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Effects of Capsaicin on Liver Cytochrome $P_{450}$ in the Rat (Capsaicin이 백서 간의 Cytochrome $P_{450}$에 미치는 영향)

  • 김명혜;김낙두;이상섭
    • YAKHAK HOEJI
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    • v.23 no.2
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    • pp.111-118
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    • 1979
  • It was previously reported that cytochrome P$_{450}$ content in liver was increased when Capsicum acetone extract was given chronically to rats. The present study is aimed to investigate the effect of capsaicin, a principal component of red pepper, on the drug metabolizing enzymes in rat liver. Capsaicin (5mg/kg) was given intraperitoneally once a day for seven days and zoxazolamine paralysis time and hexobarbital sleeping time were determined 24 hrs after the last dose of capsaicin. Plasma hexobarbital concentration was also determined five and 15 min after hexobarbital administration to rats. Zoxazolamine paralysis time and hexobarbital sleeping time were shortened by 31.6% and 37.1%, respectively, compared with control group. Plasma hexobarbital concentration was lowered by 26.2% after five min and by 35.2% after 15 min, respectively, compared with control group. However, administration of single dose of capsaicin did not affect the zoxazolamine paralysis time and hexobarbital sleeping time. Microsomal cytochrome P$_{450}$ content and NADPH-cytochrome C reductase activity were increased by 14.6% and 11.6%, respectively in the rats pretreated with capsaicin for seven days, while cytochrome b$_{5}$ content was not changed. These results suggest that treatment with capsaicin for seven days may induce the drug metabolizing enzyme in rat liver.

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Factors Influencing on Fatigue in Operating Room Nurses (수술실 간호사의 피로 예측요인)

  • Lee, Eun-Seon;Kim, In-Sook
    • Korean Journal of Occupational Health Nursing
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    • v.21 no.3
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    • pp.229-238
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    • 2012
  • Purpose: The purpose of this study was to measure the fatigue of operating room nurses and examine factors contributing to their fatigue. Methods: The subjects of this study were 115 nurses who worked in operating rooms of three hospitals. Data were collected from September 15, 2009 to September 30, 2009. Fatigue and job stress were measured by using the Symptom's Fatigue Scale and the job stress measurement tools in operating room nurses. Results: The mean score of fatigue level was $3.10{\pm}0.61$. We analyzed fatigue according to characteristics of subjects and found that there were significant differences in marital status, number of children and sleeping hours in general characteristics. Career, daily participation hours in the surgery relating to job related characteristics. Significant positive correlations were found between job stress and fatigue(r=.233, p= .012). Three significant variables influencing fatigue of operation rooms nurses were job stress, daily participation hours in the surgery, and sleeping hours (Adj. $R^2$=0.284, F=4.773, p<.001). Conclusion: An integrative care program that takes job stress, daily participation hours in the surgery and sleeping hours into consideration is essential to reduce fatigue in operating room nurses.

An experimental study of Yangsymtang's effects on the activities of Central Nervous System (중추신경계(中樞神經系)에 작용(作用)하는 양심탕(養心湯)의 실험중적(實驗中的) 연구(硏究))

  • Joa Seung-Ho;Lee Jin-Yong;Kim Deok-Gon;Jeong Gyu-Man
    • The Journal of Pediatrics of Korean Medicine
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    • v.10 no.1
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    • pp.245-263
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    • 1996
  • In order to investigate the effects of Yangsymtang on the activities of central nervous system, we observed the effects on convulsions induced by pentylenetetrazole, strychnine and picrotoxin. The sedative those on spontaneous motor activity and by rota rod method, the those on sleeping time induced by barbiturate and the alleviative those on pain induced by acetic acid and hind limb pressure also were analyzed. The results were as follows: 1. The solid extracts of Yangsymtang showed no anticonvulsive effects on convulsions induced by pentylenetetrazole, strychnine and picrotoxin. 2. As to the sedative effects by rota rod method, th solid extracts of Yangsymtang were recognized as significance(P<0.01). 3. The sleeping time induced by thiopental sodium was not prolonged by the oral administration of the solid extracts of Yangsymtang. 4. The oral administration of Yangsymtang did not influenced the sleeping induced by pentobarbital sodium significantly. 5. As to the effects on spontaneous motor activity, the oral administration of Yangsymtang made spontaneous motor activity decrease significantly(P<0.05). 6. The oral administration of Yangsymtang was significant on pain induced by acetic acid(P<0.001). 7. As to alleviative effects on pain induced by hind limb pressure. The solid extracts of Yangsymtang were not significant.

