• Archives of Pharmacal Research
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• 제18권4호
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• pp.271-276
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• 1995

Changes in the distribution of dopamine and its metabolites, activities of monoamine oxidase, and dopamine uptake were studied inhyperglycemic rat striatum. The hyperglycemia was induced by the administration of streptozotocin (STZ, 40 mg/kg, i.p. for 3 days.). The levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid were significantly decreased without change in dopamine level in the synatic cleft 14 days after STZ treatment. In the synaptosome, the dopamine level, however, was significanly increased after the treatment. But the DOPAC level in the synaptosome was decreased 14 days after the treatment. The affinity of dopamine uptake was significantly decreased without changes in the velocity 14 days after the treatment. However the response to uptqke inhibitor was unchanged. The striatal monoamine oxidase activities were also decreased in the hyperglycemic state. These results indicate that various parameters of striatal dopamine activities were decreased in the hyperglycemic rats. Furthermore, it suggests that the increase in dopamine level of synaptosome might be due to the decrease in the release of dopaine in hyperglycemic state.

• Archives of Pharmacal Research
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• 제28권11호
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• pp.1236-1238
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• 2005

A new phenolic glycoside, ophiopojaponin D (1), together with two known compounds, was isolated from the tubers of a famous traditional Chinese herb-Ophiopogon japonicus Ker-Gawl. The spectroscopic and chemical data revealed their structures to be 3-tetradecyloxy-4­hydroxy-allylbenzene-4-O-$\alpha$-L-rhamnopyranosyl (1$\rightarrow$6)-$\beta$-D-glucopyranoside (1), 3, 4-dihy-droxy-allylbenzene-4-O-$\alpha$-L-rhamnopyranosyl (1$\rightarrow$6)-$\beta$-D-glucopyranoside (2) and L-pyro­glutamic acid (3).

• Archives of Pharmacal Research
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• 제22권4호
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• pp.329-334
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• 1999

Insulin stimulates glucose uptake in muscle and adipose cells primarily by recruiting GLUT4 from an intracellular storage pool to the plasma membrane. Dysfunction of this process known as insulin resistance causes hyperglycemia, a hallmark of diabetes and obesity. Thus the understanding of the mechanisms underlying this process at the molecular level may give an insight into the prevention and treatment of these health problems. GLUT4 in rat adipocytes, for example, constantly recycles between the cells surface and an intracellular pool by endocytosis and exocytosis, each of which is regulated by an insulin-sensitive and GLUT4-selective sorting mechanism. Our working hypothesis has been that this sorting mechanism includes a specific interaction of a cytosolic protein with the GLUT4 cytoplasmic domain. Indeed, a synthetic peptide of the C-terminal cytoplasmic domain of GLUT4 induces an insulin-like GLUT4 recruitment when introduced in rat adipocytes. Relevance of these observations to a novel euglycemic drug design is discussed.

• Archives of Pharmacal Research
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• 제2권1호
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• pp.35-47
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• 1979

In order to increase the dissolution rate of furosemide(4-choro-N-furfury1-5-sulfamoy1 anthranilic acid_, various ratio coprecipitates with water-soluble polymers, such as polyvinylpyrrolidone and polythylene glycol, of different molecular weight, were prepared and quantitatively studied by comparing their dissolution characteristics of furosemide at powder state and at nondisintegrating disk state containing constant surface area at various temperatures and rotating velocities. The dissolution characteristics of furosemide from pure furosemide disks and 1:2(w/w) furosemide-PVP coprecipitate disks were in accordance with Noyes-Nernst equation and the rate constant of dissolution was proportional to the square root of rotating velocity of the disks. The intrinsic rate of dissoluton at 150 rpm, 37.deg.C was $2.21{\times}10^{-7}$ for the PVP 10, 000 COPRECIPITATE, $1.64{\times}10^{-7}$ for the PVP 40, 000 coprecipitate, and$ 1.44 {\times} 10^{-7}$for the PVP 360, 000 corprecipitate, while the rate was $1.27{\times}10^{-8}M/cm^{2} min$ for pure furosemide, repectively. The activation energy of dissolution was about 17, 000 for furosemide and about 7, 300 cal/mole for the 1:2 furosemide PVP 40, 000 coprecipitate, respectively.

• Archives of Pharmacal Research
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• 제13권1호
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• pp.113-116
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• 1990

People in some tropical countries used to use some plant extracts in folklore medicine as treatment of diabetes melitus. Of these plants is Calligonum comsum ("orta"). The present work deals with the biochemical effects of the whole plant water extract given orally to the albino rats, normals and alloxan diabetics, as to fulfil its hypoglycemic effects on rats. The results showed that "orta" extract produced a hypoglycemic effect indicated by the decrease in blood sugar level. It was observed that the diabetic state in rats treated with 300 mg/kg body weight of "orta" extract, was alleviated, showeing normal levels of blood glucose, liver fat and cholesterol contents. Liver proteins were still below the normal level in the rats. Gibenclamide, a hypoglycemic drug, was used for comparison with "ora" extract. Although it did alleviate the diabetic state, yet the liver fat and cholesterol contents were still higher than those of normal. Also the liver proteins were lower than the control levels.

