• Title/Summary/Keyword: standardized mortality

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A Study on the Relationship between the Spatial Cluster Patterns of Male Suicide Rate and the Regional Characteristics in South Korea (남성 자살률의 공간 군집패턴 변화와 지역특성요인의 관계 분석)

  • Choi, Soyoung;Lee, Kwang-Soo
    • Health Policy and Management
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    • v.29 no.3
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    • pp.312-322
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    • 2019
  • Background: Since 2003, Korea has consistently shown the highest suicide rate among the Organization for Economic Cooperation and Development countries, and suicide remains the major cause of death. In particular, men are 2-3 times more likely to commit suicide than women, which called the 'gender paradox of suicide.' The areas with frequent suicide have spatially clustered patterns because suicide with a social contagion spreads around the neighborhood. The purpose of this study was twofold. The first was to estimate the hotspot areas of age-standardized male suicide mortality from 2008 to 2015. The second was to analyze the relationship between the hotspot areas and the regional characteristics for study years. Methods: The data was collected through the Korean Statistical Information Service. The study areas were 227 si gun gu administrative districts in Korea. The hotspot area was used as a dependent variable. Socio-demographic variables (number of marriages per 1,000 population, number of divorces per 1,000 population, and urbanization rate), financial variables (financial independence and social security budget), and health behaviors (EuroQol-5 dimension [EQ-5D], and depression experience rate) were used as independents variables. Results: The hotspot areas were commonly located in Gangwon-do, Chungcheongnam-do, Gyeongsangbuk-do, and Chungceongbuk-do. According to the results of panel logit regression, the number of divorces per 1,000 population, social security budget, and EQ-5D were statistically significant variables. Conclusion: The results of hotspot analysis showed the need for establishing a prevention zone of suicide using hotspot areas. Also, medical resources could be considered to be preferentially placed in the prevention zone of suicide. This study could be used as basic data for health policymakers to establish a suicide-related policy.

Efficacy and Safety of Azithromycin for the Treatment of COVID-19: A Systematic Review and Meta-analysis

  • Mangkuliguna, Ghea;Glenardi, Glenardi;Natalia, Natalia;Pramono, Laurentius A.
    • Tuberculosis and Respiratory Diseases
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    • v.84 no.4
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    • pp.299-316
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    • 2021
  • Background: The lack of effective medications for coronavirus disease 2019 (COVID-19) has led to a trend of drug repurposing such as the case of azithromycin which shows immunomodulatory and anti-viral effect. Several clinical trials have shown conflicting results. It is currently unclear whether the available evidence is in favor or against the use of azithromycin in COVID-19 patients. Thus, the aim of this study was to investigate the efficacy and safety of azithromycin in COVID-19 patients. Methods: Four independent reviewers selected relevant studies from PubMed, ScienceDirect, EBSCO, and ProQuest published prior to March 2021. The protocol used in this study has been registered in PROSPERO (CRD42020224967). Results: We included 17 studies and found that the mortality rate (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.76-1.19), need of respiratory support (OR, 1.30; 95% CI, 0.98-1.73), hospitalization rate (standardized mean difference, 0.12; 95% CI, -0.02 to 0.27), and intensive care unit transfer (OR, 1.21; 95% CI, 0.79-1.86) of azithromycin-treated group did not differ significantly (p>0.05) from those of the control group. Azithromycin treatment did not significantly increase the risk of getting secondary infection (OR, 1.23; 95% CI, 0.83-1.82), hypoglycemia (OR, 0.73; 95% CI, 0.38-1.40), gastrointestinal problems (OR, 1.03; 95% CI, 0.73-1.45) or electrocardiogram abnormalities (OR, 1.16; 95% CI, 0.94-1.42). The overall quality of evidence ranged from low to very low. Conclusion: Azithromycin did not result in a superior clinical improvement in COVID-19 patients, although it was well-tolerated and safe to use.

