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Effect of polysaccharides from a Korean ginseng berry on the immunosenescence of aged mice

  • Kim, Miseon;Yi, Young-Su;Kim, Juewon;Han, Sang Yun;Kim, Su Hwan;Seo, Dae Bang;Cho, Jae Youl;Shin, Song Seok
    • Journal of Ginseng Research
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    • v.42 no.4
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    • pp.447-454
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    • 2018
  • Background: Korean ginseng has been widely evaluated to treat human diseases; however, most studies on Korean ginseng have focused on its root. In this study, polysaccharides [acidic-polysaccharide-linked glycopeptide (APGP) extracted with 90% ethanol and hot water] were prepared from Korean ginseng berries, and their effect on immunosenescence was explored. Methods: The effect of APGP on thymic involution was evaluated by measuring the size of thymi dissected from aged mice. The effect of APGP on populations of immune cells, including natural killer (NK) cells, dendritic cells, age-correlated CD11c-positive B cells, and several subtypes of T cells [CD4-positive, CD8-positive, and regulatory (Treg) T cells] in the thymi and spleens of aged mice was analyzed by fluorescence-activated cell sorting analysis. Serum levels of interleukin (IL)-2 and IL-6 were evaluated by enzyme-linked immunosorbent assay analysis. Profiles of APGP components were evaluated by high-performance liquid chromatography (HPLC) analysis. Results: APGP suppressed thymic involution by increasing the weight and areas of thymi in aged mice. APGP increased the population of NK cells, but showed no effect on the population of dendritic cells in the thymi and spleens of aged mice. APGP decreased the population of age-correlated CD11c-positive B cells in the spleens of aged mice. APGP showed no effect on the populations of CD4- and CD8-positive T cells in the thymi of aged mice, whereas it increased the population of Treg cells in the spleens of aged mice. APGP further decreased the reduced serum levels of IL-2 in aged mice, but serum levels of IL-6 were not statistically changed by APGP in aged mice. Finally, HPLC analysis showed that APGP had one major peak at 15 min (a main type of polysaccharide) and a long tail up to 35 min (a mixture of a variety of types of polysaccharides). Conclusion: These results suggested that APGP exerted an anti-immunosenescent effect by suppressing thymic involution and modulating several types of immune cells.

A Study on the Noxious Materials in the Waste Shipped into Solid Recovered Fuel(SRF) Facilities and Their Influence (고형연료(SRF)시설로 반입되는 폐기물의 영향 및 유해성물질 등에 관한 연구)

  • Lee, Seung-Won;Kim, Sang-Hun;Lee, Sang-Seok;Kim, Jung-Kwon
    • Journal of Environmental Science International
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    • v.27 no.2
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    • pp.91-97
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    • 2018
  • This study carried out first a component survey on the domestic waste shipped into a waste disposal facility in B city, and then heavy metal analysis of each component according to the SRF standards. Based on this, this study explored the problems with domestic waste and measures to improve them. The results are as follows. The result of the survey of physical components show that paper accounted for the largest proportion with 20.5 %~59.9 %, metals (including batteries) among incombustibles accounted for 0.0~8.3 %, other inorganic substances, glass and ceramics accounted for 0.0~43.7 % and 0.0 %~19.6 % respectively. However, the proportion of coated viny and plastics, which have high lead and cadmium content, was rather high with 2.9 %~30.9 %. This suggests the possibility that actual concentration of lead and cadmium within SRF is likely to be higher. Among the 15 components contained in the waste brought into the waste disposal facility, 10 components (food waste, textiles, vinyl, plastics, wood, rubber and leather, paper, metals, electronic substrates, and nail polish) were analyzed according to assay samples (approximately 0.1 g and 0.3 g). The result of analysis shows that the amount of Cd and Pb detected in coated vinyl for 0.109 g of assay sample was 98.6 mg/kg and 20.6 mg/kg respectively; 117.0 mg/kg and 29.0 mg/kg respectively for 0.313 g of assay sample. This is high contents exceeding the Cd standard. As for wooden component, the amount of Pb was 480.0 mg/kg for 0.3 g of assay sample. This suggests that there always exists the possibility of exceeding the exposure level of heavy metals (Cd and Pb) in SRF as long as coated wood and vinyl plastics with high contents of Pb and Cd are shipped into the waste disposal facility; and the local government and the residents need to work hard to improve the situation including development of the machine to sort electronic substrates and batteries for separate collection of the waste of coated vinyl and plastics within domestic waste.

