• 생약학회지
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• 제17권4호
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• pp.292-301
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• 1986

The combined preparations of the traditional Korean prescriptions, Sahyangsohap-won (A1) and Woohwangporyong-hwan (B1) were evaluated on pharmacological actions in rats and mice, in parallel with the preparations of their modified prescriptions (A2 and B2). The acute toxicities of the four preparations were very low of which $LD_{50}$ values were more than 4g/kg, p.o. and no systematic symptoms were found at the doses. All the preparations showed sedative action by prolongation of sleeping time induced with hexobarbital sodium. The action was more potent in the modified preparations than in the original ones. All the preparations had no anticonvulsant action both in chemoshock seizures induced by pentetrazole and strychnine and in electroshock seizure. In rat fundus preparation, A1 and A2 elicited strong contraction at the concentration of $1{\times}10^{-3}\;g/ml$ in bath, whereas B1 and B2 did neither contraction nor relaxation at the same concentration. The four preparations had no inhibitory effect against acetylcholine induced spasm. In rat intestinal preparation, the four preparations exhibited neither contraction nor relaxation. However, A1 and A2 had antagonistic effect against spasm at the concentration of $1{\times}10^{-3}\;g/ml$. Single administration of each preparation at the dose of 0.24g/kg, p.o. stimulated the secretion of pepsin in rat stomach without inciting the secretion of gastric juice. Their stimulating actions were more marked in B1 and B2 than in A1 and A2, and were more promptly exhibited in the modified preparations (A2 and B2). Accelerating action of bile secretion by single administration of each preparation was found at the dose of 0.24g/kg, p.o. in rats. All the preparations except A2 also stimulated the secretion of bile acid.

• 대한물리의학회지
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• 제8권4호
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• pp.627-635
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• 2013

PURPOSE: The purpose of this study is to identify how the body composition changes after jump-roping exercise. METHODS: The subjects are 40 college students, 20 females and 20 males. The subjects were selected among college students who had not taken any drug for more than 4 weeks before the experiment started. The experiment was performed for 4 weeks, from May 23rd to June 13rd, 2012. To collect the data, the vital signs such as pulse, blood pressure, weight), and the body composition were measured before and after the experiment. The data on the body composition were analyzed by the electrical resistance analyzer. RESULT: Muscle mass was increased and body fat was decreased for both females and males after the exercise. In particular the increase of the muscle mass and the decrease of the body fat for the females were statistically significant. The result that the body fat of the females was decreased significantly more than that of males is interpreted that the body fat of females are comparatively higher than that of males. Additionally the muscle mass of the left arm and leg of the subjects were significantly increased(p<.05). Correlation analysis between general characteristics such as body composition, abdominal obesity and specific muscle areas for both men and women showed generally positive between before and after the jump-roping exercise (p<.05, p<.01). However the correlation between sleeping time and each variable showed negative. CONCLUSION: A according to the result of this study, jump-roping exercise had a very positive effect on the body composition. The study suggests that college students keep jump roping for a long period to change their body composition favorably.

• The Journal of Korean Physical Therapy
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• 제6권1호
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• pp.37-48
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• 1994

In order to grasp the occupational add social characteristics of the onset of lumbago among elementary and high school teachers, 423 elementary and high school teachers were taken as subjects of study through questionaires. The following are the results of the study which were analyzed through data, conducted for one month in the City of Taegu, between Jun. 90, and Jul. 20 of 1993: 1. the incidence of lumbago of the entire teachers was $75.2\%$, with the elementary school teacher$(81.9\%)$ higher than high school teacher$(70.6\%)$. 2. In the relationship between the characteristics of job and lumbago. characteristics of teaching, monthly income, chores and satisfaction with job did not show significance, but weekly teaching hours, mental stress and the degree of comfort of chair reflected significantly(p<0.01). 3. In social relationship, personal nature, sleeping hours and place, smoking and drinking did not hold significance, but daily average walking hours, posture during sleep, general health conidition(p<0.01) and daily average riding hours and regular exercise(p<0.05) etc. showed significant relationships. 4. In the sistuation of lumbago of the teacher groups, no significant differences wee found in the cause of lumbago, duration of lumbago, sick leaves and recognigion of lumbago, but it was contrary in the treatment of lumbago(p<0.01). Based on the above results, lumbago is closely related to occupational and social factors, the prevention and treatment can be diversified based on occupation and environment. Consequently, regular educational program is considered imperative mainly on prevention of lumbago by putting aside time for such purpose.

