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Valproic Acid-Induced Hyperammonemic Encephalopathy as a Cause of Neurologic Deterioration after Unruptured Aneurysm Surgery

  • Lee, Sangkook;Cheong, Jinhwan;Kim, Choonghyun;Kim, Jae Min
    • Journal of Korean Neurosurgical Society
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    • v.58 no.2
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    • pp.159-162
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    • 2015
  • Neurological deficits after brain surgery are not uncommon, and correct and prompt differential diagnosis is essential to initiate appropriate treatment. We describe a patient suffering from loss of consciousness due to hyperammonemia, following valproic acid treatment after surgery for an unruptured cerebral aneurysm. A 57-year-old female patient underwent successful aneurysmal neck clipping to correct an unruptured aneurysm. Her postoperative course was good, and she received anti-epileptic therapy (valproic acid) and a soft diet. Within a few days the patient experienced mental deterioration. Her serum valproic acid reached toxic levels (149.40 mg/L), and serum ammonia was fifteen times the upper normal limit (553 mmol/L; normal range, 9-33 mmol/L). After discontinuation of valproic acid and with conservative treatment, the patient recovered without any complications. Valproate-induced hyperammonemic encephalopathy is an unusual but serious neurosurgical complication, and should not be disregarded as a possible cause of neurological deficits after neurovascular surgery. Early diagnosis is crucial, as discontinuation of valproic acid therapy can prevent serious complications, including death.

A Bibliographical Study on Namul of Koryo and Chosun Dynasty (고려와 조선시대의 문헌으로 본 한국의 나물)

  • 강은주
    • The Korean Journal of Food And Nutrition
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    • v.6 no.1
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    • pp.16-24
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    • 1993
  • The "Namul" is a Korean common vegetable food composed of edible young leaves and soft stalks of wild plants or cultivating vegetables and treated with traditional condiments. It has been widely used as not only a regular diet but seasonal foods or special ceremonial foods. In this thesis, the kinds of edible plants for namul were philologically approached by books published in Korea from Koryo to Chosun dynasty. The first historical record about cultivated vegetable as food in Korea was a garlic and a gourd in $\ulcorner$Samkuksaki$\lrcorner$. According to numerous records, edible wild plants might have played an important part as food resources, since they have variable edible portions as famine relief foods. Four kinds of namul were first introduced in Koryo age, but in Chosun dynasty over eighty kinds were recorded. The root of ballonflower and white radish were most commonly used for raw namul and bamboo shoot and squash for boils ones. Most kinds of namul were introduced in $\ulcorner$Zeungtosanrimkwungiae$\lrcorner$ and $\ulcorner$Limwonsiprwukji$\lrcorner$ influenced by pragmatism in later half period of Chosun. The chronic state of famine in later half period of Chosun caused to introduce various edible wild vegetables, and had greatly influenced on the Korean people to acquire vegetarian food habits and to favor salty taste. It seems to need a further study on recent nutritional problems including dietary fiber.ary fiber.

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Totally Laparoscopic Distal Gastrectomy with ROUX-EN-Y Reconstruction for Treatment of Duodenal Ulcer Obstruction

  • Kim, Min-Gyu;Kim, Beom-Su;Kim, Tae-Hwan;Kim, Kap-Choong;Yook, Jeong-Hwan;Oh, Sung-Tae;Kim, Byung-Sik
    • Journal of Gastric Cancer
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    • v.10 no.2
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    • pp.75-78
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    • 2010
  • Because of advancement of medical treatment, surgical management of gastric or duodenal ulcer was indicated for treatment of perforation, massive hemorrhage and obstruction. The distal gastrectomy including ulcer was known as principle method of duodenal ulcer obstruction, but actually many surgeons have performed only bypass surgery for the difficulty of formation of duodenal stump. In our case, 61-year-old male with repetitive duodenal ulcer obstruction transferred with obstruction due to deformities and inflammations of duodenal ulcer. We had performed totally laparoscopic distal gastrectomy with ROUX-EN-Y reconstruction using the clear visibility of laparoscopy and fine dissections of harmonic scalpel. The patient started soft diet on postoperative day 5 and discharged on postoperative day 8. He returned to work after discharging immediately.

