• 한국육종학회지
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• 제40권4호
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• pp.387-393
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• 2008

Ds 삽입변이체로 부터 5,400개의 FST를 분석한 결과, intragenic FST가 48.1%로 2,597개, intergenic FST가 25.6%로 1,383개였으며 hot spot을 포함한 origin insertional sequence는 1,350개로 25%로 나타났다. Intragenic FST로서 선발된 2,597개를 이용하여 Ds와의 유전자형을 분석한 결과 53.6%인 1,393개가 heterozygous 혹은 homozygous 계통으로 나타났으며 이들에 대한 염색체상의 분포도는 3번 염색체에서 422 계통으로 가장 많은 분포도를 보여주었고 다른 염색체는 56 계통에서 157 계통 범위 내에 포함되었다. 1차적으로 유전자형 분석이 끝난 1,393개의 유전자들 중에서 expressed protein 등 알려지지 않은 것은 40.6%로 566개였으며 TIGR DB에서 염기서열의 유사성 검색을 통해 유전자의 명칭이 알려진 것은 59.4%인 827개로 나타났다.

• 한국구조물진단유지관리공학회 논문집
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• 제8권4호
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• pp.165-174
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• 2004

본 연구에서는 고속철도 ${\bigcirc}{\bigcirc}$역사 공사구간 중 굴착구간에 인접하여 하천이 위치하고 공사구간 좌측에는 항상 만수위 상태의 저수지가 있어 지반 굴착시 지하 5m 깊이에서 지하수위가 존재하는 구간에 설치된 부력앵커의 수평재하시험에 관한 연구이다. 따라서 본 연구에서는 지하수위 면이 발생하는 구간에 설치된 부력앵커의 현장 수평재하시험을 통해 영구적으로 지하수위에 의해 부력을 받는 구조물의 장기적인 안정성을 평가하고자 한다. 이를 위해 고강도 강봉이나 강연선을 사용, 지반과의 마찰력을 이용하여 부력에 저항하는 방법으로 충분한 인발력을 확보할 수 있는 Bar Type 앵커를 사용하였다. 고속철도의 제동과 가속에 의해 수평력을 받는 지하구조물 바닥 슬래브에 부력방지용 앵커를 설치하였다. 이로 인해 Bar Type 부력앵커에 발생되는 거동특성을 파악하기 위해 수평재하시험을 실시하여 고속철도의 주, 정차시 열차의 급제동및 출발에 의해 발생되는 수평력에 대한 부력앵커의 거동특성을 파악하고자 하였다.

• 한국과학교육학회지
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• 제2권1호
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• pp.31-51
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• 1980

In order to research into the devel of the concept of movement and speed in our own way and compare with the Piaget's method, and then find out the formative period of such development, we have put the 192 primary school children as the model and obtained the following results. 1. As their grade upyards, all the experimental subjects showed the gradual progress generally regardless of sex or regions, while only the relative speed showed irregular progress. 2. There was no experimental subject which showed any remarkable sexual characteristics. But in the relative movement, the lower grade boys and higher grade girls made progress. In the subjects of circulation movement, intuition of speed, relative speed and speed of simultaneous movement, the boys marked better progress, whilst the girls were advanced a little in the speed of continuous movement with, different distance and time. 3. There was no conspicuous difference between the urban and rural areas, except a slight tendency that the urban children made better progress in the change of progressing direction, native continuous procedure of periodical movement, travelling road, and the speed of continuous movement with different distance and time whereas the rural children were more advanced in the relative movement, relative speed and intuition of speed. But it should be 'taken into consideration that the rural regions in our case were relatively developed in comparison with the traditional rural communities, which may explain about little regional difference. 4. Comparing our research results with the Piaget's theory, we have reached below results. Our research reports that the formative period of the conception of the problems of diverse progressing direction and a native continuous procedure of periodical movement was simultaneous, at the Piagetian level(at the fourth grade) which coincides with Piagetian theory. The travelling road should be made up a little lower at 2A/2B according' to Piagetian Level, whereas it was formed at the 4th grade as shown in our previous research. Intuition of speed should belong to the prior stage to concrete operation, but our research shows it was formed late at the 4th grade. Composition of displacement was made at the 6th grade, and it was almost equal to the first stage of formal operation(3A). But in the subjects of relative movement relative speed, the speed of continuous movement with different distance and time, relation and preservation of invariable speed, and accelerated motion, even 6th grade children marked a poor record. Summed up, the procedure conception as a basic movement conception coincides with the Piagetion level. But as for speed intuition, relative speed and speed fixation, it was Jar behind Piagetian level. Therefore it is required that we have to concentrate on the systematic training in these parts on the spot.

