• Biomolecules & Therapeutics
• /
• 제21권5호
• /
• pp.343-348
• /
• 2013

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.

• International Journal of Aerospace System Engineering
• /
• 제6권1호
• /
• pp.1-7
• /
• 2019

In the present study, structural safety and stability on the main wing and tail planes of the 1.2 ton WIG(Wing in Ground Effect) flight vehicle, which will be a high speed maritime transportation system for the next generation, was performed. The carbon-epoxy composite material was used in design of wing structure. The skin-spar with skin-stressed structural type was adopted for improvement of lightness and structural stability. As a design procedure for this study, the design load was estimated with maximum flight load. From static strength analysis results using finite element method of the commercial codes. From the stress analysis results of the main wing, it was confirmed that the upper skin structure between the second rib and the third rib was unstable for the buckling load. Therefore in order to solve this problem, three stiffeners at the buckled region were added. After design modification, even though the weight of the wing was a little bit heavier than the target weight, the structural safety and stability was satisfied for design requirements.

• 한국컴퓨터산업학회논문지
• /
• 제7권5호
• /
• pp.563-572
• /
• 2006

피부를 통한 최적의 광투과 치료방식은 국소병변에 직접적으로 광을 조사할 수 있는 장점을 가지나 피부의 가장 바깥 부분인 각질부의 다양한 피부색상으로 인해 광전달 능력에 차이가 있고 다양한 환자에 따라 치료가 부적절 할 수가 있다. 본 연구에서는 피부 임피이던스에 따른 광조사 방식에 따른 일정한 측정을 하기 위해 피부 임피이던스 방식과 피부영역 추출을 통해 색상정보와 차영상을 이용한 방법 즉, 색상정보를 이용한 HIS와 YIQ의 성분이 가장 보편적인데 실험에서는 피부색상에 해당하는 각 색상성분을 탐색한 다음, 색상정보를 이용한 결과로 환자의 피부모델 영역검출에 따라 결과를 영상정보를 통해 개개인의 피부모델을 자동적으로 생성, 측정하여 피부색깔, 에너지, 파장, 폭, 조사시간, 펄스지연 등을 추출하여 원하는 최적의 모델과 특성을 조사하며, 피부 임피이던스에 따른 병변치료 펄스모델링의 기준을 구하였고, 피부부하에 따른 최적의 광조사 펄스모델링 시스템을 설계하여 제작하여, 피부칼라에 따른 적절한 치료펄스 데이터베이스를 구축하였다.

• 디자인융복합연구
• /
• 제14권5호
• /
• pp.87-102
• /
• 2015

오늘날 디지털 미디어 환경은 개인화, 상호작용, 키네시스로 특정 지어진 새로운 디지털 미디어 패러다임으로 전환되고 있다. 이러한 변화에 따라 도시 환경에서 중요한 역할을 수행하는 미디어 스킨에도 변화가 요구되고 있다. 따라서 본 연구는 디지털 미디어 패러다임 전환에 따라 새로운 개념의 사용자 참여형 미디어 스킨 모듈을 제안하는 것을 목적으로 한다. 본 연구를 위해 생물학적 패러다임에 대한 이론적 고찰을 통해 개인화, 상호작용, 키네시스로 대표되는 새로운 디지털 미디어 패러다임의 특성으로부터 주요 세부 요소를 도출했다. 도출된 요소를 기반으로 미디어 스킨의 한계점을 파악하고, 이를 극복할 수 있는 새로운 디지털 미디어 패러다임 기반의 미디어 스킨을 제안했다. 본 연구에서 제안하는 미디어 스킨은 모듈 조합형 미디어 스킨으로 사용자가 쉽고 빠르게 다양한 형태의 미디어 스킨을 직접 조형할 수 있고, 지능화된 모듈 간의 상호작용을 통해 다양한 콘텐츠를 창출할 수 있다. 본 연구는 향후 미디어 스킨 개발을 위한 지침으로 공헌할 것으로 기대된다.

• 한국실내디자인학회논문집
• /
• 제24권4호
• /
• pp.91-98
• /
• 2015

Double skin façade is known that several features affected the building energy and daylighting performance. That is why the envelope is able to consist of all architectural materials such as glass, aluminum, wood and insulation for vision of residents and workers in buildings. Its specifications is very diverse according to the building designers and building owners. In recent times, visual environment became a major focus and resulted in the development of cutting edge engineering of diverse glazing systems and shading devices by growing interests of friendly environment. Thus this research has evaluated the fluctuations of interior lighting and atmospheric conditions based on double skin facade systems. Especially in terms of daylighting environment as dependent on solar variations, this research provides quantitative analysis of interior lighting conditions and how it affects the living conditions as well as improve the design of interior spaces.