Effect of Dietary Microalgae, Diatom-Dominant, Oil Extracts on Growth, Body Composition and Shell Color of Juvenile Abalone Haliotis discus (배합사료내 규조류 우점인 미세조류 오일 추출물 첨가가 까막전복(Haliotis discus)의 성장, 체조성 및 패각 색채에 미치는 영향)

  • Kim, Hee Sung;Lee, Ki Wook;Jeong, Hae Seung;Kim, June;Yun, Ahyeong;Cho, Sung Hwoan;Lee, Gye-An;Kim, Keun-Yong
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.50 no.6
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    • pp.738-744
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    • 2017
  • Effect of dietary inclusion of microalgae, diatom-dominant, oil extracts (MOE) on growth, body composition and shell color of juvenile abalone Haliotis discus was investigated. One thousand four hundred and seventy juvenile abalone were distributed into 21 plastic rectangular containers. Seven experimental diets were prepared: MOE0, MOE0.01, MOE0.05, MOE0.1, MOE0.5, MOE1 and MOE2 diets containing MOE at the concentrations of 0, 0.01, 0.05, 0.1, 0.5, 1 and 2% at the expense of mixture of squid liver and soybean oils, respectively. The experimental diets were fed to abalone in triplicate once a day with a little leftover for 16 weeks. Weight gain and specific growth rate of abalone fed the MOE1 and MOE2 diets were higher than those of abalone fed the all other diets. The shell length and soft body weight of abalone fed the MOE2 diet were longer and heavier than those of abalone fed the all other diets. Crude protein and ash content of the soft body of abalone were affected by dietary inclusion of MOE. The shell color of abalone fed the all experimental diets was different from that of wild abalone. In conclusion, dietary inclusion of MOE improved growth of abalone, but did not shell color of abalone.

The Effects of the Glutinicus Supplementation on Performance, Eggshell and Egg Yolk Color of Layers (산란계 사료에 Glutinicus 첨가가 산란 생산성, 난각 및 난황 색도에 미치는 영향)

  • Jung, B.Y.;Lim, H.S.;Paik, I.K.
    • Journal of Animal Science and Technology
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    • v.46 no.6
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    • pp.975-980
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    • 2004
  • An experiment was conducted to determine the effects of dietary supplementation of the yeast Rhodotorula glutinis(Glutinicus) on the performance and egg quality of layers. A total of 360 ISA Brown layers at 72 weeks old were assigned to one of the following 6 diets: control, 25 ppm$\beta$-carotene, 0.50%0, 1%0, 2% and 4% Glutinicus supplemented diets. Each treatment was replicated three times with 20 birds housed in 2 bird cage units. Glutinicus supplementation at the level of 0.5% significantly(p < 0.05) improved egg production and FCR Soft and broken egg production rate decreased as the level of Glutinicus supplementation increased. Eggshell strength was highest in 4 % Glutinicus supplementation. Egg yolk color increased linearly as the level of Glutinicus supplementation increased up to 2% of the diet. It was concluded that Glutinicus supplementation at the level of 0.5% can be recommended for the improvement of egg production while 2.0% can be recommended for egg yolk pigmentation.

Effect of the Various Sources of Dietary Additives on Growth, Body Composition and Shell Color of Abalone Haliotis discus hannai (다양한 원료의 사료첨가제가 전복의 성장, 체조성 및 패각 색채에 미치는 영향)