Preoperative Corticosteroid Use and Early Postoperative Bronchial Anastomotic Complications after Lung Transplantation

  • Kim, Ha Eun;Paik, Hyo Chae;Kim, Song Yee;Park, Moo Suk;Lee, Jin Gu
    • Journal of Chest Surgery
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    • v.51 no.6
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    • pp.384-389
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    • 2018
  • Background: Airway anastomotic complications are a leading cause of mortality after lung transplantation. Among the factors that cause airway complications, preoperative steroid use has been considered to be related with postoperative airway healing. We analyzed the influence of preoperative steroid use on postoperative airway complications. Methods: The medical records of 66 double-lung transplant recipients from January 2014 to December 2015 were reviewed. Forty patients were prescribed steroids preoperatively. The daily steroid dose was standardized using the patient's body mass index (BMI). Patients who received preoperative steroids were sub-divided into high-dose (HD) and low-dose (LD) groups (cut-off value, 1.6 mg/BMI/day). Results: Thirteen patients suffered from airway complications postoperatively (bronchopulmonary fistula, 9; bronchial stenosis, 4). There was a tendency for early development of airway complications in the steroid use group compared to the non-steroid use group, but it was not significant (percentage free from airway complications in year 1: non-steroid group, 90.9% vs. steroid group, 79.2%; p=0.43). The percentage of patients in the LD and HD groups who were free from airway complications in year 1 was not significantly different (84.0% vs. 77.8%, p=0.39). Conclusion: The airway complication rate did not vary significantly according to steroid use. Additionally, in patients who received preoperative steroids, the dose did not affect the rate of development of airway complications.

Association of Hemodialysis and Sarcopenia : A systematic review (혈액투석과 근감소증의 연관성에 관한 문헌고찰)

  • Kyoung-Wook Choi;Hwa-Gyeong Lee;Soo-Ah Kim;Yun-Jae Oh
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.3
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    • pp.185-194
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    • 2023
  • Purpose : This study aimed to investigate the relationship between the characteristics of hemodialysis patients and the occurrence of sarcopenia through a comprehensive literature review. Methods : A systematic literature search was conducted to identify eligible studies in the Cochrane library, PubMed and Embase. In this review, we included all papers published since the initiative's inception and summarized results as of december 2022. Studies that investigated association between sarcopenia diagnosis and hemodialysis patients (aged≥18 years) were included. Ultimately, 16 studies met our selection criteria. The risk of bias was assessed using the Newcastle-Ottawa scale. Results : Fourteen of the sixteen studies (88 %) reported that significant association between sarcopenia diagnosis and hemodialysis patients. However, two studies reported no association between sarcopenia diagnosis and hemodialysis patients. As a factor statistically related to sarcopenia in hemodialysis patients, Mortality (6 studies, 38 %), age (5 studies, 31 %), body composition (4 studies, 25 %), physical activity (2 studies, 13 %), diabetes (2 studies, 13 %), cardiovascular abnormalities (1 studies, 6 %), nutritional status (3 studies, 19 %), and gender (3 studies, 19 %). Conclusion : Our findings highlight the necessity of developing a physical therapy program that accurately reflects the health status of hemodialysis patients. To further investigate the association between the diagnosis of sarcopenia and hemodialysis patients, it is recommended to conduct large-scale longitudinal studies using standardized diagnostic criteria and evaluation methods, as well as analyze potential risk factors. Consequently, this study emphasizes the importance and potential of developing physical therapy programs that effectively address the health consequences associated with hemodialysis. The significance of this research lies in its ability to provide valuable insights and lay the foundation for future studies focused on developing preventive and therapeutic interventions targeting muscle wasting syndrome resulting from hemodialysis.