Symptoms and Cognitive Function in Chronic Schizophrenia: 6 Months Follow-up Study (만성 정신분열병 환자에서 증상과 인지기능:6개월 개월 추적연구)

  • Kim, Chul-Kwon;Kim, Seong-Hwan;Choe, Byeong-Moo
    • Sleep Medicine and Psychophysiology
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    • v.11 no.1
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    • pp.44-49
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    • 2004
  • Objectives: The purpose of this study was to investigate whether longitudinal changes in positive and negative symptoms affect cognitive functioning in chronic schizophrenia. Methods: Sixty-eight patients diagnosed with DSM-IV schizophrenia were examined on two occasions over 6 months for symptoms and cognitive changes. Symptoms were measured by PANSS. Cognitive functions were examined for sustained attention, executive function, concentration and attention, and verbal memory and learning using Degraded Stimulus Continuous Performance Test, Wisconsin Card Sorting Test, Digit Span, and Rey Auditory Verbal Learning Test, respectively. Twenty control subjects were assessed to compare the cognitive scores of remitted schizophrenic patients. Results: Patients showed significant improvement in symptoms and all cognitive tests after 6 months treatments. Significant improvements in positive and negative symptoms did not predict improvements in any aspect of cognitive functioning measured. Normal controls performed significantly better than remitted schizophrenic patients on all cognitive tests. The results show no relationship between change in symptoms and change in cognition in chronic schizophrenia. Conclusion: We suggest that symptomatic and cognitive impairment may be a distinct construct. These findings highlight the importance of treating cognitive impairment in addition to the clinical symptoms of schizophrenia.

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A Study on the Method of High-Speed Reading of Postal 4-state Bar Code for Supporting Automatic Processing (우편용 4-state 바코드 고속판독 방법에 관한 연구)

  • Park, Moon-Sung;Kim, Hye-Kyu;Jung, Hoe-Kyung
    • The KIPS Transactions:PartD
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    • v.8D no.3
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    • pp.285-294
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    • 2001
  • Recently many efforts on the development of automatic processing system for delivery sequency sorting have been performed in ETRI, which requires the use of postal 4-state bar code system to encode delivery points. This paper addresses the issue on the extension of read range and the improvement of image processing method. For the improvement of image processing procedure, applied information acquisition method through basic two thresholds onto the horizontal axial line of gray image based on reference information of 4-state bar code symbology. Symbol values are computed after creating two threshold values based on the obtained information through search of horizontal axial values. The implementation result of 4-state bar code reader are obtained the symbol values within 30~60 msec (58,000~116,000 mail item/hour)without noise removal or image rotation in spite of the incline $\pm 45^{\circ}$.

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Removal of PVC from Mixed Plastic Waste by Combination of Air Classification and Centrifugal Process (풍력(風力) 및 습식비중(濕式比重) 선별(選別)에 의한 혼합(混合)폐플라스틱 종말품(終末品)으로부터 PVC 제거(除去)에 관한 연구(硏究))

  • Choi, Woo-Zin;Yoo, Jae-Myung
    • Resources Recycling
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    • v.16 no.5
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    • pp.71-76
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    • 2007
  • The mixed plastic waste generated from households after hand-picking and/or mechanical sorting processes amounts to 1,750,000 ton in 2006, and most of these waste are finally end up with landfill and/or incineration due to the lacks of separation technologies and economical reasons. The mixed plastic wastes can not be used as raw materials for chemical and/or thermal recycling processes because of their high content of PVC(upto 4.0 wt.%). In the present research, gravity separation system has been developed to remove PVC from the mixed plastic waste and to recover the PO-type plastics. This system mainly consists of air classification, magnetic separation, one-step crushing, feeding system at fixed rate and wet-type gravity separation system. The gravity system based on centrifugal separation has been developed at capacity of 0.5 ton/h and it consists of mixing, precleaning, separation, dewatering, recovery system and wastewater treatment system, etc. The main objective of this process is to achieve high separation efficiency of polyolefins with less than 0.3 wt.% PVC content and less than 10% moisture content in the final products. In addition, a crushing unit of with 8 rotor system is also developed to improve the crushing efficiency of soft-type plastics. The system with a capacity of 1.0 ton/h is developed and operational results are presented.

Model of Water, Energy and Waste Management for Development of Eco-Innovation Park ; A Case Study of Center for Research of Science and Technology "PUSPIPTEK," South Tangerang City, Indonesia