  • Cho, Sung-Hwoan;Park, Jung-Eun;Kim, Chung-Il;Yoo, Jin-Hyung;Lee, Sang-Min;Choi, Cheol-Young
    • Journal of Aquaculture
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    • v.19 no.4
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    • pp.275-280
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    • 2006
  • Effect of the various sources of dietary additives on growth, body composition and shell color of abalone Haliotis discus hannai was investigated for 16 weeks. Forty juvenile abalone averaging 13.5 g were randomly stocked into 21 of 50 L plastic rectangular containers each. Eight kinds of additives were prepared for this study: four commercially available microalgae [Haeatococcus (Hae), Isochrysis galbana (Iso), Shizochytrium (Sch) and Spirulina (Spi)], three crustacean meals [krill meal (KM), shrimp head meal (Shm) and red crab meal (Rcm)], and green tea by-product (Gre). In addition, dry sea tangle (Dst), Laminaria japonica, as a control, was prepared. Casein, dextrin and a mixture corn oil and fish oil was protein, carbohydrate and lipid sources, respectively, in the experimental diets. The 2% each additive was included into the experimental diets. The experimental diets were fed to abalone once a day at the ratio of $1.5{\sim}2.0%$ total biomass of abalone with a little leftover throughout the 16-week feeding trial. Survival of abalone was not significantly (P>0.05) affected by the experimental diets. However, weight gain of abalone fed the all experimental diets containing the various sources of additives was significantly (P<0.05) higher than that of abalone fed the Dst diet. Weight gain of abalone fed the Spi diet was highest and Shi, KM and Iso diets in order. Shell length and the ratio of soft body weight to body weight of abalone was not significantly (P>0.05) affected by the experimental diets. However, shell width of abalone fed the all experimental diets containing the various sources of additives was significantly (P<0.05) higher than that of abalone fed the Dst diet. The shell color of abalone fed the Spi diet was improved the most distinctively and similar to that of natural abalone. Therefore, it can be concluded that the experimental diets with the various sources of additives (microalgae and crustacean meals) was effective to improve growth of abalone and dietary inclusion of Spirulina was most effective to improve shell color of abalone.

Laparoscopic Primary Repair with Omentopexy for Duodenal Ulcer Perforation: A Single Institution Experience of 21 Cases

  • Ma, Chung Hyeun;Kim, Min Gyu
    • Journal of Gastric Cancer
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    • v.12 no.4
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    • pp.237-242
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    • 2012
  • Purpose: Despite the great advances in laparoscopic techniques, most active general surgeons do not apply laparoscopic surgery in the treatment of duodenal ulcer perforation when facing a real-life emergency. Therefore, our study was designed to evaluate the feasibility of laparoscopic surgery in duodenal ulcer perforation, and provide a step-by-step protocol with tips and recommendations for less experienced surgeons. Materials and Methods: Between March, 2011 and May, 2012, 21 patients presenting with duodenal ulcer perforation underwent laparoscopic primary repair with omentopexy. There were no contraindications to perform laparoscopic surgery, and the choice of primary repair was decided according to the size of the perforation. The procedure for laparoscopic primary repair with omentopexy consisted of peritoneal lavage, primary suture, and omentopexy using a knot pusher. Results: During the operation, no conversion to open surgery or intra-operative events occurred. The median operation time was 45.0 minutes (20~80 minutes). Median day of commencement of a soft diet was day 6 (4~17 days). After surgery, the median hospital stay was 8.0 days (5~27 days). Postoperative complications occurred in one patient, which included a minor leakage. This complication was resolved by conservative management. Conclusions: Although our study was carried out on a small number of patients at a single institution, we conclude that laparoscopic primary repair can be an effective surgical method in the treatment of duodenal ulcer perforation. We believe that the detailed explanation of our procedure will help beginners to perform laparoscopic primary repair more easily.

Outcomes of Laparoscopic Gastrectomy after Endoscopic Treatment for Gastric Cancer: A Comparison with Open Gastrectomy