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Central nervous system depressant activity of Leucas aspera root

  • Rahman Shafiur;Sarder Mokaddez;Ali Yusuf;Rashid Abdur
    • Advances in Traditional Medicine
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    • v.6 no.3
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    • pp.174-178
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    • 2006
  • The ethanolic extract of Leucas aspera root was studied for its effect on the central nervous system (CNS) using pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to control. In open field test the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed significant from the third observation period (60 min) and persisted up to the seventh observation period (240 min) except at fourth observation (90 min) for 250 mg dose group and depressing effect was significant from second observation (30 min) up to seventh observation period (240 min) for 500 mg dose group. These results support the finding that Leucas aspera root may contain biologically active constituent(s) having CNS activity.

Relevance of Periodontal Disease According to Presence of Cognitive Stress, Sleeping Hours, and Subjective Oral-Health Status of Adults (스트레스, 수면시간 및 주관적 구강건강 상태가 치주질환에 미치는 영향)

  • Kim, Ye-Hwang;Lee, Jung-Hwa
    • The Korean Journal of Health Service Management
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    • v.11 no.4
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    • pp.169-178
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    • 2017
  • Objectives : In this study, we investigated the correlation of mental-and oral-health status with periodontal disease. Ultimately, we sought to make a positive contribution to the promotion of periodontal health and the prevention of periodontal disease. Methods : This study was analyzed using the data of KNHANES 2013-2015. The participants of this study were between 20 and 64 years old. The final selection was 1,512 adults. Results : Participants with a sleeping time of less than 6 hours and those who recognized stress showed higher periodontal disease. Number of decaying teeth, oral-health status, toothaches, and chewing problems were associated significantly with periodontal disease. To investigate the effects of general characteristics and mental and oral-health status on periodontal disease, a logistic regression analysis was conducted. Sex, age, education level, smoking status, oral-health status, and chewing problems were variables that affected periodontal disease. Conclusions : This study showed that mental-and oral-health status is closely related to periodontal disease. Therefore, it is expected that this will be used as basic data to effectively improve periodontal disease in adults.

Influencing Factors of Subjective Sleep Quality among Middle-aged Women (중년여성의 주관적 수면의 질에 영향을 미치는 요인)

  • Cho, Eun-Jung
    • Women's Health Nursing
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    • v.13 no.3
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    • pp.201-210
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    • 2007
  • Purpose: The purposes of this study were to (a) explore the prevalence of sleep patterns of middle-aged women; (b) identify the relationship between subjective sleep quality and its related variables; and (c) predict the possible explanations of how the related factors affect subjective sleep quality of middle-aged women. Methods: A total of 256 women aged 40-60 years were purposely sampled and given self-administered questionnaires in a cross-sectional, correlation coefficient design. The data was analysed using t-test, one-way ANOVA, Pearson's correlation coefficients, and stepwise multiple regression. Results: The results were as follows; (a) a total of 40% of the women were poor sleepers as defined by a global PSQI score >5; (b) there were significant differences in quality of sleep related to type of family, number of present illnesses, and use of medication; (c) health promoting behaviors, family functioning, depression, and climacteric symptoms were significantly related to subjective sleep quality; and (d) 34% of variance in subjective sleep quality can be explained by climacteric symptoms, depression, type of family, and spouse. Conclusions: Our findings suggested a high proportion of poor sleeping in middle-aged women. Poor sleeping appeared to have poor health promoting behaviors, lower family functioning, worse depression, and higher climacteric symptoms. Climacteric symptoms, depression, type of family, and spouse were independent risk factors for poor sleeping. Nurse professionals should screen for sleep problems in middle-aged women with a biopsychosocial and behavioral aspect.

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Problems Behavior and Its Related Factors in School-aged Children (학령기 아동의 문제행동과 관련요인)

  • Jung, Hyejung;Lee, Sangmi
    • Korean Parent-Child Health Journal
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    • v.20 no.1
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    • pp.1-9
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    • 2017
  • Purpose: This study aimed to investigate problem behavior and its related factors in school-aged children. Methods: A descriptive correlational study was conducted with 221 mothers of children at 1st to 6th grades. Data were collected from March to April, 2015 using self-report structured questionnaires. Questionnaires included characteristics of subjects, Korean Child Behavior Checklist for measuring problem behavior and Children's Sleep Habits Questionnaire for assessing sleeping habits. Collected data were analyzed by independent t-test, $x^2$ test, and multiple logistic regression. Results: In logistic regression analysis, having any maternal job (aOR=2.8, 95% CI=1.1~6.9) and higher daytime sleepiness (aOR=2.9, 95% CI=1.2~7.4) were statistically significant contributors of internal problems. Higher bedtime resistance (aOR=2.2, 95% CI=1.0~4.9) and higher daytime sleepiness (aOR=2.8, 95% CI=1.2~6.3) were statistically significant contributors of external problems. Higher bedtime resistance (aOR=4.3, 95% CI=1.5~12.4) was statistically significant contributors of total problem behavior. Conclusion: School-aged children with sleeping problem are at risk for problem behavior. More attention is need to consider sleeping habits for supporting behavioral improvement in school-aged children.

