• 대한약리학회지
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• 제20권2호
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• pp.15-21
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• 1984

Clonidine으로 고혈압을 치료시 부작용으로 진정작용이 심하게 나타나며 이는 Clonidine이 중추 ${\alpha}_2$-수용체를 흥분시켜서 일으킨 결과임이 보고되었다. 본 실험에서는 부화 $1{\sim}2$일이 된 병아리에 ${\alpha}_2$-수용체 효현제들을 주사하여 정좌반사가 소실될 때까지의 시간 및 수련시간을 관찰하였으며, 그리고 guanabenz 유도 수면에 대한 ${\alpha}_1$- 및 ${\alpha}_2$-수용체 길항제 및 opiate수용체 길항제가 어떻게 관여하는 지를 검토하고 다음과 같이 요약하였다. 1) ${\alpha}_2$-수용체 효현제중 guanabenz, clonidine, guanfacine 및 B-HT 933은 용량에 의존해서 정좌반사소실까지의 잠복시간을 감소시켰다. 그러나 B-HT 920 및 oxymetazoline은 잠복시간을 경미하게 연장시켰다. 2) ${\alpha}_2$-수용체 효현제들은 용량에 비례해서 수면시간을 증가시켰고 이들의 강도는 guanabenz>clonidine>oxymetazoline${\geq}$B-HT 933${\geq}$B-HT 920> guanfacine의 순위이었다. 3) ${\alpha}_2$-수용체 길항제들은 양에 비례해서 guanabenz 유도 수면시간을 감소시켰으며 이들의 강도는 yohimbine>rauwolscine>piperoxan${\geq}$RX 781094의 순위 이었다. 4) Ethanol 및 hexobarbital유도 수면은 yohimbine에 의해 봉쇄되지 아니하였다. 5) Guanabenz유도 수면시간에 대해서 ${\alpha}_1$-수용체 효현제인 methoxamine 및 Phenylephrine은 영향이 없었으나, ${\alpha}_1$-수용체 결항제인 Prazosin은 증가시켰다. 그러나 corynanthine은 반대로 수면시간을 현저히 감소시켰다. 이상의 결과로 보아 중추 ${\alpha}_2$-수용체의 흥분으로 병아리의 수면이 야기되고, 중추 ${\alpha}_1$-수용체의 역할에 대하여는 명백하지 않으나 ${\alpha}_2$-수용체 효현제 및 길항제의 성질을 규명하는 동물모델로서 부화 I${\sim}$2일의 병아리가 크게 유용할 것으로 시사되는 바이다.

• Archives of Pharmacal Research
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• 제7권1호
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• pp.53-56
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• 1984

The effect of twenty two spices on liver microsomal monooxygense activity was tested as measured by alteration of hexobarbital (HB) narcosis and strychnine mortality in mice. Oral administration of seven spices for 7 consecutive days caused a significant shortening of the duration of HB-induced sleeping time. The treatment of mice with a single i. p. injection of 9 spices resulted in a significant prolongation of the sleeping time. White pepper, dill and fennel reduced the toxicity of strychnine. These results strongly indicated that some spices might affect the activity of liver microsomal drug metabolizing enzyme (DME) function.

• Natural Product Sciences
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• 제12권1호
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• pp.44-49
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• 2006

The aqueous extract of Hydrilla verticillata (AEHV) was tested for possible pharmacological effects on experimental animals. AEHV significantly potentiated the sleeping time of mice induced by standard hypnotics viz. pentobarbitone sodium, diazepam, and meprobamate in a dose dependent manner. AEHV showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with AEHV caused significant protection against strychnine and leptazol-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the aqueous extract of H. verticillata.

• 생약학회지
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• 제8권3호
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• pp.115-119
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• 1977

Black pepper (Piper nigrum L.) among several irritating spices tested was highly effective on the duration of hexobarbital hypnosis in mice. Pretreatment of mice with the methanolic extract of black pepper (60mg/kg i.p.) prolonged markedly the duration of hexobarbital sleeping time. Three consecutive daily administrations of the same dose of black pepper extract, however, shortened (37%) the duration of hexobarbital sleeping time. The ether soluble fraction of black pepper extract caused most potent effects on the duration of hexobarbital hypnosis. From the above results, it was postulated that the lipid soluble components of black pepper might considerably change the drug action and metabolism by altering drug metabolizing enzyme systems.

• Natural Product Sciences
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• 제9권4호
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• pp.260-263
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• 2003

Ethanol extract of the root of Clitoria ternatea Linn (CTEE) was evaluated for different neuropharmacological actions, such as general behaviour, exploratory behaviour, muscle relaxant activity and phenobarbitone induced sleeping time, in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y- maze test, reduction in the muscle relaxant by rotarod, $30^{\circ}C$ inclined screen and traction tests. In addition CTEE significantly potentiated the phenobarbitone-induced sleeping time. Preliminary tests indicate that the ethanol extract of Clitoria ternatea Linn. At the doses of 100 and 150 mg/kg showed significant neuropharmacological activity.

