• 한국컴퓨터정보학회논문지
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• 제29권3호
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• pp.191-198
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• 2024

한국은 해상 운송에 의존하는 수출입 중심 경제 국가이며, 항만은 국가 경제 성장에 중요한 역할을 수행한다. 이러한 항만의 경쟁력을 확보하고 유지하기 위해서는 하드웨어와 소프트웨어적인 투자가 필요하지만, 정책적인 지원으로도 효과를 기대할 수 있다. 본 연구는 에너지 허브 항만인 울산항을 대상으로 항만시설 사용료 감면제도를 탐색적으로 분석하여 제도의 불합리성을 식별하고 이를 해소하기 위한 개선 방안을 제언하였다. 본 연구는 약 10년간의 울산항 물동량과 항만시설사용료 감면에 대하여 분석하였으며, 액체화물 특화 항만임에도 불구하고 컨테이너 화물에 대한 감면지원이 편중되어 있고 심지어는 통과선박이라는 사유로 이들에게 입출항료 100% 감면지원하고 있었으며 이것은 심각한 도덕적 해이를 초래할 수 있다는 점을 감면제도의 불합리 요소들로 식별하였다. 본 연구는 울산항의 항만시설 사용료 감면제도 개선 방안으로 컨테이너에 대한 지원을 친환경 활동 지원 강화, 외항통과선박에 대한 감면 요율 조정 또는 감면신청 절차 개선을 제안하였다.

• 공업화학
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• 제30권5호
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• pp.556-561
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• 2019

본 연구에서는 석유 부산물인 열분해잔사유의 화재, 폭발특성을 파악하기 위하여 그 물리 화학적 분석을 실시하고 주요 성분을 선정하였다. GC-SIMDIS 및 MALDI-TOF 분석을 통해 열분해잔사유의 주요 성분 분포영역을 확인하였으며, GC-MS 분석을 통해 주요 성분 분포영역에 대한 정성분석을 실시하였다. 아울러 EA, SARA, TGA 등 다양한 분석결과를 바탕으로 열분해잔사유의 주요 성분을 선정하였다. 그 결과 benzene, toluene, xylene을 주요 성분을 선정하여 PHAST 분석을 통한 화재 폭발 시 최대 피해영향범위를 고찰하였다. Toluene은 제트 화재 발생 시 $227kW/m^2$의 복사열 및 118 m의 영향범위를 나타내어 가장 높은 위험성을 보였으며, xylene과 benzene은 각각 114와 $151kW/m^2$의 최대 복사열 수치를 나타내었다, 또한, pasquill 안정도 및 풍속에 따른 피해영향범위를 분석한 결과 benzene에서 풍속에 따라 최대 55% 이상의 복사열이 증가함을 확인하였으며, 이는 영향범위를 증가시키는 주요인자인 것으로 여겨졌다.

• 한국도로학회논문집
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• 제20권1호
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• pp.35-45
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• 2018

PURPOSES : This study examines the performance changes of road networks according to the strength of a disaster, and proposes a method for estimating the quantitative resilience according to the road-network performance changes and damage scale. This study also selected high-influence road sections, according to disasters targeting the road network, and aimed to analyze their hazard resilience from the network aspect through a scenario analysis of the damage recovery after a disaster occurred. METHODS : The analysis was conducted targeting Sejong City in South Korea. The disaster situation was set up using the TransCAD and VISSIM traffic-simulation software. First, the study analyzed how road-network damage changed the user's travel pattern and travel time, and how it affected the complete network. Secondly, the functional aspects of the road networks were analyzed using quantitative resilience. Finally, based on the road-network performance change and resilience, priority-management road sections were selected. RESULTS : According to the analysis results, when a road section has relatively low connectivity and low traffic, its effect on the complete network is insignificant. Moreover, certain road sections with relatively high importance can suffer a performance loss from major damage, for e.g., sections where bridges, tunnels, or underground roads are located, roads where no bypasses exist or they exist far from the concerned road, including entrances and exits to suburban areas. Relatively important roads have the potential to significantly degrade the network performance when a disaster occurs. Because of the high risk of delays or isolation, they may lead to secondary damage. Thus, it is necessary to manage the roads to maintain their performance. CONCLUSIONS : As a baseline study to establish measures for traffic prevention, this study considered the performance of a road network, selected high-influence road sections within the road network, and analyzed the quantitative resilience of the road network according to scenarios. The road users' passage-pattern changes were analyzed through simulation analysis using the User Equilibrium model. Based on the analysis results, the resilience in each scenario was examined and compared. Sections where a road's performance loss had a significant influence on the network were targeted. The study results were judged to become basic research data for establishing response plans to restore the original functions and performance of the destroyed and damage road networks, and for selecting maintenance priorities.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3607-3612
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• 2013

