• Korean Journal of Biological Psychiatry
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• v.29 no.1
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• pp.9-14
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• 2022

Objectives Sleep is fundamental to maintaining homeostatic control and has behavioral and psychological effects on humans. To better understand the function and pathophysiology of sleep, specific gene expressions in reference to sleep deprivation have been studied. In this study, we investigated the gene expression of peripheral blood mononuclear cells after sleep deprivation to better understand the functional consequence of sleep. Methods In eight healthy men, 24 h sleep deprivation was induced. Blood was sampled at 14:00, before and after sleep deprivation. mRNA was isolated and analyzed via microarrays. cDNAs before and after sleep deprivation were coupled to Cy3 or Cy5, respectively, and normalized cDNAs were selected with a ratio greater than two as a significant gene. Results are expressed as mean. Results Among 41174 transcripts, 38852 genes were selected as reliable, and only a small minority (< 1%) of the genes were up-or down-regulated. Total six and eleven genes were selected as significant upregulated and downregulated genes, respectively. Protein tyrosine phosphatase receptor type O was most upregulated (6.9-fold), and low-density lipoprotein receptor-related protein 5-like protein showed the most substantial inhibition (0.06-fold). Conclusions This study showed significant associations between sleep deprivation and the immune system. Acute sleep deprivation affects pathways in proinflammatory cytokines as well as metabolic pathways of glutamate and purine, neurotransmitters related to sleep and wake cycle.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.1
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• pp.65-74
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• 2017

Sleep deprivation is an extremely common event in today's society. It has caused learning cognitive skill deterioration and poor concentration, increased disease such as heart disease, diabetes and obesity, sexual function decrease, infertility increase, depression and autonomic nervous system disorder. Sleep deprivation-induced stress caused NADPH oxidase and oxidative stress. And this oxidative stress induces apoptosis. Lilii bulbus and Nelumbins semen are known to mental and physical relaxation effects. In this study, we induced sleep deprivation(SD) in Sprague-Dawley rats in water for 5 days and thereafter administered orally L. bulbus and N. semen for 5 days. Brain tissues were observed by histochemical, immunohistochemical and tunel staining. The immunoreactives of Tumor necrosis factor ${\alpha}$, Neuronal nitric oxide synthases, Phospho-SAPK/JNK and gp91-phox of the L. bulbus administered group and N. semen administered group were weaker than those of sleep deprivation group. In the L. bulbus administered group and N. semen administered group, apoptosis was decreased than that of sleep deprivation group. Proapoptotic p53, Bax, Cleaved caspase 3 immunoreactives of the administered group were weaker than those of sleep deprivation group, whereas anti-apoptotic Bcl-2 immunoreactity was stronger in the L. bulbus administered group and N. semen administered group. Antioxidant mechanism such as DJ-1, superoxide dismutase 1, Nuclear factor-like 2 immunoreactives of the L. bulbus and N. semen administered group were stronger than those of sleep deprivation group. These results demonstrate that L. bulbus, N. semen had the neuroprotective effects on the sleep deprivation-induced oxidative stress in the hippocampus.

• Science of Emotion and Sensibility
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• v.1 no.1
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• pp.69-78
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• 1998

Sleep deprivation may affect the brain functions such as cognition and consequently, dynamics of the BEG. We examined the effects of sleep deprivation on chaoticity of the EEG. Five volunteers were sleep-deprived over a period of 24 hours They were checked by EEG during two days. thc first day of baseline period and the second day of total sleep deprivation period. EEGs were recorded from 16 channels for nonlinear analysis. We employed a method of minimum embedding dimension to calculate the first positive Lyapunov exponent. Fer limited noisy data, this algorithm was strikingly faster and more accurate than previous ones. Our results show that the sleep deprived volunteers had lower values of the first positive Lyapunov exponent at ten channels (Fp1, F4. F8. T4, T5. C3, C4. P3. P4. O1) compared with the values of baseline periods. These results suggested that sleep deprivation leads to decrease of chaotic activity in brain and impairment of the information processing in the brain. We suggested that nonlinear analysis of the EEG before and after sleep deprivation may offer fruitful perspectives for understanding the role if sleep and the effects of sleep deprivation on the brain function.

