• Title/Summary/Keyword: standard of diagnosis

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Modification of Cutoff Values for HE4, CA125, the Risk of Malignancy Index, and the Risk of Malignancy Algorithm for Ovarian Cancer Detection in Jakarta, Indonesia

  • Winarto, Hariyono;Laihad, Bismarck Joel;Nuranna, Laila
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.5
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    • pp.1949-1953
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    • 2014
  • Background: CA125 and HE4 are used in calculating Risk of Malignancy Algorithm (ROMA); and Risk of Malignancy Index (RMI). However, studies showed that normal levels of CA125, and HE4 differ among ethnicities such as between Asians and Caucasians, thus affecting the accuracy of the RMI score and ROMA in predicting ovarian malignancy. This study aimed to determine whether new or modified cutoff values for Ca125, HE4, the RMI score, and ROMA resulted in a better prediction of malignancy compared with the previous or standard ones. Materials and Methods: Serum level of CA125 and HE4 from 128 patients with diagnosis of ovarian tumor that had been collected before surgery at Cipto Mangunkusumo General Hospital (CMH) in Jakarta from November 2010 until May 2011 were reviewed and analysed. The standard cutoff values of these biomarkers, RMI, and ROMA were modified by using logistic regression model. The modified cutoff values were compared to the standard cutoff values in terms of sensitivity, specificity, and accuracy. Results: The modified cutoff value of CA125, HE4, RMI score and ROMA were 165.2 U/mL, 103.4 pM, 368.7, 28/54. The sensitivity and specificity of the modified cutoff values CA125, HE 4, RMI score and ROMA in differentiating benign from malignant and borderline were 67% and 75,4%; 73.1% and 85.2%; 73.1% and 80.3%; and 77.6% and 86.9%. While the sensitivity and specificity of the standard cutoff value of CA125; HE4; RMI score; and ROMA were 91% and 24.6%; 83.6% and 65%; 80.6% and 65.6%; and 91.0% and 42.6%. The accuracy of modified cutoff values compared with standard cutoff values were: 71.2% vs 59.3%, 78.9% vs 75% vs, 76.5% vs 73.4%, and 82% vs 67.9%. Conclusions: The new or modified cutoff values of Ca125, HE4, RMI score and ROMA resulted in higher accuracy compared to the previous or standard ones, at the cost of reduced sensitivity.

Report on the Survey for the Necessity of Korean Standard Differentiation of the Symptoms and signs for the Stroke (한국형 중풍변증진단 표준안의 필요성에 대한 설문조사 보고)

  • Yu Byeong-Chan;Kim Joong-Kil;Seol In-Chan;Shin Seon-Hwa;Lee In;Jo Hyun-Kyung;Choi Sun-Mi
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.1
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    • pp.273-278
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    • 2006
  • This survey was accomplished in order to find out the necessity of creation of Korean standard differentiation of the symptoms and signs for the stroke(KSDS) in clinical practice. The survey questions were developed by the consensus from the professors who major in internal traditional Korean medicine(TKM). May 11th to July 31th 2005, the questionnaire was given to 800 TKM doctors in the whole country of Korea listed on the National Korean Medical Hospital Associations address book dy postal mail. Total of 358(44.7%) questionnaires were retrieved out of the 800 subjects. The 311 (86.9%) of 358 TKM doctors given an answer to the survey responded to need development of KSDS, and 176(56.6%) of 311 TKM doctors who answered to need development of KSDS responded to have to consider consensus of clinical experts on the stroke for creation of KSDS. These results support a role for new KSDS might be usefully applied in diagnosis and treatment of the stroke.

