• Journal of Pharmaceutical Investigation
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• 제37권5호
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• pp.269-273
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• 2007

Poorly water-soluble ibuprofen and ethanol can be encapsulated in gelatin microcapsule by spray drying technique. To select an optimal formula of ibuprofen-loaded gelatin microcapsule which increased the ethanol content and ibuprofen solubility with the decreased amount of gelatin in the microcapsules, in this study, the effect of gelatin, ibuprofen and sodium lauryl sulfate on the ibuprofen solubility and the amount of ethanol and ibuprofen encapsulated in the gelatin microcapsule were investigated. Ibuprofen solubility and the amount of ethanol encapsulated increased as gelatin and sodium lauryl sulfate increased, reached maximum at 4% and 0.6%, respectively and then followed a rapid decrease. Furthermore, the ibuprofen solubility and the encapsulated ibuprofen content increased as the amount of ibuprofen increased, reaching maximum at 0.5% and beyond that, there was no change in the solubility and ibuprofen content. However, the encapsulated ethanol content remained same irrespective of the amount of ibuprofen. On the basis of increased ibuprofen solubility, our results showed that the formula of ibuprofen-loaded gelatin microcapsule at the ratio of gelatin/ibuprofen/sodium lauryl sulfate/water/ethanol of 4/0.5/0.6/30/70 with ibuprofen solubility of about $290\;{\mu}g/mL$ and ethanol content of about $160\;{\mu}g/mg$ could be a potential oral delivery system for poorly water-soluble ibuprofen.

• 한국의류학회지
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• 제20권2호
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• pp.390-397
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• 1996

The effects of the mixture of surfactants on the removal of triolein applied to cotton and polyester fabrics were studied. The sunactants which were usually formulated to the Iriundry detergents, such as sodium dodecyl sulfonate (LAS), sodium lauryl sulfate (AS), $\alpha$-olefin sulfonate (AOS, C=14), sodium laurethoxy sulfate (AES, EO=3) and lauryl ethoxylate (AE, EO=7) were used. Washing was done at 40'C, 60"C, 80'c and the surfactant concentration was 0.05%. Backscattered electron imaging was made to study the location of triolein in the yarns. Triolein was removed easily from polyester than cotton fabrics.01eic acid added triolein wa9 removed greater than triolein only, except in AE solutions. In AE solutions, the removal of triolein was increased as the tremperature went higher and the increasing rate of the removal of triolein only was greater than that of oleic acid added triolein. In the result, more triolein was removed from triolein only than from oleic acid added triolein at 80t When the other surfactant was added to LAS, AES was the best to cotton fabrics, AOS was to polyester fabrics. Triolein was located in the lumen and grooves of the fibers and the deeper interfiber spaces. Triolein did not make thin film arround the cotton fiber in the surface, but polyester fibers. These are the main reason why the removal of triolein was difficult from cotton fabrics.rics.

• 한국응용과학기술학회지
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• 제25권2호
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• pp.205-210
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• 2008

The transformation of the liquid crystal complex made by binding of anionic surfactant, sodium dodecyl sulfate (SDS), into high charge density cationic polymer, the homopolymer of diallyldimethylammonium chloride (PDADMAC) was induced by adding of nonionic surfactants and investigated by means of microscopy and FE.SEM. Among nonionic surfactants in this experiments polyethylene glycol (3 mol) ether of lauryl alcohol (laureth-3) made variation in the complex. The laureth-3 transformed the complex into spherulite vesicle with the size of ca.$100{\mu}m$. This change increased the viscosity and the turbidity of the solution phase separated originally. Microscope showed that they are spherulite particles and polarized microscope suggested they are multi.lamellar liquid crystals. FE-SEM also proved that explicitly.