• Biomolecules & Therapeutics
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• v.26 no.4
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• pp.368-373
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• 2018

Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia, has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations. In the present study, we examined whether linalool elicited an anti-stress effect, reversing the behavioral alterations observed following REM-sleep deprivation in mice. Furthermore, we investigated the underlying mechanism of the effect of linalool. Spatial memory and learning memory were assessed through Y maze and passive avoidance tests, respectively, and the forced swimming test was used to evaluate anti-stress activity. The mechanisms through which linalool improves memory loss and behavioral alterations in sleep-deprived mice appeared to be through an increase in the serotonin levels. Linalool significantly ameliorated the spatial and learning memory deficits, and stress activity observed in sleep-deprived animals. Moreover, linalool led to serotonin release, and cortisol level reduction. Our findings suggest that linalool has beneficial effects on the memory loss and behavioral alterations induced by REM-sleep deprivation through the regulation of serotonin levels.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1997.11a
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• pp.69-74
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• 1997

Sleep deprivation may affect the brain functions such as cognition and, consequentoy, dynamics of the EEG. we examiced the effects of sleep deprivation on chaoticity of EEG. Five volunteers were sleep-deprived over a period of 24 hours, They were checked by EEG during two days, the first day of baseline period, EEGs were reorded form 16 channels for nonlinear analysis. We dmployed a method of minimum cmbedding dimension to calculate the first positive Lyapunov exponent. For limited noisy data, this algorithm was strikingly faster and more accurate than previous ones. Our results show that the sleep deprived volunteers had lower values of the first positive Lyapunov exponent at ten channels (Fp$\_$1/, F$\_$4/, F$\_$8/, T$\_$4/, T$\_$5/, C$\_$3/, C$\_$4/, P$\_$3/, p$\_$4, O$\_$1/) compared with the values of baseline periods. These results suggested that sleep deprivation leads to decreawe of chaotic activity in brain and impairment of the information processing in the brain. We suggested that nonlinear analysis of the EEG before and after sleep deprivation may offer fruitful perspectives for understanding the role o f sleep deprivation on the brain function.

• Sleep Medicine and Psychophysiology
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• v.19 no.2
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• pp.63-67
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• 2012

The reciprocal interaction between sleep and pain has been reported by numerous studies. Patients with acute or chronic pain often complain of difficulty falling asleep, frequent awakenings, shorter sleep duration, unrefreshing sleep, and poor sleep quality in general. According to the majority of the experimental human studies, sleep deprivation may produce hyperalgesic changes. The selective disruption of slow wave sleep has shown this effect more consistently, while results after selective REM sleep deprivation remain unclear. Patients with chronic pain have a marked alteration of sleep structure and continuity, such as frequent sleep-stage shifts, increased nocturnal awakenings, decreased slow wave sleep (SWS), decreased rapid eye movement (REM) sleep, and alpha-delta sleep. Many analgesic medications can alter sleep architecture in a manner similar to the effects of acute and chronic pain, suppressing SWS and REM sleep.

• Sleep Medicine and Psychophysiology
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• v.6 no.1
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• pp.76-84
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• 1999

Objectives: A number of studies have shown that sleep deprivation results in reduced vigilance and increased negative affects such as tension, depression and anger. However there are few studies about effects of sleep deprivation on anxiety. The purpose of this study was to investigate the effects of 40 hour sleep deprivation on state anxiety, affects, sleepiness and fatigue. The authors also intended to study the effect of trait-anxiety on these psychological variables after sleep deprivation. Methods: Twenty nine subjects(22 men, 7 women, $24.59{\pm}1.35$ years of age) participated in this study. Subjects had no past history of psychiatric disorders and physical illnesses, and had normal sleep-waking cycle without current sleep disturbances. All of the subjects completed sleep dairy for two weeks to exclude some who suffered from chronic sleep deprivation or sleep disturbances. Subjects were instructed to get a normal sleep as usual at night before the study. After awakening, subjects remained awake for 40 hours under continuous surveillance. They completed State-Trait Anxiety Inventory, Index of General Affect, Stanford Sleepiness Scale and Fatigue Questionnaire every three hours, therefore they completed the scales 14 times totally. Subjects were dictated not to take caffeine, alcohol, or any medications on the day of the study. Heavy exercises and naps were restricted too. Results: Sleep deprivation resulted in increased state anxiety, negative general affects, and increased sleepiness and fatigue(p<.001). Dividing into high trait-anxiety group and low trait-anxiety group, there was significant sleep deprivation x traitanxiety interaction effect on general affect(p<.05). But, there was no significant sleep deprivation x trait-anxiety interaction effect on state-anxiety, sleepiness and fatigue. During sleep deprivation, the highest ratings of scales on anxiety, negative affect, sleepiness and fatigue occurred between 4 : 00AM and 7 : 00AM. Conclusions: These results show that sleep deprivation results in increased anxiety, mood state disturbance and increment of sleepiness and fatigue. These findings also suggest that trait-anxiety is a factor that influences the degree of worsening in general affect caused by sleep deprivation. During sleep deprivation, the rating curves of anxiety, affect, sleepiness and fatigue show rhythmicity that may be related to circadian rhythm.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.05a
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• pp.425-427
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• 2021