Safety of Temporary Use of Recycled Autoclaved Femoral Components in Infected Total Knee Arthroplasty: Confirming Sterility Using a Sonication Method

  • Park, Hyung-Jin;Kim, Hee-June;Kim, Shukho;Kim, Seong-Min;Mun, Jong-Uk;Kim, Jungmin;Kyung, Hee-Soo
    • Clinics in Orthopedic Surgery
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    • v.10 no.4
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    • pp.427-432
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    • 2018
  • Background: The purpose of this study was to evaluate the usefulness of sonication technique for microbiological diagnosis and the sterility of the recycled autoclaved femoral components from infected total knee arthroplasty (TKA) using a sonication method. Methods: Nineteen femoral implants explanted from patients with infected TKA were sterilized with a standard autoclave method. Standard culture of the fluid before and after sonication of the sterilized implants was performed to detect pathogenic microorganisms. Additional experiments were performed to evaluate the sterility of the recycled implant by inducing artificial biofilm formation. Methicillin-resistant Staphylococcus aureus (MRSA) was inoculated into 10 implants and sterilization in a standard autoclave was performed, and then the fluid was cultured before and after sonication. Results: Two of the 19 sterilized implants were positive for growth of bacteria after sonication, whereas no growth was detected in the cultured fluid from the sterilized implants before sonication. The bacteria were Staphylococcus species in all two cases. In one of 10 implants inoculated with MRSA, the culture was positive for growth of bacteria both before and after sonication. However, Staphylococcus epidermidis was cultured from both occasions and thus this implant was thought to be contaminated. Conclusions: We found sonication for identification of pathogens could be helpful, but this finding should be interpreted carefully because of the possibility of contamination. Sterilization of an infected femoral implant with an autoclave method could be a good method for using the temporary articulating antibiotic spacer in two-stage revision arthroplasty.

Usefulness of Clinical T-Score of Continuous Performance Test for Differential Diagnosis : among Attention-Deficit Hyperactivity Disorder, Depressive Disorder, Anxiety Disorder, and Tic Disorder (연속수행검사에서 주의력결핍 과잉행동장애 감별 진단 시 임상 T-점수의 유용성 - 주의력결핍 과잉행동장애, 우울장애, 불안장애, 틱장애를 중심으로 -)

  • Yoon, Soo-Youn;Koo, Hoon-Jung;Kim, Boong-Nyun;Cho, Soo-Churl;Shin, Min-Sup
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.19 no.2
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    • pp.112-119
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    • 2008
  • Objectives : This study was conducted to examine whether there are qualitative differences in attention problem among children with various psychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), depressive disorder, anxiety disorder, and tic disorder using clinical ADHD diagnostic system (ADS) T-scores. Methods : The subjects were 794 outpatient children aged from 5 to 15 years, including 540 children with ADHD, 95 children with depressive disorder, 86 children with anxiety disorder, and 73 children with tic disorder. Clinical T-scores on the ADS were calculated using the mean and standard deviations of four ADS variables for the ADHD group. Results : All four groups had T-scores on the ADS in the abnormal range. However, when comparing the clinical T-scores, the children with depressive and anxiety disorders performed better than the children with ADHD. We also found that although the four groups seemed to be similar in terms of clinical T-scores for omission and commission errors, there were significant differences in clinical T-scores for reaction time and the standard deviation of response time (RT) between the ADHD and other groups. Conclusions : We concluded that inattention and impulsivity might not be specific only to ADHD and that the clinical T-scores of RT and standard deviation of RT on the ADS could be used to discriminate between ADHD and other clinical groups.

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A Development of Representative Condition Evaluation Standard for LNG Storage Tank Structures (LNG 저장탱크 구조물의 종합적 상태평가기준 개발)

  • Kim, Jung-Hoon;Jo, Young-Do
    • Journal of the Korean Institute of Gas
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    • v.22 no.6
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    • pp.44-51
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    • 2018
  • As the LNG storage tank is aged, if there is a crack in the outer wall concrete or corrosion of the reinforcing steel, there is a risk of a major accident such as collapse of the structure depending on the type and degree of damage. Since 2014, LNG storage tanks have undergone precise safety diagnosis and safety inspection has been carried out. The condition evaluation criteria for each component have been revised and applied in January 2016. The condition evaluation standard is to evaluate the status of storage tanks based on the appearance survey and material test results of LNG storage tanks and it is important for maintenance. In addition, the representative condition evaluation standard that shows the comprehensive state of each LNG storage tank is important in maintenance, but the related standard for LNG storage tank outer concrete is not available in Korea and abroad, and development of the condition evaluation standard is necessary. In this paper, we examined the structural characteristics of LNG storage tanks, analyzed the status of the condition evaluation criteria for each member, and developed a comprehensive status rating system by weighting the members. We used the AHP(Analytic Hierarchy Process) technique and developed a representative conditon evaluation criteria through surveys of professional organizations.