• 생약학회지
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• 제22권2호
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• pp.95-100
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• 1991

Salviae miltiorrhizae(SM) Radix extract increased $[^3H]-thymidine$ incorporation into rat hepatocytes at the concentration ranging from $5{\times}10^{-5}\;to\;5{\times}10^{-1}mg/ml$. It decreased the activities of s-GOT and s-GPT in cirrhotic rats induced by $CCl_4$, TAA and D-GalN, respectively and reduced the sleeping time induced by hexobarbital in $CCl_4$,TAA and D-GalN intoxicated mice, respectively. SM extract shortened the half-life of sulfobromophthalein in $CCl_4$ intoxicated rats.

• Journal of Pharmaceutical Investigation
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• 제17권4호
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• pp.189-195
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• 1987

The effects of cimetidine or ranitidine pretreatment on the intestinal absorption, plasma and urine level of caffeine, gastric acidity of mouse, and sleeping time by hexobarbital sodium were investigated pharmacokinetically. Cimetidine and ranitidine pretreatments were found to increase both the rate and extent of absorption of caffeine in rats. Cimetidine pretreatment increased blood level of caffeine and decreased urine level, while ranitidine pretreatment had no effect on urine level of caffeine. Ranitidine pretreatment inhibited gastric secretion due to caffeine more than cimetidine pretreatment. Cimetidine pretreatment increased the action of caffeine and showed shorter sleeping time by hexobarbital sodium, comparing with ranitidine pretreatment.

• Journal of Preventive Medicine and Public Health
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• 제56권1호
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• pp.59-66
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• 2023

Objectives: The aim of this study was to evaluate the effect of body weight status and sleep duration on the discrete-time hazard of menarche in Korean schoolgirls using multiple-point prospective panel data. Methods: The study included 914 girls in the 2010 Korean Children and Youth Panel Study who were in the elementary first-grader panel from 2010 until 2016. We used a Gompertz regression model to estimate the effects of weight status based on age-specific and sex-specific body mass index (BMI) percentile and sleep duration on an early schoolchild's conditional probability of menarche during a given time interval using general health condition and annual household income as covariates. Results: Gompertz regression of time to menarche data collected from the Korean Children and Youth Panel Study 2010 suggested that being overweight or sleeping less than the recommended duration was related to an increased hazard of menarche compared to being average weight and sleeping 9 hours to 11 hours, by 1.63 times and 1.38 times, respectively, while other covariates were fixed. In contrast, being underweight was associated with a 66% lower discrete-time hazard of menarche. Conclusions: Weight status based on BMI percentiles and sleep duration in the early school years affect the hazard of menarche.

• 한국치위생학회지
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• 제14권4호
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• pp.485-493
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• 2014

Objectives : The study investigated and analyzed the relationship between health-related lifestyle and psychosomatic self-reported symptom in dental hygiene students. Methods : A self-reported questionnaire was filled out by 478 dental hygiene students in Gyeonggi-do and Gangwon-do from March 7 to June 21, 2012 by random sampling method after informed consent. Results : The health-related lifestyle showed the results as follows. Nonsmokers accounted for 89.1%. Those who never exercise accounted for 67.9% and 37.9% of the students sleep for 5-6 hours. Those who take alcohols twice per month accounted for 58.2%. The correlation between the symptoms and lifestyle included multiple subjective symptoms(I), respiratory(A), eyes and skin(B) and digestive organs(C) symptoms and smoking status(p<.01), mouth and anal(D), depression(K), nervousness(E). There existed the correlation in average sleeping time(p<.01) and impulsivess(H) and smoking status(p<.05) and lie scale(L) and regular exercise(p<.05) and aggressiveness(F) and drinking habits and irregular and life(G) and breakfast habits. The smoking habit, sleeping time, and snack intake had an influence on psychosomatic self-reported oral health-related symptoms. Conclusions : Cessation of smoking, adequate sleeping time, and reduction of snack intake can improve the oral health-related lifestyle and reduce the self-reported symptoms in the dental hygiene students.

• Journal of Nutrition and Health
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• 제25권7호
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• pp.656-667
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• 1992

This study was designed to investigate the effect of environmental an d physiological factors on bone mineral density(BMD) of the lumbar spine(L2longrightarrowL4) in 41 postmenopausal women. There were a positive relationships between BMD of the lumbar spine and monthly income food expenses pocket money energy expenditure(EXP) per day sociocultural EXP activity intensity time of standing and walking or age at first pregnancy. BMD of the lumbar spine was negatively correlated with age Engel index time of sleeping and sitting number of childbirty and children period of breastfeeding or menopausal period. But there were no significant relationships between BMD and physiological domestic EXP body mass index age at menar-che menstruation cycle or age at menopause. The complex interrelations between BMD and these variables were examined using stepwise multiple regression analysis. From this analysis in subject aged 50~59 years. EXP per body weight physiological EXP age at menopause time of sleeping were positively significant independent predictors of BMD. In subjects aged 60~69 years, . time of walking only and in total subjects. EXP per body weight pocket money were positively significant independent predictors ofBMD. This study suggest that EXP and pocket money are major constituents affection lumbar spine BMD in postmenopausal women.