• The Korean Journal of Physiology and Pharmacology
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• v.10 no.3
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• pp.123-129
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• 2006

In several experimental models, estrogens protect neurons against ischemic insults. However, the recent clinical studies of hormone replacement showed negative results to prevent stroke. Therefore, optimal models to study estrogen replacement for neuroprotection are needed before its clinical ap-plication. Organotypic hippocampal slice under oxygen-glucose deprivation (OGD) has been established as a model of cerebral ischemia and has advantages to study drug effects. We investigated whether estrogen protected CAI neurons and affected activation of Akt (pAkt) in CAI region under OGD. Thus, rat hippocampal slices on day 7 of culture were treated with $17-{\beta}$ estradiol (E, 1 nM) for 7 days before 30 min OGD, and cell death of CAI neurons was quantified by propidium iodide (PI) staining and expression of pAkt was studied by Western blot and immunofluorescence. PI intensity in slices treated with E was significantly reduced 72 hour after OGD compared to that of non-treated slices (p < 0.05). E pretreatment also increased the expression of pAkt 72 hour after OGD compared to that of no treatment (p<0.01). These data suggest that estrogen pretreatment may rescue neurons from ischemic insults through the activation of Akt and also indicate that our model would be a useful alternative method to study the mechanisms and effects of estrogen replacement treatment for neuroprotection.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.1
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• pp.249-257
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• 2020

This paper focused on the level of managerial centralization on chief executive officer (CEO) as a factor to affect the shared growth activities of corporate. As service corporations are becoming active in shared growth activities recently, this paper thus used CEO. Pay Slice (CPS) information to measure the level of managerial centralization on CEO of service corporation and tested the influence of the level of managerial centralization on whether shared growth activities are executed and the level of such activities respectively. The result of test shows that companies with high managerial centralization on CEO are more passive toward shared growth activities than those without such centralization. This can be interpreted that a CEO with more powerful influence may consider shared growth activities as to be negative and take a passive attitude to them. On the other hand, such result was supported by additional analysis with companies committing shared growth activities as well. This paper is expected to contribute to bring about interest on shared growth activities as the gap between major companies and small and medium sized companies is currently expanding in terms of operating profit ratio and even salary of employees.

• Journal of the Korean Institute of Telematics and Electronics
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• v.21 no.6
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• pp.7-16
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• 1984

This paper describes the overall procedure of the development of a digital audio response system. It has been developed specifically as an answering system to the inquiries of telephone numbers from subscribers. The system has been realized based on the residual excited linear prediction (RELP) algorithm that incorporates a pitch predictive loop. Its major advantage over other similar systems is that it produces high quality of synthetic speech, although its memory size is relatively small. The hardware which consists of a speech synthesizer, a controller and an I/O part has been constructed using 2900 series bit-slice microprocessors and an INTEL 8085 microprocessor. The system is capable of real time processing, reliable, and adaptable to other applications.

• Journal of Korean Biological Nursing Science
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• v.7 no.1
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• pp.47-56
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• 2005

nm23-H1 gene expression has been inversely correlated with tumor metastatic potential in certain tumors including melanomas, breast carcinomas, and hepatocellular carcinomas. However, its role with respect to the invasive behavior of central nervous system tumors has scarcely been addressed Because cell motility and invasion plays an essential role in metastatic dissemination, we have studied whether motile human glioma cell(U87MG) transfected with nm23-H1 complementary DNA have any alterations in their ability to migrate and invade. There was no significant changes in the shape and size of the cells following nm23-H1 transfection. The role of nm23-H1 in glioma migration and invasion have been evaluated by in vitro simple scratch technique and brain slice invasion model Basal migration ability of nm23-H1 transfectants cell(U87MG-pEGFP-nm23) were lesser than U87MG. Accordingly, U87MG-pEGFP-nm23 didn't migrate away apparently from the tumors implanted site comparing U87MG in brain slice invasion model. These results suggest that nm23-H1 may play an important role in suppressing the human glioma migration and invasion.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.4
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• pp.209-215
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• 1993

A stability analysis program(CSLOP) which can obtain the factor of safety and the critical failure surface at the same time is developed from this study. In order to improve existing slice methods, the general slice method of Gussmann is applied to compute the factor of safety, and the constrained simplex algorithm proposed by Box is applied to systematically locate the critical failure surface in slopes. The proposed method is applied to two examples of circular and noncircular slope stability and the results are compared to previously published solutions. Constrained simplex method is recommended to improve slope stability programs which provide for an automatic search of the critical failure mechanisms.

• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.171-171
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• 2001