  • Kwon, Hye Youn;Hyung, Woo Jin;Lee, Joong Ho;Lee, Sang Kil;Noh, Sung Hoon
    • Journal of Gastric Cancer
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    • v.13 no.1
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    • pp.51-57
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    • 2013
  • Purpose: Additional gastrectomy is needed after endoscopic resection for early gastric cancer when pathology confirms any possibility of lymph node metastasis or margin involvement. No studies depicted the optimal type of surgery to apply in these patients. We compared the short-term and long-term outcomes of laparoscopic gastrectomy with those of open gastrectomy after endoscopic resection to identify the optimal type of surgery. Materials and Methods: From 2003 to 2010, 110 consecutive patients who underwent gastrectomy with lymphadenectomy either by laparoscopic (n=74) or by open (n=36) for gastric cancer after endoscopic resection were retrospectively analyzed. Postoperative and oncological outcomes were compared according to types of surgical approach. Results: Clinicopathological characteristics were comparable between the two groups. Laparoscopic group showed significantly shorter time to gas passing and soft diet and hospital day than open group while operation time and rate of postoperative complications were comparable between the two groups. All specimens had negative margins regardless of types of approach. Mean number of retrieved lymph nodes did not differ significantly between the two groups. During the median follow-up of 47 months, there were no statistical differences in recurrence rate (1.4% for laparoscopic and 5.6% for open, P=0.25) and in overall (P=0.22) and disease-free survival (P=0.19) between the two groups. Type of approach was not an independent risk factor for recurrence and survival. Conclusions: Laparoscopic gastrectomy after endoscopic resection showed comparable oncologic outcomes to open approach while maintaining benefits of minimally invasive surgery. Thus, laparoscopic gastrectomy can be a treatment of choice for patients previously treated by endoscopic resection.

Effect of Acupuncture on Postoperative Ileus after Distal Gastrectomy for Gastric Cancer

  • Jung, Se Yun;Chae, Hyun Dong;Kang, Ung Rae;Kwak, Min Ah;Kim, In Hwan
    • Journal of Gastric Cancer
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    • v.17 no.1
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    • pp.11-20
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    • 2017
  • Purpose: Acupuncture has recently been accepted as a treatment option for managing postoperative ileus (POI) and various functional gastrointestinal disorders. Therefore, we conducted a prospective randomized study to evaluate the effect of acupuncture on POI and other surgical outcomes in patients who underwent gastric surgery. Materials and Methods: Thirty-six patients who underwent distal gastrectomy for gastric cancer from March to December 2015 were randomly assigned to acupuncture or non-acupuncture (NA) groups at 1:1 ratio. The acupuncture treatment was administered treatment once daily for 5 consecutive days starting at postoperative day 1. The primary outcome measure was the number of remnant sitz markers in the small intestine on abdominal radiograph. The secondary outcome measure was the surgical outcome, including the times to first flatus, first defecation, start of water intake, and start of soft diet, as well as length of hospital stay and laboratory findings. Results: The acupuncture group had significantly fewer remnant sitz markers in the small intestine on postoperative days 3 and 5 compared to those in the NA group. A significant difference was observed in the numbers of remnant sitz markers in the small intestine with respect to group differences by time (P<0.0001). The acupuncture group showed relatively better surgical outcomes than those in the NA group, but the differences were not statistically significant. Conclusions: In this clinical trial, acupuncture promoted the passage of sitz markers, which may reflect the possibility of reducing POI after distal gastrectomy.

Analysis of Free Flap Reconstruction of the Tongue (유리피판을 이용한 설재건술의 분석)

  • Kang, Dong Hee;Lee, Hyung Chul;Koo, Sang Hwan;Park, Seung Ha;Jung, Kwang Yoon
    • Archives of Plastic Surgery
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    • v.33 no.5
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    • pp.557-562
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    • 2006
  • Purpose: Advanced carcinoma of the tongue is a devastating disease which may cause severe speech or swallowing dysfunction. But, none to date has provided all of the complex functions of the tongue. The purpose of this study is to review our experiences with individuals who underwent glossectomy followed by reconstruction using free tissue transfer. Methods: Between February 1998 and February 2005, twenty-four patients underwent glossectomy followed by free tissue transfer reconstruction. The defects of tongue caused by partial or subtotal glossectomy were reconstructed by means of radial forearm or lateral thigh free flap with nerve innervation. Especially for the patients who underwent total glossectomy, we reconstructed deglutition muscles anatomically with nerve reinnervation, a procedure that allows the grafted muscle to maintain good tongue bulk without obvious atrophy. Results: Patients were reviewed to determine their functional outcome as it related to speech, deglutition, and aspiration. All patients achieved oral intake of a soft diet and acceptable speech. Conclusion: Although reconstruction following glossectomy using free tissue transfer is not ideal, this procedure is safe and reliable, and provides predictable results. A future challenge is the development of a surgical procedure for reconstruction of a tongue that maintains mobility and sensation using neurotized flaps.