• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.21-21
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• 2018

Natural product substances have historically served as the most significant also be prepared by source of new leads for pharmaceutical development. They can chemical synthesis(both semisynthesis and total synthesis) and have played a important role in the field of organic chemistry by providing synthetic targets. Rcently, they have also been extended for commercial purpose to refer to medicinal products, health functional foods, dietary supplements and cosmetics from natural sources. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. However, with the advent of robotics, bioinformatics, high throughput screening(HTS), molecular biology-biotechnology, combinatorial chemistry, in silico(molecular modeling) and other methodologies, the pharmaceutical industry has largely moved away from plant derived natural products as a source for leads and prospective drug candidates. The strategy for natural prduct industry is now changing from drug approaches to health foods by identifying effective natural products as preparations. In Korea, a lot of development of natural product based drugs have been done, but very few on health functional foods. The concept of natural product based health foods is not active components as lead compounds but standardized extracts or preparation mixed with other medicinal plants. The representative material has been recently known to be a standardized ginseng extract "Ginsana G 115" developed by Swiss Pharmaton company. The purpose of this presentation is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new health functional foods. It is proposed to present the development of high value added health food or health functional foods through scientific investigation on efficacy and standardization of new materials form natural products.

• Journal of Acupuncture Research
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• v.36 no.4
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• pp.264-271
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• 2019

Background: The purpose of this study was to redefine the location of acupoints in the lower abdomen by taking actual thoracic and abdominal measurements. Methods: Measurements of the length and height of the thorax, and both the upper and lower abdominal area were compared to standard values defined by the World Health Organization Western Pacific Region (WHO/WPRO), and medical text books such as Miraculous Pivot, and A-B Classic of Acupuncture and Moxibustion. These measurements were used to redefine the standard of 1 cun, and the cun value of the lower abdomen. Results: Of the 60 studies screened, all studies used the cun measurement system. Considerable variation in the localization of acupoints in the lower abdominal area were detected. The average measurement of a typical male lower abdomen was within 6.33 cun to 6.34 cun. From this data, 6.5 cun appears to be more accurate than the current standardized length of 5 cun. The standardized index values of the width of the 4 fingers, and the distance from the lateral prominence from the greater trochanter to the popliteal crease (Fm), appeared to apply to only males, as defined by the WHO/WPRO. Conclusion: Further studies on standardizing the index measurements for the lower abdominal area are necessary. For males, the more accurate standardized length of the lower abdomen was 6.5 cun, whereas for females, the measurement would typically be longer than 6.5 cun.

• Clinics in Shoulder and Elbow
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• v.25 no.1
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• pp.57-64
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• 2022

Background: There are various conservative treatment options for lateral epicondylitis (LE). The aim is to evaluate pain, daily functioning, and complications after ultrasound-standardized autologous blood injections in patients with LE. Methods: For this prospective cohort study, consecutive patients (>18 years) diagnosed with LE were included. Autologous blood was injected using a medical device containing an injection disposable with 12 small needles (Instant Tennis Elbow Cure [ITEC]) device. Patient-Rated Tennis Elbow Evaluation (PRTEE), subjective elbow score (SES), palpation and provocation pain, satisfaction, and complications of treatment were measured at baseline and two months after treatment. Paired t-tests and Fisher's exact tests were used for calculating the difference between pre- and post-treatment outcomes. Results: Fifty-five elbows were analyzed. Mean time between pre- and post-treatment was 11.1 weeks (standard deviation [SD], 8.9 weeks). The mean PRTEE score decreased from 68.2 (SD, 15.7) before surgery to 53.2 (SD, 25.9; p<0.001) after. The mean SES improved from 36.9 (SD, 20.8) to 51.7 (SD, 27.4; p<0.001). Despite this improvement, only 44.7% of patients showed relevant clinical improvement in PRTEE, and 37.3% showed significant clinical improvement based on SES. Four patients reported a complication and the injection disposable failed three times. Conclusions: Ultrasound-standardized autologous blood injection using the ITEC device is not an effective tool in reducing symptoms related to LE. This study showed that only half of all patients experienced a positive effect. In this heterogeneous cohort of patients, we showed no added value of ultrasound standardization.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.12
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• pp.21-30
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• 2018

The traditional market has formed for itself through a long time thus has special value of the place. The tangible value of the traditional market is high, however, it became jeopardized to be dismantled since it can not cope with the consumption environment of modern society. Modern industrial society provides an inefficiently and standardized solution to the traditional market by ignoring the identity of place only by the value the traditional market in the law of large distribution industry. This study aims to define the placeness of Namdaemun traditional market by considering tangible value of place. The identity of the place was analyzed as a spatial configuration, space organization, and sense of place through the place's physical setting, activities, and meanings by Edward Ralph. Based on the analysis by Ralph, we analyzed the traditional market and compare to the department store, which is the representative of large scale distributor, using comparative method. We performed quantitative and integrative analysis for the placeness and provide a way to appraise the worth of the traditional market by deviating from the traditional evaluation method.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.1
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• pp.72-81
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• 2007

Background & Objective: Pathogenesis treats cause of disease. pyungweesan is pathogenesis prescription of indigestion. prescription has been determined subjectively because there is no standardized prescription. so this study developed questionnaire for a objective and standardized prescription. Method: To determine objective pyungweesan prescription, 24 items of questionnaire are researched two times by delphi method. The questionnaire is selected through 5 reference book and opinions of korean medical doctor. Result: By delphi method and average value, 20 items of questionnaire are chosen. Conclusions: This study becomes basic data for a profound research henceforth. The questionnaire will be developed through being verified by korean medical doctor clinically.

