• 대한간호학회지
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• 제40권5호
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• pp.611-619
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• 2010

The purpose of this study was to examine the effects of exercise on muscle weight and Type I and II fiber cross-sectional area of affected and unaffected hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury. Methods: Neuropathic pain was induced by ligation and cutting of the left L5 spinal nerve. Adult male Sprague-Dawley rats were randomly assigned to one of two groups: The Pain+Exercise (PE) group (n=21) and the Sham+Exercise (SE) group (n=20). All rats had 28 sessions of treadmill exercise at grade 10 for 30 minutes, twice/day at 10 m/min for 14 days. Body weight, food intake and activity were measured every day. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles were dissected. Muscle weight and Type I, II fiber cross-sectional area of the dissected muscles were measured. Results: The PE group showed significant increases (p<.05), as compared to the SE group for body weight and total diet intake, muscle weight of the unaffected soleus and plantaris, and in Type I and II fiber cross-sectional area of unaffected three muscles and affected plantaris. Conclusion: Exercise for 14 days attenuates unaffected soleus, plantaris and gastrocnemius muscle atrophy in neuropathic pain model.

• 대한물리의학회지
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• 제2권2호
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• pp.125-134
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• 2007

Purpose : This study is to determine effects of cane-shape which influenced on the change of muscle activation, gait component in hemiplegic patients caused by cerebrovascular accident. Methods : Twenty one stroke patients using T-shape cane(TCG) and twenty one stroke patients using I-shape cane(ICG) participated in this study. Surface electromyography(SEMG) of erector spinae, transvers abdominis, tibialis anterior, soleus of both side were measured during walking without cane and walking with cane. Results : The activation of tibialis anterior was significantly increased in affected side of ICG. The activation of tibialis anterior was significantly decreased in affected side of TCG. The activation of soleus was significantly increased in affected side of ICG. The activation of soleus was significantly decreased in affected side of TCG. The activation of erector spinae was significantly increased in nonaffected side of ICG and TCG. The activation of transvers abdominis was significantly increased in nonaffected side of ICG and TCG. Conclusion : From the finding of this study, it was suggested that I-shape cane increase weight bearing of affected side in hemiplegic patient. Therefore, I-shape cane can be applied to improve gait asymmetry of hemiplegic patients.

• Journal of Korean Biological Nursing Science
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• 제10권1호
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• pp.88-95
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• 2008

Purpose: The purpose of this study was to examine the effect of neuropathic pain by peripheral nerve injury on mass and Type I and II fiber cross-sectional areas on hindlimb muscles of the neuropathic pain model rat. Method: Adult male Sprague-Dawley rats (body weight 200-220 g) were assigned to one of two groups: a neuropathic pain group (n=7) that had a ligation of the left L5 spinal nerve, a control group (n=5), a naive rat without any procedures. Withdrawal threshold, activity, body weight and food intake were measured daily. At 8 days after neuropathic pain, all rats were anesthetized and the soleus and plantaris muscles were dissected from the both hindlimbs. Body weight, food intake, muscle weight and Type I and II fiber cross-sectional area of the dissected muscles were determined. Result: The neuropathic pain group showed a significant decreases (p<.05) as compared with the control rats, in diet intake, body weight, muscle weight and Type II fiber cross-sectional area of the left (affected side) soleus and plantaris muscles, and the right (unaffected side) muscle weight of plantaris and Type II fiber cross-sectional area of the soleus muscle. Conclusion: The hindlimb muscle atrophy occurs in both affected and unaffected side due to neuropathic pain by the peripheral nerve injury. The hindlimb muscle atrophy of the affected side is more pronounced than that of the unaffected side.

• 한국운동역학회지
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• 제17권3호
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• pp.147-154
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• 2007

