The Korean Journal of Pharmacology (대한약리학회지)

The Korean Society of Pharmacology (대한약리학회)
권호 표지

Effect of Ginseng Saponin on the General Behavior in Rats

인삼(人蔘)의 중추신경계(中樞神經系)에 대(對)한 작용(作用) -인삼(人蔘) Saponin이 흰쥐 일반활동(一般活動)에 미치는 영향(影響)-

  • Sim, Sang-Jung (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Oh, Jin-Sup (Department of Pharmacology, College of Medicine, Seoul National University)
  • 심상정 (서울대학교 의과대학 약리학교실) ;
  • 오진섭 (서울대학교 의과대학 약리학교실)
  • Published : 1973.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

It is said that the chinese medicine, Ginseng root has some effects on the central nervous system . Ginseng saponin was prepared from Ginseng methanol extract and its effect on general behavioral activity was studied in rats. Each experimental group was composed of 8 rats. The behavioral activity of rats was observed in terms of 7 components i.e. sleeping, lying, grooming, rearing, walking, eating and drinking. In each group, total duration of behavior-observation was 2 hours, which were devided into four 30 min-intervals. The behavior-observation was done 10 times for each interval, so total number of observation was 40 times throughout 2 hours. Ginseng sapoain showed central nervous system stimulant action in reduced sleeping component and in increased activity components. From the results of this study, it is suggested that Ginseng saponin inhibits the extrapyramidal action of chlorpromazine.

Keywords