• Journal of Nutrition and Health
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• v.35 no.10
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• pp.1015-1022
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• 2002

This study was conducted to examine the effects of dietary xylooligosaccharides on hepatic HMG-CoA reductase activity and morphological exchange of liver in rats fed high fat diet. Sprague-Dawley male rats weighing 100 $\pm$ 10 g were randomly divided into four groups, two normal diets and two high fat diets containing 1% cholesterol and 10% lard. Two normal diets were classified into a basal diet (normal group) and 10% xylooligosaccharide diet (NX group). The high fat diet groups were classified into a HF group without xylooligosaccharides diet and HFX group supplemented 10% xylooligosacchride diet. Experimental diets were fed ad libidum to the rats for 4 weeks and then they were sacrificed. The body weight of high fat diet (HF group) was increased more than that of normal group, but it was significantly decreased by xylooligosacchrides supplementation. The food intake was not significantly different among the all groups. The weight of liver, small intestine and cecum of all xylooligosaccharide supplemented groups were significantly heavier than those of normal and HF groups. The activity of hepatic HMG-CoA reductase, a rate limiting enzyme of cholesterol biosynthesis, in xylooligosaccharide supplemented groups was higher than that of HF group. Light micrographs revealed that the structures of hepatocytes in xylooligosaccharide supplemented groups were preserved well, compared to HF group. The xylooligosaccharide supplementation exerted a lipid-lowering action by decreasing cholesterol and triglycerides contents in hepatic tissue. In conclusion, the activity of hepatic HMG-CoA reductase and damage of liver in rats fed high fat diets were improved by dietary xylooligosaccharides.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.394-394
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• 2019

본 연구에서는 최근 기상이변의 영향 및 지진 발생과 저수지 노후화 등으로 지속적으로 발생되고 있는 소규모 저수지 붕괴에 의한 재해 위험성을 경감하고자 댐 저수지 EAP 수립 기준 이하 소규모 저수지를 대상으로 EAP 수립 대상여부를 판단할 선정지표를 개발하였다. 기존의 EAP 수립지침 검토, 과거 붕괴사례 분석, 관련분야 선행 연구 등을 분석하여 저수용량, 제체높이, 경과연수, 호우인자 및 지진인자를 포함하는 5개 선정지표를 정량화 하여 제시하므로 실무적용을 용이하게 하고자 하였다. 또한 개발된 선정지표는 EAP 수립 기준 이하 소규모 저수지에 적용하기에 앞서 각 선정 지표별 저수지 붕괴와의 연관성을 파악하기 위해 과거 저수지 붕괴사례에 단일지표 및 지표간 중첩도를 파악해 보았다. 그 결과, 지진인자, 호우인자, 지진 및 호우인자, 경과연수 지표순 순으로 저수지 붕괴와 높은 연관성을 나타내어, 소규모 저수지 붕괴에 연관되는 주요 지표를 지진인자, 호우인자, 경과연수로 선정하였다. 본 연구에서 선정된 지표간의 중첩정도를 파악하기 위해 과거 저수지 붕괴사례에 적용해 본 결과 호우인자+지진인자가 가장 높은 중첩도를 나타났다. 다음으로 본 연구를 통해 도출된 EAP 수립 대상 선정지표 중 주요 지표인 지진인자, 호우인자, 경과연수를 대상으로 2개의 지표가 중첩될 경우와 3개의 지표가 중첩될 경우를 EAP 수립 대상 관찰그룹과 검토그룹의 각각 분류한 후 이를 재해위험 저수지(MOIS, 2016)에 적용하여 보았다. 그 결과, EAP 수립 대상 관찰그룹에 속하는 경우가 38.5%를 차지하였고, 검토그룹에 속하는 경우가 11.9%를 차지하였다. EAP 수립 대상 관찰그룹에 해당하는 저수지에 대해서는 전문 시설관리자에 의한 주기적 점검 및 계측기 설치를 통한 모니터링 실시 등으로 세심한 시설물 관리가 필요할 것으로 판단되며, EAP 수립 대상 검토그룹에 해당하는 저수지에 대해서는 제체 하류부 구간의 주민 거주 현황, 경작지, 축사 등 재산 현황 및 EAP 수립에 소요되는 예산 등을 종합적으로 고려하여 저수지 관리기관에서 최종적으로 EAP 수립 여부를 결정하여 잠재적인 피해 발생을 사전에 저감시켜야 하겠다. 본 연구의 결과는 기존의 EAP 수립 기준의 보완책으로 활용 가능할 것으로 사료된다.

