• Journal of Pharmaceutical Investigation
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• v.32 no.2
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• pp.73-80
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• 2002

Cefuroxime axetil is a cephalosporin antibiotic having a high activity against a wide spectrum of Grampositive and Gram-negative microorganisms. It is a cephalosporin antibiotic which exist as 2 diastereoisomers: diastereoisomer A and B. It shows polymorphism of three forms: a crystalline form having a melting point of about $180^{\circ}C$, a substantially amorphous form having a high melting point of about $135^{\circ}C$ and a substantially amorphous form having a low melting point of about 70^{\circ}C$. The crystalline form of cefuroxime axetil is slightly soluble in water because diastereoisomer A has lower solubility than B in water. Substantially amorphous form of which there are no difference in solubility between diastereoisomer A and B has better solubility than crystalline form, but it forms a thicker gel than crystalline form upon contact with an aqueous medium. Based on this reason, cefuroxime axetil is not readily absorbable in the gastrointestinal tract, rendering its bioavailability on oral administration very low. The object of this study was to develop an improved non-crystalline cefuroxime axetil composition having a high physicochemical stability and bioavailability. A non-crystalline cefuroxime axetil solid dispersant showing no peak on a Differential Scanning Calorimetry (DSC) scan is prepared by dissolving cefuroxime axetil and a surfactant in an organic solvent; suspending a water-insoluble inorganic carrier in the resulting solution; and spray drying the resulting suspension to remove the organic solvent, said solid dispersant having an enhanced dissolution and stability of cefuroxime axetil and being useful for the preparation of a pharmaceutical composition for oral administration. Tablet was formulated with this cefuroxime axetil solid dispersant, disintegrants and other ingredients. It disintegrated and dissolved easily and dynamically in dissolution medium, so showed a good dissolution profile.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1999.06a
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• pp.137-159
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• 1999

Over the last three decades, Korean farming system has been directed to maximum agricultural production and to increase farmer's income through adoption of high-yielding crop varieties and high input of agrochemicals . These farming practices have resulted in problems of water-quality deterioration, soil degradation , and food safety. At present, over 40 million tones of animal waste are bing produced annually, which amounts to disposing the waste at the annual rate of 20 tones per ha in the total area of farming land in Korea. Nearly a half of total available water resources is used as irrigation water predominantly for rice paddy field. Thus, non-point source contamination of the water resources has been linked to agriculture across the nation. However, the extent to which agriculture contributes to the water quality is not fully known. Recently, Korean government provided various institutional measures to reduce the negative impacts of agricultural practices on the environ ental quality, and the Agricultural Environment Act was also passed by the legislature in 1998 and became effective January 1999. This Act does not cover the broad spectrum of the sustainable agriculture ; thus, the limited incentives within this Act are arguably ineffective to control the non-point source pollution. Recently new bulk blending of fertilizers(BB fertilizer) are bing produced (100, 000 tones in 1998) with Government subsidies. The BB fertilizers are to balance N-P-K ratio in the soils . Although the use of the BB fertilizers are encouraged with Government subsidies, non-point source pollution is still serious and will become worse. Precision farming is regarded as a new means for sustainable agriculture. It is a new technology that modifies the existing techniques and incorporates new one such as GIS, GPS , differential applicator to produce a new set of tools for the farmer to use. Precision farming, however, has constraints for individual farming practices. For exam le , farm size or parcel unit of each farmer is too small to adopt the precision agriculture on farmhouse-hold bases and farmer's ability to adopt the new technology is limited. However, it would be appropriate to establish local or regional cooperatives to operate such a precision farming system. It is recommended that Government provide sufficient incentives to help establish local and/or regional cooperatives.