Introduction: Reported prognostic roles of hypoxic inducible factor (HIF) expression in non-small cell lung cancer (NSCLC) have varied. This meta-analysis aimed to examine the relationship between HIF expression and clinical outcome in NSCLC patients. Methods: PubMed were used to identify relevant literature with the last report up to December $20^{th}$, 2012. After careful review, survival data were collected from eligible studies. We completed the meta-analysis using Stata statistical software (Version 11) and combined hazard ratio (HR) for overall survival (OS). Subgroup specificity, heterogeneity and publication bias were also assessed. All of the results were verified by two persons to ensure accuracy. Results: Eight studies were finally stepped into this meta-analysis in which seven had available data for HIF-$1{\alpha}$ and three for HIF-$2{\alpha}$. Combined HRs suggested that higher expression of $HIF1{\alpha}$ had a negative impact on NSCLC patient survival (HR=1.50; 95%CI=1.07-2.10; p=0.019). The expression of HIF-$2{\alpha}$ was also relative to a poorer survival (HR=2.02; 95%CI=1.47-2.77; p=0.000). No bias existed in either of the two groups. Conclusion: This study suggests that elevations of HIF-$1{\alpha}$ and HIF-$2{\alpha}$ expression are both associated with poor outcome for patients with NSCLC. The data support further and high quality investigation of HIF expression for predicting poor outcome in patients with NSCLC.

• 한국임상약학회지
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• 제30권1호
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• pp.1-10
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• 2020

Objective: The aim of the study was to perform a meta-analysis of randomized clinical trials to compare the clinical efficacy and safety between combination of cyclin-dependent kinase (CDK) 4/6 inhibitors with aromatase inhibitors (AIs) and AIs alone in patients with hormone receptor+/human epidermal growth factor receptor type2-(HR+/HER2-) advanced breast cancer. Methods: Published clinical studies were identified through electronic database searches until February 2019. Literature qualities were assessed by the Scottish Intercollegiate Guidelines Network Checklist. Key endpoints of efficacy were progression-free survival (PFS), objective response rate (ORR), and clinical benefit (CB). Endpoints of safety were adverse events (AEs) (neutropenia, leukopenia, any grade 3/4 AEs, and serious AEs) and on-treatment death. Meta-analysis was performed using the RevMan 5.3 software. Results: The selected five studies were evaluated as "good" in quality assessment. Compared to AIs alone, the combination therapy significantly improved PFS (pooled hazard ratio=0.55; 95% confidence interval (CI) 0.49-0.62), ORR (odds ratio=1.78; 95% CI=1.49-2.13), and CB (odds ratio=1.86; 95% CI=1.51-2.28). The prevalence of AEs was significantly higher in the combination group than in the AIs alone group. On-treatment death was greater in the combination group than in the AIs alone group, although insignificant. Conclusion: The combination therapy of CDK4/6 inhibitors with AIs was more effective for the treatment of HR+/HER2- advanced breast cancer, but less safe than AIs alone. The combination therapy should be effectively managed through patient monitoring, and further studies are needed to reduce AEs in the combination therapy of CDK4/6 inhibitors with AIs.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6761-6766
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• 2014