목적： 뇌 자기공명영상에서 Z-score를 이용한 관류 영상과 조영전후의 감산에 의한 역동 영상의 관류 양상을 비교 관찰 하고자 한다. 대상 및 방법： 뇌 자기공명영상에서 이상 소견이 없는 젊은 환자 1명, Moya moya 환자 1, 중대뇌동맥 폐색 환자 1명, 외상후 증후군 1명, 뇌종양 1예를 대상으로 하여, 뇌의 routine 자기공명 영상과 함께 Gd-DTPA 0.1 mmol/kg를 급속 주사 후 자화율 대조 EPI 영상을 얻었다. 영상 기기는 Magnetom Vision(Siemens Medical Systems, Erlangen, Germany)이며, EPI 영상 지표들은 TR/TE는 0.8/29 msec, slice 두께 6 mm, slice 수 10, 화소수 128 $\times$ 128, FOV 215 $\times$ 215 mm, 영상획득 1 회, 1회 검사시간 1.32 초, 검사수 30 회로서, 총 검사시간은 40 초였다. 검사 후 영상처리(post processing)는 Magnetom Vision의 VB31D 자체 프로그램을 이용하였는데, 2-score를 이용한 관류영상은 조영제 유입전 영상들, 조영제 최대 유입기 영상들, 그리고 조영제 배출기 영상들 4-5 회를 각각 한 군으로 하여, Z-score 1.2에서 2.0 사이에서 여러번 반복하여 영상을 재구성하였다. 감산에 의한 역동영상은 조영제 도달 전의 영상으로부터 조영제 유입 후의 영상을 차례로 빼어서 영상을 재구성하였으며, 이들 영상을 재정리하여 각 단면의 시간 경과에 따른 관류 양상을 연속하여 관찰하였다 두 방법에 의한 영상 재구성은 각각 약 10분 정도가 소요되었다.

• Journal of Korea Society of Industrial Information Systems
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• v.17 no.3
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• pp.9-17
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• 2012

In this paper, we propose a SPN 256 bit block cipher so called XSB(eXtended SPN Block cipher) which has a symmetric structure in encryption and decryption. The proposed XSB is composed of the even numbers of N rounds where the first half of them, 1 to N/2-1 round, applies a pre-function and the last half of them, N/2+1 to N round, employs a post-function. Each round consists of a round key addition layer, a substiution layer, a byte exchange layer and a diffusion layer. And a symmetry layer is located in between the pre-function layer and the post-function layer. The symmetric layer is composed with a multiple simple bit slice involution S-Boxes. The bit slice involution S-Box symmetric layer increases difficult to attack cipher by Square attack, Boomerang attack, Impossible differentials cryptanalysis etc.

• Smart Structures and Systems
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• v.21 no.5
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• pp.601-609
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• 2018

The estimated probabilistic model of wind data based on the conventional approach may have high discrepancy compared with the true distribution because of the uncertainty caused by the instrument error and limited monitoring data. A sequential quadratic programming (SQP) algorithm-based finite mixture modeling method has been developed in the companion paper and is conducted to formulate the joint probability density function (PDF) of wind speed and direction using the wind monitoring data of the investigated bridge. The established bivariate model of wind speed and direction only represents the features of available wind monitoring data. To characterize the stochastic properties of the wind parameters with the subsequent wind monitoring data, in this study, Bayesian inference approach considering the uncertainty is proposed to update the wind parameters in the bivariate probabilistic model. The slice sampling algorithm of Markov chain Monte Carlo (MCMC) method is applied to establish the multi-dimensional and complex posterior distribution which is analytically intractable. The numerical simulation examples for univariate and bivariate models are carried out to verify the effectiveness of the proposed method. In addition, the proposed Bayesian inference approach is used to update and optimize the parameters in the bivariate model using the wind monitoring data from the investigated bridge. The results indicate that the proposed Bayesian inference approach is feasible and can be employed to predict the bivariate distribution of wind speed and direction with limited monitoring data.

• Journal of Korean Academy of Nursing
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• v.35 no.5
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• pp.817-828
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• 2005

Purpose: This study was to identify the persuasive effects of exercise promotion advertisements for obesity prevention according to the source types( ordinary people, experts, celebrity endorsers) and advertising message types(slices of life, testimonials). Method: Gender, height, body weight, BMI, attitude toward obesity(Aob) and exercise(Aex), and intention to exercise(Iex) were collected from 626 elementary school students in a pretest. After 2 months, six advertisements type attached to a questionnaire were provided for 20 minutes and then Aob, Aex, lex, source credibility and attitude toward advertisements(Aad) were collected in posttest. Result: 1) In posttest the lex of 6 the groups increased significantly compared with that of the pretest, 2) Source credibility of the Ordinary+Testimonial group was lower than the Celebrity+Testimonial, Celebrity+Slice of life, Ordinary+Slice of life, and Expert+Testimonial groups, Aad of the Celebrity+Testimonial group was higher than the Ordinary+ Testimonial group. 3) The Main effect and interaction effect of source types and advertising message types were significant in source credibility and Aad, Conclusion: Persuasive effects of exercise promotion advertisements in elementary school students was found to be the most effective in Celebrity+Testimonial. This study suggests that selection of health education advertisements according to demographic characteristics is important to promote persuasive effects.

• Journal of information and communication convergence engineering
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• v.18 no.1
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• pp.1-7
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• 2020

This paper proposes a fast-processing and low-cost hardware multiple input multiple output (MIMO) channel emulator. The channel emulator is an important component of hardware-based simulation systems. The novelty of this work is the use of sharing and pipelining functions to reduce hardware resource utilization while maintaining a high sample rate. In our proposed emulator, the samples are created sequentially and interpolated to ensure the sample rate is equal to the base band rate. The proposed 4 × 4 MIMO requires low-cost hardware resource so that it can be implemented on a single field-programmable gate array (FPGA) chip. An implementation on Xilinx Virtex-7 VX980T was found to occupy 10.47% of the available configurable slice registers and 12.58% of the FPGA's slice lookup tables. The maximum frequency of the proposed emulator is 758.064 MHz, so up to 560 different paths can be processed simultaneously to generate 560 × 758 million × 2 × 32 bit complex-valued fading samples per second.