• Biomolecules & Therapeutics
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• 제12권2호
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• pp.114-121
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• 2004

This study was undertaken to evaluate the general pharmacological properties of CJ-11828, an amlodipine adipate, in experimental animals and in vitro system. CJ-11828 had no effects on general behavior, motor coordination, writhing syndromes, pentetrazol-induced chemoshock and electric shock in mice at dose levels of 3,10, anti 30 mg/kg, po. But there were decrease of body temperature, prolongation of sleeping time, and inhibition of intestinal activity in mice treated with CJ-11828 at doses of 10 and 30 mg/kg, po. CJ-11828 decreased the blood pressure in coscuous fog at the dose level of 2mg/kg, po, but it was expected as a result of pharmacological activity of CJ-11828. Any effect on respiratory system was not observed in conscious rat at doses of 3,10, and 30 mg/kg, po. The slight decrease in spontaneous motor activity was observed in mice treated with CJ-11828 at high dose, 30 mg/kg. In vitro experiments, CJ-11828 had no effect on agonists-induced contraction of isolated guinea pig ileum at 0.1, 1, and 10 ${\mu}$M. Based on these results, it was concluded that CJ-11828 had no pharmacological effect ill these studies even up to the 36-fold anticipated clinical dose, 3 mg/kg.

• Natural Product Sciences
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• 제17권4호
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• pp.342-349
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• 2011

This study was performed to determine the composition of phenolic substances contained in the leaves of Cirsium setidens (Compositae), validate the high-performance liquid chromatography (HPLC) method, and determine the in vivo sedative effect of the main component pectolinarin. Six phenolic compounds isolated from C. setidens were spectroscopically identified as chlorogenic acid (1), hyperoside (2), 3,4-di-O-caffeoylquinic acid (3), caffeic acid methyl ester (4), linarin (5), and pectolinarin (6) and then used as standard compounds for HPLC analysis. HPLC proved to be precise, accurate, and sensitive for the simultaneous analysis of the phenolic substances. In particular, six compounds showed good regression ($R^2$ > 0.999) within test ranges and recovery was in the range of 95.4 - 104.8%. The content of pectolinarin was considerably higher (156.48 mg/g) than those of other phenolic substances including the other flavone glycoside, linarin (18.99 mg/g). The contents of other phenolic substances, in order, were chlorogenic acid (8.41 mg/g), 3,4-di-O-caffeoylquinic acid (5.74 mg/g), hyperoside (4.33 mg/g), and caffeic acid methyl ester (0.51 mg/g). Oral administration with compound 6 (10 and 20 mg/kg) enhanced the sleeping time induced by pentobarbital in mice, indicating that it has a sedative effect.

• 동의신경정신과학회지
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• 제24권1호
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• pp.75-92
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• 2013

Objectives : The objective of this study is to investigate various factors concerning Hwa-byung Methods : The research for various factors of Hwa-Byung was carried out for 686 female Participants. Hwa-Byung was diagnosed by Hwa-Byung Diagnostic Interview Schedule (HBDIS). Results : The rate of Past History about Chronic Bronchitis, Peptic Ulcer, Chronic Hepatitis/Hepatic Cirrhosis, Allergy, Arthritis, Hyperlipidemia is high in the Hwa-Byung group compared with the Control group. In the study of external environments, Hwa-Byung has tendency diagnosed in monthly income under 2,000,000 won, doing regular occupation, marriage, below graduation from high school. In the study of personal relationship, Hwa-Byung has tendency more influenced by negative influencing people than by positive influencing people. In the study of personal factors, Hwa-Byung has a short sleeping time, does not exercise regularly, feels more overburdened, and understimates their own condition to do easy tasks. Conclusions : According to the below results, in the study of Past History, the rate of Chronic Bronchitis, Peptic Ulcer, Chronic Hepatitis/Hepatic Cirrhosis, Allergy, Arthritis, and Hyperlipidemia is high in the Hwa-Byung group compared with the Control. Hwa-Byung has a tendency to be diagnosed by various factors such as the external environment, personal relationships, and personal factors.

• 동의신경정신과학회지
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• 제27권4호
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• pp.235-248
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• 2016

