• Korean Journal of Head & Neck Oncology
• /
• v.15 no.2
• /
• pp.239-242
• /
• 1999

Spindle cell carcinomas of the head and neck are unusual neoplasms that are histologically biphasic, having both squamous cell carcinoma and apparently malignant spindle cell or sarcomatous element. Controversy about the histogenesis of these tumors has resulted in various terminology ; sarcomatoid carcinoma, pseudosarcoma, carcinosarcoma, and spindle cell carcinoma. The clinical course and natural history of these tumors are also variable. We report a case of 64-year-old male who complained of a neck mass. The patient was treated with extended radical neck dissection and postoperative radiotherapy, but the primary site of spindle cell carcinoma could not be found. We reviewed the clinical course, treatment, prognosis, and histogenesis of spindle cell carcinoma of the head and neck.

• Korean Journal of Head & Neck Oncology
• /
• v.34 no.1
• /
• pp.41-43
• /
• 2018

The Spindle cell lipoma is a slow-growing benign tumor seen generally in the shoulders, upper back, and back of the neck of male. The Pleomorphic (giant-cell) lipoma is a benign tumor of adipose tissue with atypical histological features. It is mainly seen in the same lesion as the Spindle cell lipoma. The Pleomorphic lipoma is cytogenetically similar to spindle cell lipoma with a consistent loss of chromosome 16q material. For this reason, these two entities are regarded as a similar spectrum in the adipose tumors. Herein, we present a 53-year old man with Spindle cell/pleomorphic lipoma in the lateral neck. Physical and radiologic examinations of the Spindle cell/pleomorphic lipoma in the lateral neck are not specific and preoperative diagnosis is usually difficult. Therefore, clinicians should consider the possibility that Spindle cell/pleomorphic lipoma may occur in the lateral neck mimicking the other more frequently observed lesions.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.25 no.1
• /
• pp.39-41
• /
• 2014

Spindle cell carcinoma is an uncommon type of squamous cell carcinoma characterized by a mixture of malignant epithelial and mesenchymal cells. Most spindle cell tumors are polypoid and pedunculated. It is usually detected at an early stage, removed by laryngoscope guided polypectomy at the time of diagnosis, and seems to have good prognosis. The tools for diagnosing spindle cell carcinoma are histopathological analysis and immunohistochemical analysis. With reviews of literature, we report a 72-year-old patient complaining of hoarseness and dysphagia who was later diagnosed as spindle cell carcinoma.

• Journal of Veterinary Clinics
• /
• v.19 no.4
• /
• pp.464-466
• /
• 2002

A case of spindle cell tumor was presented in a 16-month-old, female syrian hamster. In the left chest area, a 3cm firm elevated recurrent mass was found, surgically removed, and submitted to the Department of Veterinary Pathology, Seoul National University for diagnosis. The mass was soft to firm and tan on sectioning, and contained hemorrhagic area. Histologically, the tumor was composed of sheets of interlacing bundles of spindle-shaped cells with moderate amount of cytoplasm and oval to fusiform nuclei. They were plemorphic and contained 1 to 3 prominent nucleoli. Based on the gross and histological findings, the tumor was diagnosed as a subcutaneous spindle cell tumor. However, the exact origin of neoplastic cells remained undetermined.

• The Korean Journal of Cytopathology
• /
• v.4 no.1
• /
• pp.35-40
• /
• 1993

We describe a case of fine needle aspiration cytology of metastatic nasopharyngeal carcinoma in the lymph node of the neck presenting a predominantly spindle cell pattern. A 36 year-old male patient complained of dysesthesia on the right face and a palpable neck mass. Fine needle aspiration was done on the neck mass. Tumor cells were present in syncytial groups or singly with mainly spindle shaped nuclei, vesicular chromatin, thin and regular nuclear membrane, occasional prominent nucleoli and a few fool of cellular cohesiveness. The cytoplasm was scant and pale with ill-defined borders. Mature lymphocytes were present in the background of aspirates and within the tumor cell clusters. Histologically, the tumor of nasopharynx showed several areas of spindle cell pattern. Because the tumor cells showed a predominantly spindle shape with vesicular nuclear chromatin, the differential diagnosis of spindle cell sarcoma or granuloma of epithelioid clils were considered, but the characteristic morphology of the nuclei with vesicular chromatin and prominent nucleoli, and cellular cohesiveness were important in making the diagnosis of nasopharyngeal carcinoma. The possibility of metastatic carcinoma should always be considered in fine needle aspiration cytology of the lymph node in the neck because the incidence of metastatic carcinoma, particularly of the nasopharyngeal carcinoma in the lymph nodes of the neck is relatively high.