• Wind and Structures
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• v.29 no.4
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• pp.235-246
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• 2019

Wind loading is one of important loadings that should be considered in the design of large hyperbolic natural-draught cooling towers. Both external and internal surfaces of cooling tower are under the action of wind loading for cooling circulating water. In the previous studies, the wind loads on the external surface attracted concernedly attention, while the study on the internal surface was relatively ware. In the present study, the wind pressure on the internal surface of a 220 m high cooling tower is measured through wind tunnel testing, and the effect of ventilation rate of the packing layer on internal pressure is a major concern. The characteristics of internal wind pressure distribution and its effect on wind-induced responses calculated by finite element method are investigated. The results indicate that the wind loading on internal surface of the cooling tower behaves remarkable three-dimensional effect, and the pressure coefficient varies along both of height and circumferential directions. The non-uniformity is particularly strong during the construction stage. Analysis results of the effect of internal pressure on wind-induced responses show that the size and distribution characteristics of internal pressure will have some influence on wind-induced response, however, the outer pressure plays a dominant role in the wind-induced response of cooling tower, and the contribution of internal pressure to the response is small.

• PNF and Movement
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• v.19 no.1
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• pp.147-152
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• 2021

Purpose: This study was conducted to investigate the functional differences of the two heads of the biceps brachii by measuring the functions in supination according to pronation by the angle of the flexion of the elbow joint, except for the activities of the elbow flexors. Methods: This study was conducted with 25 healthy men in their 20s. At a glenohumeral-joint 0˚ flexion posture, angles of flexion of the elbow joint of 0˚, 30˚, 60˚, 90˚, and 120˚ were randomly provided, and they were asked to perform supination and pronation with an elastic band. Using an eight-channel surface electromyogram, the muscle activities of the long and short heads of the biceps brachii were measured. The activities of the short and long heads according to the angle were analyzed using a one-way ANOVA, and as a post-test, LSD was employed. Results: The analysis of the impact of the resistance of the elastic band in supination on the differences in the muscle activities in the short and long heads suggests there was a significant difference between 0˚ and 30˚ (p < 0.05). Conclusion: In supination according to forearm pronation, the long head had greater action in the early flexion posture of the elbow joint, and it is judged that the ratio of the flexion of the elbow joint according to the actions of the biceps brachii was considered small.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.36 no.1
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• pp.125-136
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• 2020

This study aims to seek a proper policy direction in response to the demand for apartment remodeling. As the research methods, we diagnosed the current status of the remodeling policy and analyzed the demand for apartment remodeling nationwide. According to the result of analysis, we suggested the fundamental direction and tasks for remodeling policies to be pursued at the government level. The results of the study are summarized as follows. First, the result of analysis showed that the demand for environmental improvement(performance improvement) remodeling project was much higher than other types of remodeling projects. The percentage of unit increased-type remodeling that can secure business feasibility is about 10% and only 30% when it comes to reducing project costs. The remaining 70-90% need to be promoted in environmental improvement remodeling projects which dependent on the residents' payment. Second, in order to prepare a policy action plan in response to the demand for apartment remodeling, it is necessary to set up clear policy goals and strategies for apartment remodeling in advance at the national level. Along with proactive goals and strategies, graded policy support should be accompanied per type of remodeling and business demand. We also suggest to simplify administrative procedures and support the R&D research to develop technologies. It would help to utilize the unit increased-type remodeling. On the other hand, for utilizing the environmental improvement remodeling which takes up a relatively high proportion, the policy should take care of as follows: offering housing performance information, rationalizing long term repair reserve, fostering small companies and experts. Finally, apartment management system should be advanced from the perspectives of managing old apartments and institutional foundations such as new construction and customized regulations for differentiated remodeling should be accompanied.

• Biomolecules & Therapeutics
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• v.29 no.2
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• pp.184-194
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• 2021

Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers. Therefore, efforts have been made to find drugs or small molecules such as HDAC inhibitors that can revert acetylation levels to normal in cancer cells. We observed dose-dependent reduction in the endogenous and exogenous protein expression levels of KAT8 (also known as human MOF), a member of the MYST family of HATs, and its corresponding histone acetylation at H4K5, H4K8, and H4K16 in chemotherapy drug gemcitabine (GEM)-exposed T24 bladder cancer (BLCA) cells. Interestingly, the reduction in MOF and histone H4 acetylation was inversely proportional to GEM-induced γH2AX, an indicator of chemotherapy drug effectiveness. Furthermore, pGL4-MOF-Luc reporter activities were significantly inhibited by GEM, thereby suggesting that GEM utilizes an MOF-mediated anti-BLCA mechanism of action. In the CCK-8, wound healing assays and Transwell® experiments, the additive effects on cell proliferation and migration were observed in the presence of exogenous MOF and GEM. In addition, the promoted cell sensitivity to GEM by exogenous MOF in BLCA cells was confirmed using an Annexin V-FITC/PI assay. Taken together, our results provide the theoretical basis for elucidating the anti-BLCA mechanism of GEM.