• 한국지반환경공학회 논문집
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• 제22권3호
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• pp.45-51
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• 2021

고속도로 토공에서 대부분을 차지하는 성토부의 다짐도 평가는 일반적으로 평판재하시험에 의해 이루어진다. 평판재하시험은 전통적인 시험법으로 높은 신뢰성을 가지고 있지만, 반력장비를 공수해야 하고, 시험 시 개소당 약 40분의 시간이 소요됨에 따라 광활한 토공부 전체를 관리하기에는 한계가 발생할 수 있다. 한편, 국토해양부에서는 이를 극복하고자 2010년에 '포장 하부구조 다짐관리 잠정지침'에서 간편한 다짐도 평가방법 기준을 제시한 바 있다. 하지만 10년이 지난 지금까지 고속도로공사 현장에서는 활용하고 있지 못하고 있다. 따라서, 본 연구에서는 잠정지침에서 제시한 시험법 중 충격재하 방식의 LFWD(Light Falling Weight Deflectometer)를 활용한 다짐도 평가방법에 대한 활용성을 검증하고자 하였다. 이를 위하여 현장 토질 성상 및 다짐도별로 평판재하시험 및 LFWD시험을 실시하여 상관관계를 도출하였다. 시험결과, 80% 이하의 상대 다짐도를 가진 지반에서는 시험데이타의 일관성이 없었으나, 그 이상에서 상관도가 증가하는 경향을 가지는 것을 확인할 수 있었다. 향후 충격재하 방식의 시험값의 일관성 확보를 위하여 본 연구 결과를 참고하여 시험방법 또는 시험장비를 개선한다면 토공부 다짐도 관리 사각지대를 해소하는 데에 큰 역할을 할 수 있을 것으로 기대한다.

• 한국환경보건학회지
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• 제38권1호
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• pp.31-41
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• 2012

Objectives: Biomonitoring is used to assess human environmental exposures. Urinary biomonitoring data are typically adjusted to a constant creatinine concentration to correct for variable dilutions among spot samples. Our objective was to investigate urinary creatinine concentrations by region, gender, age and lifestyle. Methods: We studied urinary creatinine concentrations in 6,286 Koreans aged 20 years old and older who participated the fourth Korea National Health and Nutrition Survey (KNHANES IV) in 2009. Urinary creatinine concentration analysis used the Jaffe method. Results: The average urinary creatinine concentration of 6,286 Koreans was 158.99 mg/dl. The urinary creatinine concentration was significantly higher among men (184.97 mg/dl) than women (130.02 mg/dl). In both men and women, urinary creatinine concentrations were significantly different according to age group (p < 0.01). Whereas the urinary creatinine concentration of men significantly differed with smoking in adjusted comparison analysis, that of women significantly differed by education level. Ninety-two percent of urinary creatinine concentration was included within WHO guidelines effective range(30 mg/dl ${\leq}$ urinary creatinine concentration ${\leq}$ 300 mg/dl). In multiple regression analysis, creatinine was influenced by gender, age and body mass index (BMI). Conclusions: The urinary creatinine value obtained from representative samples of adult Koreans aged 20 year and older in KNHANES IV 2009 could be used as a reference value for other nationally studied surveys, such as abandoned metal mine surveys and surveys for industrial complexes.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.59-64
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• 2016

Breast cancer (BC) is the most common cancer in females (27% of the total) and the main cause of death (16%) due to cancer in women in developed and developing countries. Variations in its incidence rate among geographical areas are due to various contributing factors. Since there have been a lack of studies on this topic in our country, the present spatial analysis of breast cancer incidence in Iran in 2009 was conducted using data from the national cancer registry system. The reported incidences of the disease were standardized according to the World Health Organization population and the direct method. Then data was inserted into the GIS software and finally, using the Hot Spot Analysis (Geties-Ord Gi), high-risk areas were drawn. Provinces with incidences 1.96 SD higher or lower than the national average were considered as hot spots or cold spots, at the significance level of 0.05%. In 2009, a total of 7,582 cases of BC occurred in Iran. The annual incidence was 33.2 per hundred thousand people. Our study showed that the highest incidence of BC in women occurred in the central provinces of the country, Tehran, Isfahan, Yazd, Markazi and Fars. The results of hot spots analysis showed that the distribution of high-risk BC was focused in central parts of Iran, especially Isfahan province (p <0.01). The other provinces were not significantly different from the national average. The higher incidence in central provinces may be due to greater exposure to carcinogens in urban areas, a Western lifestyle and high prevalence of other risk factors. Further epidemiological studies about the etiology and early detection of BC are essential.