Epidemiology of Suicide by Hanging in Fars Province, Iran (2011-2019): A Population-based Cross-sectional Study

  • Leila Moftakhar;Alireza Mirahmadizadeh;Sanaz Amiri;Fariba Rezaei;Habibollah Azarbakhsh
    • Journal of Preventive Medicine and Public Health
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    • v.56 no.3
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    • pp.264-271
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    • 2023
  • Objectives: Hanging is a common method of attempted suicide. This study investigated the epidemiological profile of attempted and completed suicides by hanging in southern Iran. Methods: This cross-sectional study was performed on 1167 suicide attempts by hanging between 2011 and 2019. All data related to suicide attempts by hanging were collected from the Fars Suicide Surveillance System. The trends in suicide cases and the mean age of attempted and completed suicides were plotted. The chi-square test was used to identify suicide-related factors. Crude rates of incidence, mortality, and standardized fatality during the study period were calculated. Finally, logistic regression was used to identify the predictors of death in individuals who attempted suicide. Results: The mean age of those who attempted suicide was 33.21±16.82 years; the majority were male (80.5%). The rate of attempted and completed suicide by hanging were 3.50 and 2.79 per 100 000 people, respectively. The case-fatality rate was calculated as 79.34%. The results of our study indicated an increasing trend in suicide attempts by hanging. The likelihood of death was 2.28 times higher in individuals with a previous history of suicide attempts and 1.85 times higher in those with a psychological disorder. Conclusions: The findings of this study suggest an increasing trend in attempted and completed suicide by hanging, especially among individuals with a history of suicide attempts and psychological disorders. It is necessary to take action to reduce the rate of suicide attempts and identify the underlying causes of suicide attempts by hanging.

Suicide in the Australian Mining Industry: Assessment of Rates among Male Workers Using 19 Years of Coronial Data

  • Tania King;Humaira Maheen;Yamna Taouk;Anthony D. LaMontagne
    • Safety and Health at Work
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    • v.14 no.2
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    • pp.193-200
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    • 2023
  • Background: International evidence shows that mining workers are at greater risk of suicide than other workers; however, it is not known whether this applies to the Australian mining sector. Methods: Using data from the National Coronial Information System, rates of suicide among male mining workers were compared to those of three comparators: construction workers, mining and construction workers combined, and all other workers. Age-standardized suicide rates were calculated for 2001-2019 and across three intervals '2001-2006', '2007-2011', and '2012-2019'. Incidence rate ratios for suicide were calculated to compare incidence rates for mining workers, to those of the three comparative groups. Results: The suicide rate for male mining workers in Australia was estimated to be between 11 and 25 per 100,000 (likely closer to 25 per 100,000) over the period of 2001-2019. There was also evidence that the suicide rate among mining workers is increasing, and the suicide rate among mining workers for the period 2012-2019 was significantly higher than the other worker group. Conclusions: Based on available data, we tentatively deduce that suicide mortality among male mining workers is of concern. More information is needed on both industry and occupation of suicide decedents in order to better assess whether, and the extent to which, mining workers (and other industries and occupations) are at increased risk of suicide.

Hospital-Acquired Measles: A Systematic Review Using the Outbreak Reports and Intervention Studies of Nosocomial Infection (ORION) Statement

  • Erdenetuya Bolormaa;Cho Ryok Kang;Han Ho Kim;Young June Choe
    • Pediatric Infection and Vaccine
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    • v.31 no.1
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    • pp.64-74
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    • 2024
  • Purpose: Despite the recent increased number of nosocomial measles, the outbreak investigation reports are not usually standardized, thus posing unclear understanding of magnitude of its public health burden. We used the Outbreak Reports and Intervention Studies of Nosocomial Infection (ORION) statement, to compare nosocomial outbreaks and synthesize evidence to prevent hospital transmission of measles. Methods: A PubMed, Web of Science, Embase, Scopus, and Cochrane search in English, using the medical subject headings "measles," "nosocomial," "hospital," and "healthcare," was performed. We evaluated the quality of outbreak reports of nosocomial measles infection worldwide using the ORION statement findings and recommendations. Results: We reviewed 24 studies in accordance to the ORION statement. Measles transmission in healthcare settings is a significant burden on the morbidity, mortality, and economy of measles. The healthcare workers' booster vaccination guidelines should be monitored and enhanced during the post-elimination period of measles. The outcomes of infections must be explicit for outbreak reports. Conclusions: This study identified the epidemiological and clinical characteristics of nosocomial measles infections and provided strong evidence for infection control policies in hospitals.

