• Laboraroty Animal Research
• /
• 제34권4호
• /
• pp.211-215
• /
• 2018

The following experiments were designed to examine the effect of serum of spayed dogs on superovulation response in mice and rats. In Experiment 1, female mice at diestrus (n=30) were divided into three equal groups and superovulated with either administration of 5 IU pregnant mare serum gonadotropin (PMSG) or recombinant follicle stimulating hormone (rFSH) (reducing dose from 2.5 to 0.5 IU) and 5 IU human chorionic gonadotropin (hCG) administered 48h later. Serum of spayed dogs was administered intraperitoneally at a reduced dose from 0.1 to 0.025 mL in a 48 h period. In Experiment 2, female rats (n=30) at diestrus stage were divided into three equal groups. Superovulation was induced using either 30 IU PMSG, or a dose reduced from 5 to 1 IU rFSH and 25 IU hCG administered 48h later. Serum of spayed dogs was administered in a reduced dose from 0.6 to 0.1 mL in a 48 hour period. Female mice and rats were mated 24 h following hCG administration. On day 14 after mating, animals were euthanized and ovarian sections were fixed for histopathological evaluation and corpus luteum (CL) counting. No significant difference observed in mean (${\pm}SEM$) number of CLs between the PMSG group and the mice that received serum of spayed dog ($10.4{\pm}1.3$ vs $9.2{\pm}1.0$). Mean (${\pm}SEM$) number of CLs tended to be lower in rats that received serum of spayed dog than those of rats which received either PMSG or rFSH ($15.1{\pm}1.9$ vs $23.6{\pm}3.1$ and $23.1{\pm}2.9$, P=0.06, respectively). In conclusion, serum of spayed dogs is able to induce a superovulatory response in mice and rats.

• 한국임상수의학회지
• /
• 제30권1호
• /
• pp.53-56
• /
• 2013

10세령 중성화된 페키니즈 견이 배뇨장애와 복부 팽대와 혈뇨 증상으로 내원하였다. 복부 방사선 촬영에서 상복부의 난원형 연조직 종괴가 발견되었으며 초음파 검사에서 액이 차 있고 종괴가 있는 낭으로 확인되었다. 탐색적 개복술을 통해 직경 4 cm 크기의 낭성 구조를 발견하였으며 적갈색의 액성 물질과 벽에 붙어 있는 직경 1.5 cm 크기의 원형 종괴를 확인하고 수술적으로 제거하였다. 절개한 종괴의 날인 도말 표본에 대한 세포학적 검사 결과 여러가지 악성 조건을 만족하는 선암종 세포가 다수 관찰되었으며, 조직병리 검사에서 확진되었다. 환자는 수술 회복되어 퇴원하였으며 재발증상의 징후 없이 지내다가 술 후1년 후 증상이 재발되어 내원하였고 종괴가 재발되었음을 확인하고 종괴 제거를 위한 2차 수술을 실시하였다. 환자는 퇴원 후 2개월째에 다시 내원하였으며 종괴가 재발되고 폐 전이가 발생한 것을 확인할 수 있었다. 환자는 이후 3개월을 더 생존하다가 폐사하였다.

• 한국임상수의학회지
• /
• 제18권4호
• /
• pp.414-417
• /
• 2001

A 2-year-old, spayed female dog with the chief concern of repeated aggression to strange person at owner’s dock and house was presented to the Animal Behavior Clinic at the College of Veterinary Medicine at Cornell University. Based on the questionnaire and interview about dog, territorial aggression was diagnosed. Behavior modification protocols (protocol for deference; protocol for relaxation; ignore unwanted behaviors; reward relaxed behaviors; using Promise collar; avoid all situations that elicit aggression) were recommended. After 6 months from the first consulting, aggressive behaviors of the dog were alleviated.

• 한국임상수의학회지
• /
• 제40권4호
• /
• pp.294-297
• /
• 2023

A 6-year-old spayed female mixed-breed dog presented with noisy respiration and progressive dyspnea. A physical examination and computed tomography revealed an approximately 3-cm ill-marginated laryngeal mass. As there was no metastasis, the mass was surgically removed. Postoperatively, the dog recovered well, and the mass was diagnosed as rhabdomyosarcoma via immunohistochemical staining. At 20 months postoperatively, the dog was healthy without any clinical signs, and radiographs obtained during follow-up did not reveal any abnormalities.

• 한국임상수의학회지
• /
• 제18권4호
• /
• pp.411-413
• /
• 2001

A 14-year-old, spayed female Labrador Retriever breed dog with housesoiling problem was presented to the Animal Behavior Clinic, College of Veterinary Medicine, Gyeongsang National University. Housesoiling problem was diagnosed as geriatric incontinence based on the questionnaire and interview on the dog. Pharmacological treatment was recommended. Phenylpropanolamine was prescribed at a dosage of 1.19 mg/kg PO q48h for 3 weeks. Housesoiling problem caused by geriatric incontinence disappeared after the treatment.