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A Development of Brassiere Prototype for Attaching the Measuring Module of ECG and Body Movement while Sleeping (심전도 및 수면시 체동 측정 모듈 장착을 위한 브래지어 프로토타입 개발)

  • Kweon, Soo Ae;Sohn, Boo-hyun
    • Journal of Fashion Business
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    • v.21 no.2
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    • pp.78-90
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    • 2017
  • In this study, brassiere prototype was developed for attaching the measuring module of ECG measurement and body movement while sleeping. For ECG measurement, textile electrodes was made of stretch fabric containing polyurethane in consideration of elasticity of brassiere band. It was used as a conductive yarn by silver coating on the warp. The textile electrodes was woven with twisted twill to increase the density of conductive yarns. The pressure of the brassiere band was enough to sensing stably the ECG, and the elastic band of the brassiere was designed to be wider than 3cm to install the textile electrodes inside, so that textile electrodes was close fitting to the skin at a constant pressure without lifting. The textile electrodes coated with silicon on rear was attached to brassiere elastic band, and the module was installed with a snap connector to textile electrodes of brassiere band. The module was suitable to monitering ECG measurement of a typical R peak, pulse rate and body movement while sleeping without interfering.

Relation between Employees' Life patterns and Health conditions (직장인들의 생활습관 행태와 건강상태의 관련성)

  • Kim, Nam-Jin
    • Korean Journal of Health Education and Promotion
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    • v.24 no.2
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    • pp.63-75
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    • 2007
  • Purpose: The research was performed to provide basic information and bring importance to people's attention based upon seizing relation between employees's life patterns and health conditions in their daily lives. Method: This study was done from October 9th, 2006 to 27th and targeted on people who work more than 1 year in Seoul and Kyung-gi area including 700 people; 350 of males, 350 of females. In the experiment, there are 8 measurable variables which are weight, smoking, drinking, exercise, sleeping, having breakfast, regular time for meal and having snack. The survey questionnaire used THI. The collected data was analyzed using t-test, one way ANOVA, Pearson correlation coefficient and Multiple regression with SPSS/PC. Results: 1) It showed different data based on general traits such as gender, age, marriage, job and working time. 2) It also displayed different data in physical, mental and total health conditions depending on general traits. 3) The rate of symptom appeal was noticeably low as the body condition is in a good shape. 4) It exhibited that the variables for the rate of symptom appeal was negatively related to both male and female. 5) The variables affected to health conditions were age, exercise, having snack, sleeping, time for meal and smoking for male and weight, sleeping and time for meal for female. Conclusion: It is shown that if a person has a good life patterns in his/her daily life, he/she has a low rate of symptom appeal, which means he/she has better both physical and mental conditions.

Energy-efficient Multicast Algorithm for Survivable WDM Networks

  • Pu, Xiaojuan;Kim, Young-Chon
    • Current Optics and Photonics
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    • v.1 no.4
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    • pp.315-324
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    • 2017
  • In recent years, multicast services such as high-definition television (HDTV), video conferencing, interactive distance learning, and distributed games have increased exponentially, and wavelength-division multiplexing (WDM) networks are considered to be a promising technology due to their support for multicast applications. Multicast survivability in WDM networks has been the focus of extensive attention since a single-link failure in an optical network may result in a massive loss of data. But the improvement of network survivability increases energy consumption due to more resource allocation for protection. In this paper, an energy-efficient multicast algorithm (EEMA) is proposed to reduce energy consumption in WDM networks. Two cost functions are defined based on the link state to determine both working and protection paths for a multicast request in WDM networks. To increase the number of sleeping links, the link cost function of the working path aims to integrate new working path into the links with more working paths. Sleeping links indicate the links in sleep mode, which do not have any working path. To increase bandwidth utilization by sharing spare capacity, the cost function of the protection path is defined to use sleeping fibers for establishing new protection paths. Finally, the performance of the proposed algorithm is evaluated in terms of energy consumption, and also the blocking probability is evaluated under various traffic environments through OPNET. Simulation results show that our algorithm reduces energy consumption while maintaining the quality of service.