• Defense and Technology
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• no.2 s.264
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• pp.43-53
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• 2001

우리 군도 2000년 6월 전략화 심의를 통과한 후, 2006년부터 도입될 신형 해독제 주사기인 KHI-6에 대한 개발을 업체가 추진하고 있다. 이 HI-6 과련 해독제는 기존 PAM 관련 KMARK-1 보다 Soman 신경 작용제에 해독 능력이 증강되고, LD50 수치가 높고(자체 독성이 낮음을 의미), 이원화 자동 주사기로써 간편성을 더한다고 한다. 이에 우리도 신형 해독제 주사기에 대한 기본 구조와 해독 효과, 장점과 단점, 도입에 관련된 사전 지식, 외국군의 운용 실태 등에 대해 알아보았다

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2013.11a
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• pp.115-116
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• 2013

본 연구에서는 유기인 유도체 중 생리활성이 커서 독성이 있는 화합물의 구조를 분석하였다. 5-[(b-monoaza-15-crown-5)ethyloxy]-2iodosbenzoic acid의 IBA 촉매를 합성하여 그 반응성을 p-nitrophenyldiphenylphosphate (PNPDPP)와 Isopropyl methylphosphonofluoridate (Sarin GB), Pinacolyl methylphosphonofluoridate (Soman, GD)를 기질로 하여 연구하였다. PNPDPP 가수분해 반응에서는 긴 알킬작용기로 친유성을 증가시킨 촉매가 더 상전이 촉매로 작용함이 확인되었다.(t1/2 = 5 sec, pH = 8.07)

• Journal of Korean Elementary Science Education
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• v.33 no.1
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• pp.105-114
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• 2014

The purpose of this study was to develop a teaching strategy focused on problem solving process and explore its effects on science creative problem solving ability, science process skills, science academic achievements and scientific attitudes of students after applying it. Teaching strategy focused on problem solving process employed brainstorming and PMI thinking strategies. The participants were the third grade students of both an experimental class(26 students) and a comparative class(25 students) at the S elementary school located in Goyang-City, Kyonggi Province. The developed strategy was applied to the experimental class for 9 periods of 'Separation of mixture' unit. The results of the tests on the science creative problem solving ability, the science process skills, scientific achievement and scientific attitude were statistically higher in the experimental class.

• Journal of The Korean Association For Science Education
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• v.25 no.1
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• pp.16-25
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• 2005

Minute papers are brief papers written at the end of a lecture in response to one or two questions posed by the instructor. The answers are discussed briefly at the beginning of the next lecture. We used minute papers to follow students' understanding and response to lecture demonstrations in an introductory general chemistry course. An analysis of these minute papers suggest that the following characteristics are important, when using demonstrations as teaching aids. 1) The purpose of a demonstration should be stated as explicitly as possible. 2) Instructors should be explicit about what is happening and what students should be looking for. 3) Demonstrations should be kept as simple as possible, perhaps illustrating one concept. Finally, we note that students believe that the visual component of demonstrations enhances their comprehension of chemistry concepts.

• Journal of The Korean Society of Grassland and Forage Science
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• v.27 no.4
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• pp.263-268
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• 2007

This experiment was carried out to evaluate the effects of organic content and to select lodging resistance for six varieties in paddy field of Chungnam province from 2006 to 2007. In this experiment, plant height was increased at the high fertile field and dry matter rate (%) per fresh matter was decreased at the high fertile soil condition but dry matter rate (%) of spike was increased. The dry matter (DM) yield showed higher in Sunwoo barley (13,520kg/ha) and Youngyang barley (12,780kg/ha) at the high fertile field. Fresh yield was also high in Wooho barely (34,720kg/ha) and Youngyang barely (33,670kg/ha) at the high fertile field but yield in high and normal fertile soil condition was not difference. Total digestible nutrients (TDN) content of Youngyang barley and Yuyeon barley was high as 69.5%, 70.3%, respectively, at the high fertile soil condition. According to this result Soman barley and Youngyang barley might be recommendable for whole crop barely in lower organic content condition of paddy rice field and Wooho barley and Soman barley with the lodging resistance and high yield is suitable for paddy field with high organic content.

• Bulletin of the Korean Chemical Society
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• v.27 no.3
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• pp.395-398
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• 2006

Nerve agents (sarin, tabun, soman and VX) are class of military important substances able to cause many severe intoxications during few minutes. Currently, the threat of misuse of these agents is daily discussed. Unfortunately, there is no single antidote able to treat intoxication caused by all of these agents. Owing to this fact, new generation of antidotes, especially acetylcholinesterase (AChE; EC 3.1.1.7) reactivators, is still developed. In this study, we have tested four newly developed AChE reactivators: 1-(4-hydroxyiminomethylpyridinium)- 5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (1), 1-(3-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (2), 1,5-bis(2-hydroxyiminomethylpyridinium)-3-oxa-pentane dichloride (3) and 1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxa-pentane dibromide (4) for their potency to reactivate in vitro tabun and cyclosarin-inhibited AChE. Their reactivation efficacy was compared with currently the most promising oxime HI-6 (1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride). According to obtained results, two AChE reactivators 1 and 4 were able to reactivate tabun-inhibited AChE. On the contrary, there was no better AChE reactivator than HI-6 able to reactivate cyclosarin-inhibited AChE.

• Journal of the Korea Institute of Military Science and Technology
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• v.4 no.1
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• pp.188-197
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• 2001

Organophosphorus acid anhydrolases(OPAA) catalyzing the hydrolysis of toxic organophosphates have been found in a variety of prokaryotic and eukaryotic organisms. Of the several kinds of OPAA that can degrade nerve agents, such as DFP, sarin and soman, a OPAA gene harbored in the chromosomal DNA of Alteromonas haloplanktis strain was subcloned in order to develope an enzymatic degradation method of toxic organophosphorus compounds. For this 1481 bp DNA fragment containing OPAA gene and its flanking regions has been synthesized through PCR using chromosomal DNA of A. haloplanktis strain. After subcloning and subsequent expression, crude OPA anhydrolase was prepared and assayed. It was shown that the OPAA had a very high hydrolytic activity on DFP. The specific activity of the enzyme was 1,110 $\mu$mole.$min^{p-1}.mg^{-1}$ protein. It seemed that OPAA with such a high hydrolytic activity may give a good prospects to its use, as a biodegradation tool, in detoxifying toxic organophosphorus compounds, such as pesticides and chemical stockpiles which are posing a potential threat to the field environment and human health.

• Smart Structures and Systems
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• v.14 no.1
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• pp.55-70
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• 2014

The paper presents a multi-objective optimization strategy for a multi-type sensor placement for Structural Health Monitoring (SHM) of long span bridges. The problem is formulated for simultaneous placement of strain sensors and accelerometers (heterogeneous network) based on application demands for SHM system. Modal Identification (MI) and Accurate Mode Shape Expansion (AMSE) were chosen as the application demands for SHM. The optimization problem is solved through the use of integer Genetic Algorithm (GA) to maximize a common metric to ensure adequate MI and AMSE. The performance of the joint optimization problem solved by GA is compared with other established methods for homogenous sensor placement. The results indicate that the use of a multi-type sensor system can improve the quality of SHM. It has also been demonstrated that use of GA improves the overall quality of the sensor placement compared to other methods for optimization of sensor placement.

• Smart Structures and Systems
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• v.14 no.1
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• pp.39-54
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• 2014

Node layout optimization of structural wireless systems is investigated as a means to prolong the network lifetime without, if possible, compromising information quality of the measurement data. The trade-off between these antagonistic objectives is studied within a multi-objective layout optimization framework. A Genetic Algorithm is adopted to obtain a set of Pareto-optimal solutions from which the end user can select the final layout. The information quality of the measurement data collected from a heterogeneous WSN is quantified from the placement quality indicators of strain and acceleration sensors. The network lifetime or equivalently the network energy consumption is estimated through WSN simulation that provides realistic results by capturing the dynamics of the wireless communication protocols. A layout optimization study of a monitoring system on the Great Belt Bridge is conducted to evaluate the proposed approach. The placement quality of strain gauges and accelerometers is obtained as a ratio of the Modal Clarity Index and Mode Shape Expansion values that are computed from a Finite Element model of the monitored bridge. To estimate the energy consumption of the WSN platform in a realistic scenario, we use a discrete-event simulator with stochastic communication models. Finally, we compare the optimization results with those obtained in a previous work where the network energy consumption is obtained via deterministic communication models.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1479-1485
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• 2015

Background: Even after completion of conventional treatment, breast cancer survivors continue to exhibit a variety of psychological and physical symptoms, affecting their quality of life. The study aimed to investigate the relationship between socio-demography, medical characteristics and health-related quality of life (HR-QOL) of a sample of breast cancer survivors in Malaysia. Materials and Methods: This pilot cross-sectional survey was conducted among breast cancer survivors (n=40) who were members of Breast Cancer Support Group Centre Johor Bahru. A validated self-administered questionnaire was used to identify the relationships between socio-demography, medical characteristics and HR-QOL of the participants. Results: Living with family and completion of treatment were significant predictive factors of self-rated QOL, while living with family and ever giving birth significantly predicted satisfaction with health and physical health. Psychological health had moderate correlations with number of children and early cancer stage. Survivors' higher personal income (>MYR4,500) was the only significant predictor of social relationship, while age, income more than MYR4,500 and giving birth significantly predicted environment domain score. Conclusions: The findings suggested the survivors coped better in all four HR-QOL domains if they were married, lived with family, had children and were employed.