Autonomic Neurocardiac Function in Patients with Major Depressive Disorder - Using a Heart Rate Variability Test Battery - (주요우울장애 환자에서의 자율신경심장기능 - Heart Rate Variability 검사를 사용하여 -)

  • Park, Young-Su;Lee, Kang-Joon;Kim, Hyun;Chung, Young-Cho
    • Sleep Medicine and Psychophysiology
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    • v.11 no.2
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    • pp.100-105
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    • 2004
  • Objectives: Major depression is associated with an increased risk of cardiovascular mortality. One possible explanation for this association is that major depression influences autonomic neurocardiac regulation. However, previous studies on the relationship between heart rate variability (HRV) and major depression have revealed conflicting results. The purpose of this study is to clarify that major depressive patients compared to healthy controls show a reduction in HRV as an expression of reduced modulation of vagal activity to the heart. Methods: According to DSM-IV, the time and frequency domain HRV indices (5-min resting study) of 30 patients with major depressive disorder were compared with those of 30 healthy controls. Standardized HRV tests enable quantitative estimation of autonomic nervous system function. Results: After controlling for age and gender, subjects with major depression showed a higher heart rate and significantly lower modulation of cardiovagal activity compared to controls. The total power (TP) band, very low frequency (VLF: 0.003-0.04 Hz) band, low frequency (LF: 0.04-0.15 Hz) band, and high frequency (HF: 0.15-0.4 Hz) band were significantly reduced in subjects with major depression compared to control subjects. Conclusion: Patients with major depression may suffer from functional disturbances in the interaction between the sympathetic and parasympathetic autonomic systems.

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A Comparison of Growth and Reproduction of Lumbricus rubellus and Eisenia foetida Cultured in Three Kinds of Artificial Soil Substrates (몇가지 인공토양에서 사육한 Lumbricus rubellus와 Eisenia foetida의 성장인자의 차이)

  • Lee, Sung-Kyu
    • Korean Journal of Environmental Agriculture
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    • v.14 no.1
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    • pp.82-87
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    • 1995
  • The standardization of test procedures and reproducibility of the toxicity data are prerequisite for the toxicity testing with the earthworm culturing in the laboratory. No in-depth study on culturing conditions of earthworms has been conducted in Korea, even of massive cultural practice is common for composting and production of biochemicals. The earthworms, Lumbricus rubellus and Eisenia foetida, were cultured in three kinds of artificial soil substrates(I, II and III) based on the OECD Guideline, which consist of different ratios of components (sand, sphagnum peat and kaolinite), and fed with a mixture of grain powders. During the period of culturing, the body weight and reproduction parameters were measured. L. rubellus showed the best results for increasing body weight and cocoon production in the artificial soil substrate(I) compared with E. foetida. The cocoon production was significantly high in both species cultured in the artificial soil substrate(I) among the three kinds of soil substrates, but the cumulative cocoon production of L. rubellus was 11 cocoon per worm compared with 3.7 cocoons per worm of E.foetida. L. rubellus, therefore, was more prolific than E. foetida in these culture schemes. The cumulative mortality in both species was less than 10%, and the number of juvenile worms per cocoon ranged from 1.5 to 2.3 and thus did not show any relationships with soil substrates or species. From these data, the culture of L. rubellus in the laboratory could be standardized, but for E. foetida, further study would be necessary to establish the optimal growth conditions in the laboratory.

