• Journal of Applied Biological Chemistry
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• 제66권
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• pp.359-368
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• 2023

This study aims to explore the impact of Krill Oil (KO, Superba^TM Boost) on skin moisturization regulation. The research involved five groups: an intact control, a reference group (L-AA 100 mg/kg), and KO groups (400, 200, and 100 mg/kg), each comprising ten mice. Oral administration was conducted for 8 weeks (56 days), during which changes in body weight, hyaluronan, collagen type 1 (COL1), transforming growth factor-β1 (TGF-β1), ceramide, and water contents were analyzed in dorsal back skin tissue. Real-time PCR was employed to assess gene expression related to hyaluronic acid synthesis (HAS1, HAS2, HAS3), COL1 synthesis (COL1A1 and COL1A2), and TGF-β1. Results demonstrated that KO administration significantly increased hyaluronan content, hyaluronic acid synthesis (HAS1, HAS2, HAS3), COL1 content, COL1 synthesis (COL1A1 and COL1A2), TGF-β1 content, TGF-β1 mRNA expression, ceramide content, and water content in a concentration-dependent manner compared to the intact control. Importantly, no discernible disparities were noted between the KO and L-AA groups, even though they received equivalent oral dosages. This study accentuates the potential utility of exogenous KO in the regulation of skin moisture, thus positioning it as a promising avenue for the development of nutricosmetics. Future research endeavors should delve into the role of KO in safeguarding against both intrinsic and extrinsic aging-related skin manifestations, as well as its potential to ameliorate skin wrinkles, in conjunction with its moisturizing attributes.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.218.3-218.3
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• 2003

In this study, a FT-NIR spectroscopy was used to determine skin moisture. NIR diffuse reflectance spectra were collected from separated dorsal and abdominal hairless mouse skin. Partial least squares regression (PLSR) was applied to develop calibration models that determine the water content. The seven spectra regions, such as 833-2500, 1100-2250, 1100-1750, 1750-2250, 1200-1600, 1800-2200, and 1200-2200 except 1600-1800 nm, were investigated for the best model by PLSR. The developed model predicted skin moisture for validation set with a standard errors of prediction (SEP) of 4.43%, when used 833-2500 nm. (omitted)

• 대한본초학회지
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• 제34권3호
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• pp.37-44
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• 2019

Objectives : Acne is a common disease that affects more than 70% of adolescents. Acne patients have a poor quality of life compared to patients with other skin diseases. We tried to demonstrate the effectiveness of acne treatment using cleansing soap which is easily used in daily life. Methods : We selected 20 students with acne symptoms on their facial skin. We made herbal Cp (Cold process) soaps using Seosiokyongsan, Kyungohkgo, Hwangryunhaedoktang and Baeksoooh and distributed them to experiment participants. We let them wash their face in the morning and evening for 6 weeks using herbal Cp soap. Prior to the experiment, their skin condition was checked and assessed using A-ONE Smart One-Click Automatic Facial Diagnosis System three times at 3-week intervals. Acne status was classified into 6 stages according to KAGS and acne status was also measured 3 times in total. After the experiment, the changes of skin were analyzed through facial analysis test. Results : Based on the KAGS classification, the condition of acne has improved as a whole. The state of moisture was gradually increased and the state of skin oil was significantly decreased after 6 weeks of using soap compared to before using soap. Conclusions : Cp soaps made from four kinds of herbal medicine are believed to improve the condition of acne by increasing the moisture of the facial skin and decreasing the skin oil content.

