• BMB Reports
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• v.55 no.3
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• pp.111-112
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• 2022

We visualized the distribution of heterochromatin in a single nucleus using plasmonic nanoparticle-conjugated H3K9me3 and H3K27me3 antibodies. Due to distance-dependent plasmonic coupling effects between nanoprobes, their scattering spectra shift to longer wavelengths as the distance between heterochromatin histone markers reduced during oncogene-induced senescence (OIS). These observations were supported by simulating scattering profiles based on considerations of particle numbers, interparticle distances, and the spatial arrangements of plasmonic nanoprobes. Using this plasmon-based colourimetric imaging, we estimated changes in distances between H3K9me3 and H3K27me3 during the formation of senescence-associated heterochromatin foci in OIS cells. We anticipate that the devised analytical technique combined with high-spatial imaging and spectral simulation will eventually lead to a new means of diagnosing and monitoring disease progression and cellular senescence.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.49 no.2
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• pp.140-148
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• 2000

In this paper, using surface micromachining technology with thick photoresist and aluminum, an SLM(Spatial Light Modulator), which is applied to the fields of adaptive optics and pattern recognition system, was fabricated and the electromechanical properties of the fabricated micro SLM are measured. In order to maximize fill-factor and remove mechanical coupling between micro SLM actuators, the micro SLM is composed of three aluminum layers so that spring structure and upper electrode are placed beneath the mirror plate, and $10\times10$ each mirror plate is individually actuated. Also, the micro SLM was designed to be able to modulate phase and amplitude of incoming light in order to have a continuity of phase modulation of incoming light. In the case of amplitude and phase modulation, maximum vertical displacement is 4$\mum$, and maximum angular displacement is $\pm4.6^{\corc}$ respectively. The height difference of the fabricated mirror plate was able to be reduced to 1100A with mirror plate planarization method using negative photoresist(AZ5214). The electromechanical properties of the fabricated micro SLM were measured with the optical measurement system using He-Ne laser and PSD(position sensitive device).

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.274-276
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• 2003

The traditional crop productivity simulations based on crop models are normally site-specific. To simulate regional crop productivity, the spatial crop model is developed in this study by integrating Geographical Information System (GIS) with Erosion Productivity Impact Calculator (EPIC) model. The integration applied a loose coupling approach. Data are exchanged using ASCII or binary data format between GIS and EPIC model without a common user interface. The spatial EPIC model is conducted to simulate the average corn and wheat productivity of 1980s in North China. The results show that the simulation accuracy of the spatial EPIC model is acceptable. The simulation accuracy can be improved by using the detailed crop management information, such as irrigation, fertilizer and tillage schedule.

• Geomechanics and Engineering
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• v.28 no.6
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• pp.613-624
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• 2022

A study of the evolution of overburden fractures under the solid-fluid coupling state was conducted based on the geological and mining characteristics of the coal seam depth, weak strata cementation, and high-intensity mining in the mining areas of West China. These mining characteristics are key to achieving water conservation during mining or establishing groundwater reservoirs in coal mines. Based on the engineering background of the Daliuta Coal Mine, a non-hydrophilic simulation material suitable for simulating the weakly cemented rock masses in this area was developed, and a physical simulation test was carried out using a water-sand gushing test system. The study explored the spatial distribution and dynamic evolution of the fractured zone in the mining overburden under the coupling of stress and seepage. The experimental results show that the mining overburden can be vertically divided into the overall migration zone, the fracture extension zone and the collapse zone; additionally, in the horizontal direction, the mining overburden can be divided into the primary fracture zone, periodic fracture zone, and stop-fracture zone. The scope of groundwater flow in the overburden gradually expands with the mining of coal seams. When a stable water inrush channel is formed, other areas no longer generate new channels, and the unstable water inrush channels gradually close. Finally, the primary fracture area becomes the main water inrush channel for coal mines. The numerical simulation results indicate that the overlying rock breaking above the middle of the mined-out area allows the formation of the water-conducting channel. The water body will flow into the fracture extension zone with the shortest path, resulting in the occurrence of water bursting accidents in the mining face. The experimental research results provide a theoretical basis for the implementation of water conservation mining or the establishment of groundwater reservoirs in western mining areas, and this theoretical basis has considerable application and promotion value.

• Journal of the Korean Association of Geographic Information Studies
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• v.9 no.3
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• pp.67-81
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• 2006

The present study suggests an analytical method to overcome the spatial problems that traditional hedonic methods have. The concept of overlapping neighborhoods is introduced in order to solve the problems of global parameter estimate methods that treat the whole city by the gross. Moreover, a 3rd party program for the tight coupling of GIS and statistics is developed in order to explore hedonic methods efficiently. By using these, this study analyses the spatial variation of location variables that affect the real estate price. The results show that the influences of urban centers do not reach to the whole city, but only to the catchment areas of them. And the coefficients of location variables are different depending on the space. The tight coupling of GIS and statistics offers a powerful tool in analysing the real estate price efficiently.