• 대한수의학회지
• /
• 제51권4호
• /
• pp.319-323
• /
• 2011

A 12-year-old spayed female Yorkshire terrier dog was presented with two-weeks history of lethargy, mental dullness and polydipsia. Neurologic examination revealed proprioceptive defect of all limbs and loss of swallowing gag reflex. The dog revealed persistent dehydration, hypernatremia, hyperosmolarity and hyposthenuria. On magnetic resornance imaging (MRI), the mass were heterogeneous signality on T1 weighted images, hyperintense signality on T2 weighted image with contrast enhancement on hypothalamohypophyseal lesion. Based on these findings, the dog was suspected as having pituitary gland tumor. Through water deprivation test and response to desmopressin acetate (1-deamino-8-D-arginine, DDAVP), this case was diagnosed by central diabetes insipidus (CDI). This paper reports the clinical sign, MRI, response to the exogenous antidiuretic hormone of CDI due to suspected pituitary tumor in a dog and DDAVP administration was evaluated effective therapy to correct hypernatremia induced by CDI.

• 한국임상수의학회지
• /
• 제38권4호
• /
• pp.210-212
• /
• 2021

A 10-year-old spayed female beagle referred to the Veterinary Teaching Hospital of Chungnam National University presented with acute diarrhea, depression, anorexia, and emaciation. The laboratory findings of the dog showed leukocytosis, high C-reactive protein, and low albumin levels. Fecal examinations revealed severe infection with Strongyloides (S.) stercoralis, with a high fecal score (6/7). Consequently, the dog was diagnosed with hyperinfection of S. stercoralis, and thus, was treated with fenbendazole and ivermectin after discontinuation of prednisolone treatment. The dog showed negative on the Fecal Dx^® Antigen Panel (IDEXX Laboratories Inc., Westbrook, ME, USA) after treatment, and clinical signs disappeared with normal stool consistency.

• 한국임상수의학회지
• /
• 제40권5호
• /
• pp.349-353
• /
• 2023

A 2-year-old outdoor, spayed, female Korean Jindo dog was referred for thoracic and abdominal masses. Diagnostic imaging revealed generalized lymphadenopathy and a significant amount of pleural effusion. The cytological evaluation of the pleural effusion and fine-needle aspiration of the mediastinal lymph nodes confirmed the presence of fungal hyphae. The histopathological examination of the mediastinal lymph nodes stained with Grocott's methenamine silver revealed fungal mycelia, and Aspergillus terreus was identified based on fungal DNA sequencing. Thus, the dog was diagnosed with disseminated canine aspergillosis caused by A. terreus. This case report describes a rare case of disseminated canine aspergillosis caused by A. terreus in a Korean Jindo dog.

• 한국임상수의학회지
• /
• 제38권5호
• /
• pp.231-234
• /
• 2021

A 14-month-old, intact female Maltese (case 1) and a 26-month-old, spayed female Dachshund (case 2) had persistent regurgitation over 1 year and 2 years, respectively. In both cases, there were not specific findings in blood examination. Diagnostic imaging and fluoroscopy revealed that gastroesophageal reflux (GER) occurred when the patients ate a barium meal without abdominal contraction. They were treated with proton-pump inhibitor (esomeprazole), sucralfate and prokinetics (cisapride) while in a standing position for an hour after every meal, according to the gastroesophageal disease (GERD) suggested treatment. The case 1 dog was discharged with improved clinical signs, and the case 2 dog also had been improved clinical signs; however, aspiration pneumonia occurred in case 2, which was thought to be a complication from GERD. After receiving treatment for aspiration pneumonia, the case 2 dog was discharged from the hospital. Since there was no further improvement in symptoms after discharge, the case 1 dog was euthanized by owner's request, and the case 2 is alive, having only mild clinical signs upon the writing of this paper.

• 한국임상수의학회지
• /
• 제33권1호
• /
• pp.48-50
• /
• 2016

A 10-year-old spayed female Maltese dog weighting 3.4 kg was referred with growing firm mass at the parietal bone region from 2 weeks ago. A firm, partially calcified mass ($1.9cm{\times}4.4cm$) was palpated in the region of the frontal and parietal skulls but had no neurologic signs. Computed tomography (CT) characteristics of mass were round to oval shape, fine granular appearance, and well defined margins. Mass involving the calvarial bones had invasion into the cranial vault with a significant intracranial portion. Histologically, the tumor was characterized by the presence of multiple lobules containing osteoid or cartilage in the center that were separated by anastomosing fibrous septae. This is case report described the clinical and histopathological features of multilobular tumor of skull in a Maltese dog.