• Genomics & Informatics
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• v.10 no.2
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• pp.117-122
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• 2012

A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger sample sizes to achieve an adequate statistical power. We estimated the statistical power with increasing numbers of markers analyzed and compared the sample sizes that were required in case-control studies and case-parent studies. We computed the effective sample size and statistical power using Genetic Power Calculator. An analysis using a larger number of markers requires a larger sample size. Testing a single-nucleotide polymorphism (SNP) marker requires 248 cases, while testing 500,000 SNPs and 1 million markers requires 1,206 cases and 1,255 cases, respectively, under the assumption of an odds ratio of 2, 5% disease prevalence, 5% minor allele frequency, complete linkage disequilibrium (LD), 1:1 case/control ratio, and a 5% error rate in an allelic test. Under a dominant model, a smaller sample size is required to achieve 80% power than other genetic models. We found that a much lower sample size was required with a strong effect size, common SNP, and increased LD. In addition, studying a common disease in a case-control study of a 1:4 case-control ratio is one way to achieve higher statistical power. We also found that case-parent studies require more samples than case-control studies. Although we have not covered all plausible cases in study design, the estimates of sample size and statistical power computed under various assumptions in this study may be useful to determine the sample size in designing a population-based genetic association study.

• Korean Journal of Metals and Materials
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• v.47 no.12
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• pp.819-827
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• 2009

This work is concerned with a statistical analysis of factors affecting the irradiation-assisted stress corrosion cracking (IASCC) of austenitic stainless steels for core internals of pressurized water reactors (PWR). The microstructural and environmental factors were reviewed and critically evaluated by the statistical analysis. The Cr depletion at grain boundary was determined to have no significant correlation with the IASCC susceptibility. The threshold irradiation fluence of IASCC in a PWR was statistically calculated to decrease from 5.799 to 1.914 DPA with increase of temperature from 320 to $340^{\circ}C$. From the analysis of the relationship between applied stress and time-to-failure of stainless steel components based on an accelerated life testing model, it was found that B2 life of a baffle former bolt exposed to neutron fluence of 20 and 75 DPA was at least 2.5 and 0.4 year, respectively, within 95% confidence interval.

• The Journal of Korean Association of Computer Education
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• v.3 no.2
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• pp.107-114
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• 2000

In this study, a program for statistics education is developed. This program deals with statistical hypothesis testing which is indispensible to demonstrate the research hypothesis. Statistical inference which is the process of using data obtained from a sample to make inference about the characteristics of a population is an essential concept to peoples to learn or use statistics. But in practice, there are many cases of wrong application and peoples think that statistics is hard to understand. Therefore, it is very important subject to teach easily and rightly statistics, specially elementary statistics. This program is developed especially for non-specialist. This program under multimedia environment which includes sound, video, animation etc. can interest students greatly. It doesn't show only the result but make it possible for students to execute the program by stages. By executing it, the students can understand the method and meaning of statistical hypothesis testing naturally.

• Earthquakes and Structures
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• v.15 no.6
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• pp.595-603
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• 2018

Shake table testing has been regarded as one of the most effective experimental approaches to evaluate seismic response of structural systems subjected to earthquakes. However, reproducing a prescribed acceleration time history precisely over the frequency of interest is challenging because shake table test systems are eventually nonlinear by nature. In addition, interaction between the table and specimen could affect the control accuracy of shake table testing significantly. Various novel control algorithms have been proposed to improve the control accuracy of shake table testing; however, reference values for control performance assessment remain rare. In this study, reference values for control performance assessment of shake table testing are specified based on the statistical analyses of 1,209 experimental data provided by the Seismic Simulator Laboratory of National Center for Research on Earthquake Engineering in Taiwan. Three individual reference values are considered for the assessment including the root-mean-square error of the achieved acceleration time history; the percentage of the spectral acceleration that exceeds the determined tolerance range over the frequency of interest; and the error-ratio of the achieved peak ground acceleration. Quartiles of the real experimental data in terms of the three objective variables are obtained, providing users with solid and simple references to evaluate the control performance of shake table testing. Finally, a set of experimental data of a newly developed control framework implementation for uni-axial shake tables are used as an application example to demonstrate the significant improvement of control accuracy according to the reference values provided in this study.

• Journal of the Korean Statistical Society
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• v.18 no.1
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• pp.46-61
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• 1989

This paper is concerned with the development of a nonparametric procedure for the statistical inference about the nonlinear regression parameters. A confidence region and a hypothesis testing procedure based on a class of signed linear rank statistics are proposed and the asymptotic distributions of the test statistic both under the null hypothesis and under a sequence of local alternatives are investigated. Some desirable asymptotic properties including the asymptotic relative efficiency are discussed for various score functions.

• Communications for Statistical Applications and Methods
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• v.8 no.3
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• pp.851-858
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• 2001

Using the normalized sample Lorenz curve which is introduced by Kang and Cho (2001), we propose the test statistics for testing of normality that is very important test in statistical analysis and compare the proposed test with the other tests in terms of the power of test through by Monte Carlo method. The proposed test is more power than the other tests except some cases

• Communications for Statistical Applications and Methods
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• v.2 no.2
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• pp.198-212
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• 1995

This study provides a nonparametric procedure for the statistical inference of the parameters in stationary autoregressive processes. A confidence region and a hypothesis testing procedure based on a class of signed linear rank statistics are proposed and the asymptotic distributions of the test statistic both underthe null hypothesis and under a sequence of local alternatives are investigated. Some desirable asymptotic properties including the asymptotic relative efficiency are discussed for various score functions.

• Communications for Statistical Applications and Methods
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• v.6 no.3
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• pp.901-908
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• 1999

Using the Transformed Lorenz curve which is introduced by Cho et al.(1999) we propose the test statistic for testing of normality that is very important test in statistical analysis and compare the proposed test statistic with the Shapiro and Wilk's W test statistic in terms of the power of test through by Monte Carlo method.

• Proceedings of the KIEE Conference
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• 2003.10b
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• pp.116-118
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• 2003

This paper describes a Accelerated Life Test (ALT) with the electrical contact erosion suitable to the evaluations of high-reliability and durability devices such as magnetic contactor. Recently, an electrical devices company was interested in accelerated life test (ALT), the product liability (PL) and the short-term testing model of electrical life test (ELT). In order to estimate a model for testing fee and period, need to the statistical analysis method with the acceleration factor(AF). Usually customer/manufacturer regard their device failure to the over-current or heavy duty condition, while devices view shape of contact erosion owing to operational duty problem. In this paper, additional method of evaluation estimated the operated cycles by weight of contact erosion with a used of regression analysis by MINITAB.

• Proceedings of the Korean Reliability Society Conference
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• 2004.07a
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• pp.227-232
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• 2004

The failure of geogrids can be defined as an excessive creep strain which causes the collapse of slopes and embankments. In this study, the accelerated creep tests were applied to two different types of polyester geogrids, at 75, 80, 85$^{\circ}C$ by applying 50% load of ultimate tensile strengths using a newly designed test equipment which is allowed the creep testing at higher temperatures. And then the creep curves were shifted and superposed in the time axis by applying time-temperature supposition principles. In predicting the lifetimes of geogrids, the underlying distribution for failure times were determined based on identification of the failure mechanism. The results indicate that the conventional procedures with the newly designed test equipment are shown to be effective in prediction of the lifetimes of geogrids with shorter test times. In addition, the predicted lifetimes of geogrids having different structures at various creep strains give guidelines for users to select the proper geogrids in the fields.