• 한국복합재료학회:학술대회논문집
• /
• 한국복합재료학회 2005년도 추계학술발표대회 논문집
• /
• pp.179-184
• /
• 2005

In the present study, conceptual design of the main wing for 20 seats WIG{wing in Ground Effect) flight vehicle, which will be a high speed maritime transportation system for the next generation, was performed. The high stiffness and strength Carbon-Epoxy material was used for the major structure and the skin-spar with a foam sandwich structural type was adopted for improvement of lightness and structural stability. As a design procedure for this study, firstly the design load was estimated with maximum flight load, and then flanges of the front and the rear spar from major bending load and the skin structure and the webs of the spars were preliminarily sized using the netting rules and the rule of mixture. In order to investigate the structural safety and stability, stress analysis was performed by Finite Element Codes such as NASTRAN/PA TRAN[6] and NISA II [7]. From the stress analysis results, it was confirmed that the upper skin structure between the front spar and rear spar was very unstable for the buckling. Therefore in order to solve this problem, a middle spar and the foam sandwich structure at the upper skin and the web were added. After design modification, even thought the designed wing weight was a little bit heavier than the target wing weight, the structural safety and stability of the final design feature was confirmed. Moreover, in order to fix the wing structure at the fuselage, the insert bolt type structure with six high strength bolts was adopted for easy assembly and removal.

• 한국지반공학회:학술대회논문집
• /
• 한국지반공학회 2009년도 세계 도시지반공학 심포지엄
• /
• pp.923-932
• /
• 2009

Generally most of pile foundations are constructed with group pile rather than single pile. The study on efficiency and bearing capacity which are major elements for rational design of this group pile has been actively progressed, whereas there are truly only a few studies of negative skin friction working on group pile due to the consolidation of ground. The purpose of this study is to determine, among the elements of negative skin friction applied to pile, the occurrence modality of negative skin friction at center, side, and corner of $3{\times}3$ group pile using model test and, based on those observations, to propose the effective design direction of group pile.

• 한국생산제조학회지
• /
• 제24권5호
• /
• pp.583-587
• /
• 2015

In this study, a half-duplex mutual communication device via human skin was developed. Frequency-shift keying (FSK) digital modulation and demodulation control were used to transmit and receive data. Data communication through the human body is an effective communication technique and has high-grade security characteristics. In addition, making contact is a natural instinct of humans. Transmitting data through the human body is currently a highly conspicuous technology, because recently a lot of commercial sensors for humans have been developed. A body area network (BAN) can be easily constructed by this communication method on human skin. In this study, a half-duplex FSK mutual communication device was developed using a commercial FSK modulator and demodulator. A special control switching circuit and communication sequence were developed for mutual communication through human skin.

• 산경연구논집
• /
• 제14권4호
• /
• pp.33-46
• /
• 2023

Purpose: During the coronavirus disease-19 (COVID-19) outbreak, mask-wearing is required to protect against and limit the spread of infection, but it can directly affect skin problems. Change in skin condition might be related to mental health. This study explored the association between skin conditions and behavior of skin cares and stress levels during the Covid-19pandemics. Research design, data and methodology: A survey was conducted on 516 adults who were aware of damaged skin due to continuous wearing of masks for a long time during the COVID-19 Pandemic. The study included 164 men and 352 women in the Republic of Korea. Results: Skin conditions and behavior of skin cares associated with stress perceptions. A multiple linear regression model was used adjusting for potential confounder. Conclusion: Since management so far in the COVID-19 Pandemic can cause skin concerns and change the original skin type, it is necessary to redefine and improve the use of skin care, face-washing methods, and functional cosmetics. People with high and low interest in skin type recognition and management were evenly identified, and it was confirmed that stress awareness decreases as awareness of skin care attitude increases.

• Structural Engineering and Mechanics
• /
• 제48권1호
• /
• pp.93-102
• /
• 2013

An optimization work was developed in this work to provide design information for sandwich beam in civil engineering applications. This research is motivated by the wide-range applications of sandwich structures such as; slab, beam, girder, and railway sleeper. The design of a sandwich beam was conducted by using analytical and numerical optimization. Both analytical and numerical procedures consider the optimum design with structure mass objective minimization. Allowable deflection was considered as design constraints. It was found that the optimized core to the skins mass ratio is affected by the skin to core density and elastic modulus ratios. Finally, the optimum core to skin mass ratio cannot be constant for different skin and core materials.