• Journal of Microbiology and Biotechnology
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• v.17 no.1
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• pp.154-161
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• 2007

Human immunodeficiency virus type 1 (HIV-1) infections are responsible for a substantial number of deaths annually and represent a significant threat to public health. According to the latest study, the Tat (Transactivator of transcription) protein is essential in transcription and replication of viral genes, and is among the early expression genes involved in the life cycle of HIV. The virion NC (nucleocapsid) plays an important role in early mRNA expression and contributes to the rapid viral replication that occurs during HIV-1 infection. Therefore, we attempted to elucidate the relationship between the Tat protein and nucleocapsid protein. In a comparison of two independently prepared and hybridized samples, flag NC overexpressed HEK 293T cells and pTat overexpressed HEK 293T cells, and hybridization showed the differences in expression in each case. Among the microarray results confirmed with real-time reverse transcriptase assay, twelve genes were identified to be involved according to their gene expression profiles. Of approximately 8,208 human genes that were analyzed, we monitored candidate genes that might have been related to NC and Tat genes from gene expression profiles. Additionally, the pathways could be viewed and analyzed through the use of Pathway Studio software. The pathways from the gene list were built and paths were found among the molecules/cell objects/processes by the curation method.

• Journal of the Korea Convergence Society
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• v.9 no.6
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• pp.357-364
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• 2018

This study was attempted to develop education programs through mobile apps to promote breastfeeding for high-risk mothers. The development of mobile apps was carried out in four stages, including analysis, design, implementation and evaluation, by referring to the software development life cycle. The subjects of this study were cesarean delivery mother, premature baby and twin delivery mother, and contents of education included difficulty in breastfeeding by high risk mother. Experts and users evaluated the program and found it appropriate as an educational mobile app. The education through mobile app is not limited by time and space. Therefore, it will help knowledge and continuous practice of breastfeeding by high risk mothers. It is necessary to directly test the effects of applying the breastfeeding app developed in this study.

• KIPS Transactions on Software and Data Engineering
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• v.3 no.7
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• pp.263-270
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• 2014

This paper suggests a method for predicting a box-office success of the film. Lately, as the growth of the film industry, a variety of studies for the prediction of market demand is being performed. The product life cycle of film is relatively short cultural goods. Therefore, in order to produce stable profits, marketing costs before opening as well as the number of screen after opening need a plan. To fulfill this plan, the demand for the product and the calculation of economic profit scale should be preceded. The cases of existing researches, as a variable for predicting, primarily use the factors of competition of the market or the properties of the film. However, the proportion of the potential audiences who purchase the goods is relatively insufficient. Therefore, in this paper, in order to consider people's perception of a movie, Twitter was utilized as one of the survey samples. The existing variables and the information extracted from Twitter are defined as off-line and on-line element, and applied those two elements in machine learning by combining. Through the experiment, the proposed predictive techniques are validated, and the results of the experiment predicted the chance of successful film with about 95% of accuracy.

• Journal of KIISE:Computing Practices and Letters
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• v.7 no.1
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• pp.38-47
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• 2001

PDM is an integrated solution for managing various kinds of document and information for a whole life~cycle of product management. PDM system spans a huge and complex area and requires so many efforts and budgets for development. A framework has been considered a promising way to improve productivity by reusing the software architecture, not just one part of the design or just source code. This was the reaSon why we developed PDM (Product Data Management) framework. Framework can reduce the time and efforts to develop a new PDM application. However, it also requires supporting environment since a framework is a big set of classes where their interactions are so complex. With this supporting environment, it is easy to understand the framework at a glance and easy to identify what hot spots to be refined to meet new requirements. In this paper, a new framework-supporting reuse environment based on the meta-repository was constructed for easy and convenient reuse.

• Korean Journal of Environmental Biology
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• v.30 no.2
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• pp.77-89
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• 2012

With the advent of the genomics era powered by DNA sequencing technologies, life science is being transformed significantly and biological research and development have been accelerated. Environmental biology concerns the relationships among living organisms and their natural environment, which constitute the global biogeochemical cycle. As sustainability of the ecosystems depends on biodiversity, examining the structure and dynamics of the biotic constituents and fully grasping their genetic and metabolic capabilities are pivotal. The high-speed high-throughput next-generation sequencing can be applied to barcoding organisms either thriving or endangered and to decoding the whole genome information. Furthermore, diversity and the full gene complement of a microbial community can be elucidated and monitored through metagenomic approaches. With regard to human welfare, microbiomes of various human habitats such as gut, skin, mouth, stomach, and vagina, have been and are being scrutinized. To keep pace with the rapid increase of the sequencing capacity, various bioinformatic algorithms and software tools that even utilize supercomputers and cloud computing are being developed for processing and storage of massive data sets. Environmental genomics will be the major force in understanding the structure and function of ecosystems in nature as well as preserving, remediating, and bioprospecting them.

