• 약학회지
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• 제41권3호
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• pp.312-320
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• 1997

Pharmacokinetics and tissue distribution of DWP20349 and 20351, new quinolones, were examined in rats after a single intravenous and oral administration. Analyses of DWP20349 an d DWP20351 in plasma, tissue, and urine were determined by both HPLC and bioassay(microbiological assay). The plasma concentrations of the drugs declined biexponentially. The terminal half-lives ($t_{1/2\beta}$) of drugs were about 114 min (DWP20349) and 105 min (DWP20351) after intravenous dosing, and were 77 min (DWP20349) and 79 min (DWP20351) after oral dosing. The volume of distrbution at steady-state ($Vd_{ss}$) and total body clearances ($Cl_t$) of DWP20349 and DWP20351 were 760 ml/kg and 1126 ml/kg, and 5ml/min/kg and 10 ml/min/kg, respectively. The extents of bioavailability if DWP20349 and DWP20351 after oral administration were 29% and 28%, respectively. 24 h urinary recoveries measured by bioassay were 1.8% (DWP20349) and 1.3% (DWP20351) after oral dosing, and 2.4% (DWP20349) and 1.9% (DWP20351) after intravenous dosing. Plasma protein binding ratios ranged from 87%-90% (DWP20349) and 61%-68% (DWP20351). These drugs were highly distrbuted by the order of lung, kidney, liver and plasma (DWP20394), and lung, liver, kidney and plasma (DWP20351) after 1 hour orally administered.

• 터널과지하공간
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• 제12권3호
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• pp.220-228
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• 2002

절리암반에서의 열유동을 수치해석적으로 분석하였다. 1차원 모델 해석을 통하여 한 조의 절리군이 열전도에 미치는 영향을 비교 분석하고, 이론해와 비교하였다. 절리 내에 물이 전혀 없는 경우, 절리는 열 차단제의 역할을 하며 정상상태에서도 온도의 불연속이 관찰되었다. 따라서 암반 내 존재하는 절리가 완전 건조상태인 경우에는 개별적인 절리의 열차단 효과를 일일이 고려하여야 정확한 결과를 얻을 수 있다 그러나 절리 내에 물이 부분적으로 혹은 완전히 포화된 경우에는 열차단 효과가 현저히 줄어들어 온도 분포에 미치는 영향이 현저히 감소하였다. 따라서 절리 암반을 통한 열전도는 암반을 무결암의 열적 성질과 불연속면의 열적 성질을 포함한 열적 이방성 연속체로 가정함으로써 가능하다 할 수 있다. 절리의 포화 정도가 증가할수록 절리가 열유동에 미치는 영향이 감소하므로 암반의 열전달 특성은 등방에 가까워지며, 따라서 복잡한 모델을 이용한 해석보다는 현지 암반의 열물성을 정확히 측정하는 것이 더욱 중요함을 알 수 있었다.

• Journal of Advanced Marine Engineering and Technology
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• 제36권4호
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• pp.484-489
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• 2012

본 논문은 선박의 주 추진기관으로 사용가능한 육상 운송수단에 탑재되어있는 대형 디젤엔진에서 배출되는 입자상 물질과 질소산화물의 배출특성을 ESC mode에 적용시켜 분석하는데 초점을 두었다. 입자상 물질은 엔진의 고부하 영역에서 다량으로 배출되는 특성을 확인 할 수 있었으며 질소산화물의 경우 배기가스 온도 측정형태와 동일한 경향으로 배출되었다. 매연여과장치를 부착하여 입자상 물질의 배출특성을 분석한 결과 mode별 1/100~1/1,000배까지 저감되었다. 그러나 급격한 엔진 부하 변동 시 저감효과는 떨어졌으며 고속-고부하 영역에서는 매연여과장치내부의 온도상승으로 일부 재생현상이 발생하여 입자상 물질의 배출 증가 결과를 초래하는 현상이 발생하였다. 시험엔진에서 배출되는 입자상 물질의 입경분포를 분석한 결과 대부분 100nm 이하의 크기를 가지는 나노 입자가 배출되었으며 매연여과장치를 부착 및 탈착하여 측정한 결과 배출수준에는 차이가 있지만 입자상 물질의 입경분포는 비슷한 경향으로 분석되었다.