This study's purpose is to investigate the effects on leg muscle activity caused by perturbation, using a trapdoor system during the support phase of gait for healthy adults (n = 6, height $177.5{\pm}5.5cm$, weight $81.0{\pm}9.5kg$, age $30.0{\pm}3.3yrs$). The trapdoor had the functional ability of causing inversion or eversion. The release time for the trapdoor was specified for two times, 0.3 and 0.5 seconds after heel contact. While altering these variables, EMG was recorded for the leg muscles (rectus femoris, biceps femoris, vastus lateralis, tibialis anterior, gastrocnemius, soleus). The following conclusions were derived. The steptime was longer for the 0.5s eversion than 0.3s inversion condition. So in order to regain stability after the perturbation the unsupporting leg reached forward rapidly. This quick reflex can be observed through the center of pressure (COP) and its rapid change in direction. The gastrocnemius was activated throughout the total experiment. There was a low amount of activity recorded in the rectus femoris, vastus lateralis and tibialis anterior except for the condition of inversion 0.3s. For most of the conditions, the highest average EMG peak values were recorded during the condition of inversion 0.3s. The iEMG patterns were similar for the conditions of inversion 0.3s and eversion 0.3s. To cope with the rapid change in these conditions, the biceps femoris was activated. During the experiment except for the condition of normal gait, the activity of the soleus and gastrocnemius was relatively high. Therefore, to prevent injury from perturbation of the lower leg strengthening of the soleus and gastrocnemius is required. Likewise to prevent injury to the thigh strengthening for the biceps femoris.

• The Journal of Korean Physical Therapy
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• 제23권1호
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• pp.7-11
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• 2011

Purpose: Driving is essential to maintain independent living status in modern times. Many patients want to know when they can drive again, but it's only possible if they have the ability to control lower extremity muscles. In this study, we compared the effects of velocity on onset time of lower extremity muscles during driving tasks. Methods: Twelve participants (5 male, 7 female) were enrolled. EMGs were used to test the onset time of lower extremity muscles; tibialis anterior, soleus, rectus femoris. To analyze the data, we used two way ANOVA. Results: According to brake pedaling velocity, there was a significant difference in brake response time (p<0.05). Further, when comparing the lower extremity muscles, there was a significant difference in onset time (p<0.05). The order of muscle recruitment was tibialis anterior, rectus femoris, and soleus for achieving maximal velocity, but the order was rectus femoris, tibialis anterior, soleus for achieving submaximal velocity. Conclusion: Brake pedaling velocity has significant effects on onset time of muscle contractions in the lower extremities. We suggested that a future study needs more subjects and more detailed research such as evaluat-ions of visuo-motor coordination and fine motor dexterity.

• 한국운동역학회지
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• 제31권2호
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• pp.104-112
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• 2021

Objective: This study aimed to analyze the effects of consecutive whole body vibration through heel raise posture on the center of pressure and electromyography of anterior tibial muscle, lateral gastrocnemius and soleus muscles during single-leg stance. Method: The subjects of this study included 30 healthy males in their 20's, with the following inclusion criteria: no history of orthopaedic medical history, no participation in regular exercises, no history of whole body vibration exercise, and right leg being the dominant leg. The experimental procedure involved pretreatment measurement of eye open single-leg stance, application of whole body vibration for 30 seconds, post-treatment measurement (3 measurements in total). Static and dynamic movements have been measured over 2 separate experiments, with 72 hours gap between the experiments. Static movement involved maintaining single-leg heel raise posture for 30 seconds while applying whole body vibration, and dynamic movement involved heel raise (15 repetitions over 30 seconds) while applying whole body vibration. The strength of applied whole body vibration was 35 Hz frequency and 2~4 mm amplitude. Results: As the single-leg posture after static heel raise posture, mediolateral velocity of the center of pressure at post 2 and post 3 were significantly reduced compared to the pre-treatment measurement. In addition, the percentage for reference voluntary contraction in anterior tibial muscle and soleus and median frequency at anterior tibial muscle and lateral gastrocnemius muscle at post 3 were significantly decreased compared to the pre-treatment value. As the single-leg posture after dynamic heel raise posture, the mediolateral 95% edge frequency of the center of pressure and median frequency at anterior tibial muscle, lateral gastrocnemius muscle, and soleus muscle at post 3 were significantly reduced compared to the pre-treatment value. Conclusion: Acute whole body vibration via static and dynamic heel raise posture have positive effect on mediolateral posture control during single-leg stance.

• 대한물리의학회지
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• 제18권1호
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• pp.1-8
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• 2023

