• 대한약리학회지
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• 제20권2호
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• pp.15-21
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• 1984

Clonidine으로 고혈압을 치료시 부작용으로 진정작용이 심하게 나타나며 이는 Clonidine이 중추 ${\alpha}_2$-수용체를 흥분시켜서 일으킨 결과임이 보고되었다. 본 실험에서는 부화 $1{\sim}2$일이 된 병아리에 ${\alpha}_2$-수용체 효현제들을 주사하여 정좌반사가 소실될 때까지의 시간 및 수련시간을 관찰하였으며, 그리고 guanabenz 유도 수면에 대한 ${\alpha}_1$- 및 ${\alpha}_2$-수용체 길항제 및 opiate수용체 길항제가 어떻게 관여하는 지를 검토하고 다음과 같이 요약하였다. 1) ${\alpha}_2$-수용체 효현제중 guanabenz, clonidine, guanfacine 및 B-HT 933은 용량에 의존해서 정좌반사소실까지의 잠복시간을 감소시켰다. 그러나 B-HT 920 및 oxymetazoline은 잠복시간을 경미하게 연장시켰다. 2) ${\alpha}_2$-수용체 효현제들은 용량에 비례해서 수면시간을 증가시켰고 이들의 강도는 guanabenz>clonidine>oxymetazoline${\geq}$B-HT 933${\geq}$B-HT 920> guanfacine의 순위이었다. 3) ${\alpha}_2$-수용체 길항제들은 양에 비례해서 guanabenz 유도 수면시간을 감소시켰으며 이들의 강도는 yohimbine>rauwolscine>piperoxan${\geq}$RX 781094의 순위 이었다. 4) Ethanol 및 hexobarbital유도 수면은 yohimbine에 의해 봉쇄되지 아니하였다. 5) Guanabenz유도 수면시간에 대해서 ${\alpha}_1$-수용체 효현제인 methoxamine 및 Phenylephrine은 영향이 없었으나, ${\alpha}_1$-수용체 결항제인 Prazosin은 증가시켰다. 그러나 corynanthine은 반대로 수면시간을 현저히 감소시켰다. 이상의 결과로 보아 중추 ${\alpha}_2$-수용체의 흥분으로 병아리의 수면이 야기되고, 중추 ${\alpha}_1$-수용체의 역할에 대하여는 명백하지 않으나 ${\alpha}_2$-수용체 효현제 및 길항제의 성질을 규명하는 동물모델로서 부화 I${\sim}$2일의 병아리가 크게 유용할 것으로 시사되는 바이다.

• Archives of Pharmacal Research
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• 제7권1호
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• pp.53-56
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• 1984

The effect of twenty two spices on liver microsomal monooxygense activity was tested as measured by alteration of hexobarbital (HB) narcosis and strychnine mortality in mice. Oral administration of seven spices for 7 consecutive days caused a significant shortening of the duration of HB-induced sleeping time. The treatment of mice with a single i. p. injection of 9 spices resulted in a significant prolongation of the sleeping time. White pepper, dill and fennel reduced the toxicity of strychnine. These results strongly indicated that some spices might affect the activity of liver microsomal drug metabolizing enzyme (DME) function.

• 한국전기전자재료학회논문지
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• 제28권6호
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• pp.400-402
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• 2015

The typical winter heating unit heating mat. The product is to be found in the development of new water heating mat today. The product that circulates the water through the hose inside the mat with your existing heating mat electric heated mat is different from boiling water. However, no clear standards for noise and safety, consumer choice is giving confusing information about the product is low. We were to develop a high heat retention and stability than conventional sleeping mats to produce creative than traditional hot mats, heated mats general comparison with experimental results is a more efficient heat retention mat is produced.

• 대한한방소아과학회지
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• 제26권4호
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• pp.24-31
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• 2012

Objectives: The purpose of this study was to estimate differences in physical growth according to sleep during preschool period. Methods: Difference of height and BMI percentile according to quality and quantity of sleep obtained through survey from 377 preschool children was measured using statistical method. Results: There was no significant difference in height and BMI percentile according to bedtime, rising hour, sleeping hours and sleeping environment. Children who had woken up more from scare during sleep showed smaller height percentile. Conclusions: Children who woke up more from scare during sleep could have smaller height.