• Journal of Nutrition and Health
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• 제27권1호
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• pp.12-22
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• 1994

Effects of very low level of lead in diet and exposure time on the accumulation and distribution in organs and tissues was investigated with growing rats. 21 days old Sprague-Dawley rats were exposed to lead for 7, 14 and 21 days by feeding of 0.03, 0.42, 0.92 and 1.46mg/kg Pb as Pb-acetate containing diet, respectively. Lead concentrations in blood, liver, kidney and bone exhibit a linear relationship with lead levels in diet. After 7 days of exposure, the greatest dose dependent accumulation of lead was found in kidney and followed in bone. However, after 14 and 21 days, the dose dependent accumlation of lead in bone was about two fold greater than that in kidney. The accumulation of lead in liver and blood was relatively low. As continuous exposure to lead, the concentrations of lead in liver, kidney, blood and intestinal tracts were rather not increased with exposure time. However, bone lead concentration was increased with exposure time by feeding of 0.92 and 1.46mg/kg Pb in diet, but not 0.42mg/kg. The lead concentration in gastrointestinal tracts tends also to increasing with lead levels in diet after 7 and 14 days of exposure. However, by 21 days of exposure the lead concentration revealed relatively constant value regardless of the dietary lead levels. It is concluded that the binding capacity of the lead in blood, liver, kidney and bone seems to be increased with increasing lead levels in diet. The lead concentration in these organs, with the exception of the lead in bone, seems, however, to be standing under steady state regulation by continued exposure with the same dietary lead level. Therefore, by chronic exposure condition with environmental relevant lead level bone might be a principle targe organ for lead and blood lead repesents better the current lead exposure than the lead body burden.

• 한국지하수토양환경학회지:지하수토양환경
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• 제9권1호
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• pp.54-62
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• 2004

본 연구에서는 납으로 오염된 유기물과 철성분이 다량 함유된 철성분 함유토에 대한 정화 효율을 향상시키기 위해 세척제로 산, 킬레이트제 및 계면활성제를 사용하여 동전기 정화실험을 실시하였다. 실험결과 주입되는 세척제의 pH가 낮을수록 양극(兩極)저수조의 pH는 더 빠른 시간에 정상상태 값에 도달하였으며, 전압 분포의 경우 세척제 종류에 따른 차이는 크게 나타나지 않았고, 주입용액의 농도가 증가함에 따라 (+)극으로부터 정규화된 거리인 0.9지점에서의 전압은 더 크게 나타나는 경향을 보였다. 또한, 음이온성 계면활성제인 SDS가 가장 높은 잔류 납농도 분포를 보였다. 세척제 농도의 경우 1 mM의 Acetic acid에서 가장 양호한 정화효율을 보였지만, 아세트산의 농도 변화는 철성분 함유토(Ferrous soil)의 동전기 정화 효율에 큰 영향을 미치지 않는 것으로 나타났다.

• 한국소음진동공학회논문집
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• 제26권3호
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• pp.340-349
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• 2016

A coupled room system consists of adjacent rooms and apertures where the sound energy is exchanged between the two rooms. Acoustically, a coupled room system shows a non-exponential decay profile. Most of the related researches have been to analyze the acoustic properties of two-room coupled system so far whereas three-room coupled system were seldom studied. In this regard, this paper aims to analyse the distribution of sound pressure level, sound decay curve of three-room coupled system and sound energy flow between them by using the acoustic diffusion model and to further verify them through experiments. Firstly, the sound pressure level distribution and mean sound pressure level in the steady-state condition are analyzed at various frequencies and source locations. Good agreements are observed in both experiments and analysis results. Secondly, two double slope effect quantifiers of sound attenuation, LDT/EDT and LDT/T10 are compared at various frequencies and for different source locations. The result indicates that LDT/T10, less affected by the early reflection patterns than LDT/EDT, is more suitable to the analysis and experiments of a multi-slope sound decay curve. Lastly, the sound energy flow in each room is analyzed based on the acoustic diffusion model. After the early decay stage, the sound energy is observed to flow from the room with a long reverberation time to the room with a short one.

