• Toxicological Research
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• 제19권1호
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• pp.39-44
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• 2003

Two local irritation and skin sensitization studies of nonspecific immunostimulator, $BARODON^{\circledR}$ were carried out with New Zealand White rabbits and Hartley guinea pigs. In skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and there were no responses after treatment for 24 or 72 hours and the Primary irritation index (P.1.1.) was '0'. And, in the eye irritation test, there were chemosis in some of rabbits. One of 3 rabbits in washing group was detected chemosis after 24 and 72 h following treatment and 2 of 6 rabbits in non-washing group were detected chemosis after 24h and 7 days following treatment. Therefore, total score is '4' after 24 h and '2' after 72 h following treatment by conforming article "some blood vessel are clearly hyperemic" . However evaluation value is non-irritant because M.O.I. (Mean ocular irritation index) score is below during the all experimental period and no significance through individuals and exposure time. In skin sensitization, the score of skin reaction was graded 1 with 0% sensitization rate. Taken together, these results indicate that $BARODON^{\circledR}$ may be non-irritant material. material.

• 한국조리학회지
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• 제19권3호
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• pp.33-45
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• 2013

본 연구는 커피 실버스킨을 밀가루 중량에 대해서 0%, 3%, 5%, 7%로 대체 첨가하여 옐로우 레이어 케이크의 특성을 알아보았다. 반죽의 비중은 실버스킨 첨가량이 증가할수록 유의적으로 증가하였으며, 비용적은 실버스킨 함량이 많을수록 유의적으로 감소하였다. 부피지수는 실버스킨 첨가량이 증가함에 따라 유의적으로 감소하였으며, 대칭지수와 균일지수는 유의적인 차이가 없었다. 대조구의 부피지수, 대칭지수와 균일지수가 가장 높게 측정되었다. 조직감에서는 대조구가 가장 낮은 경도와 가장 높은 탄력성을 나타내었다. 시간이 경과함에 따라 실버스킨 첨가량이 많을수록 경도는 높아졌으나 탄력성은 낮아졌다. 관능검사 결과, 조직감을 제외한 모든 항목에서 대조구에 비해 실험군의 수치가 높았으며, 그 중에서 향과 맛은 SS5가 가장 높았고 외관과 전체적인 기호도는 SS3이 가장 높았다.

• 대한한방소아과학회지
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• 제20권3호
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• pp.129-141
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• 2006

Objectives : The purpose of this study is to determine clinical efficacy of herbal medicine by evaluating SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis Methods : Subjects are divided into two groups : Group 1(non-differentiation children treated with Saenghyeoryunbueom) and group 2(differentiation children treated with either pyungwisan, onchungum or gamitongsungsan). We determine SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis before and after taking each of herbal treatment for 12 weeks. Results : After herbal prescription for 12 weeks, A SCORAD index of both group 1 and group 2 was decreased. However, the total level of ceramides in group 1 and group 2 was not altered after 12 weeks. When the correlation between the alteration of SCORAD index and ceramides levels was determined, the SCORAD index in group 1 was inversely correlated with the total level of ceramides(r=-0.994, p=0.006) In contrast, the alteration of SCORAD index in group 2 was not correlated with ceramide levels. Conclusions : The clinical efficacy of Saenghyeoryunbueom for non-differentiation children with atopic dermatitis is paralleled with the increased level of ceramides in skin. The clinical efficacy of pyungwisan, onchungum or gamitongsungsan for differentiation children with atopic dermatitis is not correlated with ceramide level in skin.

• 동의신경정신과학회지
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• 제20권3호
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• pp.121-132
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• 2009

Objectives : This study was done to investigate the relativity of thermography to HRV(heart rate variability) in Sasang constitutional groups. Methods : We investigated 87 healthy workers consisted of 10 Taeumin, 47 Soeumin, 30 Soyangin. After diagnosing the Sasang constitution by QSCCII(Questionnaire for the Sasang Constitutional Classification), we ana lysed their HRV -time domain and frequency domain and also checked their thermography in April 2009. Results & Conclusions : Analysing the thermography, The whole skin temperature was showed equaly in many Taeumin, the face, Upper burner skin temperature was showed high in many Soeumin, and the abdomen skin temperature was showed low in many Soyangin. The relativity of the sympathetic index to skin temperature was high in Taeumin. The higher sympathetic index, the higher Upper burner skin temperature in Taeumin, the higer most of the skin temperature in Soyangin, lower the whole skin temperature in Soeumin.