A Study on Economical Efficiency Evaluation of Semiforcing under Structure Watermelon Cultivators (반촉성 시설수박 재배농가의 경제적 효율성 분석)

  • Kim, Woong;Kim, Jai Hong
    • Korean Journal of Agricultural Science
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    • v.33 no.2
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    • pp.179-193
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    • 2006
  • Technical efficiency of semiforcing watermelon growers is 0.8248 on average, and distributed between 0.6744 and 0.9268. The result showed that semiforcing watermelon growers had by 18% of technical inefficiency and could be assumed that increasing technical efficiency could induce watermelon production more increase. Consequently, if growers' technical efficiency were improved while other environments were constant, watermelon production could be increased. Following the results from the inefficiency effect model, all assumption coefficient such as growers age etc, are significant at 10% level. Estimate of dispersion parameter ${\gamma}$ is 0.89, which confirms those differences between practical output and frontier output were derived from the technical efficiencies among growers. Differences of production system between high and low level growers in production efficiency were showed at side altitude, ventilation and heat-retaining in section of facilities and automation, soil test and calcium application in section of environment management, transplant preparation and duration of pollination in section of crop management and shipment place, sorting degree and management record analysis in section of business management respectively. As a result of analyzing consulting data by using standard diagnosis table of watermelon cultivation under structure which cultivated on semi-forced watermelon growers, gap between high and low level growers was 7.0 points in facility automation section, 7.1 points in environment section, 8.8 points in crop management section and 13.6 points in business management section, respectively, which were the biggest one among them. In case of excluding information-related items from the evaluation index of business management section, changes of business achievement are to occur. Therefore, it is recommended for us to review the standard diagnostic table of watermelon cultivation under structure by dividing evaluation index of management section into management and information.

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Medical Image Compression Using JPEG International Standard (JPEG 표준안을 이용한 의료 영상 압축)

  • Ahn, Chang-Beom;Han, Sang-Woo;Kim, Il-Yoen
    • Proceedings of the KIEE Conference
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    • 1993.07a
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    • pp.504-506
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    • 1993
  • The Joint Photographic Experts Group (JPEG) standard was proposed by the International Standardization Organization (ISO/SC 29/WG 10) and the CCITT SG VIII as an international standard for digital continuous-tone still image compression. The JPEG standard has been widely accepted in electronic imaging, computer graphics, and multi-media applications, however, due to the lossy character of the JPEG compression its application in the field of medical imaging has been limited. In this paper, the JPEG standard was applied to a series of head sections of magnetic resonance (MR) images (256 gray levels, $256{\times}256$ size) and its performance was investigated. For this purpose, DCT-based sequential mode of the JPEG standard was implemented using the CL550 compression chip and progressive and lossless coding was implemented by software without additional hardware. From the experiment, it appears that the compression ratio of about 10 to 20 was obtained for the MR images without noticeable distortion. It is also noted that the error signal between the reconstructed image by the JPEG and the original image was nearly random noise without causing any special-pattern-related artifact. Although the coding efficiency of the progressive and hierarchical coding is identical to that of the sequential coding in compression ratio and SNR, it has useful features In fast search of patient Image from huge image data base and in remote diagnosis through slow public communication channel.