  • Setiawati, Sri;Alikodra, Hadi;Pramudya, Bambang;Dharmawan, Arya Hadi
    • World Technopolis Review
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    • v.3 no.2
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    • pp.89-96
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    • 2014
  • Center for Research of Science and Technology ("PUSPIPTEK") has 460 hectares land area, still maintained as a green area with more than 30% green space. There are 47 centers for research and testing technology, technology-based industries, and as well as public supporting facilities in PUSPIPTEK area. Based on the concepts developed to make this area as an ecological region, PUSPIPTEK can be seen as a model of eco-innovation. The purpose of this research is to develop a model of water, energy and waste management with eco-innovation concept. As a new approach in addressing environmental degradation and maintaining the sustainability of ecosystem, studies related to eco-innovation policy that combines the management of water, energy and waste in the region has not been done. In order to achieve the objectives of the research, a series of techniques for collecting data on PUSPIPTEK existing conditions will be carried out, which includes utilities data (water, electricity, sewage) and master plan of this area. The savings over the implementation of the concept of eco-innovation in water, energy, and waste management were calculated and analyzed using quatitative methods. The amount of cost savings and feasibility were then calculated. Eco innovation in water management among other innovations include the provision of alternative sources of water, overflow of rain water and water environments utilization, and use of gravity to replace the pumping function. Eco-innovation in energy management innovations include the use of LED and solar cell for air conditioning. Eco-innovation in waste management includes methods of composting for organic waste management. The research results: (1) The savings that can be achieved with the implementation of eco innovation in the water management is Rp. 3,032,640 daily, or Rp.1,106,913,600 annually; (2) The savings derived from the implementation of eco innovation through replacement of central AC to AC LiBr Solar Powered will be saved Rp.1,933,992,990 annually and the use of LED lights in the Public street lighting PUSPIPTEK saved Rp.163,454,433 annually; (3) Application of eco innovation in waste management will be able to raise awareness of the environment by sorting organic, inorganic and plastic waste. Composting and plastic waste obtained from the sale revenue of Rp. 44,016,000 per year; (4) Overall, implementation of the eco-innovation system in PUSPIPTEK area can saves Rp. 3,248,377,023 per year, compared to the existing system; and (5)The savings are obtained with implementation of eco-innovation is considered as income. Analysis of the feasibility of the implementation of eco-innovation in water, energy, and waste management in PUSPIPTEK give NPV at a 15% discount factor in Rp. 3,895,228,761; 23.20% of IRR and 4.48 years of PBP. Thus the model of eco-innovation in the area PUSPIPTEK is feasible to implement.

Evaluation of Cognitive Functions in Patients with Narcolepsy (기면병 환자의 인지기능 평가)

  • Jin, You-Yang;Yoon, Jin-Sang;Chung, Eun-Kyung
    • Journal of agricultural medicine and community health
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    • v.38 no.2
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    • pp.97-107
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    • 2013
  • Objective: This study aimed to evaluate attention, memory and executive function in patients with narcolepsy. Methods: This study included 23 narcoleptic patients whose diagnosis were confirmed by the International Classification of Sleep Disorders(ICSD) at Chonnam National University Hospital Sleep Disorders Clinic or an other hospital in Korea, from 2005 to 2008, as well as 23 normal controls. All participants were given an IQ test for Korean-Wechsler Adult Intelligence Scale and several neuropsychological function tests (the d2 test for attention function, the Rey Complex Figure Test for nonverbal memory, the Korean-California Verbal Learning Test [K-CVLT] for verbal memory, and the Wisconsin Card Sorting Test for executive function). Clinical features of narcoleptic patients, including the frequency of excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic hallucination, were investigated by a structured clinical interview administered by a neuropsychiatist. Excessive daytime sleepiness was evaluated by the Epworth sleepiness scale. Results: Characteristic symptoms of narcolepsy observed in this study included excessive daytime sleepiness (n=23, 100.0%), cataplexy (n=19, 82.6%), hypnagogic hallucination (n=5, 21.7%) and sleep paralysis (n=12, 52.2%). In nocturnal polysomnographic findings, stage 2 sleep and REM latency were found to be significantly decreased in narcoleptic patients compared with the control group, and were accompanied by significant increases in stage 1 sleep. Narcoleptic patients had lower scores than the control group on total number, Total Number-Total Error, Concentration Performance and Fluctuation Rate on the d2 test, which measures attention. Also, there were significant differences between the performance of patient and control groups on the B list of the K-CVLT, which measures verbal memory. Conclusion: Narcoleptic patients showed decreased attention and verbal memory performance compared to the control group; however, in many areas, narcoleptic patients still demonstrated normal cognitive function.