• Journal of Information Processing Systems
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• 제9권1호
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• pp.141-156
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• 2013

In this paper we propose a method to detect human faces in color images. Many existing systems use a window-based classifier that scans the entire image for the presence of the human face and such systems suffers from scale variation, pose variation, illumination changes, etc. Here, we propose a lighting insensitive face detection method based upon the edge and skin tone information of the input color image. First, image enhancement is performed, especially if the image is acquired from an unconstrained illumination condition. Next, skin segmentation in YCbCr and RGB space is conducted. The result of skin segmentation is refined using the skin tone percentage index method. The edges of the input image are combined with the skin tone image to separate all non-face regions from candidate faces. Candidate verification using primitive shape features of the face is applied to decide which of the candidate regions corresponds to a face. The advantage of the proposed method is that it can detect faces that are of different sizes, in different poses, and that are making different expressions under unconstrained illumination conditions.

• 대한화장품학회지
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• 제49권4호
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• pp.349-354
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• 2023

자외선 차단제는 자외선을 차단 및 산란시켜 자외선으로부터 보호하는 제품으로 이제 화장품을 넘어서 생활필수품으로 자리 잡고 있다. 자외선 차단제 바르기는 일반적이면서도 손쉬운 자외선에 의한 피부 손상 예방법이다. 이러한 중요성에 따라 자외선 차단제 평가시험은 1978 년 Fod and Drug Administration (FDA)에서 규정을 마련한 이후, 현재는 International Organization For Standardization (ISO)에서 표준화된 방법까지 발전되었다. 더불어 물이나 땀 등 신체활동에 의한 자외선 차단제 손실을 평가하기 위해 국내 식약처와 ISO에서 내수성 자외선 차단지수 평가시험을 제정하고 있다. 그러나 지금까지의 내수성 자외선 차단지수 평가시험은 주로 일반 물을 사용한 시험 방법에 국한되어 있으며, 해변에서의 레저, 스포츠 및 여가활동에 의한 해수의 영향을 고려한 시험 방법은 아직 정립되지 않았다. 본 연구는 기존의 내수성 자외선 차단지수 평가시험 방법 가이드라인을 기반으로 일반 물, 인공 해수(소금물) 및 자연 해수(바닷물)에서의 내수성 자외선 차단지수를 비교하여 해양 레저, 스포츠 및 여가활동 등과 같은 실제 상황에서의 자외선 차단지수를 평가할 수 있는 방법에 대하여 조사하였다. 이러한 결과를 통해 일반 물과 인공 해수 및 자연 해수에서의 내수성 자외선 차단지수 평가시험의 차이를 비교하여 자연 해수를 이용한 내수성 자외선 차단지수 평가시험 방법을 제시할 수 있었다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.195-195
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• 2002

In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)

• 한국정보통신학회논문지
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• 제26권4호
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• pp.533-540
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• 2022

전문의는 피부암을 조기에 발견하기 위해 피부경을 사용하여 진단하지만 다양한 형태로 인해 피부 병변을 판단하는 데 어려움이 있다. 최근 높은 성능을 보인 딥러닝을 이용한 피부 병변 분할 방법이 제안되었지만 피부와 피부 병변 경계가 명확하지 않아서 피부 병변을 분할하는 데 문제점이 있었다. 이러한 문제를 개선하기 위해 제안하는 방법은 효과적으로 피부 병변을 분할하기 위해 트랜스포머 블록을 구성하였으며, 네트워크의 각 계층마다 윤곽선 디코더를 구성하여 피부 병변을 자세히 분할하였다. 실험 결과, 제안하는 방법은 기존의 방법보다 Dice coefficient 기준 0.041 ~ 0.071, Jaccard Index 기준 0.067 ~ 0.112의 성능 향상을 보인다.

• 한국한의학연구원논문집
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• 제16권3호
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• pp.107-113
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• 2010

Objective : Active treatment for a skin condition has produced a substantial change in the history of allergic contact or wound induced dermatitis. The frequency of opportunistic contacts and allergen-related dermatitis has increased, though new skin treatments have developed. Especially, there has been a interest in the korean herbal bathing. This study was performed to investigate the effects of the korean herbal bathing candidates on skin lesions in mice model. These candidates are Korea's representative herbs on skin lesions. Method : ICR mice were divided into five groups : naive, control, experimental group A and B and C. Control and experimental groups induced skin lesions by DNFB and TMA. Each experimental group was pasted with corresponding korean herbal bathing candidates on skin lesions. Result : Significant improvements in skin wound index, epidermal thickness associated with skin lesions were seen with the korean herbal bathing candidates. Conclusion : These results suggest that the korean herbal bathing candidates could be at least as effective as steroid, anti-histamine for the treatment of skin lesions.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.138-138
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• 2002

In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary and cumulative skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)