• Journal of Korean Clinical Health Science
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• v.3 no.2
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• pp.354-360
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• 2015

Purpose. The purpose of this study was conducted to identify college students' sleep type and awareness of sleep. Methods. We researched 250 students in a college using the Korean Translation of Composite Scale(KtCS) and awareness of sleep questionnaire. Results. The sleeping hour of college students was 395.28 minute in average. The research showed that the biggest reason for the lack of sleep is using the computer, mobile and watching TV(22.6%), and most of them said that the lack of sleep is causing drowsiness during the daytime( 29.2%). For the questions asking when they feel drowsy during the daytime, most of them forcing themselves to stay awake(29.2%) and they caught up on sleep on the weekend(32.5%). Conclusions. Therefore college students to keep relevant sleep time and to know about the importance of the sleep.

• Advances in Traditional Medicine
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• v.6 no.4
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• pp.344-348
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• 2006

The crude methanolic extract of the bark of Cerbera odollam Gaertn. was evaluated for its possible antinociceptive and neuropharmacological activities in animal models. At the dose of 250 and 500 mg/kg body weight, the extract showed a significant antinociceptive effect in acetic acid induced writhing in mice comparable to that produced by aspirin, used as standard drug (P<0.001). The extract significantly reduced the time of onset of sleep (P<0.01) and potentiated the pentobarbital induced sleeping time in mice at the dose of 400 mg/kg of body weight significantly (P<0.001). It also decreased the open field score in open field test significantly at the dose of 400 mg/kg of body weight (P < 0.05). The obtained results tend to suggest the probable antinociceptive and neuropharmacological activities of the crude extract.

• Advances in Traditional Medicine
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• v.8 no.4
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• pp.448-451
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• 2008

Picrorhiza kurrooa Royle. is a well known medicinal plant among the indigenous medical practitioners of India. Present study is the first time to report the activity on the central nervous system. Preliminary study of the hot water extract showed significant depressant activity on the hole board test as evidenced from the ambulation and head dipping scores. The extract showed better activity compared to diazepam on the duration of pentobarbital induced sleeping time.

• Advances in Traditional Medicine
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• v.3 no.2
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• pp.63-71
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• 2003

The psycho-pharmacological effect of BRHAT VATACHINTAMANI RASA (BVC) an Ayurvedic preparation was investigated, both in animal and clinical models. It was observed that BVC possess a sedative or quitening effect in that it significantly decreased the spontaneous motor activity, and also lowered the exploratory behavior of the amphetamine treated animals. This was further evident by increase in climbing out time and taming effect on animal in isolation induced aggression test. Apart from very high dose it seems have little effect on pentobarbital sleeping time and narcotic analgesic test. The drug BVC increases performance of the animal in forced locomotor test. The effect of VATACHINTAMANI RASA on clinical study was not significant.

• Journal of Oriental Neuropsychiatry
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• v.11 no.2
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• pp.79-86
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• 2000

This study has been designed and performed to identify the effect on insomnia patients according to th injection of herbal medicine induced from Sanjoincho.The result of the injection shows as follows.1. Total duration of sleeping time showed 1.1500${\pm}$1.5433 hours of increase. (p〈0.01, respectively)2. Delaying time before the onset of sleep showed 0.8158${\pm}$1.3251 hours of increase in sleep onset insomnia(p〈0.05, respectively)3. The wake times showed 1.375${\pm}$1.4079 times of decrease in sleep maintenance isomnia. (p〈0.05, respectively)

• Advances in Traditional Medicine
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• v.10 no.2
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• pp.86-89
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• 2010

Two common Indian spices Carum copticum Karst (ajowan) and Cinnamomum tamala T.Nees. (bay leaves) has been investigated first time to report the activity on the central nervous system. Preliminary study of the hot water extract showed depressant activity on the hole board test as evidenced from the ambulation and head dipping scores. The extracts further quicken the onset and increased the duration of pentobarbital induced sleeping time.

• Clinical and Experimental Pediatrics
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• v.50 no.8
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• pp.718-725
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• 2007

Sleep disorders are very common among pediatric patients. Its prevalence is between 10% and 45% in preschool- and school-aged children. However parents commonly do not concern about their children's sleeping habits and for many pediatricians, there is not part of the routine office visit about a childs sleep. Sleep disorders were classified by International Classification of Sleep Disorder (ICSD) as dyssomnias, parasomnias, sleep disorders associated with mental, neurologic, or other medical disorders, and proposed sleep disorders. There are lots of differences in the causes, manifestations, and managements of sleep disorders between children and adult. The sleep disorders in childhood may manifest themselves as bedtime resistance, refusal to go to bed at a parentally described time, sleep-onset delay, inability to fall asleep within a reasonable time, prolonged nighttime awakening, and inability to return to sleep without assistance after waking during the night, and so have wide-ranging influences on children's behavior, mood, school performance, and family life. It's very important for pediatrician to concern about the sleep disturbances in childhood and so the problems of sleep in children should be early detected and managed.

• The Korean Journal of Pharmacology
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• v.5 no.1
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• pp.23-28
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• 1969

Saponin, essential oil and fat oil fractions were fractionated from Panax Ginseng and their potentiating or inhibiting actions during the combined use of several central nervous system stimulants or depressants were observed to elucidate the possible role of Ginseng fractions on the central nervous system. Saponin, essential oil and fat oil fractions shortened nembutal sleeping time at low dosage (10 mg/kg) but contrarily they produced potentiation of nembutal hypnosis at high dosage (50mg/kg). In the toxicity study of amphetamine, saponin and essential oil fractions reduced the toxicity in aggregated mice at high dosage (100 mg/kg) but such decreased lethality was not observed in isolated mice. Ginseng fractions, especially high dose of saponin fraction (100mg/kg) prolonged the survival time after injection of convulsive dose of metrazol or cocaine and saponin fraction also prolonged the onset of cocaine convulsion at high dosage (100 mg/kg).

• Advances in Traditional Medicine
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• v.6 no.2
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• pp.157-160
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• 2006

Chandanasav is an Ayurvedic preparation slightly reduced the gastrointestinal motility at the 15 min time interval. It increased the latent period of castor oil induced diarrhoea, slightly decreased number of stool count and lowered the purging index values. Chandanasav significantly reduced the onset and increased the duration of pentobarbital induced sleeping time. No significant analgesic effect was observed from the hot plate study Thus it may have mild constipating and central nervous system depressant activity without any effect on peripheral nervous system.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.598-601
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• 2010

This experiment was performed to investigate whether the combined-preparation of water extracts of germinated brown rice (WGR), water extracts of cultured mountain ginseng (WCG) and 70% ethanol extracts of Longanae Arillus (ELA) has hypnotic effects and/or enhances pentobarbital-induced sleep behaviors through the GABAergic system. The combined-preparation of WGR and WCG reduced sleep latency and prolonged sleep time induced by pentobarbital. ELA also reduced sleep latency and prolonged sleep time induced by pentobarbital. However, WGR or WCG itself did not induce sleep. The combined-preparation of WGR, WCG and ELA strongly reduced sleep latency and prolonged sleep time via chloride influx into primary cultured cerebellar granule cells. In conclusion, the combined-preparation of WGR, WCG and ELA augments pentobarbital-induced sleep behaviors through the modification of GABAergic system.