• Environmental Mutagens and Carcinogens
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• v.9 no.2
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• pp.87-96
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• 1989

Studies on the biodisposition of beta-nicotyrine by lung and liver microsomes was examined in order to provide a better understanding of its fate in this tissue. beta-nicotyrine (100$\mu$M) was incubated with microsomes (1 mg/ml) prepared from New Zealand White rabbits. The rate of oxidation observed in lung microsomal incubations was 1.7 nmoles $\beta$-nicotyrine oxidized mg$^{-1}$ min$^{-1}$ compared with 2.7 nmoles $\beta$-nicotyrine oxidized mg$^{-1}$ min$^{-1}$ by the liver microsomal preparation. However, when these rates were expressed as a function of cytochrome P-450 content, the specific activity of the metabolic oxidation catalyzed by lung (8.3 nmoles $\beta$-nicotyrine oxidized nmole cytochrome P-450$^{-1}$ min$^{-1}$) was approxiamtely 4 times greater than liver microsomes (2.3 nmoles $\beta$-nicotyrine oxidized nmole cytochrome P-450$^{-1}$ min$^{-1}$). Isozyme studies on the oxidation of $\beta$-nicotyrine employed several methods of altering activities of specific isozymes present in pulmonary microsomes, including the use of the isozyme 2 and 6 specific inhibitor $\alpa$-methyl ABT, metabolic inhibitor(MI) complex formation. The results of this inhibition study would appear to indicate the $\beta$-nicotyrine is metabolized predominantly by pulmonary isozyme 5.

• Journal of Biosystems Engineering
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• v.30 no.5 s.112
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• pp.268-273
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• 2005

This study was conducted to investigate the specificities of four fulcrum types for geo-statistical analysis of elevation within rice paddy field. In Korea, the spaces between inter-rows and between hills for rice transplanting are 30cm and 11cm to 14cm, respectively. So, the size and shape of fulcrum for field elevation measurement should be considered according to the inter-row and the hill spaces. Four kinds of fulcrum were chosen such as round-shape with 2.5cm diameter, circular-shape with 10cm diameter, 10cm (one third of inter-row space) by 24cm (double of hill space) rectangular-shape, and 20cm (two-thirds of inter-row space) by 24cm rectangular-shape. The resulting descriptive statistics couldn't determine the best fulcrum type to measure the rice paddy field elevation. But the results of geo-statistical analysis could determine the best fulcrum type. In the case of 10cm by 24cm rectangular-shape fulcrum, Nugget and range, meaning measurement error and/or noise, and limit of spatial connection, respectively, were minimum; Q value meaning weight of spatial structure and $r^2$ value were minimum, and residual sum of squares was minimum. It means that 10cm by 24 cm rectangular-shape fulcrum could best describe the rice paddy field elevation.

• Proceedings of the Korean Society of Toxicology Conference
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• 2004.05a
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• pp.27-29
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• 2004

Drug transporters play an essential role in the absorption, distribution and elimination of clinical drugs, nutrients and toxicants. The importance of the transporters is exampled by therapeutic failure in cancer chemotherapy that is mainly caused by the overexpression of multidrug resistance (MDR)-related transporters. In addition, the transporters may involve in drug-drug interactions that lead to serious adverse drug responses and some transporters also contribute to inter-individual variation in drug responses. As an effort to understand the mechanism underlying the inter-individual variation of transporters activity, genetic and environmental factors influencing the expression or function of the transporters have extensively explored through last decade. Among them, genetic polymorphism of drug transporter encoding genes has generated much interest since the discovery of functional single nucleotide polymorphisms (SNP) of MDRl gene. Besides drug transporters, xenobiotic receptors also modulate drug disposition by regulating the transcription of drug metabolizing enzymes and drug transporters. Among many xenobiotic receptors, pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two most well characterized since these receptors show wide substrate specificities and regulate the expression of various enzymes involved in drug disposition. Recently, several functional genetic polymorphisms were reported in PXR coding gene. In the present study, genetic polymorph isms of two drug transporters, MDR1 and BCRP, and two xenobiotic receptors, PXR and CAR, were investigated in Korean population.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.796-801
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• 2004