• Korean Journal of Veterinary Service
• /
• v.37 no.4
• /
• pp.313-317
• /
• 2014

A bitch was presented for investigation of the mass in left 5th mammary gland. The partial mastectomy was performed and submitted for the histopathological diagnosis. The mammary mass was firm and white colored. The cut surface was separated with several lobules and developed vessels. The central area of the mass formed the cavity filled with inflammatory exudates. The dominant component of the tumor was the bundles of spindle-shaped cells. Some tumor cells possessed atypical nuclei and were arranged in a solid nest. Cysts were microscopically composed of hemorrhage, necrosis, and exudates, partially surrounded by tumor cells and granulation tissues. Histopathologically, the mammary mass revealed spindle cell carcinoma. The bitch made a complete recovery following the mastectomy. This case was a rare mammary spindle cell carcinoma in a dog.

• Archives of Craniofacial Surgery
• /
• v.21 no.1
• /
• pp.58-63
• /
• 2020

Spindle cell squamous cell carcinoma (SpSCC) is a biphasic tumor composed of squamous cell epithelial and spindle cell mesenchymal components, both of which are malignant. Cutaneous SpSCC can cause diagnostic and therapeutic difficulties because of its rarity, heterogeneity, morphological similarity to other cutaneous spindle cell neoplasms, and uncertain pathogenesis and prognosis, particularly when the squamous cell carcinoma component is minimal or missing. Intransit metastasis and satellite lesion (satellitosis) constitute a spectrum of non-nodal regional metastases. Here the author reports the first known case of cutaneous SpSCC presenting with intransit metastases and a satellite lesion, which were exceptionally aggressive. A 77-year-old female patient presented with a 3×3×0.5 cm mass on her right cheek. Despite wide excision and postoperative radiation, the patient resulted in local recurrence and multiple distant metastases within 3 months. If many high-risk factors-particularly satellitosis and in-transit metastases are observed in a tumor with epithelial to mesenchymal transition, then further wide excision and adjuvant chemoradiation should be considered early in the treatment process. A multidisciplinary approach could be the key to cure the most aggressive malignancies of the skin, as in other organs.

• Archives of Craniofacial Surgery
• /
• v.15 no.2
• /
• pp.102-104
• /
• 2014

Spindle cell lipoma, a rare variant of lipoma, is a benign tumor found in the posterior neck and shoulder. A 24-year-old man with a close family history of malignant lymphoma had presented with a large, firm, nodular mass found in the right supraclavicular area. Excision of the deeply located mass revealed a pale yellow, rubbery nodule which grossly resembled an enlarged lymph node, with a variant of lymphoma as a primary suspect. However, pathological studies revealed the lesion to be a spindle cell lipoma. Although atypical in location, spindle cell lipoma should always be kept in differential diagnosis of a newly-noted soft tissue mass, as this entity may be easily cured by simple excision.

• Molecules and Cells
• /
• v.27 no.1
• /
• pp.1-3
• /
• 2009

Mitotic spindle mediates the segregation of chromosomes in the cell cycle and the proper function of the spindle is crucial to the high fidelity of chromosome segregation and to the stability of the genome. Nucleation of microtubules (MTs) from centrosomes and chromatin represents two well-characterized pathways essential for the assembly of a dynamic spindle in mitosis. Recently, we identified a third MT nucleation pathway, in which existing MTs in the spindle act as a template to promote the nucleation and polymerization of MTs, thereby efficiently amplifying MTs in the spindle. We will review here our current understanding on the molecular mechanism, the physiological function and the cell-cycle regulation of MT amplification.

• Journal of Microbiology and Biotechnology
• /
• v.15 no.4
• /
• pp.694-700
• /
• 2005

Defects in the mitotic spindle or in the attachment of chromosomes to the spindle are believed to release an activated form of spindle checkpoint complex that inhibits APC-dependent ubiquitination and subsequently arrests the cell cycle at metaphase. When the spindle assembly is disrupted, the fission yeast mitotic arrest deficient (mad) mutants fail to arrest and rapidly lose viability. To enhance our understanding of the molecular mechanisms for the pathway of checkpoint function, the functional characterizations of Mad 1 p from Schizosaccharomyces pombe involved in this process have been carried out. Yeast two-hybrid and various deletion analyses of S. pombe Mad1 p reveal that the C terminus of Mad1p is critical for the binding of Mad2p and maintenance of Mad 1 p-Mad2p interaction. In addition, it was found. that the Mad1p region (residues 206-356) is essential for Mad1p-other checkpoint components. Mad1p truncating this region is sufficient to bind Mad2p but abolishes the checkpoint function, indicating that the checkpoint function is necessary for interaction of Mad 1 p-other checkpoint components. The possible functions of S. pombe Mad1p at the cell cycle checkpoint are discussed.