Background: CD44v6 (CD44 variant exon 6) is the chief CD44 variant isoform regulating tumor invasion, progression, and metastasis. The prognostic value of CD44v6 expression in non small cell lung cancer (NSCLC) has been evaluated in many studies, but the results have remained controversial. Thus, we performed a meta-analysis of currently available studies to investigate the prognostic value of CD44v6 expression in NSCLC patients and the relationship between the expression of CD44v6 and clinicopathological features. Materials and Methods: Two independent reviewers searched the relevant literature in Pubmed, Medline and Embase from 1946 to January 2014. Overall survival (OS) and various clinicopathological features were collected from included studies. This meta-analysis was accomplished using STATA 12.0 and Revman 5.2 software. Pooled hazard ratios (HRs) with 95% confidence intervals (95%CIs) were calculated to estimate the effects. Results: A total of 921 NSCLC patients from ten studies met the inclusion criteria. The results showed that CD44v6 high expression was a prognostic factor for poor survival (HR=1.91, 95%CI=1.12-3.26, p<0.05). With respect to clinicopathological features, CD44v6 high expression was related to histopathologic type (squamous cell carcinoma versus adenocarcinoma: OR=2.72, 95%CI=1.38-5.38, p=0.004), and lymph node metastasis (OR=3.02, 95%CI=1.93-4.72, p<0.00001). Conclusions: Our results suggested CD44v6 high expression as a poor prognostic factor for NSCLC, and CD44v6 expression is associated with lymph node metastasis and histopathologic type. Therefore, CD44v6 expression can be used as a novel prognostic marker in NSCLC cases.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6715-6719
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• 2013

Objective: To explore the incidence, clinical characteristics, diagnosis and treatment strategies, prognosis of patients with malignancy-associated hypercalcemia (MAH). Methods: The data of 115 patients with MAH who were treated at the Medical Oncology Department of Chinese PLA General Hospital from Jan., 2001 to Dec., 2010 was retrospectively reviewed. Survival analysis was performed using the Kaplan-Meier method and the Cox proportional hazard model with statistic software SPSS 18.0. Results: The patients had blood calcium levels ranging from 2.77 to 4.87 mmol/L. Except for 9 cases who died or were discharged within 5 days after admission, all other patients recovered to normal blood calcium level after treatment with bisphosphonates or intravenous hydration and diuretics; their survival after occurrence of MAH was from 1 day to 4,051 days, and the median survival time was only 50 days. In the log-rank test, the male, renal metastasis, central nervous system symptoms and hypercalcemia occurring over 140 days after cancer diagnosis were predictors of poor survival (P=0.002, P=0.046, P=0.000, P=0.009). In the COX analysis, being male, central nervous system symptoms and hypercalcemia lasting over 140 days after cancer diagnosis were independent prognostic factors for survival time (RR=2.131, P=0.027; RR=3.054, P=0.002; RR=2.403, P=0.001). According to these factors, a score system was established to predict the patient prognosis and adjust the treatment. Conclusion: Cancer patients with MAH have an extremely poor median survival. Some independent factors indicate poor prognosis, including male gender, central nervous system symptoms and hypercalcemia lasting over 140 days after cancer diagnosis. The prognostic score can serve as a reference for MAH prognosis and treatment, worthy of further investigation.

• 한국융합학회논문지
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• 제11권9호
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• pp.1-6
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• 2020

본 연구에서는 도로 위험 탐지를 위한 데이터 편향성 최적화 기반 연관 추론 모델을 제안한다. 이는 사용자의 개인적 특성과 주변 환경 데이터를 수집하고 교통사고 방지 서비스를 제공하기 위한 연관분석 기반의 마이닝 모델이다. 이는 다양한 상황 변수들로 구성된 트랜잭션 데이터를 생성한다. 생성된 정보를 바탕으로 연관 패턴 분석을 통해 각 트랜잭션 내 변수들의 유의미한 연관관계를 도출한다. 분류된 범주형 데이터의 편향성을 고려하여 최적화된 지지도 및 신뢰도 값으로 가지치기를 진행한다. 추출된 상위 연관규칙을 바탕으로 사용자에게 개인 특성과 주행 도로 상황에 대한 위험 탐지모델을 제공한다. 이는 데이터 편향성 문제를 극복하고 데이터간 연관성을 고려하여 잠재적인 도로 사고를 예방하는 교통 서비스가 가능하다. 성능 평가는 제안하는 방법이 정확도에서 0.778, Kappa 계수에서 0.743로 우수하게 평가된다.