The thing that should be considered preferentially when we introduce sounds to the space we are living in is to clarify the notion - for whom when, what kinds of sounds, where, for what and how to. There are two physical habitate conditions which affect the quality of soundscape. The one is 'Background sound' of the space which should be masked or applied in accordance with its qualify. The other is features of the habitat which would be the factor building up ambience and the index for us to decide specificities of the sounds to be introduced. Selecting or producing the sounds to be introduced, we should consider those to make these represent the community, influence people's behavior, be in harmony with surroundings, and give the identity to the space. There are two ways to introduce the sounds. The one is to put sound sources which actually make the sound. The other is to put the sounds without practical sound source but with objects related to those. For later, it's important not to introduce the sounds people prefer but what would be in harmony with the place. In this study, we've researched what kinds of sounds could be utilized for soundscape designing. And, we've studied if those can be, how those should be introduced and what other factors should be considered.

• Bulletin of the Korean Chemical Society
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• v.19 no.5
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• pp.569-575
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• 1998

Investigation of the structure of the gangliosides has proven to be very important in the understanding of their biological roles. We have determined the tertiary structure of asialoganglioside GM1 $(GA_1)$ using NMR spectroscopy and distance geometry calculations. All of the structures are very similar except the glycosidic torsion angles in the ring IV and ring III linkages. There are two low-energy structures for GA1, G1 and G2. G1 differs from G2 only in the IV-III glycosidic linkages and the orientation of acetamido group in ring III. There is a stable intramolecular hydrogen bond between the third hydroxyl group in ring I and the ring oxygen atom in ring II. Also, there may be a weak hydrogen bond between the second hydroxyl group in ring IV and the acetamido group in ring III. Small coupling constants of $^3J_{IH3,IOH3}\; and\; ^3J_{IVH2,IVOH2}$ support this result. Overall structural features of $(GA_1)$ are very similar to those of $(GM_1)$. It implicates that specificities of the sugar moieties in GM1 are caused not by their tertiary foldings, but mainly by the electrostatic interactions between the polar sialic acid and its receptors. Since it is evident that $(GA_1)$ is more hydrophobic than $(GA_1)$, a receptor with a hydrophobic binding site can recognize the $(GA_1)$ better than $(GA_1)$. Studies on the conformational properties of $(GA_1)$ may lead to a better understanding of the molecular basis of its functions.

• Journal of Arbitration Studies
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• v.31 no.2
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• pp.23-46
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• 2021

Sports disputes have specific characteristics compared to disputes that arise in the field of commerce. One particularity is the judicial system in which the CAS plays a key role as the International Supreme Court for sports-related matters. The CAS Code applies whenever the parties agree to submit a sports-related dispute to the CAS(Art. R27). Once the parties to the arbitration agreement have decided that the CAS Code should govern their proceedings. The parties' autonomy is, however, limited to the provisions of the CAS Code that provide for such a corresponding autonomy. The application of the mandatory rules contained in the CAS Code cannot be excluded. In CAS appeals arbitration proceedings, the Panel shall decide the dispute according to the applicable sports regulations and, subsidiarily, to the rules of law chosen by the parties(Art. R58). In international sports disputes, the uniform application and interpretation of the relevant regulations are essential. Therefore, Art. R58 should be applied as a mandatory rule without any changes. Regulations of the sports organizations are to be qualified as valid rules of law. CAS panels may also apply the so-called lex sportiva to the merits before considering statutory provisions of national jurisdictions. In this way, the specificities in (international) sports disputes can be taken into account without the need to further examine the application of national legal standards.