PURPOSE: This study analyzed how proprioceptive neuromuscular facilitation (PNF) combined with auricular acupuncture affected the activation of the leg muscles of stroke patients and measured the effects of this combination to provide clinical data. METHODS: The subjects were divided randomly into experimental group I, which received PNF combined with auricular acupuncture, and experimental group II, which received PNF alone. Each group had ten members. A 30-minute intervention was performed four days a week for six weeks. Before the six weeks of intervention, pre-tests were conducted to measure muscle activation in the legs. After six weeks, post-tests were also conducted to measure muscle activation in the legs. RESULTS: Experimental group I showed a statistically significant difference in muscle rectus femoris, muscle biceps femoris, muscle tibialis anterior, and muscle soleus. Experimental group II also showed a statistically significant difference in the muscle rectus femoris, muscle biceps femoris, muscle tibialis anterior, and muscle soleus (p < .05). In a between-group comparison of the changes, a statistically significant difference was observed between the two groups in terms of muscle rectus femoris, muscle biceps femoris, muscle tibialis anterior, and muscle soleus (p < .05). CONCLUSION: Intervention in experimental group I increased the activation of the leg muscles more effectively because auricular acupuncture was applied to various spots on the ear corresponding to the spleen, liver, kidney, pelvis, knee, ankle, and toe. Auricular acupuncture is expected to be used more widely in the future because it is a safe way of stimulating muscle activation.

• 생명과학회지
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• 제20권4호
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• pp.572-577
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• 2010

본 연구에서 60 주령된 쥐를 대상으로 8 주간 트레드밀 운동강도와 근섬유 유형에 따른 apoptosis 관련 인자를 연구하였다. 결론적으로 노후된 쥐의 apoptosis 관련 인자는 운동강도와 근육유형에 따라 차이가 났다. EDL이 Soleus보다 apoptosis인자의 변화가 운동강도에 의해 더 민감하게 나타났다. 또한 casepase-3의 발현은 고강도 운동에서 나타났으나 DNA 절편화는 나타나지 않았기에 실질적인 apoptosis는 발생되지 않았다. 이는 노후된 개체의 운동 수행방법으로 고강도 운동은 적합하지 않으며, 고강도 운동상태를 지속할 경우 근섬유의 apoptosis를 유도할 가능성이 있다는 것을 시사한다. 그러므로 추후 실험에서는 운동시간과 빈도에 의한 apoptosis의 time-course impact 관찰과 외재적 경로(caspase independent apoptosis)에서의 apoptosis 관련 단백질 변화에 대한 연구를 통하여 노화에 의한 근손실의 원인 규명이 요구된다.

• 생명과학회지
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• 제21권11호
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• pp.1532-1540
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• 2011

본 연구는 7주령의 S D계 흰쥐를 이용하여 12주 동안의 사다리 오르기 저항성 운동 수행 후 가자미근과 비복근 내 GLUT-4 발현량 및 LDH 동위효소들의 변화를 측정하여 당 대사 및 젖산 기전에 대한 연구로 다음과 같은 결론을 얻었다. 12주간의 사다리 오르기 저항성 운동은 체중감소에 효과적인 것으로 나타났으며, 가자미근 및 비복근 조직 GLUT-4 단백질 발현을 유의하게 증가시키는 것으로 나타났다. 또한 가자미근 및 비복근 조직 LDHA B-type 동위효소의 발현을 유의하게 증가시키는 것으로 나타났다. 본 연구의 결과를 종합해 볼 때 12주간의 저항성훈련은 체중의 감소와 골격근 내 GLUT-4의 증가 그리고 LDH A4 동위효소를 제외한 LDH B-type 동위 효소의 증가와 같은 신체조성의 균형과 당대사능력 및 미토콘드리아의 기능 개선에 영향을 미치는 것으로 사료된다. 추후 연구에서는 휴식시간이나 운동 강도의 차이와 근형태별에 따른 유 무산소적 저항훈련 프로그램의 효과에 따른 다양한 연구가 실시되어야 할 것으로 생각된다.

• Journal of Nutrition and Health
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• 제44권5호
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• pp.355-365
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• 2011