• 대한한방종양학회지
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• 제8권1호
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• pp.9-21
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• 2002

Object The effect of Banhasasim-tang extracts on the hepatic, splenic toxicity and induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice. Method The changes of body weigh, organ weights of liver and spleen were observed with blood GOT and GPT level. Results 1. Increase of absolute and relative liver weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhasasim-tang extracts. In addition, the degrees of liver congestion and necrotic spot were significantly and dose-dependently decreased after Banhasasim-tang extracts dosing groups compared to that of Doxorubicin treatment group. It is also demonstrated that elevated serum GOT and GPT levels in Doxorubicin treatment group were significantly decreased in Banhasasim-tang extracts dosing groups. 2. Decrease of absolute and relative spleen weight observed in Doxorubicin treatment group were dose dependently inhibited by Banhasasim-tang extracts. In addition, the degrees of splenic atrophy were significantly and dose-dependently decreased after Banhasasim-tang extracts dosing groups compared to that of Doxorubicin treatment group.

• Journal of Microbiology and Biotechnology
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• 제17권2호
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• pp.287-296
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• 2007

A Lactobacillus paraplantarum strain producing a bacteriocin was isolated from kimchi using the spot-on-the lawn method and named L. paraplantarum C7 [15]. The bacteriocin, paraplantaricin C7, was found to inhibit certain Lactobacillus strains, including L. plantarum, L. pentosus, and L. delbrueckii subsp. lactis. It also inhibited Enterococcus faecalis, yet did not inhibit most of the other LAB (lactic acid bacteria) tested. The maximum level of paraplantaricin C7 activity was observed under the culture conditions of $25^{\circ}C$ and a constant pH of 4.5. Paraplantaricin C7 retained 90% of its activity after 10 min of treatment at $100^{\circ}C$ and remained stable within a pH range of 2-8. Based on a culture supernatant, paraplantaricin C7 was purified by DEAE-Sephacel column chromatography and $C_{18}$ reverse-phase HPLC. SDS-PAGE and activity staining were then conducted using the purified paraplantaricin C7, and its molecular mass determined to be about 3,800 Da. The 28 N-terminal amino acids from the purified paraplantaricin C7 were determined, and the structural gene encoding paraplantaricin C7, ppnC7, was cloned by PCR using degenerate primers based on the N-terminal amino acid sequence. The nucleotide sequences for ppnC7 and other neighboring orfs exhibited a limited homology to the previously reported plantaricin operon genes. Paraplantaricin C7 is a novel type II bacteriocin containing a double glycine leader sequence.

• Restorative Dentistry and Endodontics
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• 제28권6호
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• pp.485-490
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• 2003

Complete understanding of the exterior and interior structure of the tooth would be prerequisite to the successful clinical results, especially in the restorative and endodontic treatment. Although three-dimensional reconstruction method using x-ray microtomography could not be used in clinical cases, it may be the best way to reconstruct the morphologic characteristics of the tooth structure in detail without destructing the tooth itself. This study was done to three dimensionally reconstruct every teeth in the arch in order to increase the understanding about the endodontic treatment and to promote the effective restorative treatment by upgrading the knowledge of the tooth morphology. After placing tooth between the microfocus x-ray tube and the image intensifier to obtain two-dimensional images of each level. scanning was done under the condition of 80 keV, $100{\;}\mu\textrm{m}$, 16.8 magnification with the spot size of $8{\;}\mu\textrm{m}$. Cross-section pixel size of $16.28{\;}\mu\textrm{m}$ and 48.83 cross-section to cross-section distance were also used. From the results of this study, precise three dimensional reconstructed images of every teeth could be obtained. Furthermore, it was possible to see image that showed interested area only, for example. enamel portion only, pulp and dentin area without enamel structure, pulp only, combination image of enamel and pulp, etc. It was also possible to see transparent image without some part of tooth structure. This image might be used as a guide when restoring and preparing the full and partial crown by showing the positional and morphological relationship between the pulp and the outer tooth structure. Another profit may be related with the fact that it would promote the understanding of the interior structure by making observation of the auto-rotating image of AVI file from the various direction possible.

• 국토계획
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• 제54권6호
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• pp.68-79
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• 2019

The purpose of this study is to propose a transit accessibility analysis method based on temporal variability of travel time. In this study, transit accessibility was defined in three levels (in transit route, spot and region unit) to present findings from different spatial scopes. Recently, Jeju special self-governing province reorganized bus system of the island. To compare transit accessibility before and after transit policy implementation, the reorganized bus system of Jeju special self-governing province was selected as a case study. This study used General Transit Feed Specification (GTFS) data format as storage public transit information, and calculated travel time using ArcGIS GTFS networks analysis tools. In the analysis of individual transit route level, we found the 3 types of accessibility changes which is increments, no significant changes and reductions and these results come from transit route change (number of transfer, distance change) rather than changes of vehicle interval. We found increases of inflow and outflow speed in most target spots and overall transit accessibility has been substantially improved in Jeju island. This study implies that accounting for temporal variability of travel time in accessibility analysis can result in more useful and sophisticated accessibility information in decision-making processes.