• Korean Journal of Organic Agriculture
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• v.20 no.4
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• pp.475-490
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• 2012

Since 1997, Korean Ministry of Knowledge Economy and Ministry of Environment have established data on some 400 basic raw and subsidiary materials and process like energy, petro-chemical, steel, cement, glass, paper, construction materials, transportation, recycling and disposal etc by initiating establishment of LCI database. Regarding agriculture, Rural Development Administration has conducted establishment of LCI database for major farm products like rice, barley, beans, cabbage and radish etc from 2009, and released that they would establish LCI database for 50 items until 2020 later on. The domestic LCI database for seeds, seedling, agrochemical, inorganic, fertilizer and organic fertilizer etc is only at initial stage of establishment, so overseas LCI databases are brought and being used. However, since the domestic and overseas natural environments differ, they fall behind in reliability. Therefore, this study has the purpose to select organic farming materials, survey the production process for various types of organic farming materials and establish LCI database for the effects of greenhouse gas emitted by each crop during the process. As for selecting methods, in this study organic farming materials were selected in the method of direct observation of material and bottom-up method a survey method with focus on the organic farming materials admitted into rice production. For the basic unit of carbon emission amount by the production of 1kg of organic farming material, the software PASS 4.1.1 developed by Korea Accreditation Board under Ministry of Knowledge Economy was used. The study had the goal to ultimately provide basic unit to calculate carbon emission amount in executing many institutions like goal management system and carbon performance display system etc in agricultural sector to be conducted later on. As a result, emission basic units per 1kg of production were calculated to be 0.04968kg-$CO_2$ for oystershells, 0.004692kg-$CO_2$ for expanded rice hull, and 1.029kg-$CO_2$ for bordeaux mixture liquid.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.6
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• pp.657-668
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• 2002

Software life cycle consists of requirement analysis, design, implementation, and maintenance phases, and the product of each phase has various format. The UML normalizes such products, and the class diagram, use case diagram, activity diagram and collaboration diagram are usually used for the requirement analysis phase. Because most of UML development tools store such diagrams in a file, there nay be some difficulties of information retrieval and co-work among users. To cope with the difficulties, this paper proposes a database supported methodology to store and manage the diagrams produced by the requirement analysis. In this methodology, the constituents of class, use case, activity and collaboration diagram are first analyzed and then transformed in the form of relational fables. The constituents of such diagrams are stored as tables in a database, and can be easily retrieved from the database by using some queries. This database supported methodology provides the concurrent sharing and high reuse of diagrams.

• Journal of Information Processing Systems
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• v.15 no.6
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• pp.1472-1488
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• 2019

Critical elements in the China's Lunar Exploration reside in that the lunar rover travels over the surrounding undetermined environment and it conducts scientific exploration under the ground control via teleoperation system. Such an interplanetary transportation mission teleoperation system belongs to the ground application system in deep space mission, which performs terrain reconstruction, visual positioning, path planning, and rover motion control by receiving telemetry data. It plays a vital role in the whole lunar exploration operation and its so-called trustworthy evidence must be assessed before and during its implementation. Taking ISO standards and China's national military standards as trustworthy evidence source, the net assessment model and net assessment method of teleoperation system are established in this paper. The multi-dimensional net assessment model covering the life cycle of software is defined by extracting the trustworthy evidences from trustworthy evidence source. The qualitative decisions are converted to quantitative weights through the net assessment method (NAM) combined with fuzzy analytic hierarchy process (FAHP) and entropy weight method (EWM) to determine the weight of the evidence elements in the net assessment model. The paper employs the teleoperation system for interplanetary transportation as a case study. The experimental result drawn shows the validity and rationality of net assessment model and method. In the final part of this paper, the untrustworthy elements of the teleoperation system are discovered and an improvement scheme is established upon the "net result". The work completed in this paper has been applied in the development of the teleoperation system of China's Chang'e-3 (CE-3) "Jade Rabbit-1" and Chang'e-4 (CE-4) "Jade Rabbit-2" rover successfully. Besides, it will be implemented in China's Chang'e-5 (CE-5) mission in 2019. What's more, it will be promoted in the Mars exploration mission in 2020. Therefore it is valuable to the development process improvement of aerospace information system.

• Journal of the Korea Convergence Society
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• v.8 no.6
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• pp.17-27
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• 2017

Recently, as cyber attacks have been activated, many such attacks have come into contact with various media. Research on security engineering and reverse engineering is active, but there is a lack of research that integrates them and applies attack systems through cost effective attack engineering. In this paper, security - enhanced information systems are developed by security engineering and reverse engineering is used to identify vulnerabilities. Using this vulnerability, we compare and analyze lifecycle models that construct or remodel attack system through attack engineering, and specify structure and behavior of each system, and propose more effective modeling. In addition, we extend the existing models and tools to propose graphical attack specification models that specify attack methods and scenarios in terms of models such as functional, static, and dynamic.

• Korean Chemical Engineering Research
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• v.44 no.6
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• pp.579-587
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• 2006

Recently, each country has been trying to promote Eco-Industrial Park (EIP) development for industrial sustainability. Technological modeling is required to realize EIP practically even though the project contains the political concerns for many companies, government, and self-governing bodies. The four main technologies of the EIP developments include energy exchange, material flow analysis, water pinch, and life cycle assessment. Material flow analysis (MFA) methodology can be utilized in EIP modeling in view of the fact that the analysis of material flows and the optimized modeling are major purposes for the technological modeling of EIP. Through MFA methodology in POHANG EIP project, how to apply MFA modeling to EIP modeling and how to utilize software for MFA modeling are shown in this research.