• Journal of Oriental Neuropsychiatry
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• v.29 no.4
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• pp.305-314
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• 2018

Objectives: The objective of this study was to report the clinical effectiveness of the complex Korean medicine therapy and M&L (Mindfulness & Loving presence) psychotherapy on the patient with panic disorder. Methods: The subject for this study was the patient diagnosed with panic disorder who complained about intermittent panic attack and accompanying insomnia. During the treatment period, the patient received complex Korean therapy and M&L psychotherapy. The clinical effects were evaluated through Beck Depression Inventory (BDI), Hamilton Depression Rating Scale (HDRS), State-Trait Anxiety Inventory (STAI), Panic Disorder Severity Scale (PDSS), and Pittsburgh Sleep Quality Index (PSQI). Results: After the complex Korean medicine therapy and M&L psychotherapy, the overall symptoms of depression, anxiety, panic disorder and insomnia of the patient were lessened in a relatively short period. No specificities or adverse effects were reported during the treatment period. Conclusions: This study established that the complex Korean medicine therapy and M&L psychotherapy was effective in treating patients with panic disorder.

• Journal of Oriental Neuropsychiatry
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• v.30 no.3
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• pp.287-293
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• 2019

Objectives: The purpose of this study was to report the clinical effectiveness of the complex Korean medicine therapy on a patient with BPSD (Behavioral and Psychological Symptoms of Dementia) due to suspected Alzheimer's disease. Methods: We experienced an age 73 female who complained of a depressive mood, insomnia, and accompanying symptoms such as abnormal behavior. During treatment, the patient received acupuncture and herbal medicine. The clinical effects were evaluated through KGDS (Korean Form of Geriatric Depression Scale) and subjective statements of the patient. Results: After the complex Korean medicine therapy, the treatments ameliorated overall symptoms that the patient complained about. The patient was more positive and slept better after the treatment. No specificities or adverse effects were reported during treatment. Conclusions: This study suggests the possibility of treating patients with BPSD with complex Korean medicine therapy.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.10
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• pp.119-130
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• 2018

In the late 1950s, departing from their unquestioning following of Soviet architecture, North Koreans attempted to discover the specificities of traditional Korean architecture and apply them to their contemporary monuments. This paper examines the ways in which North Korean architects developed their unique version of Socialist realism in the making of Pyongyang Grand Theater. The traditional elements in harmony with North Korea's political ideology-an early form of Juche ideology-and modern building technologies were to be viewed as contemporary elements, and not as a simple revival of the past. This study applies Socialist realism's compositional principle "national in form and socialist in content" to Pyongyang Grand Theater and examines specifically what "socialist content" and "national form" were and how the two were combined in the construction of Pyongyang Grand Theater. By situating the building in the context of localization of Socialist realism which is universal art principle of the communist world, this study contributes to the deeper and wider understanding of North Korea's Modern Joseon Architecture.

• Journal of Korea Trade
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• v.23 no.2
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• pp.14-33
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• 2019

Purpose - This paper aims to articulate determinants of inter-organizational cooperation based on to the extent to which inter-organizational tasks are related to product development and production processes. Design/Methodology - This research conducted OLS regression analysis based on the data acquired from questionnaire survey in Korean auto industry. Findings - Our analysis has verified that complementary and compatible resources, as well as physical and human asset specificities, positively affect inter-organizational product development cooperation. Conversely, in the production process, only complementary resources positively affect inter-organizational cooperation, whereas compatible resources and physical asset specificity have a negative influence. The changing characteristics of compatible resources (with IT innovations and AI), and physical asset specificity (influenced by a rising need to reduce production costs), cause inter-organizational cooperation in production to decrease. Originality/value - This research attempts to expound upon these determining factors of inter-organizational cooperation by considering both complementary-compatible resources and asset specificity in product development and production simultaneously. The reason why the impact of complementary-compatible resources and asset specificity on inter-organizational cooperation is critical in understanding the determinants of inter-organizational cooperation is that the attributes of complementary-compatible resources and asset specificity in production have changed drastically due to the continuing diffusion of IT innovations and AI (Artificial Intelligence).