• Korean Journal of Remote Sensing
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• v.38 no.1
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• pp.83-101
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• 2022

Accurate atmospheric correction is essential for the analysis of land surface and environmental monitoring. Aerosol optical depth (AOD) information is particularly important in atmospheric correction because the radiation attenuation by Mie scattering makes the differences between the radiation calculated at the satellite sensor and the radiation measured at the land surface. Thus, it is necessary to use high-quality AOD data for an appropriate atmospheric correction of high-resolution satellite images. In this study, we examined the Second Simulation of a Satellite Signal in the Solar Spectrum (6S)-based atmospheric correction results for the Sentinel-2 images in South Korea using raster AOD (MODIS) and single-point AOD (AERONET). The 6S result was overall agreed with the Sentinel-2 level 2 data. Moreover, using raster AOD showed better performance than using single-point AOD. The atmospheric correction using the single-point AOD yielded some inappropriate values for forest and water pixels, where as the atmospheric correction using raster AOD produced stable and natural patterns in accordance with the land cover map. Also, the Sentinel-2 normalized difference vegetation index (NDVI) after the 6S correction had similar patterns to the up scaled drone NDVI, although Sentinel-2 NDVI had relatively low values. Also, the spatial distribution of both images seemed very similar for growing and harvest seasons. Future work will be necessary to make efforts for the gap-filling of AOD data and an accurate bi-directional reflectance distribution function (BRDF) model for high-resolution atmospheric correction. These methods can help improve the land surface monitoring using the future Compact Advanced Satellite 500 in South Korea.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.31B no.2
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• pp.69-79
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• 1994

The conventional machine vision system which has uniform rectangular grid requires tremendous amount of computation for processing and analysing an image especially in 2-D image transfermations such as scaling, rotation and 3-D reconvery problem typical in robot application environment. In this study, the imaging system with nonuiformly distributed image sensors simulating human visual system, referred to as Ploar Exponential Grid(PEG), is compared with the existing conventional uniform rectangular grid system in terms of image resolution and computational complexity. By mimicking the geometric structure of the PEG sensor cell, we obtained PEG-like images using computer simulation. With the images obtained from the simulation, image resolution of the two systems are compared and some basic image processing tasks such as image scaling and rotation are implemented based on the PEG sensor system to examine its performance. Furthermore Fourier transform of PEG image is described and implemented in image analysis point of view. Also, the range and heading-angle measurement errors usually encountered in 3-D coordinates recovery with stereo camera system are claculated based on the PEG sensor system and compared with those obtained from the uniform rectangular grid system. In fact, the PEC imaging system not only reduces the computational requirements but also has scale and rotational invariance property in Fourier spectrum. Hence the PEG system has more suitable image coordinate system for image scaling, rotation, and image recognition problem. The range and heading-angle measurement errors with PEG system are less than those of uniform rectangular rectangular grid system in practical measurement range.

• Journal of the Ergonomics Society of Korea
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• v.29 no.4
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• pp.575-584
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• 2010

The aim of study is to suggest the design procedure of automobile headlamp by considering driver's experience in regard of the visibility and glare during nighttime driving. The characteristics of driver were investigated in terms of the drivers' cognitive ability and reaction time, headlamp specification and visibility, light source and glare. And, the degree of visual discomfort was categorized and recognized as a tool to represent the subjective user experience. The UX point of view was stated when the existing results were seemingly lacking of it. The visual comfort and safety of elderly drivers were also discussed by reviewing the studies of ageing regarding the visibility and driving responses. Finally, this study suggested how to reduce the negative effect of nighttime driving due to the height of headlamp, angle of lighting, color spectrum, discomfort glare, source of light by using the UX perspective and methodology.

• Journal of the Optical Society of Korea
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• v.1 no.2
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• pp.74-80
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• 1997

300mm F/4.0 telephotolens with diffractive hybrid lens was designed, and its optical performance was tested and compared with a traditional lens system. DOE(Diffractive Optical Element) reconstructs wavefronts using wave phenomena of light to focus the incident light onto the focal point and has negative Abbe number while a traditional lens uses geometrical phenomena of light and has positive Abbe number. Therefore, a diffractive hybrid lens containing both refractive and diffractive elements can remarkably correct chromatic aberration and spherical aberration of an optical system. We investigated and analyzed the optical properties of a diffractive hybrid lens for the visible spectrum, and we used a difractive hybrid lens to design and evaluate a 300mm F/4.0 telephotolens without the special LD(Low Dispersive) glass lens which is costly and difficult to manufacture. Most traditional telephotolenses use the special LD glass for chromatic aberration correcton. Optical performance tests such as resolution and characteristics of aberration of both lens systems using a diffractive hybrid lens and traditional lens were performed.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.46 no.2
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• pp.106-111
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• 2001