• Korean journal of food and cookery science
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• v.14 no.1
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• pp.97-105
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• 1998

This study was carried out in order to standardize the processing method of spiced soy sauce, to get the sensory scores for organoleptic properties in different cooking of each food items, and to analyze the microbiological and chemical properties during storage periods. In determining the optimum conditions for standardizing of spiced soy sauce, the best sensory score was found in the ratio of soy sauce to sugar of 1:0.7. In the result of microbial experiment on standardized spiced soy sauce, the stability of storage at 40$^{\circ}C$ up to 6 weeks was proved. The standardized spiced soy sauce which was composed of about 45.5% water, 6% crude protein, 11.7% reducing sugar and 32.1% invert sugar has not shown any significant difference during storage for 6 weeks at 40$^{\circ}C$ compared with the state immediately after processing. In the test of saltiness, specific gravity, viscosity and Hunter's color value, there was no notable change during storage at 40$^{\circ}C$. In the experiment of free amino acid and total amino acid, main amino acids were glutamic acid and aspartic acid, which were not significantly changed during storage compared with processing state. In the analysis of mineral contents, sodium accounts for 95% of the total minerals, followed by phosphorus, magnesium, etc., in order, and there was no change during storage.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.24 no.1
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• pp.137-147
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• 1994

A digital imaging system using Machintosh Ⅱ ci computer, high resolution Sony XC-77 CCD camera, Quickcapture Frame Grabber Board was evaluated for quantitative analysis of standardized periapical film with aluminum step wedge. The results were as follows: 1. Correlation between Al thickness and gray level was high-positively associated(r²=0.99, p<0.001). 2. Correlation between measured weight of experimental lesion and estimated relative lesion volume by digital subtracted radiography was also high-positively associated (r²=0.98, p<0.001). 3. As exposure time was increased, mean gray level was decreased(p<0.01) and slope of regression line between Al thickness and gray level was also decreased (p<0.01). And when the exposure time was shorter than 0.2 second, the value of r² was relatively low. On the basis of the above results, it is considered that this digital imaging system using a Macintosh Ⅱ ci computer & a high resolution CCD monochrome camera will be useful in evaluating digitized image from standardized periapical film quantitatively.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7821-7824
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• 2014

Background: We investigated the correlation between standardized uptake value (SUVmax), tumor size and Fuhrman grade in patients with renal cell carcinoma (RC). Materials and Methods: We retrospectively analyzed the data of 54 patients with clear cell renal cell carcinoma histopathologically diagnosed who underwent fluorine-18 fluoro-2 deoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) between January 2005 and March 2014. Results: Avarage tumor sizes were $5.64{\pm}1.85$, $6.85{\pm}2.24$ and $7.98{\pm}2.45$ in low, medium and high SUVmax groups, respectively. The Spearman's correlation coefficient between the tumor size and SUVmax was 0.385 (p=0.004) and between the Fuhrman grade and SUVmax was 0.578 (p<0.001). Conclusions: SUVmax appears highly correlated with tumor size and Fuhrman grade in patients with histopathologically confirmed clear cell RC. Multicenter studies are needed to provide larger series for more accurate results.

• Textile Coloration and Finishing
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• v.20 no.1
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• pp.1-7
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• 2008

The study has attempted to introduce a new coating than the conventional standardized method of spray, padding and roll coating. The study has focused on finding condition for separating water and organic layer in marble bath and surface effects according to kind of raw hide. It was found that dyestuff-free was to be used in water layer and the input amount of initial insoluble pigment to be added in marble bath should be adjusted following the change of surface area of the marble bath in order to get efficient marble effect while preventing coagulation of water and organic layers. Eventually, amorphous high value-added leather could be obtained treated in process other than the conventional standardized method. Even raw hides of low grades($C{\sim}E$ grades) could be processed into amorphous marble effect that could conceal or shield surface scratches by the colorant, which eventually eliminated necessity of using excessive amount of chemicals in the coating process leading to achieving high quality marble leather of natural look.

• International journal of advanced smart convergence
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• v.7 no.3
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• pp.73-78
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• 2018

This study focuses on presenting the IT program module provided by BKLS measure in order to solve the problem of capital cost due to information asymmetry of external investors and corporate executives. Barron at al(1998) set up a BKLS measure to guide the market by intermediate analysts. The BKLS measure was measured by using the changes in the analyst forecast dispersion and analyst mean forecast error squared. This study suggests a model of the algorithm that the BKLS measure can be provided to all investors immediately by IT program in order to deliver the meaningful value in the domestic capital market as measured. This is a method of generating and analyzing real-time or non-real-time prediction models by transferring the predicted estimates delivered to the Big Data Log Analysis System through the statistical DB to the statistical forecasting engine. Because BKLS measure is not carried out in a concrete method, it is practically very difficult to estimate the BKLS measure. It is expected that the BKLS measure of Barron at al(1998) introduced in this study and the model of IT module provided in real time will be the starting point for the follow-up study for the introduction and realization of IT technology in the future.