• Applied Microscopy
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• 제40권4호
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• pp.245-251
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• 2010

본 연구는 15% 글리콜산과 30% 글리콜산이 포함된 각각의 필링제를 털이 제거된 mice 등쪽 피부에 처리하여 시술 전후의 피부 수분량, 유분량 및 pH를 Cutometer로 분석하였고 표피 각 질의 변화에 대한 미세구조를 더마스코프와 주사전자현미경을 사용하여 관찰하였다. 15% 글리콜산을 처리한 실험군 I과 30% 글리콜산을 처리한 실험군 II에서 피부의 수분량, 유분량 및 pH의 변화는 필링제의 농도가 높을수록 감소하는 것으로 확인되었다. Mice 피부의 표면을 더마스코프로 관찰한 결과 정상 대조군의 피부는 전반적으로 투명한 상태로 표피에서 각질이 분리되어 있거나 탈락되기 직전의 상태로 나타났다. 15% 글리콜산으로 처리한 mice 피부 표면의 각질은 많이 제거된 상태로 관찰되었으며 30% 글리콜산으로 처리한 mice 피부 표면은 매끄러운 상태로 선홍색을 띠고 있었다. Mice 피부 각질층을 인위적으로 탈락시켜서 주사전자현미경으로 관찰한 결과 정상 대조군의 각질층 표면은 각화세포 막의 함입에 의해서 불규칙하였다. 15% 글리콜산으로 처리한 mice 피부의 각질층 표면은 비교적 매끄러웠으며 노출된 각화세포의 세포질 표면은 약간의 주름이 형성되어 있었다. 30% 글리콜산으로 처리한 mice 피부에서 각질층 표면은 매끄러웠으며 이들 표면은 주름이 형성되어 있지 않았다.

• 한국응용과학기술학회지
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• 제37권6호
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• pp.1773-1778
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• 2020

본 연구는 히알루론산을 함유한 온도 감응성 하이드로겔 마스크 팩을 이용하여 피부개선효과 및 사용감을 평가하였다. 임상시험 기준에 적합한 30~40대 여성 10명의 시험대상자에게 4주간 주3회 하이드로겔 마스크 팩을 적용하고 수분, 유분, 피부 톤을 측정하였다. 그 결과 피부 수분량은 1회 사용 후 11.3%, 4주 사용 후 58.36% 증가하였고, 유분량은 1회 사용 후 67% 증가 후 일정 값을 유지하고 더 이상 증가하지 않았다. 피부 톤은 4주 사용 후 좌우 뺨 모두 피부 톤이 밝아졌고 사용감 및 체감효능 평가는 87.6% 이상의 긍정적인 답변을 보였다. 이상의 결과로 하이드로겔 마스크 팩은 피부개선에 도움을 주는 우수한 소재로 판단된다.

• 대한본초학회지
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• 제38권2호
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• pp.35-41
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• 2023

Objectives : Washing face is the first step in skin beauty and health. I wanted to study the cleansing effect by using Placenta cp (cold process) soap. The skin condition is greatly influenced by the external environment such as lifestyle, drinking, smoking, and stress etc. I tried to measure the skin change state without environmental factors. Methods : In order to examine the effect before and after washing face under the same conditions, the same water and towel were used in the same place. The skin test was performed before and 10 minutes after washing. As a control group, a case of washing with water and foam cleanser. I compared and analyzed three cases: water washing, F/C (foam cleanser) washing, and Placenta cp soap washing. Results : In the case of water washing, it was significantly reduced in pores and increased in facial temperature. In the case of F/C washing, the facial temperature was significantly increased, but the decrease in moisture. In the case of washing with Placenta cp soap, significant reductions in T-zone and U-zone oil content, reduction in pore size, and increase in facial skin temperature were observed. Conclusion : In the case of Placenta cp soap, it is thought to be suitable for oily skin type, because of significant decrease in T-zone and U-zone oil content. It is thought to have the effect of increasing blood circulation in the facial skin and to reduce pores for oily skin types.

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.124-131
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• 2008

Objectives : The aim of this study was conducted to test dry infant skin by external application with herbs in cosmetics. Methods : A total of 25 infants who visited Daegu Hanny Oriental Medical Center from March 5th, 2008 to May 18th, 2008 were included in this study. In this study, they were treated with the cosmetic products(body wash, rotion, cream) containing herbs. For 4 weaks skin moisture content was measured by corneometer ClVI825. And satisfaction after using body wash, rotion, cream was checked. Results : There were no significant differences on sex and age. Change of skin moisture content between before treatment and after treatment (2, 4 weeks) showed significant changes(p<0.05). Satisfaction after using body wash, rotion, cream was near good. Conclusions : Considering the above results, we have concluded that cosmetics containing herbs have the remarkable effect on infant skin mosturizing.