• 동의신경정신과학회지
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• 제20권3호
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• pp.229-236
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• 2009

Objectives : This study is designed investigate the effect of oriental medial therapy on a 63 year old female patient had Miller Fisher Syndrome with sleeplessness. Methods : We experienced a case of Miller Fisher Syndrome and treated with herbal medicine, eletro-acupuncture. The effects of treatment were measured by sleeping hour, taken measurements with a ruler(eyeball movement). Results : Whole condition (ophthalmoplegia, ataxia and so on) was improved and Oriental treatment had a good effect on sleeping hour. Conclusions : Oriental medical treatments were very effective for the patient had Miller Fisher Syndrome with sleeplessness.

• 대한한의학회지
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• 제21권3호
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• pp.209-212
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• 2000

A 69-year old female stroke patient was admitted on August 7, 1998. She had seborrheic dermatitis on her lower abdomen for 25 years. The patient received many treatments but was unable to find a cure. During her hospitalization for stroke, the patient had trouble sleeping. The doctors hypothesized the dermatitis to be the cause of the sleeping disorder and attempted to treat it. The doctors chose Hwangyeonhaedog-tang Gagambang for treatment and smeared it on the patient's abdomen. After ten days of treatment, the dermatitis disappeared and did not reoccur. The patient's abdomen continued to show no symptoms of dermatitis after being released for 2 years.

• 한국식품과학회지
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• 제2권1호
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• pp.93-95
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• 1970

동면 직전과 직후의 독사 살모사 능사로 사주(蛇酒)를 만들고 사주(蛇酒) 중(中)에 유리(遊離)되어 있는 cholesterol 을 정량, 검토한 결과는 다음과 같다. 1. 동면 후의 뱀을 원료로 한 사주(蛇酒)는 동면 직전의 뱀을 원료로 한 것에 비하여 유리(遊離)된 cholesterol 함량이 뚜렷이 적었다. 2. 사주( 蛇酒) 중(中)의 유리(遊離) cholesterol 양은 원료 뱀의 지방(脂肪)함량이 많을수록 많았다.

• Natural Product Sciences
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• 제12권1호
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• pp.44-49
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• 2006

The aqueous extract of Hydrilla verticillata (AEHV) was tested for possible pharmacological effects on experimental animals. AEHV significantly potentiated the sleeping time of mice induced by standard hypnotics viz. pentobarbitone sodium, diazepam, and meprobamate in a dose dependent manner. AEHV showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with AEHV caused significant protection against strychnine and leptazol-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the aqueous extract of H. verticillata.

• 생약학회지
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• 제8권3호
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• pp.115-119
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• 1977

Black pepper (Piper nigrum L.) among several irritating spices tested was highly effective on the duration of hexobarbital hypnosis in mice. Pretreatment of mice with the methanolic extract of black pepper (60mg/kg i.p.) prolonged markedly the duration of hexobarbital sleeping time. Three consecutive daily administrations of the same dose of black pepper extract, however, shortened (37%) the duration of hexobarbital sleeping time. The ether soluble fraction of black pepper extract caused most potent effects on the duration of hexobarbital hypnosis. From the above results, it was postulated that the lipid soluble components of black pepper might considerably change the drug action and metabolism by altering drug metabolizing enzyme systems.

• 대한약리학회지
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• 제9권2호
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• pp.9-16
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• 1973

It is said that the chinese medicine, Ginseng root has some effects on the central nervous system . Ginseng saponin was prepared from Ginseng methanol extract and its effect on general behavioral activity was studied in rats. Each experimental group was composed of 8 rats. The behavioral activity of rats was observed in terms of 7 components i.e. sleeping, lying, grooming, rearing, walking, eating and drinking. In each group, total duration of behavior-observation was 2 hours, which were devided into four 30 min-intervals. The behavior-observation was done 10 times for each interval, so total number of observation was 40 times throughout 2 hours. Ginseng sapoain showed central nervous system stimulant action in reduced sleeping component and in increased activity components. From the results of this study, it is suggested that Ginseng saponin inhibits the extrapyramidal action of chlorpromazine.