• Journal of Pharmaceutical Investigation
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• 제33권2호
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• pp.141-144
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• 2003

The transdermal therapeutic system (TTS) of scopolamine has various advantages over its oral dosage forms. The ideal scopolamine TTS requires high skin permeation rate in short time after it is applied on the skin. In order to increase the initial skin permeation rate of scopolamine from TTS, various permeation enhancers were employed. Enhancers employed were fatty acids (oleic and linolenic acids), cyclic monoterpenes (menthol, camphor, cineole and limonene) and others (isopropyl myristate, sodium lauryl sulfate and glyceryl monostearate). The concentration of enhancers in the base were fixed to 5% (w/w). While fatty acids had little enhancing effect on the skin permeation of scopolamine, cyclic monoterpenes, isopropyl myristate and sodium lauryl sulfate resulted in $1.5{\sim}2.6-fold$ higher skin permeation rate of the drug compared to the control. However, lag time was not affected by enhancers studied.

• 약학회지
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• 제46권2호
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• pp.102-107
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• 2002

The particle size of medicinal materials is an important physical property which affects the pharmaceutical behaviors such as dissolution, chemical stability, compressibility and bioavailability of solid dosage forms. The size reduction of raw pharmaceutical powder is needed to formulize insoluble drugs or slightly soluble drugs and to improve the pharmaceutical properties such as the solubility, the pharmaceutical mixing and the dispersion. The objective of the present study is to evaluate the grinding characteristics of ursodeoxycholic acid(UDCA) as a model of insoluble drugs. The effects of the grinding time and the amount of additive on particle size distribution of ground UDCA were investigated. Grinding of insoluble drug, UDCA and a series of dry co-grinding experiments of UDCA with sodium lauryl sulfate(SLS) as an additive were carried out using a planetary ball mill. It was measured that the median diameter and the particle size distribution of ground products with grinding UDCA and additive SLS by Mastersizer. As a result of co-grinding of UDCA and SLS, the particle size of co-grinding products was decreased more than single grinding one. However, it was observed that co-grinding products were reaggregated to larger particles after 120 min.

• 대한화학회지
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• 제17권6호
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• pp.411-415
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• 1973

Cyanide ion과 triphenylmethane dye와의 반응은 cetyltrimethyl ammonium bromide(CTABr)의 cationic micelle에 의하여 현저히 반응속도가 빨라지며 sodium lauryl sulfate(NaLS)의 anionic micelle에 의하여 반응속도가 늦어진다. 또한 CTABr존재하의 반응은 inorganic anion에 의하여 inhibition, 되며 NaLS존재하의 반응은 inorganic cation중의 몇가지, 특히 $Zn^{++},\;Cd^{++}$등에 의하여 현저하게 반응이 빨라지는 salt effect를 나타낸다. 물과 잘 혼합되는 몇가지 유기용매의 micelle catalysis에 대한 영향은 대체로 수용액 일때보다 작게 나타나서 반응속도가 늦어지거나 malachite green과의 반응에서 methanol은 수용액일때보다 반응속도가 빨라지는 특이한 solvent effect를 나타내었다.

• 공업화학
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• 제29권5호
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• pp.620-625
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• 2018

SLES를 주성분으로 사용한 액체세정제는 공기 중에 노출하여 방치하는 경우 표면에 피막이 형성되는 경우가 있다. 이는 제형 중의 수분이 증발하면서 세정제 주성분인 계면활성제의 농도변화로 인한 미셀의 상변화로 판단된다. SLES는 30~60% 영역에서 강한 육방정계 액정상이 나타나고, 60% 이상에서는 라멜라 액정상을 보인다. 본 연구에서는 SLES 주성분으로 사용된 액체세정제의 표면 겔링 현상은 내용물에서 수분 증발로 인하여 발생하는 현상이다. 액체세정제에서 수분이 증발되면서 계면활성제의 농도가 높아지는 결과였다. 표면 겔링 상태는 편광현미경으로 관찰한 결과 혼합 계면활성제 시스템의 액정상으로 확인되었다. 결론적으로 SLES를 주성분으로 사용하는 처방에서 겔링 필름 형성을 방지하기 위하여 수용성이 좋은 AOS를 증량하고 액정형성을 방지할 수 있는 이차 계면활성제인 SAS를 도입하고, 하이드로트로프로 SXS와 PEG1500을 적용하였다. 이와 같이 개선된 액체세정제 처방4와 5는 공기 중에 노출되어도 표면에 피막이 형성되는 겔링현상을 방지할 수 있었다.