• Biomolecules & Therapeutics
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• 제25권6호
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• pp.648-658
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• 2017

7-O-Succinyl macrolactin A (SMA) exerts several pharmacological effects including anti-bacterial, anti-inflammation, and anti-cancer activities. Recently, SMA has been extensively evaluated as an anti-cancer drug. Thus, the objectives of the present study were to characterise the pharmacokinetics of SMA via both non-compartmental and compartmental analysis in mice, rats, and dogs, and to derive an appropriate first-in-man dose based on allometric scaling of the animal data. The time courses of plasma SMA concentrations after intravenous administration to rats and dogs were analysed retrospectively, as were data collected after intraperitoneal SMA injection in mice. Pharmacokinetic parameters were estimated via both noncompartmental and compartmental analysis, and were correlated with body weight and/or the potential maximum life-span. The clearance and distribution volume of SMA in humans were predicted, and a first-in-man dose proposed. A two-compartment model best described the time courses of SMA plasma concentrations after a saturation elimination process was applied to fit the dataset obtained from rats. Incorporation of the maximum potential life-span during allometric scaling was required to improve the estimation of human clearance. The SMA clearance and the distribution volume in the steady state, in a 70-kg adult male, were estimated to be 30.6 L/h and 19.5 L, respectively. To meet the area under the curve (AUC) required for anti-tumour activity, a dose of 100 mg (~1.5 mg/kg) was finally proposed as the first dose for a 70-kg human. Although toxicological profiles derived from non-clinical studies must be considered before any final decision is made, our work will facilitate clinical studies on SMA.

• 한국항공우주학회지
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• 제30권6호
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• pp.84-91
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• 2002

본 연구에서는 열전달 해석을 통하여 발전용 터빈 블레이드의 온도 분포를 계산하였고, 열하중과 원심력에 의한 선형응역 해석을 수행하였다. 정상상태 열전달 해석 결과, 블레이드의 앞전과 끝단에서 높은 온도 분포가 나타났으며 열응력은 다른 부분에 비해 압력면 부분에서 높게 나타났다. 온도의 영향을 고려하지 않은 원심응력 해석에는 fir tree 앞전 부분에서 가장 높은 등가 응력이 나타났다. 온도와 원심력을 모두 고려한 해석 결과에서도 최대 등가 응력은 fir tree부분에서 발생하였다. 열하중과 원심력에 대한 선형응력 해석 결과 GTD111 터빈 블레이드는 항복응력에 도달하지 않아 안전하다.

• 대한전자공학회논문지
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• 제21권5호
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• pp.90-99
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• 1984

양면에서 텅스텐 램프를 조사하는 실리콘 재결정시의 SOI(silicon-on-insulator) 다층구조에 대한 1차원적 온도 및 열원(열원)의 분포를 SOR(successive over-relaxation)방법을 이용하여 정상상태의 열방정식의 해로부터 구하였다. 열원의 분포는 광원의 스펙트럼, SOI sample 내부 계면에서의 다중반사, 광흡수 계수의 온도, 주파수 의존성 등을 고려하여 구하였으며, 열 방정식의 경계조건이 되는 wafer의 전면과 후면의 온도는 혹체복사 조건으로부터 구하였다. 내부계면에서는 전도열속(conduction heat flux)과 복사열속(radiation heat flux)에 의한 연속조건을 만족하도록 하였다. 본 문제에서의 온도분포와 열원의 분포는 상호간에 큰 영향을 주게 되므로, 두가지 변수가 일치되는 값을 보일 때까지 iteration을 계속하였다. Pyrometer을 이용하여 측정한 wafer 전면의 온도는 약1200°K이었고 이때의 simulation 결과는 1120°K 정도로 나타났다.

• Structural Engineering and Mechanics
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• 제25권4호
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• pp.445-466
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• 2007

As the LNG (Liquefied Natural Gas) tank contains cryogenic liquid, realistic thermal analyses are of a primary importance for a successful design. The structural details of the LNG tank are so complicated that some strategies are necessary to reasonably predict its temperature distribution. The proposed heat transfer model can consider the beneficial effects of insulation layers and a suspended deck on temperature distribution of the outer concrete tank against cryogenic conditions simply by the boundary conditions of the outer tank model. To this aim, the equilibrium condition or heat balance in a steady state is utilized in a various way, and some aspects of heat transfer via conduction, convection and radiation are implemented as necessary. Overall thermal analysis procedures for the LNG tank are revisited to examine some unjustifiable assumptions of conventional analyses. Concrete and insulation properties under cryogenic condition and a reasonable conversion procedure of the temperature-induced nonlinear stress into the section forces are discussed. Numerical examples are presented to verify the proposed schemes in predicting the actual temperature and stress distributions of the tank as affected by the cryogenic LNG for the cases of normal operation and leakage from the inner steel tank. It is expected that the proposed schemes enable a designer to readily detect the effects of insulation layers and a suspended deck and, therefore, can be employed as a useful and consistent tool to evaluate the thermal effect in a design stage of an LNG tank as well as in a detailed analysis.