The Relationship between Labor Market Flexibility and Outcome Variables and Its Moderating Effect on Union Power (노동시장의 유연성과 결과변수와의 관계 및 노조 힘의 조절효과)

  • Bae, Seung-Hyun;Park, Se-Yul
    • Management & Information Systems Review
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    • v.30 no.4
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    • pp.475-509
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    • 2011
  • Taking 195 Korean businesses and sorting them out according to the unit types, this study looks into how flexibility strategy in labor market, which consists of numerical flexibility and functional flexibility, takes effect on the organization's outcome variable, which in turn consists of productivity, labor-management cooperation, and job security. In addition, the present study analyzes the role of labor union's moderating effect on the relationship among labor market flexibility, labor-management cooperation, and job security. It is found out as a result that numerical flexibility has no meaningful relation with productivity, labor-management cooperation, and job security, while functional flexibility has a considerably positive relation with them. This result confirms the importance of functional flexibility of business strategy in labor market. The West has continuously insisted the importance of functional flexibility, pointing out problems of numerical flexibility. On the other hand, considering that this study has confirmed functional flexibility's meaningful relation, while it has not found out numerical flexibility's negative relation, it is necessary to study further on the relationship between these two kinds of flexibility. The result of analysis on the role of union power's moderating effect confirms only the union power's interaction effect in the relation between numerical flexibility and labor-management cooperation. The possibility of union's opportunistic behavior can be detected in this result.

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Seismic exploration for understanding the subsurface condition of the Ilwall-dong housing construction site in Pohang-city, Kyongbook (경북 포항시 일월동 택지개발지구의 지반상태 파악을 위한 탄성파탐사)

  • Seo, Man Cheol
    • Journal of the Korean Geophysical Society
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    • v.2 no.1
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    • pp.45-56
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    • 1999
  • Seismic refracrion and reflection surveys were conducted along an E-W trending track of 482 m long in Ilwall-dong, Pohang. End-on spread was employed as source-receiver configuration with 2 m for both geophone interval and offset. Seismic data were acquired using 24 channels at every shot fired every 2 m along the track. Refraction data were interpreted using equations for multi-horizontal layers. Reflection data were processed in the sequence of trace edit, gain control, CMP sorting, NMO correction, mute, common offset gathering, and filtering to produce a single fold seismic section. There are two layers in shallow subsurface of the study area. Upper layer has the P-wave velocities ranging from 267 to 566 m/s and is interpreted as a layer of unconsolidated sediments. Lower layer has P-wave velocities of 1096-3108 m/s and is interpreted as weathered rock to hard rock. Most of the lower layer classified as soft rock. Upper layer has lateral variations in both P-wave velocity and thickness. The upper layer in the eastern part of the seismic line is 3-5 m thick and has P-wave velocity of 400 m/s in average. The upper layer in the western part is 8-10 m thick and has P-wave velocity of 340 m/s in average. The eastern part is interpreted as unconsolidated beach sand, while the western part is interpreted as infilled soil to develop a construction site. Three fault systems of high angle are imaged in seismic reflection section. It is interpreted that the area between these fault systems are relatively safe. Large buildings should be located in the safe ground condition of no fault and footings should be designed to be in the basement rock of 3-10 m deep below the surface.

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A Taxonomy of Workflow Architectures

  • Kim, Kwang-Hoon;Paik, Su-Ki
    • Proceedings of the Korea Database Society Conference
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    • 1998.09a
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    • pp.525-543
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    • 1998
  • This paper proposes a conceptual taxonomy of architectures far workflow management systems. The systematic classification work is based on a framework for workflow architectures. The framework, consisting of generic-level, conceptual-level and implementation-level architectures, provides common architectural principles for designing a workflow management system. We define the taxonomy by considering the possibilities for centralization or distribution of data, control, and execution. That is, we take into account three criteria. How are the major components of a workflow model and system, like activities, roles, actors, and workcases, concretized in workflow architecture? Which of the components is represented as software modules of the workflow architecture? And how are they configured and operating in the architecture? The workflow components might be embodied, as active (processes or threads) modules or as passive (data) modules, in the software architecture of a workflow management system. One or combinations of the components might become software modules in the software architecture. Finally, they might be centralized or distributed. The distribution of the components should be broken into three: Vertically, Horizontally and Fully distributed. Through the combination of these aspects, we can conceptually generate about 64 software Architectures for a workflow management system. That is, it should be possible to comprehend and characterize all kinds of software architectures for workflow management systems including the current existing systems as well as future systems. We believe that this taxonomy is a significant contribution because it adds clarity, completeness, and "global perspective" to workflow architectural discussions. The vocabulary suggested here includes workflow levels and aspects, allowing very different architectures to be discussed, compared, and contrasted. Added clarity is obtained because similar architectures from different vendors that used different terminology and techniques can now be seen to be identical at the higher level. Much of the complexity can be removed by thinking of workflow systems. Therefore, it is used to categorize existing workflow architectures and suggest a plethora of new workflow architectures. Finally, the taxonomy can be used for sorting out gems and stones amongst the architectures possibly generated. Thus, it might be a guideline not only for characterizing the existing workflow management systems, but also for solving the long-term and short-term architectural research issues, such as dynamic changes in workflow, transactional workflow, dynamically evolving workflow, large-scale workflow, etc., that have been proposed in the literature.

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