• The Korean Journal of Pain
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• v.34 no.2
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• pp.156-164
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• 2021

Several types of pain occur following spinal cord injury (SCI); however, neuropathic pain (NP) is one of the most intractable. Invasive and non-invasive brain stimulation techniques have been studied in clinical trials to treat chronic NP following SCI. The evidence for invasive stimulation including motor cortex and deep brain stimulation via the use of implanted electrodes to reduce SCI-related NP remains limited, due to the small scale of existing studies. The lower risk of complications associated with non-invasive stimulation, including transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), provide potentially attractive alternative central neuromodulation techniques. Compared to rTMS, tDCS is technically easier to apply, more affordable, available, and potentially feasible for home use. Accordingly, several new studies have investigated the efficacy of tDCS to treat NP after SCI. In this review, articles relating to the mechanisms, clinical efficacy and safety of tDCS on SCI-related NP were searched from inception to December 2019. Six clinical trials, including five randomized placebo-controlled trials and one prospective controlled trial, were included for evidence specific to the efficacy of tDCS for treating SCI-related NP. The mechanisms of action of tDCS are complex and not fully understood. Several factors including stimulation parameters and individual patient characteristics may affect the efficacy of tDCS intervention. Current evidence to support the efficacy of utilizing tDCS for relieving chronic NP after SCI remains limited. Further strong evidence is needed to confirm the efficacy of tDCS intervention for treating SCI-related NP.

• Textile Coloration and Finishing
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• v.33 no.4
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• pp.280-287
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• 2021

Generating electricity by using water in many energy harvesting system is due to their simplicity, sustainability and eco-friendliness. Evaporation-driven moist-electric generators (EMEGs) are an emergent technology and show great potential for harvesting clean energy. In this study, we report a transpiration driven electro kinetic power generator (TEPG) that utilize capillary flow of water in an asymmetrically wetted cotton fabric coated with carbon black. When water droplets encounter this textile EMEG, the water flows spontaneously under capillary action without requiring an external power supply. First carbon black sonicated and dispersed well in three different solvent system such as dimethylformamide (DMF), sodiumdedecylbenzenesulfonate (SDBS-anionic surfactant) and cetyltrimethylammoniumbromide (CTAB-cationic surfactant). A knitted cotton/PET fabric was coated with carbon black by conventional pad method. Cotton/PET fabrics were immersed and stuttered well in these three different systems and then transferred to an autoclave at 120 ℃ for 15 minutes. Cotton/PET fabric treated with carbon black dispersed in DMF solvent generated maximum current up to 5 µA on a small piece of sample (2 µL/min of water can induce constant electric output for more than 286 hours). This study is high value for designing of electric generator to harvest clean energy constantly.

• Journal of Microbiology and Biotechnology
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• v.32 no.9
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• pp.1195-1208
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• 2022

Silver nanoparticles (AgNPs) have potential applications in medicine, photocatalysis, agriculture, and cosmetic fields due to their unique physicochemical properties and strong antimicrobial activity. Here, AgNPs were synthesized using actinobacterial SL19 strain, isolated from acidic forest soil in Poland, and confirmed by UV-vis and FTIR spectroscopy, TEM, and zeta potential analysis. The AgNPs were polydispersed, stable, spherical, and small, with an average size of 23 nm. The FTIR study revealed the presence of bonds characteristic of proteins that cover nanoparticles. These proteins were then studied by using liquid chromatography with tandem mass spectrometry (LC-MS/MS) and identified with the highest similarity to hypothetical protein and porin with molecular masses equal to 41 and 38 kDa, respectively. Our AgNPs exhibited remarkable antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. The combined, synergistic action of these synthesized AgNPs with commercial antibiotics (ampicillin, kanamycin, streptomycin, and tetracycline) enabled dose reductions in both components and increased their antimicrobial efficacy, especially in the case of streptomycin and tetracycline. Furthermore, the in vitro activity of the AgNPs on human cancer cell lines (MCF-7, A375, A549, and HepG2) showed cancer-specific sensitivity, while the genotoxic activity was evaluated by Ames assay, which revealed a lack of mutagenicity on the part of nanoparticles in Salmonella Typhimurium TA98 strain. We also studied the impact of the AgNPs on the catalytic and photocatalytic degradation of methyl orange (MO). The decomposition of MO was observed by a decrease in intensity of absorbance within time. The results of our study proved the easy, fast, and efficient synthesis of AgNPs using acidophilic actinomycete SL19 strain and demonstrated the remarkable potential of these AgNPs as anticancer and antibacterial agents. However, the properties and activity of such particles can vary by biosynthesized batch.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.4_2
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• pp.655-662
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• 2022

Recently, with the increase in the use of UAV(unmanned aerial vehicles), research on horizontal maintenance stations that can take off and land in various environments has been actively conducted. These stations can safely land UAV through multiple DOF(degrees of freedom) or at least 2-DOF-based actuator actuation. Among them, many researchers are dealing with the multi-DOF stewart platform due to its high safety. However, the stewart platform requires high-precision control technology because it requires a lot of torque to actuate according to the load action. Therefore, in this paper, to solve the mentioned problem, a bevel gear-based 2-DOF horizontal maintenance station system is proposed. The proposed system is configured to prevent damage due to air resistance when maintaining ships and to install it in a small space. Also, in terms of system configuration, the bevel gear-based horizontal maintenance system has the main advantage of being able to take off and land UAVs of various sizes through the replacement of station pads. The driving of the system consists of a simple form that can control the motor by adjusting the rotation speed of the motor according to the sea waveform.