• 한국산림과학회지
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• 제108권4호
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• pp.469-483
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• 2019

북한은 1970년대부터 이어진 산림황폐화로 인해 매년 홍수와 산지토사재해가 발생하고 있다. 북한의 산지토사재해 피해저감과 통일 이후의 국토관리를 위해서는 북한 내 산림복구와 사방사업 관련 기술 및 동향을 파악하는 것이 무엇보다 우선적이다. 이 연구에서는 북한에서 발행된 사방공학 관련 논문 146편을 분석대상으로 하였으며, 문헌학적 특성과 논문의 통계적 분석을 실시하였다. 이후 VOSviewer 프로그램을 이용하여 연구영역을 구분하였으며, 이상의 연구결과를 토대로 시간적 변화에 따라 연구동향을 파악하였다. 그 결과, 1990년대부터 관련 논문이 꾸준히 증가하였다. 관련 연구주제는 (i) 토양침식 및 유실, 산지토사재해 위험지 평가, (ii) 산림의 수리·수문학적 이해, (iii) 사방구조물의 합리적인 시공, (iv) 사방사업 효과 및 관리방안으로 구분되었다. 특히, 김일성 집권시기에는 (ii) 산림의 수리·수문학적 이해에 관한 연구영역의 점유비율이 높았으나, 김정일과 김정은 집권시기에는 (i) 토양침식 및 유실, 산지토사재해 위험지 평가에 관한 연구영역의 점유비율이 증가하였다. 이러한 결과를 통해 사방공학에 대한 북한의 관심과 필요성이 꾸준히 증가하고 있는 것을 유추할 수 있었다. 이 연구의 결과가 북한의 사방공학 분야를 올바르게 이해하는 기초자료로써 본격적인 남북 산림협력을 대비하기 위한 발판이 될 수 있을 것으로 판단된다.

• 한국안전학회지
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• 제32권5호
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• pp.168-178
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• 2017

In order to prevent major and chemical accidents, some of the plants which would like to install and operate hazard chemicals handling facilities must submit Off-site Consequence Analysis due to recent arisen leak accidents since 2015. A lot of chemical industrials choose gas detectors as mitigation equipment to early detect gas vapor. The way of placement of gas detectors has two methods; Code-based Design(CBD) and Performance-based Design. The CBD has principles for gas detectors to be installed with consideration for the place that is expected to accumulate gas, and the leak locations according to legal standards and technical guidelines, and has a possibility to be unable to detect by these rules to locate gas detectors by vapor density information. The PBD has two methods; a Geographic Method and Scenario based Method. The Scenario-based Method has been suggested to make up for the Geographic Coverage Method. This Scenario-based Method draw the best optimum placement of gas detectors by considering leak locations, leak speed information, leak directions and etc. However, the domestic placement guidelines just refers to the CBD. Therefore, this study is to compare existing placement location of gas detectors by the domestic CBD with placement locations, coverages and the number of gas detectors in accordance with the Scenario-based Method. Also this study has measures for early detecting interest of Vapor Cloud and suitable placement of gas detectors to prevent chemical accidents. The Phast software was selected to simulate vapor cloud dispersion to predict the consequence. There are two cases; an accident hole size of leak(8 mm) from API which is the highst accident hole size less than 24.5 mm, and a normal leak hole size from KOSHA Guide (1.8 mm). Detect3D was also selected to locate gas detectors efficiently and compare CBD results and PBD results. Currently, domestic methods of gas detectors do not consider any risk, but just depend on domestic code methods which lead to placement of gas detectors not to make personnels recognize tolerable or intolerable risks. The results of the Scenario-based Method, however, analyze the leak estimated range by simulating leak dispersion, and then it is able to tell tolerable risks. Thus it is considered that individuals will be able to place gas detectors reasonably by making objectives and roles flexibly according to situations in a specific plant.