• Steel and Composite Structures
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• 제52권1호
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• pp.15-29
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• 2024

This research investigates the application of novel functionally graded small-scale materials (FGSMs) in sport and sports structures through an engineering design lens. Functionally graded materials (FGMs) offer tailored material properties, promising enhanced performance and durability. Utilizing an interdisciplinary approach, this study explores the integration of FGSMs in sports equipment and infrastructure. Design considerations specific to sports engineering are emphasized, including lightweight, high-strength materials capable of withstanding dynamic loads. Advanced manufacturing techniques, such as additive manufacturing and nanotechnology, enable precise control over material composition and microstructure. Computational modeling is employed to evaluate the mechanical behavior and performance characteristics of FGSM-based components. Through case studies and comparative analyses, the study showcases the potential of FGSMs to revolutionize sports equipment and structures, offering improved performance, safety, and sustainability. This research contributes to the advancement of sports engineering by exploring the design and application of FGSMs in sport and sports structures.

• JSTS:Journal of Semiconductor Technology and Science
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• 제16권2호
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• pp.236-250
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• 2016

Electrical Designs for Application Specific Integrated Circuits (ASIC) has undergone a change recently with the advent of the sub-wavelength lithography. The optical projection with 193 nm wavelength has been further extended with the use of immersion and other techniques. The competing trends for printing smaller design features have been discussed in this paper with the discussion of the electrical layout analysis to find unfriendly design features. The early knowledge of the unfriendly design features allows remedial actions in time for better yield on the wafer. There are existing standard design qualification criteria being used in the design and fabrication community, but they seem to be insufficient to guarantee defect free designs. This paper proposes an integrated approach for screening the layout with multiple aspects: layout geometry based, graphical analysis and process model based verification. The results have been discussed with few example design features from the 28nm design layout.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.147-150
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• 2005

Proper PCR primer design determines the success or failure of Polymerase Chain Reaction (PCR) reactions. In this project, we develop GENE-PRIMER, a genomes specific PCR primer design program that is amenable to a genome-wide scale. To achieve this, we incorporated various parameters with biological significance into our program, namely, primer length, melting temperature of primers Tm, guanine/cytosine (GC) content of primer, homopolymeric runs in primer and self-hybridization tendency of primer. In addition, BLAST algorithm is utilized for the purpose of primer specificity check. In summary, selected primers adhered to both physico-chemical criteria and also display specificity to intended binding site in the genome.

• 한국정밀공학회지
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• 제20권9호
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• pp.32-39
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• 2003

Pulse electrochemical machining process with high or low current density may produce a non-lustrous surface on workpiece surface. The usual polishing process to remove a black layer from the surface has been hand polish the part. But the milli-to-micro meter scale structure formed by the electrochemical machining process may be destroyed while polishing process. The application of ultra short voltage pulses based on the analysis of electrical double layer charging process allows high resolution electrochemical machining and polishing. This technique was based on the specific polarization resistance from the comparison of ideal and experimental potential variation during short voltage pulses.

• Toxicological Research
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• 제22권4호
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• pp.323-328
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• 2006

Global gene expression profile was analyzed by microarray analysis of rat liver RNA after acute acetaminophen (APAP) administration. A single dose of 1g/kg body weight of APAP was given orally, and the liver samples were obtained after 24, 48 h, and 2 weeks. Histopathologic and biochemical studies enabled the classification of the APAP effect into injury (24 and 48 h) and regeneration (2 weeks) stages. The expression levels of 4900 clones on a custom rat gene microarray were analyzed and 484 clones were differentially expressed with more than a 1.625-fold difference(which equals 0.7 in log2 scale) at one or more time points. Two hundred ninety seven clones were classified as injury-specific clones, while 149 clones as regeneration-specific ones. Characteristic gene expression profiles could be associated with APAP-induced gene expression changes in lipid metabolism, stress response, and protein metabolism. We established a global gene expression profile utilizing microarray analysis in rat liver upon acute APAP administration with a full chronological profile that not only covers injury stage but also later point of regeneration stage.

• Applied Microscopy
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• 제46권1호
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• pp.14-19
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• 2016

Currently, focused ion beams (FIB) are widely used for specimen preparation in atom probe tomography (APT), which is a three-dimensional and atomic-scale compositional analysis tool. Specimen preparation, in which a specific region of interest is identified and a sharp needle shape created, is the first step towards successful APT analysis. The FIB technique is a powerful tool for site-specific specimen preparation because it provides a lift-out technique and a controllable manipulation function. In this paper, we demonstrate a general procedure containing the crucial points of FIB-based specimen preparation. We introduce aluminum holders with moveable pin and an axial rotation manipulator for specimen handling, which are useful for flipping and rotating the specimen to present the backside and the perpendicular direction. We also describe specimen preparation methods for nanowires and nanopowders, using a pick-up method and an embedding method by epoxy resin, respectively.

• Genomics & Informatics
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• 제17권3호
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• pp.23.1-23.6
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• 2019

The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data.

• 한국가구학회지
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• 제12권1호
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• pp.131-142
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• 2001

Cultural needs of human have grown enormously. Consumer trend and individual taste have become more individualistic and diversified. Efforts to improve the quality of life have changed the concept of lift space as well as the concept of interior life supplies. Products are no longer standardized and produced in massive scale, thus a shift of value has risen. Damages done by the economical development have made consumers take interests in products that are more natural and in harmony with human beings. It is a tendency that wooden materials are becoming a preference as a specific alternative. There is a great social change with a new paradigm like this. Considering the change, we propose a new vision and activation plan on design development of wooden products through specific and practical studies by the system of educational and industrial cooperation which is an organic association system for developing human resources of educational system and producing profits of industry. From it, we can expect great effects as a competitive design of coming future.

• 대한한의학회지
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• 제31권2호
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• pp.64-70
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• 2010

Objective: This study aimed to construct an overview of health-related quality of life (HRQOL) scales for application in studies of traditional Korean medicine (TKM). Methods: We analyzed all HRQOL scales from the PROQOLID web site (www.proqolid.org) regarding to classification, application purposes, and translation to Korean version. We also searched clinical studies focused on "Quality of Life" using TKM. Results: A total of 660 HRQOL instruments were analyzed; 99 were for general condition while 559 were disease-specific. Twenty clinical studies for TKM were conduced using HRQOL scales. Conclusion: The adaptation of the international HRQOL instrument is strongly recommended in TKM-associated clinical study, and development of a TKM-specific HRQOL scale is needed for globalization of TKM.

• Environmental Engineering Research
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• 제11권4호
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• pp.201-207
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• 2006

A simple empirical model with good quantitative prediction of inter-particle and intra-particle distance in a cake layer with respect to ionic strength was developed. The model is an inverse length scale with functions of interaction energy and hydrodynamic factor and it explains that the inter-particle and intra-particle distance in a cake is directly related to the effective size of particles. Particle compressibility with respect to ionic strength was also predicted by the model. The model corroborated very well with experimental results of polystyrene microsphere latex particles microfiltation in a dead end operation. From the results of the model, specific cake resistance could be controlled by the same variables affecting the height of particle energy barrier described by the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory.