• 제목/요약/키워드: solubility

검색결과 3,014건 처리시간 0.031초

Effects of Polyoxyl 40 Hydrogenated Castor Oil on Solubility and Bioavailability of Silymarin in Combined Preparation Containing Silymarin and Ursodeoxycholic Acid (Polyoxyl 40 Hydrogenated Castor Oil이 실리마린과 우루소데옥시콜린산 복합제제중 실리마린의 용해성 및 생체이용률에 미치는 영향)

  • 장우익;남권호;조재열;이재희;유영호;박명호;김재환
    • Biomolecules & Therapeutics
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    • 제5권3호
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    • pp.272-277
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    • 1997
  • The effect of nonionic surfactant(polyoxyl 40 hydrogenated castor oil, PHCO), a common solubi-lizer, on the solubility of silymarin in the combined preparation containing ursoseoxycholic acid(UDCA) and silymarin was investigated in vivo using HPLC. The solubility of silybin, a major component of silymarin, was enhanced by increasing the amount of PHCO. The effect of PHCO on bioavailability was also evaluated in rats. The bioavailability was calculated by silybin content in bile juice that was excreted for 24 hr after oral administration. It was found that the bioavailability of silymarin containing PHCO was significantly increased compared to that of control. These results suggest that PHCO may improve the solubility and bioavailabilty of silymarin when it is combined with UDCA and silymarin.

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Effect of Co-doping in Indium-Zinc-Tin Oxide based transparent conducting oxides sputtering target

  • Seo, Han;Choe, Byeong-Hyeon;Ji, Mi-Jeong;Won, Ju-Yeon;Nam, Tae-Bang;Ju, Byeong-Gwon
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 한국전기전자재료학회 2009년도 추계학술대회 논문집
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    • pp.108-108
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    • 2009
  • ITO에 사용되는 주된 재료인 인듐의 bixbyite 구조는 TCOs의 전기적 특성에서 매우 중요한 것으로 알려져 있다. 때문에 인듐의 Bixbyite구조를 유지하면서 인듐의 사용량을 줄이기 위해 최적의 Solubility limit에 관해 연구하였다. 이를 위해 In2O3-ZnO-SnO2의 삼성분계 기본 조성에 두가지 물질을 추가로 첨가하여 첨가량에 따른 Solubility limit을 연구하였다. Solubility limit의 측정을 위해 X-ray Diffractometer(XRD)를 사용하였으며, 첨가 원소의 양이 증가할수록 TCOs target의 Latice parameter값은 작아졌다, SEM을 통한 미세구조의 관찰로 원소첨가에 따른 샘플의 소결에너지 변화를 분석할 수 있었다. 제작된 시편의 정성분석 및 Chemical binding Energy를 측정하기 위해 X-ray Photo Spectroscopy (XPS)를 이용하였으며, 전기적인 특성 측정을위해 4-Point prove mesurement 방법을 사용하였다.

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Effects of Previous History on Diffusivity and Solubility of Gas in the Polymer Matrix (이력이 고분자 재료 안으로의 확산 및 용해에 미치는 영향)

  • 윤재동;차성운;최광용;조현종
    • Journal of the Korean Society for Precision Engineering
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    • 제17권3호
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    • pp.108-113
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    • 2000
  • An important process for making a new class of polymeric material is called microcellular plastics invented at the Massachusetts Institute of Technology. Many researches for microcellular plastics have been done in various ways and fields. But a research for the polymer which has previous history has not been tried yet. In this paper, weight gain of $CO_2$ was measured in a polymer matrix which had previous history and no history. In each case, experimental data for solubility and diffusivity was shown. A model for $CO_2$ solution process in molecular range was made. The conclusion of this paper is that the previous history has an effect on diffusivity but not solubility and the previous history made by $CO_2$ in supercritical state makes diffusivity of $CO_2$ larger.

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Production of Peptides Enhancing Calcium Solubility in the Presence of Phosphate Ions In Vitro (In Vitro 상에서인 이온 존재 하에서의 칼슘 용해도를 증대시키는 펩타이드의 생산)

  • 이윤동;이현수
    • The Korean Journal of Food And Nutrition
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    • 제10권4호
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    • pp.485-490
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    • 1997
  • Gluten peptide was produced from corn gluten by enzymatic hydrolysis. This peptide had an ability to increased the solubility of calcium owing to protect calcium ions from forming precipitates of calcium phosphate in the presence of phosphate ions. The solubility of calcium was increased 5.2 times in the presence of 8.3 mg peptide produced by the treatment of papain. These peptides contained high acidic amino acids and fractionated by Delta pack column into fractions No. 1, No. 2 and No. 3. Among them the fraction No. 3 had the highest calcium binding capacity.

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The Effect of Nonionic Surfactants on the Solubility and Biodegradation of PAHs in Soil Slurry (PAHs의 용해도와 생분해에 미치는 비이온계 계면활성제의 영향)

  • 박종섭;김인수
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • 한국지하수토양환경학회 1998년도 공동 심포지엄 및 추계학술발표회
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    • pp.174-177
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    • 1998
  • The effects of surfactants affecting polycyclic Aromatic Hydrocarbon(PAHs) solubility and biodegradation in soil slurry were investigated. The critical micelle concentration(CMC) values of surfactants used in this study were 12.7mg/L(Brij 30), 13.4mg/L(Tween 80), 13.6mg/t(Triton X-100). The solubility of PAH increased as the Hydrophile-Lipophile Balance(HLB) value of surfactant decrease. At surfactant biodegradation and toxicity experiement using respirometer, Brij 30 did not show any toxic effect and substrate inhibition upon the level of 1.5g/L. Also, biodegradation of Brij 30 gave no reduction on the phenanthrene biodegradation rate. When the desorption rate of phenanthrene between sand and clay is compared, lower percentage of phenanthrene was desorbed at clay because of the larger surface aera and higher organic content of clay. At the biodegradation experiments of phenanthrene in soil slurry phase, more than 90% of initial phenanthrene adsorbed onto both sand and clay were biodegraded by phenanthrene- acclimated cultures.

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Quality Characteristics of Oral Liquid Supplement with Pork Meat Oligopeptide (돈육 Oligopeptide를 첨가한 경구영양액의 품질특성)

  • Kim, Jong-Hee;Hong, Soon-Kwang
    • The Korean Journal of Food And Nutrition
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    • 제25권1호
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    • pp.116-122
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    • 2012
  • The objective of this study was to address the issues associated with the solubility of the pork meat oligopeptide, while maintaining its original nutritional value and improving its digestibility. The pork meat oligopeptide was used to produce an oral liquid supplement that was contained in a 200 $m{\ell}$ can. The formulation was designed to satisfy 20% of the daily recommended nutrition intake of an adult male aged between 20 and 29. Analysis of the quality characteristics showed that this formulation was highly homogenized as an oral liquid supplement with advanced solubility. In addition, based on the viscosity, pH, color value, turbidity, and brix, the product was shown to advanced processing quality with great solubility; however, there was some concern that the taste would be deteriorated due to the bitter taste of the peptide. Thus, further studies need to be performed before this formulation can be commercialized.

Production of White Zein Using Aqueous Ethanol (물-에탄올 혼합액을 이용한 백색 제인의 생산)

  • Kim, Kang Sung
    • Korean journal of food and cookery science
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    • 제29권6호
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    • pp.647-652
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    • 2013
  • Solubility profiles of zein and carotenoid in aqueous ethanol were studied. Zein showed minimum turbidity at the aqueous ethanol concentration of 87-92%, indicating least aggregations between protein molecules. Solubilities of zein and carotenoid increased linearly with the content of yellow zein up to 20% in the aqueous ethanol range of 60-95% tested. At room temperature of $20^{\circ}C$, zein showed maximum solubility in broad ethanol concentration ranges of 60-95%, while that for carotenoid was somewhat narrower with ethanol concentration range of 85-95%. However, at incubation temperature of $-20^{\circ}C$, solubilities of both carotenoid and zein were lowered, with dramatic reduction being exhibited at aqueous ethanol concentration of 60% for both compounds, while substantial reduction in solubility was shown at 95% ethanol by zein only. Zein was practically insoluble in absolute ethanol, regardless of temperature range tested, while carotenoid remained largely soluble, though there was pronounced decrease in solubility at the subfreezing temperature.

Physical Solubility and Diffusivity of Carbonyl Sulfide in Aqueous Diethanolamine

  • Park, Moon-Ki
    • Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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    • 제4권4호
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    • pp.241-247
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    • 2000
  • This paper reports on an experimental study of the absorption of COS in a secondary amine diethanolamine. The primary objectives were to investigate an analogy between $N_2$O and COS, thereby allowing an estimation of the physical solubility and diffusivity of the sulfur gases in the reacting amine solutions. The solubilities and diffusivities of $N_2$O and COS in 5~25% aqueous polyethylene glycol at $25^{\circ}C$ were measured. The results appeared to verify the use of an $N_2$O-COS analogy for estimating the solubility and diffusivity of COS in aqueous solutions of alkanolamines up to an approximate 25 weight % concentration. The mean deviation of the $N_2$O analogy relative to the measured solubilities was 3.7%, and the mean deviation between the analogy and the measured diffusion coefficients using the experimental values for Hcos/PEG was 14.6%.

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Solubility and density of p-dioxanone in organic solvent systems

  • Lee, Sang-Won;Kim, Sung-Il;Park, So-Jin
    • Journal of the Korean Applied Science and Technology
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    • 제25권4호
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    • pp.429-437
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    • 2008
  • The p-dioxanone can be used to make a variety of commercially useful products particularly where biodegradability is desired, such as fibers, sutures, molded articles, containers, medical devices and surgical clips, film and compostable trash bags. The mole fraction solubility of p-dioxanone in various solvents such as acetone, ethylacetate, tetrahydrofuran, methanol, ethanol, 1-propanol, 1-butanol and 1-pentanol were measured over the temperature range from 263.05 K to 288.45 K. The solubility of p-dioxanone increases with increasing polarity of the solvents.

Water-solubility of β-Glucans in Various Edible Mushrooms - Research Note -

  • Lee, Young-Tack;Kim, Young-Soo
    • Preventive Nutrition and Food Science
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    • 제10권3호
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    • pp.294-297
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    • 2005
  • The amount of $\beta-glucans$ in 12 edible mushroom species was determined and their water-solubility was assessed. A large variability in $\beta-glucans$ content was observed in the mushroom species, ranging from 4.71 to $46.20\%$ on a dry basis. Gyrophora esculenta, Lentinus edodes, Coriolus versicolor, Ganodenna lucidum, and Flammulina velutipes had high levels of $\beta-glucans$ Soluble $\beta-glucans$ content, which plays a key role in the physiological effects of mushrooms, also varied greatly according to the mushroom species, ranging from 2.12 to $19.66\%$. Water-solubility of $\beta-glucans$ in the edible mushrooms, as a percentage of total $\beta-glucans$ content varied from 42.55 to $73.35\%$.