The applicability of near infrared reflectance spectroscopy(NIRS) was tested to determine the protein and oil contents in ground soybean [Glycine max (L.) Merr.] seeds. A total of 189 soybean calibration samples and 103 validation samples were used for NIRS equation development and validation, respectively. In the NIRS equation of protein, the most accurate equation was obtained at 2, 8, 6, 1(2nd derivative, 8 nm gap, 6 points smoothing and 1 point second smoothing) math treatment condition with SNV-D (Standard Normal Variate and Detrend) scatter correction method and entire spectrum by using MPLS (Modified Partial Least Squares) regression. In the case of oil, the best equation was obtained at 1, 4, 4, 1 condition with SNV-D scatter correction method and near infrared (1100-2500nm) region by using MPLS regression. Validation of these NIRS equations showed very low bias (protein:-0.016%, oil : -0.011 %) and standard error of prediction (SEP, protein: 0.437%, oil: 0.377%) and very high coefficient of determination ($R^2$, protein: 0.985, oil : 0.965). Therefore, these NIRS equation seems reliable for determining the protein and oil content, and NIRS method could be used as a mass screening method of soybean seed.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2012.11a
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• pp.7-11
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• 2012

Plasma electrolytic oxidation of magnesium alloys is a well known technique to produce corrosion and wear resistant coatings. The addition of particles to the electrolyte provides a possibility to produce coatings with an increasing range of composition by in-situ incorporation of those particles into the coating. An extensive literature review has revealed that the mode of incorporation depends mainly on the melting point of the used particles and the energy provided by the discharges of the PEO process. The spectrum ranges from inert to partly reactive incorporation, but a complete reactive incorporation and a formation of a new single phase coating was not observed so far. Thus a new approach in PEO processing is introduced using specific particles as a kind of sintering additive, changing not only the composition but lowering the melting temperature and increase the liquid phase fraction during the discharges, resulting in a new amorphous coating.

• Journal of Acupuncture Research
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• v.22 no.6
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• pp.173-180
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• 2005

Objectives : The purpose of this study was to assess the effect auricular acupuncture for acute mental stress using power spectrum analysis of the heart rate variability(HRV). Methods : 10 healthy volunteers participated in this study. After 5 minute rest, the first mental stress was provided for 5 minute. And then subjects rested for 15 minute. The second mental stress was provided for 5 minute. The acupoint, Shin-Mun point of the ear was stimulated for 15 minute. HRV was recorded before and after the first and second mental stress, and after auricular acupuncture stimulation. Results : After mental stress, normalized LF and LF/HF ratio is significantly increased. Before and after simple rest, normalized LF and normalized HF is significantly changed, but LF and LF/HF ratio is not significantly changed. On the other hand, before and after auricular acupuncture treatment, normalized LF, normalized HF is significantly changed, and also LF and LF/HF ratio is significantly decreased. Conclusion : The result suggest that auricular acupuncture can decrease more significantly in cardiac sympathetic activity due to mental stress than simple rest.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.54 no.4
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• pp.139-143
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• 2005

For application of carbon nano-tube (CNT) as a counter electrode materials of dye-sensitized solar cell (DSSC), the electrochemical behavior of CNT electrode was studied, employing cyclic-voltammetry (C-V) and impedance spectroscopy. Fabrication of CNT-paste and formation of CNT-counter electrode for characteristic measurement have been carried out using ball-milling and doctor blade process, respectively. Unit cell for measurements was assembled using Pt electrode, CNT electrode, and iodine-embedded electrolyte. Field emission-scanning electron microscopy (FE-SEM) was used for structural investigation of CNT powder and electrode. Sheet resistance of electrode was measured with 4-point probe method. Electrochemical properties of electrode, C-V and impedance spectrum, were studied, employing potentiogalvanostat (EG&G 273A) and lock in amplifier (EG&G 5210). As a results, the sheet resistance of CNT electrode is almost similar to that of F-doped SnO2 (FTO) coated glass substrate as approximately 10 ohm/sq. From C-V and impedance spectroscopy measurements, it was found that CNT electrode has high reaction rate and low interface reaction resistance between CNT surface and electrolyte. These results provides that CNT electrode were superior to that of conventional Pt electrode. Particularly, the reaction rate in the CNT electrode is about thrice high than Pt electrode. Therefore. CNT electrode is to be good candidate material for counter electrode in DSSC.