• Interaction and multiscale mechanics
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• v.3 no.4
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• pp.333-342
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• 2010

The Pseudo-Excitation Method (PEM) is applied to study the stochastic space vibration responses of train-bridge coupling system. Each vehicle is modeled as a four-wheel mass-spring-damper system with two layers of suspension system possessing 15 degrees-of- freedom. The bridge is modeled as a spatial beam element, and the track irregularity is assumed to be a uniform random process. The motion equations of the vehicle system are established based on the d'Alembertian principle, and the motion equations of the bridge system are established based on the Hamilton variational principle. Separate iteration is applied in the solution of equations. Comparisons with the Monte Carlo simulations show the effectiveness and satisfactory accuracy of the proposed method. The PSD of the 3-span simply-supported girder bridge responses, vehicle responses and wheel/rail forces are obtained. Based on the $3{\sigma}$ rule for Gaussian stochastic processes, the maximum responses of the coupling system are suggested.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.12
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• pp.5401-5421
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• 2016

Both low-density parity-check (LDPC) codes and the multiple access technique of spatially coupling data transmission (SCDT) can be expressed in bipartite graphs. To improve the performance of iterative demodulation and decoding for SCDT, a novel joint sparse graph (JSG) with SCDT and LDPC codes is constructed. Based on the JSG, an approach for iterative joint demodulation and decoding by belief propagation (BP) is presented as an exploration of the flooding schedule, and based on BP, density evolution equations are derived to analyze the performance of the iterative receiver. To accelerate the convergence speed and reduce the complexity of joint demodulation and decoding, a novel serial schedule is proposed. Numerical results show that the joint demodulation and decoding for SCDT based on JSG can significantly improve the system's performance, while roughly half of the iterations can be saved by using the proposed serial schedule.

• Economic and Environmental Geology
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• v.35 no.6
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• pp.567-573
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• 2002

Two-dimensional MT (Magneto-Telluric) modeling is performed to verify the validity of difference arrow for GDS(Geomagnetic Depth Sounding) survey. The electromagnetic mutual coupling between the sea and in-land conductor is used as a criterion that judges the validity of difference arrow. In this study, the mutual coupling between them is examined according to the spatial distance between them and the period of magnetic variations. The difference arrow is valid for conductors located at surface which are far from the sea or when the long period is used, but the mutual coupling is weak for buried conductor in all the periods. However, when a conductor extends vertically down to the deep part, the validity of difference arrow is in doubt, since the strong mutual coupling influences up to the long period. Therefore, to remove the known conductor effect such as sea effect from the observed induction arrow, the mutual coupling between them must be examined and the caution must be exercised in interpreting the resultant difference arrow if mutual coupling between them is strong.

• Korean Institute of Interior Design Journal
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• v.25 no.6
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• pp.3-14
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• 2016

According to Plato's ontology, we lead our lives by establishing a relationship with others in the society. However in rapidly changing era, our lives was gradually moving towards personal tendency. Even for the relationship with family, not with others. Thus, awareness about owning properties has changed due to the sociocultural factors and increase number of single-person households. So in this study, the considerations for single-person housing were perceived through preceding research, and the elements making spatial boundary of shared housing were drawn to make rational space sharing based on the boundary with others and of the living environment. With overall analysis based on the spatial boundary features of planned shared housing, the plan characteristics according to the spatial boundary of the current shared housing is to be drawn and analyzed. Third, The expressive and structural features of spatial boundary as above appear with mutual flexible connectivity, And the result shows that the modularity was the highest. Among them variable coupling modularity of shows how it is possible to combine efficiently and variously the private and public spaces with regularity of 'space of optimal unit'. This study drew plan characteristics from more detailed space border of shared housing. Therefore, The basic framework of the characteristics spin for the cases that newly emerge later on.

• International Journal of Naval Architecture and Ocean Engineering
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• v.12 no.1
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• pp.376-386
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• 2020

The aim of this study was to develop a new efficient strategy that uses the Vector form Intrinsic Finite-element (VFIFE) method to conduct the static and dynamic analyses of marine pipes. Nonlinear problems, such as large displacement, small strain, and contact and collision, can be analyzed using a unified calculation process in the VFIFE method according to the fundamental theories of point value description, path element, and reverse motion. This method enables analysis without the need to integrate the stiffness matrix of the structure, because only motion equations of particles established according to Newton's second law are required. These characteristics of the VFIFE facilitate the modeling and computation efficiencies in analyzing the nonlinear dynamic problem of flexible pipe with large deflections. In this study, a three-dimensional (3-D) dynamical model based on 3-D beam element was established according to the VFIFE method. The deep-sea flexible pipe was described by a set of spatial mass particles linked by 3-D beam element. The motion and configuration of the pipe are determined by these spatial particles. Based on this model, a simulation procedure to predict the 3-D dynamical behavior of flexible pipe was developed and verified. It was found that the spatial configuration and static internal force of the mining pipe can be obtained by calculating the stationary state of pipe motion. Using this simulation procedure, an analysis was conducted on the static and dynamic behaviors of the flexible mining pipe based on a 1000-m sea trial system. The results of the analysis proved that the VFIFE method can be efficiently applied to the static and dynamic analyses of marine pipes.