Entering the modern society, due to changes in daily life as well as social life, the sleep deprivation and unsatisfactory sleep environment that modern people have, ranked the lowest in the sleep deprivation nation in the world and the lowest in the nation considered to be sleep deprivation. This is about 'sleep pillows using Arduino,' which can improve the 'sleep environment', which is the 2nd largest cause of sleep deprivation. The few minutes before you go to sleep, the moment of time, can determine the quality of your sleep, and the quality of your sleep determines the satisfaction of your daily life. Using Arduino, you can improve the quality of your sleep through various functions. Through Arduino, you can create a sleeping environment for the sleeper by adjusting the sleeper's breathing measurement, lighting, and Bluetooth speaker and create an environment that suits you. Through this, we will be able to improve the sleep deprivation of modern people and have a more prosperous life.

• Sleep Medicine and Psychophysiology
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• v.26 no.2
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• pp.67-74
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• 2019

Anger is a multi-dimensional concept ranging from feeling irritable to violent aggression. A growing body of literature suggests the relevance of sleep in regard to anger. The current study aims to review previous studies on the association between anger and diverse aspects of sleep including sleep disruption, chronotype, sleep disorders and sleep deprivation. An association between sleep and anger has been observed starting in the early stage of life, with sleep of infants or toddlers affecting emotional and behavioral aspects of anger. However, the association between anger and sleep is not clear in adolescents and might be due to the effects of psychosocial factors on both sleep and anger during adolescence. Subjective but not objective sleep disturbances of adults have been also associated with anger. Evening types showed more anger, which might be mediated by psychological characteristics or social jet lag of evening people. Increased anger has also been found in those with insomnia, sleep apnea, or experimental sleep-deprivation. Previous studies have reported that diverse sleep disturbances are related to anger. Future study assessing the various sleep or circadian indices and considering the multidimensional aspects of anger are needed.

• Korean Journal of Health Education and Promotion
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• v.26 no.4
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• pp.11-22
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• 2009

Objectives: The researchers investigated the relationship between sleep pattern (circadian rhythm/sleep deprivation), eating habit, and the perceived skin condition of female adults, in orders to provide valuable information to women who want to maintain healthy skin and professionals in health promotion. Methods: The participants were 297 female adults whose ages ranged from 20 to 60 (M=35.14, SD=10.37). The questionnaires and psychological tests used in this research included the following: Circadian Rhythm Questionnaire, Sleep Deprivation Scale, Eating Habit Questionnaire, Skin Condition Questionnaire, Scale for Perceived Skin Health. Results: Results indicated that evening type women had more fatty skin and felt their skins less healthier than morning type. Although women who did not deprived their sleep had more fatty and sensitive skin and felt their skins less healthier than women who deprived their sleep, sleep deprivation was positively related to the morningness, and the morningness was negatively related to the preference of fatty and spicy foods. Only the preference of fatty foods among eating habit was positively related to the fatty and sensitive skin, and negatively to the perceived skin health. Regression analyses with circadian rhythm and the preference of fatty foods revealed that only circadian rhythm was significant predictor for the fatty skin, while the preference of fatty foods was only significant predictor for the sensitive skin and the perceived skin health. And, circadian rhythm and the preference of fatty foods accounted for around 12.0% variance of the fatty skin. Conclusion: This study reiterates the roles of fatty foods on skin health, and found the role of circadian rhythm on skin health, and it is needed to explore the relationship between sleep deprivation and skin condition further. These results may provide useful information for health practitioners.