본 연구는 지방의 종류와 함량이 다른 식이의 섭취가 하지 고정 흰 쥐의 근육 내 화학 조성, PPAR${\delta}$ 및 관련 효소의 발현에 미치는 영향을 근육 종류에 따라 알아 보기 위해 수행되었다. 연구결과를 요약하면 다음과 같다. 1) 10일 간의 하지고정과 식이 중재에 의해 실험동물의 체중, 식이섭취량 및 혈청 지방산에는 유의적인 차이가 없었다. 2) 10일 간의 하지고정에 따라 근육 양은 하지 근육 종류에 따라, 각각 soleus 에서 약 57%, plantaris에서 약 39% 그리고 gastrocnemius에서 약 38%로 달리 감소되었다 (p < 0.01). 특히 soleus에서 가장 많은 감소 현상을 보였다. 이러한 감소 경향은 식이 지방의 종류 및 함량에 영향을 받지 않았다. 3) 10일 간의 하지고정에 따라 근육 내 조성 변화의 경우, gastrocnemius에서 분석한 근육 총 단백질량은 정상 다리(contralateral)와 비교하여 하지고정에 따라 유의적으로 감소 (CO, 41%; FO, 40%; HCO, 37%; HBT, 38%)하였다. Plantaris, gastrocnemius에서 분석한 근육 내 중성지방량의 경우에도, 정상다리와 비교하여 하지고정에 따라 plantaris(CO, 39%; FO, 27%; HCO, 38%; HBT, 35%)와 gastrocnemius(CO, 38%; FO, 34%; HCO, 33%; HBT, 34%) 모두에서 유의적으로 감소하였다. 그러나, 근 단백질량과 중성지방량의 감소 현상은 모두 식이군 간의 차이는 나타나지 않았다. 4) PPAR${\delta}$ 단백질은 하지고정에 의해 plantaris에서는 유의적으로 증가 (p < 0.05)하였고, gastrocnemius, soleus에서는 증가하는 경향을 나타내었다. PPAR${\delta}$ 단백질과는 반대로 PPAR${\delta}$ mRNA는 하지고정에 의해 plantaris에서는 유의적으로 감소 하였고, soleus에서는 FO군만 PPAR${\delta}$ mRNA 발현 양이 유의적으로 감소하였다. PPAR${\alpha}$의 경우 하지고정에 따라 두 근육에서 모두 영향을 받지 않았다. mCPT1 mRNA는 하지고정에 따라 soleus와 plantaris 모두에서 변화가 없었지만, PDK4 mRNA는 하지고정에 따라 plantaris에서 유의적으로 감소하였고, 반대로 soleus에서는 유의적으로 증가하였다. 5) PPAR${\delta}$ 단백질은 세 근육의 FO군에서 모두 크게 증가하는 경향을 보였지만, 식이에 따른 유의적인 차이를 보이지는 않았다. PPAR${\delta}$ mRNA의 경우, plantaris의 CO군과 비교해 FO군에서 mRNA 발현이 유의적으로 낮은 수준이었고, 다른 군에서는 유의적인 차이가 없었다. Soleus의 PPAR${\delta}$ mRNA는 CO군과 비교해 FO, HCO 그리고 HBT군 모두에서 발현 양이 유의적으로 낮은 수준을 보였다. 반면, PPAR${\alpha}$의 mRNA 발현은 두 근육에서 모두 식이에 의한 영향을 받지 않았다. mCPT1 mRNA 발현의 경우, plantaris에서는 CO군과 비교해 FO군에서 발현 양이 유의적으로 낮은 수준을 보였지만, 고지방 식이 군에서는 유의적인 차이가 없었다. 반대로, soleus에서는 CO군과 비교해 FO군에서 발현이 유의적으로 높은 수준을 보였지만, 고지방 식이 군에서는 CO군과 비교해 유의적인 차이는 없었다. PDK4 mRNA의 경우, plantaris에서는 CO군과 비교해 FO군의 mRNA 발현 양이 유의적으로 높은 수준을 보였다. 고지방 식이 군에서는 CO군과 비교해 발현 양의 유의적인 차이가 없었다. 한편, soleus에서는 FO군에서 발현이 낮은 경향을 보였을 뿐, 식이에 따른 mRNA 발현에는 모든 군에서 유의적인 차이가 없었다. 본 연구에서는 10일간의 하지고정에 의해서 모든 근육에서 유의적인 근 위축이 유발되었고, 이에 따라 근육 양의 감소와 함께 근육 총 단백질의 유의적인 감소가 나타났다. 하지만 근육 총 단백질과 중성지방의 유의적인 감소에도 불구하고, 하지고정에 의한 근육 내 중성지방 축적은 일어나지 않았다. 이는 하지고정에 의해 모든 근육에서 증가된 PPAR${\delta}$ 단백질이 하지고정 초기에 근육 내 중성지방의 축적을 억제했을 것으로 사료된다. 결론적으로, 하지고정에 따른 근 위축에 의해 근육 내 지질대사를 조절하는 PPAR${\delta}$의 mRNA 발현은 감소하였지만, ${\omega}$-3 PUFA를 함유한 어유 식이는 PPAR${\delta}$ 단백질 및 관련 효소의 발현 수준과 활성에 근 섬유별특성에 따라 긍정적인 영향을 줌으로써 근육 내 지질축적을 비롯한 근위축의 경감에 도움을 줄 수 있다는 가능성을 제시하였다.