• 한국기록관리학회지
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• 제7권2호
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• pp.113-138
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• 2007

이 연구는 우리나라의 건설기록물 관리에 관한 문제의식에서 출발하여 국가에서 수행중인 가장 큰 국책사업인 고속철도공사를 비롯한 일반철도 건설사업을 수행하고 있는 시설공단을 선정하여 건설기록물 관리의 현황을 살펴보았다. 현황을 살펴본 방법은 기록물 관리 국제/국가표준 KS X ISO 15489의 기록물 처리과정 기능요건인 획득, 등록, 분류, 저장, 접근, 추적, 처분을 기준으로 하였다. 먼저 획득부터 처분까지의 기능요건을 관련조항에 근거하여 각 단계별로 3~4개 정도의 항목으로 구성하여 총 22개의 원칙을 정하였다. 22개의 지침의 준수 여부를 준수, 부분준수, 미흡, 미준수의 4단계로 구분하여 시설공단의 기록물 관리 현황을 평가하였다. 그리고 지침의 준수 여부를 바탕으로 문제점을 지적하고, 그에 따른 개선방안을 KS X ISO 15489 원칙에 준거하여 시설공단에서 개선해야 할 사항과 제도적으로 개선해야 할 사항으로 나누어 제시하였다.

• 기록학연구
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• 제14호
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• pp.359-388
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• 2006

본 논문은 1881년 독일 프로이센의 국립 비밀 아카이브의 보존 기록 정리를 위한 규정에서 제정된 출처주의/원질서 원칙이 일정 부분 18세기 후반부터 시작되어 19세기 중반에 정립된 역사주의 실증사학의 학문적 목적과 방법에 근원하고 있음을 밝히고 있다. 총체적 유기적 관계에 놓인 민족을 단위로 하는 역사의 개별성을 확인하고 실현하는 것을 목적으로 하는 역사주의는 실증사학의 연구 방법에서 이론적 토대를 얻었다. 이러한 실증사학 전통은 기록 관리의 체계적인 제도를 구축하는데 크게 이바지 하였다. 역사 사실의 상호 유기적인 관계의 입체성을 실증적으로 인식하게 해주는 출처주의/원질서 원칙의 정립은 그 귀결이었다. 이에 대한 역사적 설명을 위해 필자는 랑케로 대변되는 역사주의 실증사학의 내용과 그 정립과정 그리고 랑케의 제자인지벨과 그의 제자인 레만의 프로이센 국립 비밀 아카이브에서의 활동을 분석 서술하였다.

• 한국기록관리학회:학술대회논문집
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• 한국기록관리학회 2019년도 춘계학술대회
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• pp.17-23
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• 2019

기상정보를 주로 제공받아온 시민은 인터넷 기술 기반의 크라우드소싱을 통해 기상정보를 제공하는 주체 중 하나로 자리잡아가고 있다. 국내외에서 국가 기상 서비스 기관과 기업은 시민들이 생산한 기상관측정보를 기상예보에 활용하고 있는 추세이다. 최근 기록학계에서 데이터를 포함한 정보 관리의 중요성을 인지하고 있는 만큼 기상 분야에서 일어나고 있는 기상기록정보 생산주체의 변화와 현황에 대해 주목할 필요가 있다. 그리하여 본 논문에서는 첫째, 각 기상정보생산 주체가 구축한 기상관측망의 현황과 문제점에 대해 확인하였다. 둘째, 기상 영역에서 이루어지고 있는 크라우드소싱을 확인하기 위해 크라우드소싱을 통한 기상예보과정에 직접 참여하여 기상기록정보의 수집, 활용과 그 가능성에 대해 분석하였다. 셋째, 향후 크라우드소싱을 통한 기상정보의 활용에 대한 발전 전망을 제시하였다.

• Archives of Pharmacal Research
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• 제25권6호
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• pp.978-983
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• 2002

Small intestinal transit (SIT) has often been regarded as an index of pathophysiological state of postoperative ileus (PI) in rats. The reliability of SIT as an index of PI was examined in the present study. PI was induced via abdominal surgery (i.e., laparotomy with evisceration and manipulation) in rats. For one group of PI-induced rats, SIT of a charcoal test meal was measured. When necessary, the physical state (i.e., severity and site of distension) of the gastrointestinal (GI) tract in each rat was visually examined. For another group of PI-induced rats, abdominal X-ray radiographs were obtained after introducing the barium sulfate suspension. The abdomen was then opened and the physical state of the GI tract was visually examined. The SIT was decreased in most of the PI-induced rats, and the GI distension was observed, with substantial intersubject variations, in all of the PI-induced rats. However, no linear relationship was evident between the SIT and the severity of GI distension (e.g., at 20 h after PI induction). Instead, the severity and site of GI distension could be monitored by the X-ray radiology. Therefore, the use of SIT as an index of PI should be substantially limited.

• Archives of Pharmacal Research
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• 제28권1호
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• pp.115-119
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• 2005

The clearance of ICG, a known hepatic blood flow marker was investigated in rats in order to examine whether DDB-S influences hepatic blood flow. The effect of DDB-S on the protein binding and blood-to-plasma partition of ICG was measured. The steady-state plasma concentration of ICG was monitored before and after co-administration of various concentration of DDB-S, and ICG clearance was estimated from the steady-state concentration and the infusion rate of ICG. There was no significant difference in protein binding and blood-to-plasma partition of ICG with and without addition of DDB-S (10, 20, and 40 ${\mu}g/mL)$. When ICG was infused into DDB-S pretreated rats, the steady-state concentrations of ICG decreased and the calculated ICG clearance increased. However, no dose-dependency of ICG Css on DDB-S Css was observed. Since DDB-S did not affect the protein binding and blood-to-plasma partition of ICG, the increased clearance of ICG with co-administration of DDB-S seems to be due to the increased hepatic blood flow by DDB-S.