• Journal of the Korea Society of Computer and Information
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• v.10 no.6 s.38
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• pp.233-238
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• 2005

In general CELP(Code Excited Linear Prediction) type vocoders provide good speech qualify around 4.8kbps. Among them, G.723.1 developed for Internet Phone and video-conferencing includes two vocoders, 5.3kbps ACELP(Algebraic-CELP) and 6.3kbps MP-MLQ(Multi-Pulse Maximum Likelihood Quantization) In order to improve the speech qualify in CELP vocoder, in this paper. we proposed a new spectrum analysis algorithm with variable window In CELP vocoder, the spectrum of the synthesised speech signal is distorted because the fixed size windows is used for spectrum analysis. So we have measured the spectral leakage and in order to minimize the spectral leakage have adjusted the window size. Applying this method G.723.1 ACELP, we can got SD(Spectral Distortion) reduction 0.084(dB), residual energy reduction 6.3$\%$ and MOS(Mean Opinion Score) improvement 0.1.

• The Journal of the Acoustical Society of Korea
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• v.24 no.6
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• pp.343-352
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• 2005

Phonation type index k (PTI In) presents a single and simplified measure of the spectral tilt. which is free from the effects of fundamental frequency and vowel qualify This study investigates PTI k with vowels /i . e. a. o, u/ obtained from 10 Korean male subjects. Specifically. this study tests the significance of differences in PTI k across Positions, Phonation types. vowels, and speakers, respectively The results showed that there was a significant difference in PTI k across positions, Phonation types, vowels. and speakers.

• Journal of KIISE:Software and Applications
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• v.34 no.10
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• pp.889-899
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• 2007

In proteomics, recent advancements In mass spectrometry technology and in protein extraction and separation technology made high-throughput analysis possible. This leads to thousands to hundreds of thousands of MS/MS spectra per single LC-MS/MS experiment. Such a large amount of data creates significant computational challenges and therefore effective data analysis methods that make efficient use of computational resources and, at the same time, provide more peptide identifications are in great need. Here, SIFTER system is designed to avoid inefficient processing of shotgun proteomic data. SIFTER provides software tools that can improve throughput of mass spectrometry-based peptide identification by filtering out poor-quality tandem mass spectra and estimating a Peptide charge state prior to applying analysis algorithms. SIFTER tools characterize and assess spectral features and thus significantly reduce the computation time and false positive rates by localizing spectra that lead to wrong identification prior to full-blown analysis. SIFTER enables fast and in-depth interpretation of tandem mass spectra.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.4105-4105
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• 2001

Near infrared spectroscopy (NIRS) was employed to qualify and quantify on survival, the injury rate and apoptosis of the human breast cancer cell line MCF-7 cells. MCF-7 cells were cultured in RPMI medium supplemented with 10% FCS in a 95% air and 5% CO2 atmosphere at 37$^{\circ}C$. For the viable cells preparation, cells were de-touched by 0.1% of trypsin treatment and washed with RPMI supplemented with 10% FCS medium by centrifugation at 1000 rpm for 3min. For the dead cells preparation, cells were de-touched by a cell scraper. The cells were counted by a hemacytometer, and the viability was estimated by the exclusion method with frypan blue dye. Each viable and dead cells were suspended in PBS (phosphate bufferred saline) or milk at the cell density desired. For the quantitative determination of cell death by measuring the LDH (lactate dehydrogenase) activity liberated from cells with cell membrane injuries, LDH-Cytotoxic Test Wako (Wako, Pure Pharmaceutical Co. Ltd., Japan) was used. We found that NIRS measurement of MCF-7 cells at the density range could evaluate and monitor the different characteristics of living cells and dead cells. The spectral analysis was performed in two wavelength ranges and with 1,4, 10 mm pathlength. Different spectral data pretreatment and chemometrics methods were used. We applied SIMCA classificator on spectral data of living and dead cells and obtained good accuracy when identifying each class. Bigger variation in the spectra of living cells with different concentrations was observed when compared to the same concentrations of dead cells. PLS was used to measure the number of cells in PBS. The best model for measurement of dead cells, as well as living cells, was developed when raw spectra in the 600-1098 nm region and 4 mm pathlength were used. Smoothing and second derivative spectral data pretreatment gave worst results. The analysis of PLS loading explained this result with the scatter effect found in the raw spectra and increased with the number of cells. Calibration for cell count in the 1100-2500 nm region showed to be very inaccurate.

• The Journal of the Acoustical Society of Korea
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• v.24 no.3
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• pp.150-159
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• 2005

This paper addresses a voice personality transformation algorithm which makes one person's voices sound as if another person's voices. In the proposed method, one person's voices are represented by LPC cepstrum, pitch period and speaking rate, the appropriate transformation rules for each Parameter are constructed. The Gaussian Mixture Model (GMM) is used to model one speaker's LPC cepstrums and conditional probability is used to model the relationship between two speaker's LPC cepstrums. To obtain the parameters representing each probabilistic model. a Maximum Likelihood (ML) estimation method is employed. The transformed LPC cepstrums are obtained by using a Minimum Mean Square Error (MMSE) criterion. Pitch period and speaking rate are used as the parameters for prosody transformation, which is implemented by using the ratio of the average values. The proposed method reveals the superior performance to the previous VQ-based method in subjective measures including average cepstrum distance reduction ratio and likelihood increasing ratio. In subjective test. we obtained almost the same correct identification ratio as the previous method and we also confirmed that high qualify transformed speech is obtained, which is due to the smoothly evolving spectral contours over time.

• The Journal of the Acoustical Society of Korea
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• v.24 no.5
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• pp.248-254
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• 2005

In this Paper, the structure of a split bandwidth wideband speech coder and its highband coder for tone qualify elevation are Proposed. The lowband and highband by the split bandwidth method are encoded independently applying the G.729E and MLT (Modulated Lapped Transform) residual model. In the highband structure which is encoded by low bit rate of 4kbps, the MLT residual signals are distinguished to voice and unvoice signal . The voice signals are applied to MLT peak picking method by lowband pitch period. Because transformed MLT residual signals are represented by periodic signal that have periodic peak. The unvoice signals are applied to MLT which linear prediction spectral response is added and do vector quantization. Performance for proposed 15.8kbps wideband speech coder was verified through subjective listening test.

• Korean Journal of Optics and Photonics
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• v.16 no.1
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• pp.63-70
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• 2005

We propose a method for evaluating the image quality of color liquid crystal display(LCD) monitors by using the polychromatic modulation transfer function(PMTF), which is calculated from the modulation transfer function(MTF) weighted by the overall color response of the system including the test LCD monitor. We confirm that experimental results using the PMTF agree well with simulated results of the PMTF of a color LCD monitor by using three bar targets with different amplitudes and three elementary colors such as red(R), green(G), and blue(B). As a results, we should choose the PMTF instead of the white color MTF or monochromatic MTF in order to evaluate correctly the image quality of color LCD monitors.