• 대한지역사회영양학회지
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• 제11권1호
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• pp.63-71
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• 2006

The objective of this study was to evaluate whether nutrient intakes and serum biochemical indices are associated with the skin condition of humans. Anthropometric data, skin surface hydration, ceramide content, dietary intake of nutrients and serum lipids (total cholesterol, HDL-, LDL-cholesterol, TG, MDA: malondialdehyde, TAS: total antioxidant status) were obtained from 36 healthy young women. Subjects were classified into 2 groups {LM: Low Moisture Group (n = 20) , HM: High Moisture Group (n = 16)} by forehead skin hydration. The results of this study were as follows: The average age, BMI, total body water, LBM, body fat$\%$, WHR, forehead hydration, ceramide content were 20.2 yrs, 20.7, 28.81, 39.2 kg, $28.0\%$, 0.8, $44.3\%$, and 1.05 $\mu$g/$\mu$g protein, repectively. The intakes of SF A (saturated fatty acid) , MUFA (monounsaturated fatty acid) in the HM group were significantly higher (p < 0.05) than in the LM group, but zinc intakes in the LM group were higher than in the HM group. Serum levels of TAS in the LM group (1.27 mmol/l) were significantly higher (p < 0.05) than that of in the HM group (1.20 mmol/l). Whereas other lipid levels were not significantly different, intakes of vitamin $B_{6}$ and folate showed significant positive correlation with the forehead hydration (r = 0.447, r = 0.377). Intakes of calcium and phosphorus showed significant negative correlation with forearm ceramide content (r = -0.496, r = -0.485). Several associations between nutrient intakes and skin conditions were observed, indicating that changes in baseline nutritional status may affect skin health.

• 한국융합학회논문지
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• 제10권3호
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• pp.237-242
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• 2019

본 연구는 파라핀 왁스 마스크팩의 피부개선 효과를 확인하기 위한 연구이다. 연구 대상은 20대 성인 남녀 13명을 대상으로 시행하였다. 연구는 4주간 8회 대상자에게 파라핀왁스 마스크팩을 적용하였다. 파라핀왁스 마스크팩의 피부개선 효과를 확인하기 위해 피부 유 수분도, 피부 표면온도, 피부 부드러움 정도 및 피부상태 주관적 만족도를 측정하였다. 파라핀 왁스 마스크팩 도포 후 피부의 유수분도, 피부표면 온도가 상승하였으며, 피부 부드러움 정도와 유 수분도 및 피부톤의 내용을 포함한 피부 주관적 만족도도 개선되었음을 확인하였다. 따라서 본 연구결과 파라핀왁스 마스크팩은 피부개선에 효과가 있음을 확인하였고, 피부관리를 위한 피부미용기기 개발에 유용성과 가치가 있을 것이다.

• 대한본초학회지
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• 제39권3호
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• pp.1-9
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• 2024

Objectives : The purpose of this study was to find out the efficacy of placenta on the skin by comparing the difference effect between only MTS (microneedle therapy system) and the placenta extract application after MTS treatment. Methods : The present author performed once a week and total 4 times of MTS treatment. The treatment time took about 5~10 minutes and the depth of the needle was adjusted according to the participant's skin condition. One week after each treatment, the change of skin condition was measured. Two weeks after the end of the clinical trial, the skin condition was checked again. Results : In the case of moisture and elasticity, significant increases were observed in both the experimental and control groups. In the experimental group, skin temperature significantly decreased one week after the second treatment, and pore size significantly increased one week after the third treatment. In the case of skin tone, there was a significant temporary decrease after the first treatment in the control group, and in the experimental group, the skin tone showed a total decrease. Conclusion : When placenta extract was applied after MTS, skin temperature decreased and pores enlarged in the second and third treatments, and side effects such as rash and itchiness appeared. The final result showed a significant increase in skin moisture and elasticity. When animal-based ingredients containing high fat content are applied to the skin, the effect on the skin is good, but hypersensitivity reactions may occur, so use them with caution.