Objectives: The aim of this review was to investigate whether evidence of complementary and alternative medicine (CAM) was reflected in clinical practice guidelines (CPGs) for insomnia based on relevant clinical trials. Methods: We conducted a systematic search on domestic and international CPG databases and medical databases. In addition, we conducted manual searches of relevant articles. Three authors independently searched and selected relevant studies; any disagreement was resolved by discussion. We extracted and analyzed the following data: published language, country, development group, participants, interventions, presence or absence of recommendations for CAM, level of evidence, grade of recommendation for CAM, and methods of development. Results: We identified 8,241 records from domestic and international databases, and 22 CPGs were included. Eleven of the 22 CPGs mentioned CAM interventions including herbal medicine, relaxation, acupuncture moxibustion, Tai Chi, meditation, hypnosis, biofeedback, Tuina, and external herbal medicine. However, most of the CPGs indicated 'no recommendation' or 'weak recommendation' for CAM interventions. Only Valeriana dageletiana Nakai and relaxation were considered to have experimental evidence. Valeriana dageletiana Nakai was recommended for improvement of sleep latency, sleep maintenance, total sleeping time, and sleep cycle. Relaxation was recommended as effective intervention for relieving physical and psychological arousal. Conclusions: Despite systematic reviews and randomized controlled trials on CAM for insomnia, most of the CPGs for insomnia did not reflect the evidence obtained. Further CPGs for insomnia should be developed by considering the current advanced studies in the field of CAM.

• Toxicological Research
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• 제26권3호
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• pp.223-232
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• 2010

Artesunate, a semi-synthetic derivative of artemisinin, is used primarily as a treatment for malaria. Its effects on the central nervous system, general behavior, and cardiovascular, respiratory, and other organ systems were studied using mice, rats, guinea pigs, and dogs. Artesunate was administered orally to mice at doses of 125, 250, and 500 mg/kg and to rats and guinea pigs at 100, 200, and 400 mg/kg. In dogs, test drugs were administered orally in gelatin capsules at doses of 50, 100, and 150 mg/kg. Artesunate induced insignificant changes in general pharmacological studies, including general behavior, motor coordination, body temperature, analgesia, convulsion modulation, blood pressure, heart rate (HR), and electrocardiogram (ECG) in dogs in vivo; respiration in guinea pigs; and gut motility or direct effects on isolated guinea pig ileum, contractile responses, and renal function. On the other hand, artesunate decreased the HR and coronary flow rate (CFR) in the rat in vitro; however, the extent of the changes was small and they were not confirmed in in vivo studies in the dog. Artesunate increased hexobarbital-induced sleeping time in a dose-related manner. Artesunate induced dose-related decreases in the volume of gastric secretions and the total acidity of gastric contents, and induced increases in pH at a dose of 400 mg/kg. However, all of these changes were observed at doses much greater than clinical therapeutic doses (2.4 mg/kg in humans, when used as an anti-malarial). Thus, it can be concluded that artesunate is safe at clinical therapeutic doses.

• The Korean Journal of Physiology and Pharmacology
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• 제16권1호
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• pp.49-57
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• 2012

It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT to search for any side effects of it in rats, mice, guinea pigs, and cats. In a single dose toxicity study, QGC EXT didn't show toxicological effects in rats and mice, and the $LD_{50}$ was over 5 g/kg in both animals, and there were also no changes in weight, feed and water intake during these toxicological experimental periods. We examined the general pharmacological action on central controlled behavior responses, and peripheral organs including blood pressure, heart rate, respiration and gastrointestinal system, We found that there were no significant changes in body temperature, locomotors activity, stereotyped behaviors, sleeping time, and convulsion. In other studies, writhing reaction, normal body temperature, there did not appear to be any changes. The large intestine movement and electrical field stimulation-induced contraction was not changes by its EXT. In addition, the influences on blood pressure, heart rates, and respiration by QGC EXT were not found. These results indicate that QGC EXT may be very safe as a new drug, since its $LD_{50}$ was very high over 5 g/kg and any side effects were not found.

• 한국항행학회논문지
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• 제19권5호
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• pp.458-463
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• 2015

본 논문에서는 IEEE 802.15.4 기반 무선 센서 네트워크와 압력패드와 가드센서를 이용하여 병실 내 환자의 동작을 감지하는 시스템을 개발 하였다. 이 시스템은 주간에 환자의 일상적인 활동 뿐 만 아니라 특히 야간 취침 시에 발생하는 낙상 사고 감지를 위해 설계 되었다. 환자의 침대에 설치된 노드는 압력 패드 및 가드 센서에서 환자의 활동 및 낙상을 감지하여 게더로 송신하고 게더에 수신된 데이터는 TCP/IP 통신으로 업무 지원 센터의 모니터로 보내도록 하였다. 이때 압력 패드 및 가드 센서가 on, off 동작 시에 발생하는 스위치 채터링 현상을 방지하기 위해 타이머를 사용 하였다. 그리고 통신 모듈의 송신 파워를 조절하여 병실의 다양한 환경에서 적용이 가능 하도록 구성 하였으며 수집된 데이터를 바탕으로 간호사가 실시간으로 병상의 환자 상태를 확인하고 관리 할 수 있게 하였다.