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Changes in the Standardized Uptake Value According to the Type of Metal of Dental Prosthesis in PET-CT Fusion Image (PET-CT 융합 영상에서 치과보철물의 금속 종류에 따른 표준섭취계수 값의 변화)

  • Han, Sang-Hyun
    • Journal of the Korea Convergence Society
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    • v.9 no.9
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    • pp.117-122
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    • 2018
  • In this study, HU(hounsfield unit) value of CT generated by dental prosthesis was measured according to the type of metal when PET-CT was performed, and the degree of distortion and standard deviation of SUV(standard uptake value) and to propose a method to reduce errors in image reading. PET-CT was performed using actual teeth, metal crown, gold crown, titanium, and zirconia dental prosthesis. Compared with general teeth, the SUV value increased with increasing HU value. The SUV value of metal crown, titanium, and zirconia was increased by 37% and the gold crown increased by 45.4%. In addition, image distortions were small in general teeth, metal crown, titanium, and zirconia, but hard curing of the gold crown occurred and image distortion occurred. Therefore, since the metal type of the dental prosthesis affects the SUV value, the NAC(non attenuation correction) PET image of the dental prosthesis can be helpful in the diagnosis of the patient using the gold material.

"Beach Lifeguards' Sun Exposure and Sun Protection in Spain"

  • de Troya Martin, Magdalena;Sanchez, Nuria Blazquez;Garcia Harana, Cristina;Leiva, Ma Carmen Alarcon;Arjona, Jose Aguilera;Ruiz, Francisco Rivas;de Galvez Aranda, Ma Victoria
    • Safety and Health at Work
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    • v.12 no.2
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    • pp.244-248
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    • 2021
  • Background: Sunburn is the main avoidable cause of skin cancer. Beach lifeguards spend many hours exposed to the effects of solar radiation during their work day, precisely at times of the year when levels of solar irradiation are highest. The aim of this study is to quantify the risk to beach lifeguards of sun exposure. Methods: A descriptive cross-sectional study was carried out in the Western Costa del Sol, southern Spain, during the summer of 2018. The research subjects were recruited during a skin cancer prevention course for beach lifeguards. All participants were invited to complete a questionnaire on their habits, attitudes, and knowledge related to sun exposure. In addition, ten were specially monitored using personal dosimeters for three consecutive days, and the results were recorded in a photoprotection diary. A descriptive analysis (mean and standard deviation for the quantitative variables) was performed, and inter-group differences were evaluated using the Mann-Whitney U test. Results: Two hundred fifteen lifeguards completed the questionnaire, and 109 met the criteria for inclusion in this analysis. The mean age was 23.8 years (SD: 5.1), 78.0% were male, 71.5% were phototype III or IV (Fitzpatrick's phototype), and 77.1% had experienced at least one painful sunburn during the previous summer. The mean daily personal ultraviolet exposure per day, the minimal erythema dose, and the standard erythema dose, in J/m2, were 634.7 [standard deviation (SD): 356.2], 2.5 (SD: 1.4) and 6.35 (SD: 3.6), respectively. Conclusion: Beach lifeguards receive very high doses of solar radiation during the work day and experience correspondingly high rates of sunburn. Intervention strategies to modify their sun exposure behavior and working environment are necessary to reduce the risk of skin cancer for these workers and to promote early diagnosis of the disease.

A Design and Implementation of Mobile Healthcare System based on Smart Gateway (스마트 게이트웨이 기반 모바일 헬스케어시스템의 설계 및 구현)

  • Kang, Sung-In;Oh, Am-Suk
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.16 no.9
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    • pp.1970-1976
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    • 2012
  • Home healthcare system has lot of things to do for the integration with medical instruments in the sense of standardization. We will design and implement mobile healthcare system based on smart gateway thru adaptation of ISO/IEEE 11073, and HL7 standard. And also we are willing to research heart rate monitor, pulse-oxygen meter and ECG monitor in order to develop mobile healthcare system for medical appliance. We studied the connection of standard medical devices, i.e, continua health alliance under the Android 4.x Bluetooth HDP(Health Device Profile) environments. We also tried to implement healthcare system which can support diagnosis for healthcare provider and user based on HL7 standard.