalent, taking the following characteristics of RT into consideration;(1) rapid onset of the effect is not required, (2) $C_{max1}$ and $T_{max2}$ do not seem to influence the effectiveness of the drug during a long-term treatment by the usual administration of twice a day. Results from this study were combined with plarmacokinetic data for RT in dogs and humans to develop a basis for interspecies scale-up of the disposition characteristics of the drug. there were similarities in the general disposition of the drug. Allometric relationships were sought between pharmacokinetic parameters nd species body weight. Significant interspecies correlations were found for total body clearance($Cl_{t}$) and steady state volume of distribution ($Bd_{ss}$). Thus, plasma RT concentrations in humans can be predicted from pharmacokinetic parameters obtained in rats.

• Archives of Pharmacal Research
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• 제27권2호
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• pp.259-264
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• 2004

The purpose of the present study was to investigate the pharmacokinetics of PEG-hemoglobin SB 1, a modified bovine hemoglobin with polyethylene glycol, after its single and multiple administration in beagle dogs. For this purpose, the analytical method of free hemoglobin in the plasma was developed and validated. Excellent linearity ($r^2$=0.999) was observed in the calibration curve data, with the limit of quantification of 0.005 g/dL. The precision and the deviation of the theoretical values for accuracy were always within $\pm$15％ in both the between-and the within-day results. The method was tested by measuring the plasma concentrations following intravenous administration to beagle dogs and was shown to be suitable for pharmacokinetic studies. In a single dose study, the plasma half-life (t$_{1}$2/) increased and the total body clearance (Cl$_{t}$) decreased with the dose (i.e., 0.017 to 0.75 gHb/kg as PEG-hemoglobin SB1) in both sexes. The volume of distribution at steady-state (Vd$_{ss}$ ) showed no difference with the dose. In contrast, the values of t$_{1}$2/, CL$_{t}$ and the area under the plasma concentration-time curve (AUC) after the multiple dose were significantly different from those of the single dose administration. The values of t$_{1}$2/ in the multiple administration were about two times higher-than that of the single dose. As a result, t$_{1}$2/ of hemoglobin after the administration of PEG-hemoglobin SB1 was about 15-30 h, indicating the PEG modification of the hemoglobin lead to a prolongation of plasma concentration of the protein. Therefore, these observations suggested that the PEG modification of hemoglobin is potentially applicable in the hemoglobin-based therapeutics.tics.