• 공업화학
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• 제10권1호
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• pp.41-45
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• 1999

모의폐액으로 제조한 50 ppm의 코발트이온을 sodium lauryl sulfate의 계면활성제를 사용하여 침전부상법으로 제거하였다. 침전부상으로 코발트 이온을 제거하기 전에 35% $H_2O_2$를 모의폐액에 첨가하여 폐액의 전처리 과정을 도입하였다. 그 결과 최적 pH 및 처리후 잔존용액의 pH가 낮아졌고, 넓은 범위의 pH에서 높은 제거율을 나타내었다. 초기 코발트 이온농도, pH, 계면활성제 농도, 제거시간, 공급기체 유속, 외부이온 농도 등을 변수로 하여 실험한 결과, 초기 코발트 이온농도 50 ppm, pH 9.5, 공급기체 유속 70 mL/min, 제거시간 30분 등의 조건에서 99.8%의 제거율을 나타내었다. 침전물과 계면활성제의 흡착은 zeta potential 뿐만 아니라 침전물의 용해도 및 pH에 따라 변화하는 화학종과의 친화력과도 관계가 되는 것으로 추축되었다. 외부 이온으로서 $NO_3{^-}$, ${SO_4}^{-2}$, $Na^+$, $Ca^{+2}$를 첨가하여 그 영향을 관찰하였으며, ${SO_4}^{-2}$가 0.1 M 함유된 cobalt 용액을 침전부상법으로 처리한 결과 zeta potential의 감소 및 침전방해 등의 이유로 제거효율은 90%를 나타내었다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.412.1-412.1
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• 2002

Purpose. To prepare PVP-based solid dispersions containing lovastatin (LOS) and solubilizers (sodium lauryl sulfate. Tween80. oleic acid) to enhance dissolution of practically insoluble LOS. Methods. Solid dispersions containing LOS were prepared by dissolving two different organic solvent systems (acetone/ethanol or acetonitrile/ethanol). Results. The stickiness and flowability of solid dispersion powders were dependent on the composition and ratio of the solubilizers. (omitted)

• Korean Chemical Engineering Research
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• 제50권6호
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• pp.1076-1081
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• 2012

라텍스 개질 콘크리트의 혼화용 라텍스를 개발할 목적으로 carboxylated styrene butadiene 라텍스를 이단계 유화중합법으로 제조하고 콘크리트에 적용하는 실험을 수행하였다. 음이온 유화제로는 sodium dodecylbenzene sulfonate와 sodium salt of lauryl sulfate를 선정하였고, 라텍스 안정제로는 nonylphenoxy poly(ethyleneoxy) ethanol 계열의 동족체들(n=10, 20, 40)을, 그리고 potassium persulfate와 sodium bisulfite를 redox 개시제로, $Na_2HPO_4$와 $K_2CO_3$를 전해질로 각각 사용하였다. 중합안정성에 대한 음이온 유화제의 종류와 사용량의 영향 및 입자크기의 전해질 농도 의존성을 실험적으로 고찰하여 LMC용 라텍스 제조에 적합한 중합처방을 제시하였다. 이 중합처방으로 제조한 라텍스의 LMC 용도에 대한 적용성을 시험한 결과, 슬럼프와 공기량은 한국도로공사의 품질기준을 충족하며, 역학적 물성시험 결과에서는 28일간 경화시킨 시편의 압축강도와 휨강도가 품질기준보다 각각 39.6, 87.3% 더 높은 증진효과가 발현됨을 확인하였다.