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The Relationship between Local Fiscal Indices and Standardized Mortality rate (지역 재정지표와 표준화 사망률의 관련성)

  • Han, Ji-Yeon;Na, Bak-Ju;Lee, Moo-Sik;Hong, Jee-Young;Lim, Nam-Gu
    • Proceedings of the KAIS Fall Conference
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    • 2010.05b
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    • pp.1072-1076
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    • 2010
  • 본 지역 재정지표와 표준화사망률간의 관계에 대한 것으로, 연구대상지역은 1998년부터 2007년까지의 전국 232개 시 군 구이며 이를 5개 광역권과 4개 도시 종류에 따라 분류하였다. 지역 재정지표는 1인당 지방세부담액과 재정자립도, 재정자주도, 의존재원비율을 활용하였고, 지역 총사망률은1998년에서 2007년까지의 통계청 사망 원자료 상의 사망자수를 분자로, 주민등록인구를 분모로 직접 표준화법을 사용하여 연구대상 지역의 성 연령표준화사망률을 산출하였다. 자료의 분석은 SPSS 12.0K를 이용하여 상관분석, 일원배치분산분석(Tukey b 사후검정) 및 회귀분석을 실시하였다. 주요 결과로는 첫째, 재정지표와 표준화사망률간의 상관분석을 실시하여 연도별로 계수 값을 구한 결과 1인당 지방세부담액을 제외하고 재정자립도, 재정자주도, 의존재원비율 모두 남자, 여자, 전체 모두가 전 연도에 걸쳐 상관계수 값이 통계적으로 유의하였으며, 남자가 여자보다 높은 상관관계를 보였다. 둘째, 재정자립도, 재정자주도 각각을 표준화사망률과 단순 회귀분석을 실시한 결과, 표준화사망률 남자, 여자, 전체가 전 연도에서 통계적으로 유의하였고, 재정자립도와 재정자주도가 낮을수록 사망률이 높은 것으로 나타났다. 셋째, 광역권역, 도시 종류까지 고려한 재정지표의 다중회귀분석을 실시한 결과, 1인당 지방세부담액과 의존재원비율, 광역권역과 도시 종류에 따른 지역을 고려하고도 재정자주도의 효과는 전체사망과 남자, 여자, 전 연도에 걸쳐 모두 통계적으로 매우 유의하여 재정자주도가 높을수록 사망률이 낮은 것으로 나타났고 이런 경향은 여자보다 남자에서 더욱 강하게 나타났다. 넷째, 광역권별 분석의 경우, 충청권은 수도권에 비해서 표준화사망률에서 유의한 차이는 없었으며 호남권과 영남권은 전체 표준화사망률의 경우 전체 연도의 절반 이상에서 수도권에 비해서 통계적으로 유의하게 높았고, 남자와 여자에서는 이런 경향이 약해졌다. 강원 제주권은 전체 사망에서 수도권에 비해 전체 연도의 절반 이상이 유의하게 사망률이 낮았으며, 여자도 이와 비슷한 양상을 보여주었다. 다섯째, 도시 종류에 따른 분석에서 대도시에 비해 중소도시는 통계적으로 유의한 차이는 없었으나, 전 연도에 걸쳐 도농통합도시와 군지역은 대도시에 비해 통계적으로 사망률이 높았다. 여섯째, 전 연도에 걸쳐 의존재원비율이 높아질수록 사망률이 유의하게 높아졌다. 이는 남자, 여자 모두에서 유사하게 나타났다. 마지막으로 연도별 분석 이후 1998년에서 2007년 전체 다중 회귀분석을 실시한 결과 전체 사망과 여자의 경우 1인당 지방세부담액을 제외한 모든 변수에서 통계적으로 유의하였다. 지역의 재정력이 성 연령 표준화사망률에 영향을 미치는 것으로 파악되었는데 이를 단서로 지역의 건강 격차가 발생하는 원인과 기전을 밝히기 위해 향후 보다 면밀한 후속 연구가 이뤄져야 하겠고 지역 간 건강 격차를 완화하기 위한 여러 방법론적 고찰 안에 지역간 재정력의 격차를 완화하려는 정책적인 접근도 필요할 것으로 사료된다.

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