• Journal of Integrative Natural Science
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• v.9 no.2
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• pp.113-120
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• 2016

Monopolar spindle 1 (Mps1) is an attractive cancer target due to its high expression levels in a wide range of cancer cells. Mps1 is a dual specificity kinase. It plays an essential role in mitosis. The high expression od Mps1 was observed in various grades of breast cancers. In the current study, we have developed a CoMFA model of pyridazine derivatives as Mps1 kinase inhibitors. The developed CoMFA model ($q^2=0.797$; ONC=6; $r^2=0.992$) exhibited a good predictive ability. The model was then validated by Leave out five, progressive sampling and bootstrapping and found to be robust. The analysis of the CoMFA contour maps depicted favorable and unfavorable regions to enhance the activity. Bulky positive substitution at $R^3$ position and Negative substitution in $R^1$ position is favored could increase the activity. In contrast, bulky substitution in $R^1$ position is not favored. Our results can be used in designing a potent Mps1 (TTK) inhibitor.

• Journal of the Korean Society for Precision Engineering
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• v.15 no.4
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• pp.76-82
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• 1998

Sealing an oil-air mixture plays important roles to have an enhanced lubrication for high speed spindle. Current work is emphasized on the investigation of the air jet effect on the protective collar type labyrinth seal. To improve the sealing capability of conventional labyrinth seal, air jet is injected against through the leakage flow. It has a combined geometry of a protective collar type and an air jet type. In this study, both of a numerical analysis by CFD(Computational Fluid Dynamics) and experimental measurements are carried out to verify sealing improvement. Both of the turbulence and the compressible flow model are introduced in CFD analysis. The sealing effect of the leakage clearance and the air jet magnitude are studied for various parameter in the experiment. The results of pressure drop in the experiment match reasonably to those of the simulation by introducing a flow coefficient. Effects of sealing improvement are explained as decreasing of effective leakage clearance by air jetting. Thus, sealing effect is improved by amount of air jetting even though clearance becomes larger.

• Proceedings of the KIEE Conference
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• 2002.07b
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• pp.1143-1145
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• 2002

IPMSM (Interior Permanent Magnet Synchronous Motor) is widely used in many applications such as an electric vehicle, compressor drives of air conditioner and machine tool spindle drives. In order to maximize the efficiency in such applications, this paper is proposed the optimal control method of the armature current. The controllable electrical loss which consists of the copper loss and the iron loss can be minimized by the optimal control of the armature current. The minimization of loss is possible to realize efficiency optimization control for the proposed IPMSM. The proposed control algorithm is applied to IPMSM drive system, the operating characteristics controlled by efficiency optimization control are examined in detail by simulation.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.319-322
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• 1997

In vector control technique, stator currents of an induction motor are transformed to equivalent d-q currents in reference frame consist of d and q axis, each of which is coincide with flux and torque direction respectively. In this paper, the new algorithm is suggested where the stator current through an induction motor torque is monitored by using a vector control method where an additional equipment is not need. The G-programming is used to apply the suggested algorithm in the experiment and this is applied to an actual system to monitor the torque value of an induction motor on real time. To solve the vibration trouble of estimated torque caused from an unbalanced real rotating speed of an induction motor and measured rotating speed by suggesting the reconstructed in a method based on measurement current signal. This produced system testifies an accuracy of an induction motor through the experiment by comparing the reference value of the control method.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.13 no.2
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• pp.88-93
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• 2004

The main objective of the research is to Propose an algorithm that to estimate the screwing torque from parameters of DC motor current without using any stain gage and torque cell. The auto screw drive system is divided into two parts, one is the DC motor ind the other is mechanical part in which the friction torque and damping ratio are a function of rotational of spindle electro motive force constant. The torque is estimated from the friction torque. The research is concerned with applying the method to an auto screw drive and the advantages and limitations are also discussed in this paper.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.08a
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• pp.55-58
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• 2003

IPMSM (Interior Permanent Magnet Synchronous Motor) is widely used in many applications such as an electric vehicle, compressor drives of air conditioner and machine tool spindle drives. In order to maximize the efficiency in such applications, this paper is proposed the optimal control method of the armature current. The controllable electrical loss which consists of the copper loss and the iron loss can be minimized by the optimal control of the armature current. The minimization of loss is possible to realize efficiency optimization control for the proposed IPMSM The proposed control algorithm is applied to IPMSM drive system, the operating characteristics controlled by efficiency optimization control are examined in detail by simulation.

• Journal of the Semiconductor & Display Technology
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• v.3 no.1
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• pp.15-20
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• 2004

Through shallow trench isolation (STI) chemical mechanical polishing (CMP) tests, we investigated the dependence of pad surface temperature on the abrasive and additive concentrations in ceria slurry under varying pressure using blanket film wafers. The pad surface temperature after CMP increased with the abrasive concentration and decreased with the additive concentration in slurries for the constant down pressure. A possible mechanism is that the additive adsorbed on the film surfaces during polishing decreases the friction coefficient, hence the pad surface temperature gets lower with increasing the additive concentration. This difference in temperature was more remarkable for the higher concentration of abrasives. In addition, in-situ measurement of spindle motor was carried out during oxide and nitride polishing. The averaged motor current for oxide film was higher than that for nitride film, meaning the higher friction coefficient.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.17 no.4
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• pp.35-41
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• 2008

R/In order to satisfy the customer's variant needs for a product quality in recent years, a demand for developing higher precision machining technologies in a lot of application areas such as automobile, cellular phone and semiconductor has been increased more and more. Magnetic abrasive polishing(MAP) process is one of these precision technologies. In this study, to verify the parameters' effect of the MAP process on the surface roughness improvement of the plane and the inclined workpiece, well planned experiments which was called the design of experiments were carried out. Considered polishing factors were spindle speed, supplied current, abrasive type and working gap between the workpiece and the solid tool. As a result, it was seen that the supplied current and the working gap greatly affected the surface roughness improvement.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.2
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• pp.468-473
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• 2017

This paper presents an in-process measurement system for shaft radius measurement during grinding process. This system does not require to stop the grinding process, which can enhance productivity and quality. In order to measure the radius, the system employs an eddy current sensor that can measure without any contact with the shaft. This type of sensor is very appropriate because it is insensitive to interference such as cutting fluid, coolant, contact pressure, and wear. For data analysis, the measurement system is modeled as a linearized discrete form where the states with noise are estimated by an extended Kalman filter. This system has been validated through simulations and experiments.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.09a
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• pp.121-125
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• 2005

In this paper, the web-based monitoring system is developed for the process monitoring of mold manufacturing. The cutting force is measured by hall-sensors which is low cost and useful to be installed in machine tool indirectly. Specially, the current of main spindle in machine tool is converted into cutting force by various experiments. For effective emote monitoring, the interface that is able to offer the information of current process and cutting signal to client is establish.